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Protein

Kynurenine--oxoglutarate transaminase 3

Gene

KYAT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).By similarity

Catalytic activityi

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
An L-cysteine-S-conjugate + H2O = RSH + NH3 + pyruvate.
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53SubstrateBy similarity1
Binding sitei71Substrate; via amide nitrogenBy similarity1
Binding sitei218SubstrateBy similarity1
Binding sitei429SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Lyase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS06422-MONOMER.
ZFISH:HS06422-MONOMER.
BRENDAi2.6.1.7. 2681.
ReactomeiR-HSA-71240. Tryptophan catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine--oxoglutarate transaminase 3 (EC:2.6.1.7)
Alternative name(s):
Cysteine-S-conjugate beta-lyase 2 (EC:4.4.1.13)
Kynurenine aminotransferase 3Imported
Kynurenine aminotransferase III
Short name:
KATIII
Kynurenine--glyoxylate transaminase (EC:2.6.1.63)
Kynurenine--oxoglutarate transaminase III
Gene namesi
Name:KYAT3Imported
Synonyms:CCBL2, KAT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:33238. KYAT3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi56267.
OpenTargetsiENSG00000137944.
PharmGKBiPA162381274.

Chemistry databases

ChEMBLiCHEMBL2046260.

Polymorphism and mutation databases

BioMutaiCCBL2.
DMDMi74710502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002877041 – 454Kynurenine--oxoglutarate transaminase 3Add BLAST454
Isoform 3 (identifier: Q6YP21-3)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116N6-acetyllysine; alternateCombined sources1
Modified residuei116N6-succinyllysine; alternateBy similarity1
Modified residuei280N6-(pyridoxal phosphate)lysineBy similarity1
Isoform 3 (identifier: Q6YP21-3)
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6YP21.
MaxQBiQ6YP21.
PaxDbiQ6YP21.
PeptideAtlasiQ6YP21.
PRIDEiQ6YP21.

PTM databases

iPTMnetiQ6YP21.
PhosphoSitePlusiQ6YP21.

Expressioni

Gene expression databases

BgeeiENSG00000137944.
CleanExiHS_CCBL2.
ExpressionAtlasiQ6YP21. baseline and differential.
GenevisibleiQ6YP21. HS.

Organism-specific databases

HPAiHPA026538.
HPA027168.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi121128. 13 interactors.
IntActiQ6YP21. 6 interactors.
MINTiMINT-1402454.
STRINGi9606.ENSP00000260508.

Chemistry databases

BindingDBiQ6YP21.

Structurei

3D structure databases

ProteinModelPortaliQ6YP21.
SMRiQ6YP21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0257. Eukaryota.
COG0436. LUCA.
GeneTreeiENSGT00650000093238.
HOGENOMiHOG000223045.
HOVERGENiHBG008391.
InParanoidiQ6YP21.
KOiK00816.
OMAiTEICVTC.
OrthoDBiEOG091G06LU.
PhylomeDBiQ6YP21.
TreeFamiTF352342.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6YP21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLAQRSLCS LSGRAKFLKT ISSSKILGFS TSAKMSLKFT NAKRIEGLDS
60 70 80 90 100
NVWIEFTKLA ADPSVVNLGQ GFPDISPPTY VKEELSKIAA IDSLNQYTRG
110 120 130 140 150
FGHPSLVKAL SYLYEKLYQK QIDSNKEILV TVGAYGSLFN TIQALIDEGD
160 170 180 190 200
EVILIVPFYD CYEPMVRMAG ATPVFIPLRS KPVYGKRWSS SDWTLDPQEL
210 220 230 240 250
ESKFNSKTKA IILNTPHNPL GKVYNREELQ VIADLCIKYD TLCISDEVYE
260 270 280 290 300
WLVYSGNKHL KIATFPGMWE RTITIGSAGK TFSVTGWKLG WSIGPNHLIK
310 320 330 340 350
HLQTVQQNTI YTCATPLQEA LAQAFWIDIK RMDDPECYFN SLPKELEVKR
360 370 380 390 400
DRMVRLLESV GLKPIVPDGG YFIIADVSLL DPDLSDMKNN EPYDYKFVKW
410 420 430 440 450
MTKHKKLSAI PVSAFCNSET KSQFEKFVRF CFIKKDSTLD AAEEIIKAWS

VQKS
Length:454
Mass (Da):51,400
Last modified:July 5, 2004 - v1
Checksum:i2059D4646058BBB3
GO
Isoform 2 (identifier: Q6YP21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-167: VILIVPFYDCYEPMVR → YNACTVKFTNLKCTAG
     168-454: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):18,352
Checksum:i6CA0C2A9BC6BA211
GO
Isoform 3 (identifier: Q6YP21-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:420
Mass (Da):47,753
Checksum:i1BB37BC0D96DB2EE
GO

