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Q6YNI2 (GPR6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor 6
Alternative name(s):
Sphingosine 1-phosphate receptor GPR6
Gene names
Name:Gpr6
Synonyms:Gm233
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons By similarity. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein Probable. Note: Highly expressed and localized along the cytoplasmic membrane as well as in a perinuclear compartment. Ref.3

Tissue specificity

Mainly expressed in the brain. Selectively expressed in striatopallidal neurons in the striatum. Ref.3 Ref.4

Disruption phenotype

Deficient mice show reduced striatal cyclic AMP production and selective alterations in instrumental conditioning. Ref.4

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

Was originally (Ref.1) thought to be a receptor for sphingosine 1-phosphate. It has been demonstrated that it is not the case in human.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363G-protein coupled receptor 6
PRO_0000069515

Regions

Topological domain1 – 7575Extracellular Potential
Transmembrane76 – 9520Helical; Name=1; Potential
Topological domain96 – 10712Cytoplasmic Potential
Transmembrane108 – 13124Helical; Name=2; Potential
Topological domain132 – 14312Extracellular Potential
Transmembrane144 – 16522Helical; Name=3; Potential
Topological domain166 – 18621Cytoplasmic Potential
Transmembrane187 – 20620Helical; Name=4; Potential
Topological domain207 – 23125Extracellular Potential
Transmembrane232 – 25019Helical; Name=5; Potential
Topological domain251 – 27828Cytoplasmic Potential
Transmembrane279 – 30527Helical; Name=6; Potential
Topological domain306 – 3105Extracellular Potential
Transmembrane311 – 33222Helical; Name=7; Potential
Topological domain333 – 36331Cytoplasmic Potential
Compositional bias21 – 288Poly-Ala
Compositional bias46 – 505Poly-Gly

Amino acid modifications

Modified residue3571Phosphoserine Potential
Modified residue3591Phosphoserine Potential
Modified residue3611Phosphoserine Potential
Lipidation3461S-palmitoyl cysteine By similarity
Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation521N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6YNI2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 6870FF769BAAF093

FASTA36338,085
        10         20         30         40         50         60 
MNASAAALNE SQVVAVAAEG AAAAATAAGA PDTGEWGPPA ASAALGGGGG PNGSLELSSQ 

        70         80         90        100        110        120 
LPAGPSGLLL SAVNPWDVLL CVSGTVIAGE NALVVALIAS TPALRTPMFV LVGSLATADL 

       130        140        150        160        170        180 
LAGCGLILHF VFQYVVPSET VSLLMVGFLV ASFAASVSSL LAITVDRYLS LYNALTYYSR 

       190        200        210        220        230        240 
RTLLGVHLLL AATWTVSLGL GLLPVLGWNC LADRTSCSVV RPLTRSHVAL LSTSFFVVFG 

       250        260        270        280        290        300 
IMLHLYVRIC QVVWRHAHQI ALQQHCLAPP HLAATRKGVG TLAVVLGTFG ASWLPFAIYC 

       310        320        330        340        350        360 
VVGSQEDPAI YTYATLLPAT YNSMINPIIY AFRNQEIQRA LWLLFCGCFQ SKVPFRSRSP 


SEV 

« Hide

References

« Hide 'large scale' references
[1]"Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway."
Ignatov A., Lintzel J., Kreienkamp H.J., Schaller H.C.
Biochem. Biophys. Res. Commun. 311:329-336(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: C57BL/6.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain cortex.
[3]"Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth."
Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y.
J. Biol. Chem. 282:10506-10515(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[4]"Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6."
Lobo M.K., Cui Y., Ostlund S.B., Balleine B.W., Yang X.W.
Nat. Neurosci. 10:1395-1397(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY064488 mRNA. Translation: AAL40876.1.
AK139367 mRNA. Translation: BAE23977.1.
RefSeqNP_951013.1. NM_199058.1.
XP_006512596.1. XM_006512533.1.
UniGeneMm.290693.

3D structure databases

ProteinModelPortalQ6YNI2.
SMRQ6YNI2. Positions 78-346.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY85.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ6YNI2.

Protocols and materials databases

DNASU140741.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061796; ENSMUSP00000057323; ENSMUSG00000046922.
GeneID140741.
KEGGmmu:140741.
UCSCuc007exj.1. mouse.

Organism-specific databases

CTD2830.
MGIMGI:2155249. Gpr6.

Phylogenomic databases

eggNOGNOG327877.
GeneTreeENSGT00750000117639.
HOGENOMHOG000294075.
HOVERGENHBG079561.
InParanoidQ6YNI2.
KOK04313.
OMACGCFQSK.
OrthoDBEOG7966H0.
PhylomeDBQ6YNI2.
TreeFamTF330052.

Gene expression databases

BgeeQ6YNI2.
CleanExMM_GPR6.
GenevestigatorQ6YNI2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001151. GPR6.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00649. GPR6ORPHANR.
PR00644. GPRORPHANR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio369959.
PROQ6YNI2.
SOURCESearch...

Entry information

Entry nameGPR6_MOUSE
AccessionPrimary (citable) accession number: Q6YNI2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries