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Q6YQX2

- PNP_ONYPE

UniProt

Q6YQX2 - PNP_ONYPE

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, PAM_251
Organism
Onion yellows phytoplasma (strain OY-M)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi498 – 4981Magnesium By similarity
Metal bindingi504 – 5041Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMORG262768:GHF5-265-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:PAM_251
OrganismiOnion yellows phytoplasma (strain OY-M)
Taxonomic identifieri262768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus PhytoplasmaCandidatus Phytoplasma asteris
ProteomesiUP000002523: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329745Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262768.PAM_251.

Structurei

3D structure databases

ProteinModelPortaliQ6YQX2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini565 – 62561KH
Add
BLAST
Domaini635 – 70672S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTHEIMEQ.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6YQX2-1 [UniParc]FASTAAdd to Basket

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MLKKVFETTN LKDSFQVEIG TYARNVDASI LVRYQDTVVL TTTVFSRKPN    50
NLDFLPLTVI YQEKLYAAGK IPGSFLRREG RSNDHEILTS RLIDRSLRPL 100
FPDYFQQEVQ VINTVLSLDP DFKSELASML GSSLSLLISE IPFFEAISGV 150
YVGKINDKFI INPTLQQLAN STLHLMVAGT KHNVTMIEAH ANEVSEQDFL 200
EAINFAHQYI KKLCLFQENI KQQFAPAKIT NTLHQTEQTQ QQAFFAKHQS 250
QVKQAILSCN SKNDLQQLKE QILDQAKQTP FFKTIDTATV FDYEAHKKHL 300
QTTETLFQKL SKQETRSLIL QEKIRPDKRG LEEIRTLESQ IDLLPRAHGS 350
ALFTRGQTQS LAAVTLGCLS ESKIIDGLSD EQNKRFMLHY NFPPFSVGAV 400
GRYTAPSRRE IGHGTLAEKA ISQVLPEEKD FPYTIRVVSE ILESNGSSSQ 450
ATVCASSLAL MASGVPLKKA VAGMSVGLVF DQATNKYVIL SDIQGLEDHV 500
GDMDLKIAGT NKGITALQMD LKIQGIHFKI LQEAFLQAKK GRLHILEHMS 550
QTISQPRLEV SKYAPKVCMM QIKPEKIRDI IGSGGKIINQ IIESHDGVKI 600
DIEQDGRVFV MHSNLETVKK TVAFIESLIQ EIQIGTCYQA SILRFLSDKQ 650
GKMIGAVAQV CPGIEGLIHV NQKKFQKITD VLKIGETVSV KCTKINDRGR 700
IDFLLLPKNT QEKNS 715
Length:715
Mass (Da):80,121
Last modified:July 5, 2004 - v1
Checksum:iF77537184C982E9B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006628 Genomic DNA. Translation: BAD04336.1.
RefSeqiNP_950503.1. NC_005303.2.

Genome annotation databases

EnsemblBacteriaiBAD04336; BAD04336; PAM_251.
GeneIDi2673026.
KEGGipoy:PAM_251.
PATRICi22810024. VBIOniYel86799_0327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006628 Genomic DNA. Translation: BAD04336.1 .
RefSeqi NP_950503.1. NC_005303.2.

3D structure databases

ProteinModelPortali Q6YQX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262768.PAM_251.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD04336 ; BAD04336 ; PAM_251 .
GeneIDi 2673026.
KEGGi poy:PAM_251.
PATRICi 22810024. VBIOniYel86799_0327.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi THEIMEQ.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci MORG262768:GHF5-265-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma."
    Oshima K., Kakizawa S., Nishigawa H., Jung H.-Y., Wei W., Suzuki S., Arashida R., Nakata D., Miyata S., Ugaki M., Namba S.
    Nat. Genet. 36:27-29(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OY-M.

Entry informationi

Entry nameiPNP_ONYPE
AccessioniPrimary (citable) accession number: Q6YQX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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