Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Onion yellows phytoplasma (strain OY-M)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei217ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOYEL262768:G1G26-172-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:PAM_140
OrganismiOnion yellows phytoplasma (strain OY-M)
Taxonomic identifieri262768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus PhytoplasmaCandidatus Phytoplasma asteris
Proteomesi
  • UP000002523 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196171 – 449Glutamate--tRNA ligaseAdd BLAST449

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi262768.PAM_140

Structurei

3D structure databases

ProteinModelPortaliQ6YR76
SMRiQ6YR76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi214 – 218"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 2 hits
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6YR76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIKVRYAP SPTGFLHIGN ARTALFNYLF AKQNQGEFII RIEDTDFSRN
60 70 80 90 100
VEGGEASQLK NLRWLGIDWS EGPDIQGPFG PYRQSERLAI YQKYAQKLLD
110 120 130 140 150
QDLAYKEFQE GHTTFAIRFR VPTNQTFAFD DLIRGKLTFQ SQEIEDFIIL
160 170 180 190 200
KSNGYPSYNF AVVIDDHLMQ ISHIFRGEEH ITNTPKQIMI YQAFQWHLPQ
210 220 230 240 250
FAHMTLILNE NKKKLSKRDA NIMQFIEQYE KLGYLPQALF NFLSLLGFSP
260 270 280 290 300
LSQTEILSPQ ELINLFDVAR LNKAPAMFDK TKLDYLNNQH LRKLLPEVIA
310 320 330 340 350
SFILQKKYLA LTTAPTNYKE WMTKFVALFQ DRMHYMQQIT DFYQLFFQST
360 370 380 390 400
PFLSQEATHF LQTNPQTTLI LKTFYNVFDV IVFEKDVIAN SIKQVTTQND
410 420 430 440
FAKKTLFMAL RIGTTCKMHG PSIALLLELL GKKQVLKNLS YVLEQAQKF
Length:449
Mass (Da):52,352
Last modified:July 5, 2004 - v1
Checksum:iE3C2C2FD0D9CA4FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006628 Genomic DNA Translation: BAD04225.1
RefSeqiWP_011160515.1, NC_005303.2

Genome annotation databases

EnsemblBacteriaiBAD04225; BAD04225; PAM_140
KEGGipoy:PAM_140

Similar proteinsi

Entry informationi

Entry nameiSYE_ONYPE
AccessioniPrimary (citable) accession number: Q6YR76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health