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Q6YN16

- HSDL2_HUMAN

UniProt

Q6YN16 - HSDL2_HUMAN

Protein

Hydroxysteroid dehydrogenase-like protein 2

Gene

HSDL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Has apparently no steroid dehydrogenase activity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421NADP1 Publication
    Binding sitei74 – 741NADP1 Publication
    Active sitei168 – 1681Proton acceptorPROSITE-ProRule annotation
    Binding sitei172 – 1721NADP1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 237NADP1 Publication

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxysteroid dehydrogenase-like protein 2 (EC:1.-.-.-)
    Gene namesi
    Name:HSDL2
    Synonyms:C9orf99
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18572. HSDL2.

    Subcellular locationi

    Peroxisome 1 Publication

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. mitochondrion Source: Ensembl
    3. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Peroxisome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134980105.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Hydroxysteroid dehydrogenase-like protein 2PRO_0000319888Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei116 – 1161N6-acetyllysineBy similarity
    Modified residuei318 – 3181N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ6YN16.
    PaxDbiQ6YN16.
    PRIDEiQ6YN16.

    2D gel databases

    UCD-2DPAGEQ6YN16.

    PTM databases

    PhosphoSiteiQ6YN16.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ6YN16.
    BgeeiQ6YN16.
    CleanExiHS_HSDL2.
    GenevestigatoriQ6YN16.

    Organism-specific databases

    HPAiHPA042890.
    HPA050453.

    Interactioni

    Protein-protein interaction databases

    BioGridi123990. 6 interactions.
    IntActiQ6YN16. 2 interactions.
    STRINGi9606.ENSP00000381785.

    Structurei

    Secondary structure

    1
    418
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni7 – 104
    Beta strandi12 – 165
    Turni17 – 193
    Helixi21 – 3111
    Turni32 – 343
    Beta strandi36 – 427
    Beta strandi48 – 503
    Helixi54 – 6310
    Beta strandi67 – 726
    Helixi78 – 9215
    Beta strandi97 – 1004
    Turni110 – 1123
    Helixi115 – 12410
    Helixi126 – 14015
    Beta strandi147 – 1515
    Helixi159 – 1613
    Beta strandi163 – 1653
    Helixi166 – 18520
    Turni186 – 1894
    Beta strandi191 – 1966
    Helixi204 – 2096
    Helixi215 – 2173
    Helixi222 – 23211
    Beta strandi242 – 2443
    Helixi245 – 2517
    Helixi257 – 2604
    Beta strandi261 – 2633

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3KVOX-ray2.25A/B1-293[»]
    ProteinModelPortaliQ6YN16.
    SMRiQ6YN16. Positions 1-276, 326-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6YN16.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini306 – 415110SCP2Add
    BLAST

    Sequence similaritiesi

    Contains 1 SCP2 domain.Curated

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG107982.
    InParanoidiQ6YN16.
    OMAiWFKNHTA.
    OrthoDBiEOG77T155.
    PhylomeDBiQ6YN16.
    TreeFamiTF101523.

    Family and domain databases

    Gene3Di3.30.1050.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    IPR003033. SCP2_sterol-bd_dom.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    PF02036. SCP2. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    SUPFAMiSSF55718. SSF55718. 1 hit.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6YN16-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPNTGRLAG CTVFITGASR GIGKAIALKA AKDGANIVIA AKTAQPHPKL    50
    LGTIYTAAEE IEAVGGKALP CIVDVRDEQQ ISAAVEKAIK KFGGIDILVN 100
    NASAISLTNT LDTPTKRLDL MMNVNTRGTY LASKACIPYL KKSKVAHILN 150
    ISPPLNLNPV WFKQHCAYTI AKYGMSMYVL GMAEEFKGEI AVNALWPKTA 200
    IHTAAMDMLG GPGIESQCRK VDIIADAAYS IFQKPKSFTG NFVIDENILK 250
    EEGIENFDVY AIKPGHPLQP DFFLDEYPEA VSKKVESTGA VPEFKEEKLQ 300
    LQPKPRSGAV EETFRIVKDS LSDDVVKATQ AIYLFELSGE DGGTWFLDLK 350
    SKGGNVGYGE PSDQADVVMS MTTDDFVKMF SGKLKPTMAF MSGKLKIKGN 400
    MALAIKLEKL MNQMNARL 418
    Length:418
    Mass (Da):45,395
    Last modified:July 5, 2004 - v1
    Checksum:iA8B27CC7D6F1B636
    GO
    Isoform 2 (identifier: Q6YN16-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         94-166: Missing.

    Show »
    Length:345
    Mass (Da):37,320
    Checksum:iA8CE6A7AC163A2D1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621E → G in BAF82618. (PubMed:14702039)Curated
    Sequence conflicti89 – 891I → V in BAF85175. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei94 – 16673Missing in isoform 2. 2 PublicationsVSP_031529Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY093428 mRNA. Translation: AAM14670.1.
    AK292486 mRNA. Translation: BAF85175.1.
    AK289929 mRNA. Translation: BAF82618.1.
    AL162732 Genomic DNA. Translation: CAM17151.1.
    AL162732 Genomic DNA. Translation: CAM17152.1.
    CH471105 Genomic DNA. Translation: EAW59105.1.
    CH471105 Genomic DNA. Translation: EAW59106.1.
    BC004331 mRNA. Translation: AAH04331.1.
    BC095451 mRNA. Translation: AAH95451.1.
    AL833735 mRNA. Translation: CAH56256.1.
    CCDSiCCDS43864.1. [Q6YN16-1]
    CCDS56582.1. [Q6YN16-2]
    RefSeqiNP_001182751.1. NM_001195822.1. [Q6YN16-2]
    NP_115679.2. NM_032303.4. [Q6YN16-1]
    UniGeneiHs.59486.

