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Protein

Putative multidrug resistance protein

Gene

Os02g0190300

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi394 – 4018ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1032 – 10398ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative multidrug resistance protein
Alternative name(s):
P-glycoprotein
Gene namesi
Ordered Locus Names:Os02g0190300, LOC_Os02g09720
ORF Names:OSJNBb0031B09.19
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 2

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei83 – 10321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei158 – 18023HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei184 – 20623HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei264 – 28421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei296 – 31621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei679 – 69921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei717 – 73721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei797 – 81721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei821 – 84121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei897 – 91721HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12451245Putative multidrug resistance proteinPRO_0000247627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence analysis
Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence analysis
Glycosylationi771 – 7711N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6YUU5.
PRIDEiQ6YUU5.

Expressioni

Gene expression databases

ExpressionAtlasiQ6YUU5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os02g09720.1.

Structurei

3D structure databases

ProteinModelPortaliQ6YUU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 324290ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini359 – 595237ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini674 – 962289ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini999 – 1233235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ6YUU5.
OMAiMSSTNTH.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6YUU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGDGGAGK AKARPVFSSF MTVFMHADAA DVALMVLGLL GAMGDGISTP
60 70 80 90 100
VMLLITSRIF NDLGSGADIV KEFSSKVNVN ARNLVFLAAA SWVMAFLEGY
110 120 130 140 150
CWARTAERQA SRMRARYLRA VLRQDVEYFD LKKGSTAEVI TSVSNDSLVV
160 170 180 190 200
QDVLSEKVPN FVMNAAMFAG SYAVGFALLW RLTLVALPSV VLLIIPGFMY
210 220 230 240 250
GRILVGLARR IREQYTRPGA IAEQAVSSAR TVYSFVAERT TMAQFSAALE
260 270 280 290 300
ESARLGLKQG LAKGIAVGSN GITFAIWAFN VWYGSRLVMY HGYQGGTVFA
310 320 330 340 350
VSAAIVVGGL ALGSGLSNVK YFSEASSAAE RILEVIRRVP KIDSESDTGE
360 370 380 390 400
ELANVTGEVE FRNVEFCYPS RPESPIFVSF NLRVPAGRTV ALVGGSGSGK
410 420 430 440 450
STVIALLERF YDPSAGEVMV DGVDIRRLRL KWLRAQMGLV SQEPALFATS
460 470 480 490 500
IRENILFGKE EATAEEVVAA AKAANAHNFI SQLPQGYDTQ VGERGVQMSG
510 520 530 540 550
GQKQRIAIAR AILKSPKILL LDEATSALDT ESERVVQEAL DLASMGRTTI
560 570 580 590 600
VIAHRLSTIR NADIIAVMQS GEVKELGPHD ELIANDNGLY SSLVRLQQTR
610 620 630 640 650
DSNEIDEIGV TGSTSAVGQS SSHSMSRRFS AASRSSSARS LGDARDDDNT
660 670 680 690 700
EKPKLPVPSF RRLLMLNAPE WKQALMGSFS AVVFGGIQPA YAYAMGSMIS
710 720 730 740 750
VYFLTDHAEI KDKTRTYALI FVGLAVLSFL INIGQHYNFG AMGEYLTKRI
760 770 780 790 800
REQMLAKILT FEIGWFDRDE NSSGAICSQL AKDANVVRSL VGDRMALVIQ
810 820 830 840 850
TISAVLIACT MGLVIAWRLA LVMIAVQPLI IVCFYARRVL LKSMSKKSIH
860 870 880 890 900
AQAESSKLAA EAVSNLRTIT AFSSQERILR LFEQSQDGPR KESIRQSWFA
910 920 930 940 950
GLGLGTSMSL MTCTWALDFW YGGRLMAEHH ISAKELFQTF MILVSTGRVI
960 970 980 990 1000
ADAGSMTTDL AKGADAVASV FAVLDRETEI DPDNPQGYKP EKLKGEVDIR
1010 1020 1030 1040 1050
GVDFAYPSRP DVIIFKGFTL SIQPGKSTAL VGQSGSGKST IIGLIERFYD
1060 1070 1080 1090 1100
PIRGSVKIDG RDIKAYNLRA LRRHIGLVSQ EPTLFAGTIR ENIVYGTETA
1110 1120 1130 1140 1150
SEAEIEDAAR SANAHDFISN LKDGYDTWCG ERGVQLSGGQ KQRIAIARAI
1160 1170 1180 1190 1200
LKNPAILLLD EATSALDSQS EKVVQEALDR VMIGRTSVVV AHRLSTIQNC
1210 1220 1230 1240
DLITVLEKGT VVEKGTHASL MAKGLSGTYF SLVNLQQGGN QQVQH
Length:1,245
Mass (Da):135,053
Last modified:July 5, 2004 - v1
Checksum:iF1EDE693F68665C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005849 Genomic DNA. Translation: BAD16475.1.
AP014958 Genomic DNA. Translation: BAS77393.1.
RefSeqiXP_015625016.1. XM_015769530.1.
UniGeneiOs.79819.

Genome annotation databases

EnsemblPlantsiOS02T0190300-01; OS02T0190300-01; OS02G0190300.
GeneIDi4328570.
GrameneiOS02T0190300-01; OS02T0190300-01; OS02G0190300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005849 Genomic DNA. Translation: BAD16475.1.
AP014958 Genomic DNA. Translation: BAS77393.1.
RefSeqiXP_015625016.1. XM_015769530.1.
UniGeneiOs.79819.

3D structure databases

ProteinModelPortaliQ6YUU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os02g09720.1.

Proteomic databases

PaxDbiQ6YUU5.
PRIDEiQ6YUU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS02T0190300-01; OS02T0190300-01; OS02G0190300.
GeneIDi4328570.
GrameneiOS02T0190300-01; OS02T0190300-01; OS02G0190300.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ6YUU5.
OMAiMSSTNTH.

Gene expression databases

ExpressionAtlasiQ6YUU5. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiMDR_ORYSJ
AccessioniPrimary (citable) accession number: Q6YUU5
Secondary accession number(s): A0A0N7KEU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.