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Q6YR76

- SYE_ONYPE

UniProt

Q6YR76 - SYE_ONYPE

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Onion yellows phytoplasma (strain OY-M)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei217 – 2171ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMORG262768:GHF5-142-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:PAM_140
    OrganismiOnion yellows phytoplasma (strain OY-M)
    Taxonomic identifieri262768 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus PhytoplasmaCandidatus Phytoplasma asteris
    ProteomesiUP000002523: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Glutamate--tRNA ligasePRO_0000119617Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi262768.PAM_140.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6YR76.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi10 – 2011"HIGH" regionAdd
    BLAST
    Motifi214 – 2185"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252720.
    KOiK01885.
    OMAiKRDANIM.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 2 hits.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6YR76-1 [UniParc]FASTAAdd to Basket

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    MKKIKVRYAP SPTGFLHIGN ARTALFNYLF AKQNQGEFII RIEDTDFSRN    50
    VEGGEASQLK NLRWLGIDWS EGPDIQGPFG PYRQSERLAI YQKYAQKLLD 100
    QDLAYKEFQE GHTTFAIRFR VPTNQTFAFD DLIRGKLTFQ SQEIEDFIIL 150
    KSNGYPSYNF AVVIDDHLMQ ISHIFRGEEH ITNTPKQIMI YQAFQWHLPQ 200
    FAHMTLILNE NKKKLSKRDA NIMQFIEQYE KLGYLPQALF NFLSLLGFSP 250
    LSQTEILSPQ ELINLFDVAR LNKAPAMFDK TKLDYLNNQH LRKLLPEVIA 300
    SFILQKKYLA LTTAPTNYKE WMTKFVALFQ DRMHYMQQIT DFYQLFFQST 350
    PFLSQEATHF LQTNPQTTLI LKTFYNVFDV IVFEKDVIAN SIKQVTTQND 400
    FAKKTLFMAL RIGTTCKMHG PSIALLLELL GKKQVLKNLS YVLEQAQKF 449
    Length:449
    Mass (Da):52,352
    Last modified:July 5, 2004 - v1
    Checksum:iE3C2C2FD0D9CA4FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006628 Genomic DNA. Translation: BAD04225.1.
    RefSeqiNP_950392.1. NC_005303.2.
    WP_011160515.1. NC_005303.2.

    Genome annotation databases

    EnsemblBacteriaiBAD04225; BAD04225; PAM_140.
    GeneIDi2673455.
    KEGGipoy:PAM_140.
    PATRICi22809738. VBIOniYel86799_0197.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006628 Genomic DNA. Translation: BAD04225.1 .
    RefSeqi NP_950392.1. NC_005303.2.
    WP_011160515.1. NC_005303.2.

    3D structure databases

    ProteinModelPortali Q6YR76.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262768.PAM_140.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD04225 ; BAD04225 ; PAM_140 .
    GeneIDi 2673455.
    KEGGi poy:PAM_140.
    PATRICi 22809738. VBIOniYel86799_0197.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252720.
    KOi K01885.
    OMAi KRDANIM.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci MORG262768:GHF5-142-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 2 hits.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma."
      Oshima K., Kakizawa S., Nishigawa H., Jung H.-Y., Wei W., Suzuki S., Arashida R., Nakata D., Miyata S., Ugaki M., Namba S.
      Nat. Genet. 36:27-29(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OY-M.

    Entry informationi

    Entry nameiSYE_ONYPE
    AccessioniPrimary (citable) accession number: Q6YR76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3