Sequence cautioni

The sequence AAC72959 differs from that shown. Reason: Frameshift at position 336.Curated
The sequence AAH00819 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAG29278 differs from that shown. Reason: Frameshift at position 336.Curated
The sequence CAI21695 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI21696 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41339 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41340 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251W → R in CAG29278 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032352206S → P.2 PublicationsCorresponds to variant rs1059370dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428411 – 34Missing in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_025603152 – 167VILIV…EPMVR → YNACTVKFTNLKCTAG in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_025604168 – 454Missing in isoform 2. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028624 mRNA. Translation: AAK26163.1.
CR627392 mRNA. Translation: CAH10487.1.
AK057176 mRNA. Translation: BAG51875.1.
AL445991 Genomic DNA. Translation: CAI41345.1.
AL139416, AL445991 Genomic DNA. Translation: CAI21695.1. Sequence problems.
AL445991, AL139416 Genomic DNA. Translation: CAI41339.1. Sequence problems.
AL139416, AL445991 Genomic DNA. Translation: CAI21696.1. Sequence problems.
AL445991, AL139416 Genomic DNA. Translation: CAI41340.1. Sequence problems.
BC000819 mRNA. Translation: AAH00819.1. Different initiation.
AF091090 mRNA. Translation: AAC72959.1. Frameshift.
CR450282 mRNA. Translation: CAG29278.1. Frameshift.
CCDSiCCDS30766.1. [Q6YP21-1]
CCDS30767.1. [Q6YP21-3]
RefSeqiNP_001008661.1. NM_001008661.2. [Q6YP21-1]
NP_001008662.1. NM_001008662.2. [Q6YP21-3]
UniGeneiHs.481898.

Genome annotation databases

EnsembliENST00000260508; ENSP00000260508; ENSG00000137944. [Q6YP21-1]
ENST00000370491; ENSP00000359522; ENSG00000137944. [Q6YP21-3]
GeneIDi56267.
KEGGihsa:56267.
UCSCiuc001dmp.3. human. [Q6YP21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028624 mRNA. Translation: AAK26163.1.
CR627392 mRNA. Translation: CAH10487.1.
AK057176 mRNA. Translation: BAG51875.1.
AL445991 Genomic DNA. Translation: CAI41345.1.
AL139416, AL445991 Genomic DNA. Translation: CAI21695.1. Sequence problems.
AL445991, AL139416 Genomic DNA. Translation: CAI41339.1. Sequence problems.
AL139416, AL445991 Genomic DNA. Translation: CAI21696.1. Sequence problems.
AL445991, AL139416 Genomic DNA. Translation: CAI41340.1. Sequence problems.
BC000819 mRNA. Translation: AAH00819.1. Different initiation.
AF091090 mRNA. Translation: AAC72959.1. Frameshift.
CR450282 mRNA. Translation: CAG29278.1. Frameshift.
CCDSiCCDS30766.1. [Q6YP21-1]
CCDS30767.1. [Q6YP21-3]
RefSeqiNP_001008661.1. NM_001008661.2. [Q6YP21-1]
NP_001008662.1. NM_001008662.2. [Q6YP21-3]
UniGeneiHs.481898.

3D structure databases

ProteinModelPortaliQ6YP21.
SMRiQ6YP21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121128. 13 interactors.
IntActiQ6YP21. 6 interactors.
MINTiMINT-1402454.
STRINGi9606.ENSP00000260508.

Chemistry databases

BindingDBiQ6YP21.
ChEMBLiCHEMBL2046260.

PTM databases

iPTMnetiQ6YP21.
PhosphoSitePlusiQ6YP21.

Polymorphism and mutation databases

BioMutaiCCBL2.
DMDMi74710502.

Proteomic databases

EPDiQ6YP21.
MaxQBiQ6YP21.
PaxDbiQ6YP21.
PeptideAtlasiQ6YP21.
PRIDEiQ6YP21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260508; ENSP00000260508; ENSG00000137944. [Q6YP21-1]
ENST00000370491; ENSP00000359522; ENSG00000137944. [Q6YP21-3]
GeneIDi56267.
KEGGihsa:56267.
UCSCiuc001dmp.3. human. [Q6YP21-1]

Organism-specific databases

CTDi56267.
DisGeNETi56267.
GeneCardsiCCBL2.
HGNCiHGNC:33238. KYAT3.
HPAiHPA026538.
HPA027168.
MIMi610656. gene.
neXtProtiNX_Q6YP21.
OpenTargetsiENSG00000137944.
PharmGKBiPA162381274.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0257. Eukaryota.
COG0436. LUCA.
GeneTreeiENSGT00650000093238.
HOGENOMiHOG000223045.
HOVERGENiHBG008391.
InParanoidiQ6YP21.
KOiK00816.
OMAiTEICVTC.
OrthoDBiEOG091G06LU.
PhylomeDBiQ6YP21.
TreeFamiTF352342.

Enzyme and pathway databases

BioCyciMetaCyc:HS06422-MONOMER.
ZFISH:HS06422-MONOMER.
BRENDAi2.6.1.7. 2681.
ReactomeiR-HSA-71240. Tryptophan catabolism.

Miscellaneous databases

GenomeRNAii56267.
PROiQ6YP21.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137944.
CleanExiHS_CCBL2.
ExpressionAtlasiQ6YP21. baseline and differential.
GenevisibleiQ6YP21. HS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKAT3_HUMAN
AccessioniPrimary (citable) accession number: Q6YP21
Secondary accession number(s): B3KQ13
, O95335, Q5JS27, Q5T9T7, Q5T9T8, Q6AI27, Q6ICW1, Q9BVY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The first non-coding exon of CCBL2 is in common with that of RBMXL1.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.