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Protein

RNA replication protein

Gene
N/A
Organism
Botrytis virus X (isolate Botrytis cinerea/New Zealand/Howitt/2006) (BOTV-X)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RNA replication. The central part of this protein possibly functions as an ATP-binding helicase (Probable).Curated

Catalytic activityi

ATP + H2O = ADP + phosphate.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi643 – 650ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA replication protein
Including the following 2 domains:
RNA-directed RNA polymerase (EC:2.7.7.48)
Helicase (EC:3.6.4.13)
OrganismiBotrytis virus X (isolate Botrytis cinerea/New Zealand/Howitt/2006) (BOTV-X)
Taxonomic identifieri686947 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTymoviralesAlphaflexiviridaeBotrexvirus
Virus hostiBotryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) [TaxID: 40559]
Proteomesi
  • UP000001664 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004010671 – 1413RNA replication proteinAdd BLAST1413

Structurei

3D structure databases

ProteinModelPortaliQ6YNQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 226Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST168
Domaini614 – 771(+)RNA virus helicase ATP-bindingAdd BLAST158
Domaini772 – 905(+)RNA virus helicase C-terminalAdd BLAST134
Domaini1143 – 1249RdRp catalyticPROSITE-ProRule annotationAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi424 – 429Poly-Pro6
Compositional biasi500 – 505Poly-Thr6

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG0900004V.

Family and domain databases

InterProiView protein in InterPro
IPR027351. (+)RNA_virus_helicase_core_dom.
IPR002588. Alphavirus-like_MT_dom.
IPR027417. P-loop_NTPase.
IPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
PfamiView protein in Pfam
PF00978. RdRP_2. 1 hit.
PF01443. Viral_helicase1. 1 hit.
PF01660. Vmethyltransf. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS51743. ALPHAVIRUS_MT. 1 hit.
PS51657. PSRV_HELICASE. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6YNQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALRSLASD LSDPTTKAAA NEIAFKHFSD GIKSTKLSFP YKVDESTAIL
60 70 80 90 100
LEKEGVLTNP FSTTLHTHAA EKMLENRTLN EVGKKLKVHT GPFTFIQFKT
110 120 130 140 150
GKLGHVGRGH NQGDQIINYA REAKDLSRFE TLDTAVVPPV HNRVALLHDT
160 170 180 190 200
LHFLSPRQLA QLFHHNPNLH LLYATLVLPV EALHNLPSLN PHAYTLEYFS
210 220 230 240 250
NGDFAYMPGG HAGSGYYHSA ETLHWLRAGQ IKLGHFSLSL NKEDSFGAHH
260 270 280 290 300
IFTVTRQFIP PAPRYLYAET ELVTLHDIFY PADSNVQRPY PATLINRMEL
310 320 330 340 350
YCRSVKAVSL RDIFAKFRQV TETAQLRHMR ISDVIRLANY FLFSASLSGT
360 370 380 390 400
NDYPSLVGHG LFKKMRVSFQ ERVKEVLAPL VGHTQYRTLM SFVQPKPFTF
410 420 430 440 450
SLTPVTFHAA QGRKWSNPLG PMDPPPPGPA GPDEPSDPLI GPTLSLLALG
460 470 480 490 500
IPDDDLDADL DKIAKRNTRK DELLAELTQT PTKVEVPPAP EDAAGPQNPT
510 520 530 540 550
TTTPTAADPP TTPADEPTPE APKHHPTLTA VDIQLLNDLR FTDLDIQHGI
560 570 580 590 600
DGPILPLHRN PAELTPTLIA DINCAPFVEM LSARHIPIIS RPVNNARAHA
610 620 630 640 650
LASDVKNAKI GKLLTKQPQD WLKSWDARCS TSELQLNVAV IHGAGGSGKS
660 670 680 690 700
YSIQETLRNK RETLEHTTIV TPTVELRNDW SGKIPRMAPD RIKTYEKAML
710 720 730 740 750
QPGTATVILD DYGKLPPGYL DSYAVLHPNV ELFILTGDHR QTTYHVSDPE
760 770 780 790 800
ANTFHLTSEI QEFRPLCAYY INATHRQPRR LANVLGTHSS KTSGGAVLEA
810 820 830 840 850
DMIPDDATVL VPSRVEQAKL IDLNRRAMTY AGCQGLTAKN VTIVLDRDTP
860 870 880 890 900
LCTDETMYTA LSRASESITF VNTYSKEPGF LAKLDCAPYL KTMLTGVHEE
910 920 930 940 950
EYQPDDTPAN DNPTEPELTK THLPVENDNV FFEPLVEQCT DKDTRELFTA
960 970 980 990 1000
EHGKTNLAQT SSLEVQLFPH QQAKDDALMT ETMKARITTS TRDANLRELH
1010 1020 1030 1040 1050
DTNALSGLLF EFYADFMKVP KDPMPFNPTL WAESRARAER TYLSKTAAQI
1060 1070 1080 1090 1100
LNGANRQDPD FPDNFVALFL KSQWVKKLEK VGMQFKAGQT ISSFKQQVVL
1110 1120 1130 1140 1150
LTTTLALYLR ACRNSHQPDN VFIMCEKTSN QFNDFVKDWN FERDNYTSDY
1160 1170 1180 1190 1200
TQYDKSQDGL FLNFELRKAR HFGVPQAVLD AYTAIKTDAK VFADTLKIMR
1210 1220 1230 1240 1250
LSGEGPTFDA NTECNIAYDA ARFQLSDVKA CYAGDDLARD RNCPERASWK
1260 1270 1280 1290 1300
YISHQFTLQA KPLVTRKPDF CGWSLTKHGI VKNPKQLWQS MQLGLKLDKL
1310 1320 1330 1340 1350
KDIVPSYSLD FHHAYALGDK VYDIFTEEEM AYHQATVRLM HKMGVHPKIA
1360 1370 1380 1390 1400
GDHLPVFHIT SDRLLKETKP IPALVPTISI TPPATPPPEA EVELTTFTTH
1410
IPDSRPIRNV HFD
Length:1,413
Mass (Da):158,250
Last modified:July 5, 2004 - v1
Checksum:iA60AB3DA931DED2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY055762 Genomic RNA. Translation: AAL17722.1.
RefSeqiNP_932306.1. NC_005132.1.

Genome annotation databases

GeneIDi2943228.
KEGGivg:2943228.

Entry informationi

Entry nameiRDRP_BOTVX
AccessioniPrimary (citable) accession number: Q6YNQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families