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Q6YT73

- GLO5_ORYSJ

UniProt

Q6YT73 - GLO5_ORYSJ

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Protein
Peroxisomal (S)-2-hydroxy-acid oxidase GLO5
Gene
GLO5, Os07g0152900, LOC_Os07g05820, B1364A02.33-1, OsJ_23125, OSJNBb0050B07.1-1
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Photorespiratory enzyme that can exert a strong regulation over photosynthesis, possibly through a feed-back inhibition on Rubisco activase. Not required for oxalate accumulation By similarity.

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

FMN By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251Substrate Reviewed prediction
Binding sitei107 – 1071FMN By similarity
Binding sitei128 – 1281FMN By similarity
Binding sitei130 – 1301Substrate By similarity
Binding sitei156 – 1561FMN By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei231 – 2311FMN By similarity
Active sitei255 – 2551Proton acceptor By similarity
Binding sitei258 – 2581Substrate Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi286 – 31025FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. glycolate oxidase activity Source: UniProtKB
  3. long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity Source: UniProtKB-EC
  4. medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
  5. very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. modulation by virus of host morphology or physiology Source: UniProtKB
  2. oxidative photosynthetic carbon pathway Source: UniProtKB-UniPathway
  3. photorespiration Source: UniProtKB
  4. regulation of photosynthesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolate pathway, Host-virus interaction, Photorespiration

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

UniPathwayiUPA00951; UER00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal (S)-2-hydroxy-acid oxidase GLO5 (EC:1.1.3.15)
Alternative name(s):
Glycolate oxidase 5
Short name:
GOX 5
Short name:
OsGLO5
Short chain alpha-hydroxy acid oxidase GLO5
Gene namesi
Name:GLO5
Ordered Locus Names:Os07g0152900, LOC_Os07g05820
ORF Names:B1364A02.33-1, OsJ_23125, OSJNBb0050B07.1-1
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 7

Organism-specific databases

GrameneiQ6YT73.

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Peroxisomal (S)-2-hydroxy-acid oxidase GLO5
PRO_0000403417Add
BLAST

Proteomic databases

PaxDbiQ6YT73.
PRIDEiQ6YT73.

Interactioni

Subunit structurei

Homotetramer or homooctamer. Interacts with rice dwarf virus (RDV) P8. This interaction promotes viral P8 relocation to virus factories peripheral to peroxisomes By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6YT73.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 360360FMN hydroxy acid dehydrogenase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi367 – 3693Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
KOiK11517.
OMAiYSSGANN.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6YT73-1 [UniParc]FASTAAdd to Basket

« Hide

MGEITNVTEY QAIAKQKLPK MIYDYYASGA EDEWTLQENR EAFARILFRP    50
RILIDVSKID MATTVLGFKI SMPIMIAPSA MQKMAHPDGE YATARAASAA 100
GTIMTLSSWA TSSVEEVAST GPGIRFFQLY VYKDRRVVEQ LVRRAERAGF 150
KAIALTVDTP RLGRREADIK NRFVLPPFLT LKNFEGLELG KMDQASDSGL 200
ASYVAGQIDR TLSWKDVKWL QTITTLPILV KGVITAEDTR LAVENGAAGI 250
IVSNHGARQL DYVPATISAL EEVVKAARGQ LPVFLDGGVR RGTDVFKALA 300
LGAAGVFIGR PVVFSLAAAG EAGVRNVLQM LRDEFELTMA LSGCTSLADI 350
TRNHVITEAD KLGVMPSRL 369
Length:369
Mass (Da):40,245
Last modified:July 5, 2004 - v1
Checksum:iFE652FD1115F2681
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti265 – 2651A → S in EEE66581. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006163 Genomic DNA. Translation: BAC84719.1.
AP005632 Genomic DNA. Translation: BAD31578.1.
AP008213 Genomic DNA. Translation: BAF20823.1.
CM000144 Genomic DNA. Translation: EEE66581.1.
AK062189 mRNA. Translation: BAG88242.1.
AK103933 mRNA. Translation: BAG96328.1.
RefSeqiNP_001058909.1. NM_001065444.1.
UniGeneiOs.51287.

Genome annotation databases

EnsemblPlantsiOS07T0152900-01; OS07T0152900-01; OS07G0152900.
OS07T0152900-03; OS07T0152900-03; OS07G0152900.
OS07T0152900-04; OS07T0152900-04; OS07G0152900.
GeneIDi4342420.
KEGGiosa:4342420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006163 Genomic DNA. Translation: BAC84719.1 .
AP005632 Genomic DNA. Translation: BAD31578.1 .
AP008213 Genomic DNA. Translation: BAF20823.1 .
CM000144 Genomic DNA. Translation: EEE66581.1 .
AK062189 mRNA. Translation: BAG88242.1 .
AK103933 mRNA. Translation: BAG96328.1 .
RefSeqi NP_001058909.1. NM_001065444.1.
UniGenei Os.51287.

3D structure databases

ProteinModelPortali Q6YT73.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q6YT73.
PRIDEi Q6YT73.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS07T0152900-01 ; OS07T0152900-01 ; OS07G0152900 .
OS07T0152900-03 ; OS07T0152900-03 ; OS07G0152900 .
OS07T0152900-04 ; OS07T0152900-04 ; OS07G0152900 .
GeneIDi 4342420.
KEGGi osa:4342420.

Organism-specific databases

Gramenei Q6YT73.

Phylogenomic databases

eggNOGi COG1304.
KOi K11517.
OMAi YSSGANN.

Enzyme and pathway databases

UniPathwayi UPA00951 ; UER00912 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  3. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.
  5. "Inducible antisense suppression of glycolate oxidase reveals its strong regulation over photosynthesis in rice."
    Xu H.-W., Zhang J., Zeng J., Jiang L., Liu E., Peng C., He Z.-H., Peng X.-X.
    J. Exp. Bot. 60:1799-1809(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiGLO5_ORYSJ
AccessioniPrimary (citable) accession number: Q6YT73
Secondary accession number(s): B9FVJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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