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Q6YQX2

- PNP_ONYPE

UniProt

Q6YQX2 - PNP_ONYPE

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Onion yellows phytoplasma (strain OY-M)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi498 – 4981MagnesiumUniRule annotation
    Metal bindingi504 – 5041MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciMORG262768:GHF5-265-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:PAM_251
    OrganismiOnion yellows phytoplasma (strain OY-M)
    Taxonomic identifieri262768 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus PhytoplasmaCandidatus Phytoplasma asteris
    ProteomesiUP000002523: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 715715Polyribonucleotide nucleotidyltransferasePRO_0000329745Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262768.PAM_251.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6YQX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini565 – 62561KHUniRule annotationAdd
    BLAST
    Domaini635 – 70672S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiTHEIMEQ.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6YQX2-1 [UniParc]FASTAAdd to Basket

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    MLKKVFETTN LKDSFQVEIG TYARNVDASI LVRYQDTVVL TTTVFSRKPN    50
    NLDFLPLTVI YQEKLYAAGK IPGSFLRREG RSNDHEILTS RLIDRSLRPL 100
    FPDYFQQEVQ VINTVLSLDP DFKSELASML GSSLSLLISE IPFFEAISGV 150
    YVGKINDKFI INPTLQQLAN STLHLMVAGT KHNVTMIEAH ANEVSEQDFL 200
    EAINFAHQYI KKLCLFQENI KQQFAPAKIT NTLHQTEQTQ QQAFFAKHQS 250
    QVKQAILSCN SKNDLQQLKE QILDQAKQTP FFKTIDTATV FDYEAHKKHL 300
    QTTETLFQKL SKQETRSLIL QEKIRPDKRG LEEIRTLESQ IDLLPRAHGS 350
    ALFTRGQTQS LAAVTLGCLS ESKIIDGLSD EQNKRFMLHY NFPPFSVGAV 400
    GRYTAPSRRE IGHGTLAEKA ISQVLPEEKD FPYTIRVVSE ILESNGSSSQ 450
    ATVCASSLAL MASGVPLKKA VAGMSVGLVF DQATNKYVIL SDIQGLEDHV 500
    GDMDLKIAGT NKGITALQMD LKIQGIHFKI LQEAFLQAKK GRLHILEHMS 550
    QTISQPRLEV SKYAPKVCMM QIKPEKIRDI IGSGGKIINQ IIESHDGVKI 600
    DIEQDGRVFV MHSNLETVKK TVAFIESLIQ EIQIGTCYQA SILRFLSDKQ 650
    GKMIGAVAQV CPGIEGLIHV NQKKFQKITD VLKIGETVSV KCTKINDRGR 700
    IDFLLLPKNT QEKNS 715
    Length:715
    Mass (Da):80,121
    Last modified:July 5, 2004 - v1
    Checksum:iF77537184C982E9B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006628 Genomic DNA. Translation: BAD04336.1.
    RefSeqiNP_950503.1. NC_005303.2.

    Genome annotation databases

    EnsemblBacteriaiBAD04336; BAD04336; PAM_251.
    GeneIDi2673026.
    KEGGipoy:PAM_251.
    PATRICi22810024. VBIOniYel86799_0327.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006628 Genomic DNA. Translation: BAD04336.1 .
    RefSeqi NP_950503.1. NC_005303.2.

    3D structure databases

    ProteinModelPortali Q6YQX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262768.PAM_251.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD04336 ; BAD04336 ; PAM_251 .
    GeneIDi 2673026.
    KEGGi poy:PAM_251.
    PATRICi 22810024. VBIOniYel86799_0327.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi THEIMEQ.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci MORG262768:GHF5-265-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma."
      Oshima K., Kakizawa S., Nishigawa H., Jung H.-Y., Wei W., Suzuki S., Arashida R., Nakata D., Miyata S., Ugaki M., Namba S.
      Nat. Genet. 36:27-29(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OY-M.

    Entry informationi

    Entry nameiPNP_ONYPE
    AccessioniPrimary (citable) accession number: Q6YQX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3