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Protein

Hydroxysteroid dehydrogenase-like protein 2

Gene

HSDL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has apparently no steroid dehydrogenase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42NADP1 Publication1
Binding sitei74NADP1 Publication1
Active sitei168Proton acceptorPROSITE-ProRule annotation1
Binding sitei172NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 23NADP1 Publication7

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxysteroid dehydrogenase-like protein 2 (EC:1.-.-.-)
Alternative name(s):
Short chain dehydrogenase/reductase family 13C member 1
Gene namesi
Name:HSDL2
Synonyms:C9orf99, SDR13C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:18572. HSDL2.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • mitochondrion Source: Ensembl
  • peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi84263.
OpenTargetsiENSG00000119471.
PharmGKBiPA134980105.

Polymorphism and mutation databases

BioMutaiHSDL2.
DMDMi74749521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003198881 – 418Hydroxysteroid dehydrogenase-like protein 2Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116N6-acetyllysineBy similarity1
Modified residuei318N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6YN16.
MaxQBiQ6YN16.
PaxDbiQ6YN16.
PeptideAtlasiQ6YN16.
PRIDEiQ6YN16.

2D gel databases

UCD-2DPAGEQ6YN16.

PTM databases

iPTMnetiQ6YN16.
PhosphoSitePlusiQ6YN16.
SwissPalmiQ6YN16.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000119471.
CleanExiHS_HSDL2.
ExpressionAtlasiQ6YN16. baseline and differential.
GenevisibleiQ6YN16. HS.

Organism-specific databases

HPAiHPA042890.
HPA050453.

Interactioni

Protein-protein interaction databases

BioGridi123990. 22 interactors.
IntActiQ6YN16. 13 interactors.
STRINGi9606.ENSP00000381785.

Structurei

Secondary structure

1418
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni7 – 10Combined sources4
Beta strandi12 – 16Combined sources5
Turni17 – 19Combined sources3
Helixi21 – 31Combined sources11
Turni32 – 34Combined sources3
Beta strandi36 – 42Combined sources7
Beta strandi48 – 50Combined sources3
Helixi54 – 63Combined sources10
Beta strandi67 – 72Combined sources6
Helixi78 – 92Combined sources15
Beta strandi97 – 100Combined sources4
Turni110 – 112Combined sources3
Helixi115 – 124Combined sources10
Helixi126 – 140Combined sources15
Beta strandi147 – 151Combined sources5
Helixi159 – 161Combined sources3
Beta strandi163 – 165Combined sources3
Helixi166 – 185Combined sources20
Turni186 – 189Combined sources4
Beta strandi191 – 196Combined sources6
Helixi204 – 209Combined sources6
Helixi215 – 217Combined sources3
Helixi222 – 232Combined sources11
Beta strandi242 – 244Combined sources3
Helixi245 – 251Combined sources7
Helixi257 – 260Combined sources4
Beta strandi261 – 263Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KVOX-ray2.25A/B1-293[»]
ProteinModelPortaliQ6YN16.
SMRiQ6YN16.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6YN16.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini306 – 415SCP2Add BLAST110

Sequence similaritiesi

Contains 1 SCP2 domain.Curated

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
KOG4170. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00730000111071.
HOVERGENiHBG107982.
InParanoidiQ6YN16.
OMAiLPCVVDI.
OrthoDBiEOG091G0EVM.
PhylomeDBiQ6YN16.
TreeFamiTF101523.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR003033. SCP2_sterol-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
PF02036. SCP2. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF55718. SSF55718. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6YN16-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPNTGRLAG CTVFITGASR GIGKAIALKA AKDGANIVIA AKTAQPHPKL
60 70 80 90 100
LGTIYTAAEE IEAVGGKALP CIVDVRDEQQ ISAAVEKAIK KFGGIDILVN
110 120 130 140 150
NASAISLTNT LDTPTKRLDL MMNVNTRGTY LASKACIPYL KKSKVAHILN
160 170 180 190 200
ISPPLNLNPV WFKQHCAYTI AKYGMSMYVL GMAEEFKGEI AVNALWPKTA
210 220 230 240 250
IHTAAMDMLG GPGIESQCRK VDIIADAAYS IFQKPKSFTG NFVIDENILK
260 270 280 290 300
EEGIENFDVY AIKPGHPLQP DFFLDEYPEA VSKKVESTGA VPEFKEEKLQ
310 320 330 340 350
LQPKPRSGAV EETFRIVKDS LSDDVVKATQ AIYLFELSGE DGGTWFLDLK
360 370 380 390 400
SKGGNVGYGE PSDQADVVMS MTTDDFVKMF SGKLKPTMAF MSGKLKIKGN
410
MALAIKLEKL MNQMNARL
Length:418
Mass (Da):45,395
Last modified:July 5, 2004 - v1
Checksum:iA8B27CC7D6F1B636
GO
Isoform 2 (identifier: Q6YN16-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-166: Missing.

