Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6YNI2

- GPR6_MOUSE

UniProt

Q6YNI2 - GPR6_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

G-protein coupled receptor 6

Gene

Gpr6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).By similarity

GO - Molecular functioni

  1. sphingosine-1-phosphate receptor activity Source: MGI

GO - Biological processi

  1. positive regulation of cytosolic calcium ion concentration Source: MGI
  2. sphingosine-1-phosphate signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 6
Alternative name(s):
Sphingosine 1-phosphate receptor GPR6
Gene namesi
Name:Gpr6
Synonyms:Gm233
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:2155249. Gpr6.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Highly expressed and localized along the cytoplasmic membrane as well as in a perinuclear compartment.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deficient mice show reduced striatal cyclic AMP production and selective alterations in instrumental conditioning.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363G-protein coupled receptor 6PRO_0000069515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Lipidationi346 – 3461S-palmitoyl cysteineBy similarity
Modified residuei357 – 3571PhosphoserineSequence Analysis
Modified residuei359 – 3591PhosphoserineSequence Analysis
Modified residuei361 – 3611PhosphoserineSequence Analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ6YNI2.

Expressioni

Tissue specificityi

Mainly expressed in the brain. Selectively expressed in striatopallidal neurons in the striatum.2 Publications

Gene expression databases

BgeeiQ6YNI2.
CleanExiMM_GPR6.
ExpressionAtlasiQ6YNI2. baseline.
GenevestigatoriQ6YNI2.

Structurei

3D structure databases

ProteinModelPortaliQ6YNI2.
SMRiQ6YNI2. Positions 78-346.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575ExtracellularSequence AnalysisAdd
BLAST
Topological domaini96 – 10712CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini132 – 14312ExtracellularSequence AnalysisAdd
BLAST
Topological domaini166 – 18621CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini207 – 23125ExtracellularSequence AnalysisAdd
BLAST
Topological domaini251 – 27828CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini306 – 3105ExtracellularSequence Analysis
Topological domaini333 – 36331CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei76 – 9520Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei108 – 13124Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei144 – 16522Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei187 – 20620Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei232 – 25019Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei279 – 30527Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei311 – 33222Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 288Poly-Ala
Compositional biasi46 – 505Poly-Gly

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG327877.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiQ6YNI2.
KOiK04313.
OMAiCGCFQSK.
OrthoDBiEOG7966H0.
PhylomeDBiQ6YNI2.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001151. GPR6.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00649. GPR6ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6YNI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNASAAALNE SQVVAVAAEG AAAAATAAGA PDTGEWGPPA ASAALGGGGG
60 70 80 90 100
PNGSLELSSQ LPAGPSGLLL SAVNPWDVLL CVSGTVIAGE NALVVALIAS
110 120 130 140 150
TPALRTPMFV LVGSLATADL LAGCGLILHF VFQYVVPSET VSLLMVGFLV
160 170 180 190 200
ASFAASVSSL LAITVDRYLS LYNALTYYSR RTLLGVHLLL AATWTVSLGL
210 220 230 240 250
GLLPVLGWNC LADRTSCSVV RPLTRSHVAL LSTSFFVVFG IMLHLYVRIC
260 270 280 290 300
QVVWRHAHQI ALQQHCLAPP HLAATRKGVG TLAVVLGTFG ASWLPFAIYC
310 320 330 340 350
VVGSQEDPAI YTYATLLPAT YNSMINPIIY AFRNQEIQRA LWLLFCGCFQ
360
SKVPFRSRSP SEV
Length:363
Mass (Da):38,085
Last modified:July 5, 2004 - v1
Checksum:i6870FF769BAAF093
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY064488 mRNA. Translation: AAL40876.1.
AK139367 mRNA. Translation: BAE23977.1.
CCDSiCCDS23802.1.
RefSeqiNP_951013.1. NM_199058.1.
XP_006512596.1. XM_006512533.1.
UniGeneiMm.290693.

Genome annotation databases

EnsembliENSMUST00000061796; ENSMUSP00000057323; ENSMUSG00000046922.
GeneIDi140741.
KEGGimmu:140741.
UCSCiuc007exj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY064488 mRNA. Translation: AAL40876.1 .
AK139367 mRNA. Translation: BAE23977.1 .
CCDSi CCDS23802.1.
RefSeqi NP_951013.1. NM_199058.1.
XP_006512596.1. XM_006512533.1.
UniGenei Mm.290693.

3D structure databases

ProteinModelPortali Q6YNI2.
SMRi Q6YNI2. Positions 78-346.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 85.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q6YNI2.

Protocols and materials databases

DNASUi 140741.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061796 ; ENSMUSP00000057323 ; ENSMUSG00000046922 .
GeneIDi 140741.
KEGGi mmu:140741.
UCSCi uc007exj.1. mouse.

Organism-specific databases

CTDi 2830.
MGIi MGI:2155249. Gpr6.

Phylogenomic databases

eggNOGi NOG327877.
GeneTreei ENSGT00760000118804.
HOGENOMi HOG000294075.
HOVERGENi HBG079561.
InParanoidi Q6YNI2.
KOi K04313.
OMAi CGCFQSK.
OrthoDBi EOG7966H0.
PhylomeDBi Q6YNI2.
TreeFami TF330052.

Miscellaneous databases

NextBioi 369959.
PROi Q6YNI2.
SOURCEi Search...

Gene expression databases

Bgeei Q6YNI2.
CleanExi MM_GPR6.
ExpressionAtlasi Q6YNI2. baseline.
Genevestigatori Q6YNI2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001151. GPR6.
IPR000723. GPR_3/6/12_orphan.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00649. GPR6ORPHANR.
PR00644. GPRORPHANR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway."
    Ignatov A., Lintzel J., Kreienkamp H.J., Schaller H.C.
    Biochem. Biophys. Res. Commun. 311:329-336(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: C57BL/6.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  3. "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth."
    Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y.
    J. Biol. Chem. 282:10506-10515(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  4. "Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6."
    Lobo M.K., Cui Y., Ostlund S.B., Balleine B.W., Yang X.W.
    Nat. Neurosci. 10:1395-1397(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR6_MOUSE
AccessioniPrimary (citable) accession number: Q6YNI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally (PubMed:14592418) thought to be a receptor for sphingosine 1-phosphate. It has been demonstrated that it is not the case in human.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3