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Protein

Putative multidrug resistance protein

Gene

Os02g0190300

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi394 – 401ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1032 – 1039ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-159418. Recycling of bile acids and salts.
R-OSA-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-OSA-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative multidrug resistance protein
Alternative name(s):
P-glycoprotein
Gene namesi
Ordered Locus Names:Os02g0190300, LOC_Os02g09720
ORF Names:OSJNBb0031B09.19
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei83 – 103HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei158 – 180HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei184 – 206HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei264 – 284HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei296 – 316HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei679 – 699HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei717 – 737HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei797 – 817HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei821 – 841HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei897 – 917HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002476271 – 1245Putative multidrug resistance proteinAdd BLAST1245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi771N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6YUU5.
PRIDEiQ6YUU5.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os02g09720.1.

Structurei

3D structure databases

ProteinModelPortaliQ6YUU5.
SMRiQ6YUU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 324ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST290
Domaini359 – 595ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini674 – 962ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST289
Domaini999 – 1233ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ6YUU5.
KOiK05658.
OMAiMCADGKI.
OrthoDBiEOG093600PV.

Family and domain databases

Gene3Di1.20.1560.10. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6YUU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGDGGAGK AKARPVFSSF MTVFMHADAA DVALMVLGLL GAMGDGISTP
60 70 80 90 100
VMLLITSRIF NDLGSGADIV KEFSSKVNVN ARNLVFLAAA SWVMAFLEGY
110 120 130 140 150
CWARTAERQA SRMRARYLRA VLRQDVEYFD LKKGSTAEVI TSVSNDSLVV
160 170 180 190 200
QDVLSEKVPN FVMNAAMFAG SYAVGFALLW RLTLVALPSV VLLIIPGFMY
210 220 230 240 250
GRILVGLARR IREQYTRPGA IAEQAVSSAR TVYSFVAERT TMAQFSAALE
260 270 280 290 300
ESARLGLKQG LAKGIAVGSN GITFAIWAFN VWYGSRLVMY HGYQGGTVFA
310 320 330 340 350
VSAAIVVGGL ALGSGLSNVK YFSEASSAAE RILEVIRRVP KIDSESDTGE
360 370 380 390 400
ELANVTGEVE FRNVEFCYPS RPESPIFVSF NLRVPAGRTV ALVGGSGSGK
410 420 430 440 450
STVIALLERF YDPSAGEVMV DGVDIRRLRL KWLRAQMGLV SQEPALFATS
460 470 480 490 500
IRENILFGKE EATAEEVVAA AKAANAHNFI SQLPQGYDTQ VGERGVQMSG
510 520 530 540 550
GQKQRIAIAR AILKSPKILL LDEATSALDT ESERVVQEAL DLASMGRTTI
560 570 580 590 600
VIAHRLSTIR NADIIAVMQS GEVKELGPHD ELIANDNGLY SSLVRLQQTR
610 620 630 640 650
DSNEIDEIGV TGSTSAVGQS SSHSMSRRFS AASRSSSARS LGDARDDDNT
660 670 680 690 700
EKPKLPVPSF RRLLMLNAPE WKQALMGSFS AVVFGGIQPA YAYAMGSMIS
710 720 730 740 750
VYFLTDHAEI KDKTRTYALI FVGLAVLSFL INIGQHYNFG AMGEYLTKRI
760 770 780 790 800
REQMLAKILT FEIGWFDRDE NSSGAICSQL AKDANVVRSL VGDRMALVIQ
810 820 830 840 850
TISAVLIACT MGLVIAWRLA LVMIAVQPLI IVCFYARRVL LKSMSKKSIH
860 870 880 890 900
AQAESSKLAA EAVSNLRTIT AFSSQERILR LFEQSQDGPR KESIRQSWFA
910 920 930 940 950
GLGLGTSMSL MTCTWALDFW YGGRLMAEHH ISAKELFQTF MILVSTGRVI
960 970 980 990 1000
ADAGSMTTDL AKGADAVASV FAVLDRETEI DPDNPQGYKP EKLKGEVDIR
1010 1020 1030 1040 1050
GVDFAYPSRP DVIIFKGFTL SIQPGKSTAL VGQSGSGKST IIGLIERFYD
1060 1070 1080 1090 1100
PIRGSVKIDG RDIKAYNLRA LRRHIGLVSQ EPTLFAGTIR ENIVYGTETA
1110 1120 1130 1140 1150
SEAEIEDAAR SANAHDFISN LKDGYDTWCG ERGVQLSGGQ KQRIAIARAI
1160 1170 1180 1190 1200
LKNPAILLLD EATSALDSQS EKVVQEALDR VMIGRTSVVV AHRLSTIQNC
1210 1220 1230 1240
DLITVLEKGT VVEKGTHASL MAKGLSGTYF SLVNLQQGGN QQVQH
Length:1,245
Mass (Da):135,053
Last modified:July 5, 2004 - v1
Checksum:iF1EDE693F68665C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005849 Genomic DNA. Translation: BAD16475.1.
AP014958 Genomic DNA. Translation: BAS77393.1.
RefSeqiXP_015625016.1. XM_015769530.1.
UniGeneiOs.79819.

Genome annotation databases

EnsemblPlantsiOS02T0190300-01; OS02T0190300-01; OS02G0190300.
GeneIDi4328570.
GrameneiOS02T0190300-01; OS02T0190300-01; OS02G0190300.
KEGGiosa:4328570.

Similar proteinsi

Entry informationi

Entry nameiMDR_ORYSJ
AccessioniPrimary (citable) accession number: Q6YUU5
Secondary accession number(s): A0A0N7KEU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families