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Protein

Kynurenine--oxoglutarate transaminase 3

Gene

KYAT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).By similarity

Caution

The first non-coding exon of CCBL2 is in common with that of RBMXL1.Curated

Catalytic activityi

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
An L-cysteine-S-conjugate + H2O = RSH + NH3 + pyruvate.
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53SubstrateBy similarity1
Binding sitei71Substrate; via amide nitrogenBy similarity1
Binding sitei218SubstrateBy similarity1
Binding sitei429SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Lyase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS06422-MONOMER
BRENDAi2.6.1.7 2681
ReactomeiR-HSA-71240 Tryptophan catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine--oxoglutarate transaminase 3 (EC:2.6.1.7)
Alternative name(s):
Cysteine-S-conjugate beta-lyase 2 (EC:4.4.1.13)
Kynurenine aminotransferase 3Imported
Kynurenine aminotransferase III
Short name:
KATIII
Kynurenine--glyoxylate transaminase (EC:2.6.1.63)
Kynurenine--oxoglutarate transaminase III
Gene namesi
Name:KYAT3Imported
Synonyms:CCBL2, KAT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000137944.16
HGNCiHGNC:33238 KYAT3
MIMi610656 gene
neXtProtiNX_Q6YP21

Pathology & Biotechi

Organism-specific databases

DisGeNETi56267
OpenTargetsiENSG00000137944
PharmGKBiPA162381274

Chemistry databases

ChEMBLiCHEMBL2046260
DrugBankiDB00142 L-Glutamic Acid
DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

BioMutaiCCBL2
DMDMi74710502

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002877041 – 454Kynurenine--oxoglutarate transaminase 3Add BLAST454
Isoform 3 (identifier: Q6YP21-3)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116N6-acetyllysine; alternateCombined sources1
Modified residuei116N6-succinyllysine; alternateBy similarity1
Modified residuei280N6-(pyridoxal phosphate)lysineBy similarity1
Isoform 3 (identifier: Q6YP21-3)
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6YP21
MaxQBiQ6YP21
PaxDbiQ6YP21
PeptideAtlasiQ6YP21
PRIDEiQ6YP21

PTM databases

iPTMnetiQ6YP21
PhosphoSitePlusiQ6YP21

Expressioni

Gene expression databases

BgeeiENSG00000137944
CleanExiHS_CCBL2
ExpressionAtlasiQ6YP21 baseline and differential
GenevisibleiQ6YP21 HS

Organism-specific databases

HPAiHPA026538
HPA027168

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121128, 14 interactors
IntActiQ6YP21, 6 interactors
STRINGi9606.ENSP00000260508

Chemistry databases

BindingDBiQ6YP21

Structurei

3D structure databases

ProteinModelPortaliQ6YP21
SMRiQ6YP21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0257 Eukaryota
COG0436 LUCA
GeneTreeiENSGT00650000093238
HOGENOMiHOG000223045
HOVERGENiHBG008391
InParanoidiQ6YP21
KOiK00816
OMAiYWTTYPE
OrthoDBiEOG091G06LU
PhylomeDBiQ6YP21
TreeFamiTF352342

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR034612 KAT_III
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43807:SF6 PTHR43807:SF6, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6YP21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLAQRSLCS LSGRAKFLKT ISSSKILGFS TSAKMSLKFT NAKRIEGLDS
60 70 80 90 100
NVWIEFTKLA ADPSVVNLGQ GFPDISPPTY VKEELSKIAA IDSLNQYTRG
110 120 130 140 150
FGHPSLVKAL SYLYEKLYQK QIDSNKEILV TVGAYGSLFN TIQALIDEGD
160 170 180 190 200
EVILIVPFYD CYEPMVRMAG ATPVFIPLRS KPVYGKRWSS SDWTLDPQEL
210 220 230 240 250
ESKFNSKTKA IILNTPHNPL GKVYNREELQ VIADLCIKYD TLCISDEVYE
260 270 280 290 300
WLVYSGNKHL KIATFPGMWE RTITIGSAGK TFSVTGWKLG WSIGPNHLIK
310 320 330 340 350
HLQTVQQNTI YTCATPLQEA LAQAFWIDIK RMDDPECYFN SLPKELEVKR
360 370 380 390 400
DRMVRLLESV GLKPIVPDGG YFIIADVSLL DPDLSDMKNN EPYDYKFVKW
410 420 430 440 450
MTKHKKLSAI PVSAFCNSET KSQFEKFVRF CFIKKDSTLD AAEEIIKAWS

VQKS
Length:454
Mass (Da):51,400
Last modified:July 5, 2004 - v1
Checksum:i2059D4646058BBB3
GO
Isoform 2 (identifier: Q6YP21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-167: VILIVPFYDCYEPMVR → YNACTVKFTNLKCTAG
     168-454: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):18,352
Checksum:i6CA0C2A9BC6BA211
GO
Isoform 3 (identifier: Q6YP21-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:420
Mass (Da):47,753
Checksum:i1BB37BC0D96DB2EE
GO

Sequence cautioni

The sequence AAC72959 differs from that shown. Reason: Frameshift at position 336.Curated
The sequence AAH00819 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAG29278 differs from that shown. Reason: Frameshift at position 336.Curated
The sequence CAI21695 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI21696 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41339 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41340 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251W → R in CAG29278 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032352206S → P2 PublicationsCorresponds to variant dbSNP:rs1059370Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428411 – 34Missing in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_025603152 – 167VILIV…EPMVR → YNACTVKFTNLKCTAG in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_025604168 – 454Missing in isoform 2. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028624 mRNA Translation: AAK26163.1
CR627392 mRNA Translation: CAH10487.1
AK057176 mRNA Translation: BAG51875.1
AL445991 Genomic DNA Translation: CAI41345.1
AL139416, AL445991 Genomic DNA Translation: CAI21695.1 Sequence problems.
AL445991, AL139416 Genomic DNA Translation: CAI41339.1 Sequence problems.
AL139416, AL445991 Genomic DNA Translation: CAI21696.1 Sequence problems.
AL445991, AL139416 Genomic DNA Translation: CAI41340.1 Sequence problems.
BC000819 mRNA Translation: AAH00819.1 Different initiation.
AF091090 mRNA Translation: AAC72959.1 Frameshift.
CR450282 mRNA Translation: CAG29278.1 Frameshift.
CCDSiCCDS30766.1 [Q6YP21-1]
CCDS30767.1 [Q6YP21-3]
RefSeqiNP_001008661.1, NM_001008661.2 [Q6YP21-1]
NP_001008662.1, NM_001008662.2 [Q6YP21-3]
UniGeneiHs.481898

Genome annotation databases

EnsembliENST00000260508; ENSP00000260508; ENSG00000137944 [Q6YP21-1]
ENST00000370491; ENSP00000359522; ENSG00000137944 [Q6YP21-3]
GeneIDi56267
KEGGihsa:56267
UCSCiuc001dmp.3 human [Q6YP21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKAT3_HUMAN
AccessioniPrimary (citable) accession number: Q6YP21
Secondary accession number(s): B3KQ13
, O95335, Q5JS27, Q5T9T7, Q5T9T8, Q6AI27, Q6ICW1, Q9BVY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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