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Q6YRB1

- KITH_ONYPE

UniProt

Q6YRB1 - KITH_ONYPE

Protein

Thymidine kinase

Gene

tdk

Organism
Onion yellows phytoplasma (strain OY-M)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei91 – 911Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 238ATPUniRule annotation
    Nucleotide bindingi90 – 934ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMORG262768:GHF5-106-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:PAM_104
    OrganismiOnion yellows phytoplasma (strain OY-M)
    Taxonomic identifieri262768 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus PhytoplasmaCandidatus Phytoplasma asteris
    ProteomesiUP000002523: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Thymidine kinasePRO_0000175001Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi262768.PAM_104.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6YRB1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiDHISEST.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6YRB1-1 [UniParc]FASTAAdd to Basket

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    MTQKEQGQGF IEVVCGPMFA GKTEALIQRS NQALQLNKKI LSFKPQIDDR    50
    YSVKEEIVSH NQNTIPAILI DKSKDILPFI TPEINVVIID EAQFLDNDIV 100
    AIVDYLANCN IEVIISGLEL DFCGKPFGPM PYLLAIADTV TKLTSICAIS 150
    GKKANRTQRL IDGKPAQSNE PVVLVGGKEY HEPRCRKHHC LADIDKTKIN 200
    WQNFTNQSK 209
    Length:209
    Mass (Da):23,351
    Last modified:July 5, 2004 - v1
    Checksum:i4C432E38F5AB8AA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006628 Genomic DNA. Translation: BAD04189.1.
    RefSeqiNP_950356.1. NC_005303.2.

    Genome annotation databases

    EnsemblBacteriaiBAD04189; BAD04189; PAM_104.
    GeneIDi2673579.
    KEGGipoy:PAM_104.
    PATRICi22809656. VBIOniYel86799_0156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006628 Genomic DNA. Translation: BAD04189.1 .
    RefSeqi NP_950356.1. NC_005303.2.

    3D structure databases

    ProteinModelPortali Q6YRB1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262768.PAM_104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD04189 ; BAD04189 ; PAM_104 .
    GeneIDi 2673579.
    KEGGi poy:PAM_104.
    PATRICi 22809656. VBIOniYel86799_0156.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi DHISEST.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci MORG262768:GHF5-106-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma."
      Oshima K., Kakizawa S., Nishigawa H., Jung H.-Y., Wei W., Suzuki S., Arashida R., Nakata D., Miyata S., Ugaki M., Namba S.
      Nat. Genet. 36:27-29(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OY-M.

    Entry informationi

    Entry nameiKITH_ONYPE
    AccessioniPrimary (citable) accession number: Q6YRB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3