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Q6YNI2

- GPR6_MOUSE

UniProt

Q6YNI2 - GPR6_MOUSE

Protein

G-protein coupled receptor 6

Gene

Gpr6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons By similarity.By similarity

    GO - Molecular functioni

    1. sphingosine-1-phosphate receptor activity Source: MGI

    GO - Biological processi

    1. positive regulation of cytosolic calcium ion concentration Source: MGI
    2. sphingosine-1-phosphate signaling pathway Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 6
    Alternative name(s):
    Sphingosine 1-phosphate receptor GPR6
    Gene namesi
    Name:Gpr6
    Synonyms:Gm233
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2155249. Gpr6.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Highly expressed and localized along the cytoplasmic membrane as well as in a perinuclear compartment.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Deficient mice show reduced striatal cyclic AMP production and selective alterations in instrumental conditioning.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363G-protein coupled receptor 6PRO_0000069515Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Lipidationi346 – 3461S-palmitoyl cysteineBy similarity
    Modified residuei357 – 3571PhosphoserineSequence Analysis
    Modified residuei359 – 3591PhosphoserineSequence Analysis
    Modified residuei361 – 3611PhosphoserineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiQ6YNI2.

    Expressioni

    Tissue specificityi

    Mainly expressed in the brain. Selectively expressed in striatopallidal neurons in the striatum.2 Publications

    Gene expression databases

    BgeeiQ6YNI2.
    CleanExiMM_GPR6.
    GenevestigatoriQ6YNI2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6YNI2.
    SMRiQ6YNI2. Positions 78-346.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini96 – 10712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini132 – 14312ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini166 – 18621CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini207 – 23125ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini251 – 27828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini306 – 3105ExtracellularSequence Analysis
    Topological domaini333 – 36331CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9520Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 13124Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20620Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei232 – 25019Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei279 – 30527Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei311 – 33222Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi21 – 288Poly-Ala
    Compositional biasi46 – 505Poly-Gly

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG327877.
    GeneTreeiENSGT00750000117639.
    HOGENOMiHOG000294075.
    HOVERGENiHBG079561.
    InParanoidiQ6YNI2.
    KOiK04313.
    OMAiCGCFQSK.
    OrthoDBiEOG7966H0.
    PhylomeDBiQ6YNI2.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001151. GPR6.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00649. GPR6ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6YNI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNASAAALNE SQVVAVAAEG AAAAATAAGA PDTGEWGPPA ASAALGGGGG    50
    PNGSLELSSQ LPAGPSGLLL SAVNPWDVLL CVSGTVIAGE NALVVALIAS 100
    TPALRTPMFV LVGSLATADL LAGCGLILHF VFQYVVPSET VSLLMVGFLV 150
    ASFAASVSSL LAITVDRYLS LYNALTYYSR RTLLGVHLLL AATWTVSLGL 200
    GLLPVLGWNC LADRTSCSVV RPLTRSHVAL LSTSFFVVFG IMLHLYVRIC 250
    QVVWRHAHQI ALQQHCLAPP HLAATRKGVG TLAVVLGTFG ASWLPFAIYC 300
    VVGSQEDPAI YTYATLLPAT YNSMINPIIY AFRNQEIQRA LWLLFCGCFQ 350
    SKVPFRSRSP SEV 363
    Length:363
    Mass (Da):38,085
    Last modified:July 5, 2004 - v1
    Checksum:i6870FF769BAAF093
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY064488 mRNA. Translation: AAL40876.1.
    AK139367 mRNA. Translation: BAE23977.1.
    CCDSiCCDS23802.1.
    RefSeqiNP_951013.1. NM_199058.1.
    XP_006512596.1. XM_006512533.1.
    UniGeneiMm.290693.

    Genome annotation databases

    EnsembliENSMUST00000061796; ENSMUSP00000057323; ENSMUSG00000046922.
    GeneIDi140741.
    KEGGimmu:140741.
    UCSCiuc007exj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY064488 mRNA. Translation: AAL40876.1 .
    AK139367 mRNA. Translation: BAE23977.1 .
    CCDSi CCDS23802.1.
    RefSeqi NP_951013.1. NM_199058.1.
    XP_006512596.1. XM_006512533.1.
    UniGenei Mm.290693.

    3D structure databases

    ProteinModelPortali Q6YNI2.
    SMRi Q6YNI2. Positions 78-346.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 85.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q6YNI2.

    Protocols and materials databases

    DNASUi 140741.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061796 ; ENSMUSP00000057323 ; ENSMUSG00000046922 .
    GeneIDi 140741.
    KEGGi mmu:140741.
    UCSCi uc007exj.1. mouse.

    Organism-specific databases

    CTDi 2830.
    MGIi MGI:2155249. Gpr6.

    Phylogenomic databases

    eggNOGi NOG327877.
    GeneTreei ENSGT00750000117639.
    HOGENOMi HOG000294075.
    HOVERGENi HBG079561.
    InParanoidi Q6YNI2.
    KOi K04313.
    OMAi CGCFQSK.
    OrthoDBi EOG7966H0.
    PhylomeDBi Q6YNI2.
    TreeFami TF330052.

    Miscellaneous databases

    NextBioi 369959.
    PROi Q6YNI2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6YNI2.
    CleanExi MM_GPR6.
    Genevestigatori Q6YNI2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001151. GPR6.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00649. GPR6ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway."
      Ignatov A., Lintzel J., Kreienkamp H.J., Schaller H.C.
      Biochem. Biophys. Res. Commun. 311:329-336(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: C57BL/6.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex.
    3. "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth."
      Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y.
      J. Biol. Chem. 282:10506-10515(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    4. "Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6."
      Lobo M.K., Cui Y., Ostlund S.B., Balleine B.W., Yang X.W.
      Nat. Neurosci. 10:1395-1397(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGPR6_MOUSE
    AccessioniPrimary (citable) accession number: Q6YNI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally (PubMed:14592418) thought to be a receptor for sphingosine 1-phosphate. It has been demonstrated that it is not the case in human.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3