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Q6YT00

- PSA7A_ORYSJ

UniProt

Q6YT00 - PSA7A_ORYSJ

Protein

Proteasome subunit alpha type-7-A

Gene

Os08g0548900

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
    REACT_212204. Separation of Sister Chromatids.
    REACT_214064. ER-Phagosome pathway.
    REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-7-A (EC:3.4.25.1)
    Alternative name(s):
    20S proteasome alpha subunit D-1
    20S proteasome subunit alpha-4-A
    Gene namesi
    Ordered Locus Names:Os08g0548900, LOC_Os08g43540
    ORF Names:OJ1112_E06.28, OJ1479_B11.3, OsJ_000765
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 8

    Organism-specific databases

    GrameneiQ6YT00.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249Proteasome subunit alpha type-7-APRO_0000301664Add
    BLAST

    Proteomic databases

    PaxDbiQ6YT00.
    PRIDEiQ6YT00.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6YT00.
    SMRiQ6YT00. Positions 4-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    KOiK02731.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6YT00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARYDRAITV FSPDGHLFQV EYALEAVRKG NAAVGVRGTD TVVLGVEKKS    50
    TPKLQDSRSM RKIASLDTHI ALACAGLKAD ARVLINRARV ECQSHRLTVE 100
    DPVTVEYITR YIAGLQQKYT QSGGVRPFGL STLIVGFDPY TEKPALYQTD 150
    PSGTFSAWKA NATGRNSNSM REFLEKNYKD TSGKETIKLA IRALLEVVES 200
    GGKNIEIAVM THKDGLRELE EAEIDEYVAE IEAEKAAAEA AKKGAPKET 249
    Length:249
    Mass (Da):27,296
    Last modified:July 5, 2004 - v1
    Checksum:iD6F10209082B4797
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881A → V in AK061808. (PubMed:12869764)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003912 Genomic DNA. Translation: BAD08948.1.
    AP006265 Genomic DNA. Translation: BAD10760.1.
    AP008214 Genomic DNA. Translation: BAF24351.1.
    CM000138 Genomic DNA. No translation available.
    AK061808 mRNA. No translation available.
    RefSeqiNP_001062437.1. NM_001068972.1.
    UniGeneiOs.7903.

    Genome annotation databases

    EnsemblPlantsiOS08T0548900-01; OS08T0548900-01; OS08G0548900.
    GeneIDi4346245.
    KEGGiosa:4346245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003912 Genomic DNA. Translation: BAD08948.1 .
    AP006265 Genomic DNA. Translation: BAD10760.1 .
    AP008214 Genomic DNA. Translation: BAF24351.1 .
    CM000138 Genomic DNA. No translation available.
    AK061808 mRNA. No translation available.
    RefSeqi NP_001062437.1. NM_001068972.1.
    UniGenei Os.7903.

    3D structure databases

    ProteinModelPortali Q6YT00.
    SMRi Q6YT00. Positions 4-231.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q6YT00.
    PRIDEi Q6YT00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS08T0548900-01 ; OS08T0548900-01 ; OS08G0548900 .
    GeneIDi 4346245.
    KEGGi osa:4346245.

    Organism-specific databases

    Gramenei Q6YT00.

    Phylogenomic databases

    eggNOGi COG0638.
    KOi K02731.

    Enzyme and pathway databases

    Reactomei REACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
    REACT_212204. Separation of Sister Chromatids.
    REACT_214064. ER-Phagosome pathway.
    REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    3. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiPSA7A_ORYSJ
    AccessioniPrimary (citable) accession number: Q6YT00
    Secondary accession number(s): A2ZQE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3