    Genome annotation databases

    EnsembliENST00000398803; ENSP00000381783; ENSG00000119471. [Q6YN16-2]
    ENST00000398805; ENSP00000381785; ENSG00000119471. [Q6YN16-1]
    GeneIDi84263.
    KEGGihsa:84263.
    UCSCiuc004bga.2. human. [Q6YN16-1]
    uc004bgc.2. human. [Q6YN16-2]

    Polymorphism databases

    DMDMi74749521.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY093428 mRNA. Translation: AAM14670.1 .
    AK292486 mRNA. Translation: BAF85175.1 .
    AK289929 mRNA. Translation: BAF82618.1 .
    AL162732 Genomic DNA. Translation: CAM17151.1 .
    AL162732 Genomic DNA. Translation: CAM17152.1 .
    CH471105 Genomic DNA. Translation: EAW59105.1 .
    CH471105 Genomic DNA. Translation: EAW59106.1 .
    BC004331 mRNA. Translation: AAH04331.1 .
    BC095451 mRNA. Translation: AAH95451.1 .
    AL833735 mRNA. Translation: CAH56256.1 .
    CCDSi CCDS43864.1. [Q6YN16-1 ]
    CCDS56582.1. [Q6YN16-2 ]
    RefSeqi NP_001182751.1. NM_001195822.1. [Q6YN16-2 ]
    NP_115679.2. NM_032303.4. [Q6YN16-1 ]
    UniGenei Hs.59486.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3KVO X-ray 2.25 A/B 1-293 [» ]
    ProteinModelPortali Q6YN16.
    SMRi Q6YN16. Positions 1-276, 326-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123990. 6 interactions.
    IntActi Q6YN16. 2 interactions.
    STRINGi 9606.ENSP00000381785.

    PTM databases

    PhosphoSitei Q6YN16.

    Polymorphism databases

    DMDMi 74749521.

    2D gel databases

    UCD-2DPAGE Q6YN16.

    Proteomic databases

    MaxQBi Q6YN16.
    PaxDbi Q6YN16.
    PRIDEi Q6YN16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398803 ; ENSP00000381783 ; ENSG00000119471 . [Q6YN16-2 ]
    ENST00000398805 ; ENSP00000381785 ; ENSG00000119471 . [Q6YN16-1 ]
    GeneIDi 84263.
    KEGGi hsa:84263.
    UCSCi uc004bga.2. human. [Q6YN16-1 ]
    uc004bgc.2. human. [Q6YN16-2 ]

    Organism-specific databases

    CTDi 84263.
    GeneCardsi GC09P115142.
    HGNCi HGNC:18572. HSDL2.
    HPAi HPA042890.
    HPA050453.
    neXtProti NX_Q6YN16.
    PharmGKBi PA134980105.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG107982.
    InParanoidi Q6YN16.
    OMAi WFKNHTA.
    OrthoDBi EOG77T155.
    PhylomeDBi Q6YN16.
    TreeFami TF101523.

    Miscellaneous databases

    EvolutionaryTracei Q6YN16.
    GenomeRNAii 84263.
    NextBioi 73798.
    PROi Q6YN16.

    Gene expression databases

    ArrayExpressi Q6YN16.
    Bgeei Q6YN16.
    CleanExi HS_HSDL2.
    Genevestigatori Q6YN16.

    Family and domain databases

    Gene3Di 3.30.1050.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    IPR003033. SCP2_sterol-bd_dom.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    PF02036. SCP2. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    SUPFAMi SSF55718. SSF55718. 1 hit.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human hydroxysteroid dehydrogenase-like 2 (HSDL2) cDNA from fetal brain."
      Dai J., Xie Y., Wu Q., Wang L., Yin G., Ye X., Zeng L., Xu J., Ji C., Gu S., Huang Q., Zhao R.C., Mao Y.
      Biochem. Genet. 41:165-174(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Hippocampus and Testis.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Blood vessel and Uterus.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-418 (ISOFORM 1).
      Tissue: Stomach.
    7. "In search for function of two human orphan SDR enzymes: Hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain dehydrogenase/reductase-orphan (SDR-O)."
      Kowalik D., Haller F., Adamski J., Moeller G.
      J. Steroid Biochem. Mol. Biol. 117:117-124(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Crystal structure of the catalytic domain of human hydroxysteroid dehydrogenase like 2 (HSDL2)."
      Structural genomics consortium (SGC)
      Submitted (MAR-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 1-293 IN COMPLEX WITH NADP.

    Entry informationi

    Entry nameiHSDL2_HUMAN
    AccessioniPrimary (citable) accession number: Q6YN16
    Secondary accession number(s): A8K1L4
    , A8K8X1, A8MSV3, Q658M8, Q9BT58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3