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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Onion yellows phytoplasma (strain OY-M)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi498 – 4981MagnesiumUniRule annotation
Metal bindingi504 – 5041MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMORG262768:GHF5-265-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:PAM_251
OrganismiOnion yellows phytoplasma (strain OY-M)
Taxonomic identifieri262768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus PhytoplasmaCandidatus Phytoplasma asteris
ProteomesiUP000002523 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Polyribonucleotide nucleotidyltransferasePRO_0000329745Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262768.PAM_251.

Structurei

3D structure databases

ProteinModelPortaliQ6YQX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini565 – 62561KHUniRule annotationAdd
BLAST
Domaini635 – 70672S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6YQX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKVFETTN LKDSFQVEIG TYARNVDASI LVRYQDTVVL TTTVFSRKPN
60 70 80 90 100
NLDFLPLTVI YQEKLYAAGK IPGSFLRREG RSNDHEILTS RLIDRSLRPL
110 120 130 140 150
FPDYFQQEVQ VINTVLSLDP DFKSELASML GSSLSLLISE IPFFEAISGV
160 170 180 190 200
YVGKINDKFI INPTLQQLAN STLHLMVAGT KHNVTMIEAH ANEVSEQDFL
210 220 230 240 250
EAINFAHQYI KKLCLFQENI KQQFAPAKIT NTLHQTEQTQ QQAFFAKHQS
260 270 280 290 300
QVKQAILSCN SKNDLQQLKE QILDQAKQTP FFKTIDTATV FDYEAHKKHL
310 320 330 340 350
QTTETLFQKL SKQETRSLIL QEKIRPDKRG LEEIRTLESQ IDLLPRAHGS
360 370 380 390 400
ALFTRGQTQS LAAVTLGCLS ESKIIDGLSD EQNKRFMLHY NFPPFSVGAV
410 420 430 440 450
GRYTAPSRRE IGHGTLAEKA ISQVLPEEKD FPYTIRVVSE ILESNGSSSQ
460 470 480 490 500
ATVCASSLAL MASGVPLKKA VAGMSVGLVF DQATNKYVIL SDIQGLEDHV
510 520 530 540 550
GDMDLKIAGT NKGITALQMD LKIQGIHFKI LQEAFLQAKK GRLHILEHMS
560 570 580 590 600
QTISQPRLEV SKYAPKVCMM QIKPEKIRDI IGSGGKIINQ IIESHDGVKI
610 620 630 640 650
DIEQDGRVFV MHSNLETVKK TVAFIESLIQ EIQIGTCYQA SILRFLSDKQ
660 670 680 690 700
GKMIGAVAQV CPGIEGLIHV NQKKFQKITD VLKIGETVSV KCTKINDRGR
710
IDFLLLPKNT QEKNS
Length:715
Mass (Da):80,121
Last modified:July 5, 2004 - v1
Checksum:iF77537184C982E9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006628 Genomic DNA. Translation: BAD04336.1.
RefSeqiNP_950503.1. NC_005303.2.
WP_011160625.1. NC_005303.2.

Genome annotation databases

EnsemblBacteriaiBAD04336; BAD04336; PAM_251.
KEGGipoy:PAM_251.
PATRICi22810024. VBIOniYel86799_0327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006628 Genomic DNA. Translation: BAD04336.1.
RefSeqiNP_950503.1. NC_005303.2.
WP_011160625.1. NC_005303.2.

3D structure databases

ProteinModelPortaliQ6YQX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262768.PAM_251.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD04336; BAD04336; PAM_251.
KEGGipoy:PAM_251.
PATRICi22810024. VBIOniYel86799_0327.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.

Enzyme and pathway databases

BioCyciMORG262768:GHF5-265-MONOMER.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma."
    Oshima K., Kakizawa S., Nishigawa H., Jung H.-Y., Wei W., Suzuki S., Arashida R., Nakata D., Miyata S., Ugaki M., Namba S.
    Nat. Genet. 36:27-29(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OY-M.

Entry informationi

Entry nameiPNP_ONYPE
AccessioniPrimary (citable) accession number: Q6YQX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.