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Protein

Proteasome subunit alpha type-7-A

Gene

Os08g0548900

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-OSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-OSA-4641258. Degradation of DVL.
R-OSA-5632684. Hedgehog 'on' state.
R-OSA-5668541. TNFR2 non-canonical NF-kB pathway.
R-OSA-5689603. UCH proteinases.
R-OSA-5689880. Ub-specific processing proteases.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-7-A (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit D-1
20S proteasome subunit alpha-4-A
Gene namesi
Ordered Locus Names:Os08g0548900, LOC_Os08g43540
ORF Names:OJ1112_E06.28, OJ1479_B11.3, OsJ_000765, OsJ_00782Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003016641 – 249Proteasome subunit alpha type-7-AAdd BLAST249

Proteomic databases

PaxDbiQ6YT00.
PRIDEiQ6YT00.

Expressioni

Gene expression databases

GenevisibleiQ6YT00. OS.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

Protein-protein interaction databases

STRINGi39947.LOC_Os08g43540.1.

Structurei

3D structure databases

ProteinModelPortaliQ6YT00.
SMRiQ6YT00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0183. Eukaryota.
ENOG410XP21. LUCA.
InParanoidiQ6YT00.
KOiK02731.
OMAiEVAIMEN.
OrthoDBiEOG09360M33.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6YT00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARYDRAITV FSPDGHLFQV EYALEAVRKG NAAVGVRGTD TVVLGVEKKS
60 70 80 90 100
TPKLQDSRSM RKIASLDTHI ALACAGLKAD ARVLINRARV ECQSHRLTVE
110 120 130 140 150
DPVTVEYITR YIAGLQQKYT QSGGVRPFGL STLIVGFDPY TEKPALYQTD
160 170 180 190 200
PSGTFSAWKA NATGRNSNSM REFLEKNYKD TSGKETIKLA IRALLEVVES
210 220 230 240
GGKNIEIAVM THKDGLRELE EAEIDEYVAE IEAEKAAAEA AKKGAPKET
Length:249
Mass (Da):27,296
Last modified:July 5, 2004 - v1
Checksum:iD6F10209082B4797
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88A → V in AK061808 (PubMed:12869764).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003912 Genomic DNA. Translation: BAD08948.1.
AP006265 Genomic DNA. Translation: BAD10760.1.
AP008214 Genomic DNA. Translation: BAF24351.1.
AP014964 Genomic DNA. Translation: BAT06571.1.
CM000138 Genomic DNA. Translation: EEE54073.1.
AK061808 mRNA. No translation available.
RefSeqiXP_015650855.1. XM_015795369.1.
UniGeneiOs.7903.

Genome annotation databases

EnsemblPlantsiOS08T0548900-01; OS08T0548900-01; OS08G0548900.
GeneIDi4346245.
GrameneiOS08T0548900-01; OS08T0548900-01; OS08G0548900.
KEGGiosa:4346245.

Similar proteinsi

Entry informationi

Entry nameiPSA7A_ORYSJ
AccessioniPrimary (citable) accession number: Q6YT00
Secondary accession number(s): A2ZQE3, B9ETZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families