Show »
Length:345
Mass (Da):37,320
Checksum:iA8CE6A7AC163A2D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62E → G in BAF82618 (PubMed:14702039).Curated1
Sequence conflicti89I → V in BAF85175 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03152994 – 166Missing in isoform 2. 2 PublicationsAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093428 mRNA. Translation: AAM14670.1.
AK292486 mRNA. Translation: BAF85175.1.
AK289929 mRNA. Translation: BAF82618.1.
AL162732 Genomic DNA. Translation: CAM17151.1.
AL162732 Genomic DNA. Translation: CAM17152.1.
CH471105 Genomic DNA. Translation: EAW59105.1.
CH471105 Genomic DNA. Translation: EAW59106.1.
BC004331 mRNA. Translation: AAH04331.1.
BC095451 mRNA. Translation: AAH95451.1.
AL833735 mRNA. Translation: CAH56256.1.
CCDSiCCDS43864.1. [Q6YN16-1]
CCDS56582.1. [Q6YN16-2]
RefSeqiNP_001182751.1. NM_001195822.1. [Q6YN16-2]
NP_115679.2. NM_032303.4. [Q6YN16-1]
UniGeneiHs.59486.

Genome annotation databases

EnsembliENST00000398803; ENSP00000381783; ENSG00000119471. [Q6YN16-2]
ENST00000398805; ENSP00000381785; ENSG00000119471. [Q6YN16-1]
GeneIDi84263.
KEGGihsa:84263.
UCSCiuc004bga.3. human. [Q6YN16-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093428 mRNA. Translation: AAM14670.1.
AK292486 mRNA. Translation: BAF85175.1.
AK289929 mRNA. Translation: BAF82618.1.
AL162732 Genomic DNA. Translation: CAM17151.1.
AL162732 Genomic DNA. Translation: CAM17152.1.
CH471105 Genomic DNA. Translation: EAW59105.1.
CH471105 Genomic DNA. Translation: EAW59106.1.
BC004331 mRNA. Translation: AAH04331.1.
BC095451 mRNA. Translation: AAH95451.1.
AL833735 mRNA. Translation: CAH56256.1.
CCDSiCCDS43864.1. [Q6YN16-1]
CCDS56582.1. [Q6YN16-2]
RefSeqiNP_001182751.1. NM_001195822.1. [Q6YN16-2]
NP_115679.2. NM_032303.4. [Q6YN16-1]
UniGeneiHs.59486.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KVOX-ray2.25A/B1-293[»]
ProteinModelPortaliQ6YN16.
SMRiQ6YN16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123990. 22 interactors.
IntActiQ6YN16. 13 interactors.
STRINGi9606.ENSP00000381785.

PTM databases

iPTMnetiQ6YN16.
PhosphoSitePlusiQ6YN16.
SwissPalmiQ6YN16.

Polymorphism and mutation databases

BioMutaiHSDL2.
DMDMi74749521.

2D gel databases

UCD-2DPAGEQ6YN16.

Proteomic databases

EPDiQ6YN16.
MaxQBiQ6YN16.
PaxDbiQ6YN16.
PeptideAtlasiQ6YN16.
PRIDEiQ6YN16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398803; ENSP00000381783; ENSG00000119471. [Q6YN16-2]
ENST00000398805; ENSP00000381785; ENSG00000119471. [Q6YN16-1]
GeneIDi84263.
KEGGihsa:84263.
UCSCiuc004bga.3. human. [Q6YN16-1]

Organism-specific databases

CTDi84263.
DisGeNETi84263.
GeneCardsiHSDL2.
HGNCiHGNC:18572. HSDL2.
HPAiHPA042890.
HPA050453.
neXtProtiNX_Q6YN16.
OpenTargetsiENSG00000119471.
PharmGKBiPA134980105.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
KOG4170. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00730000111071.
HOVERGENiHBG107982.
InParanoidiQ6YN16.
OMAiLPCVVDI.
OrthoDBiEOG091G0EVM.
PhylomeDBiQ6YN16.
TreeFamiTF101523.

Miscellaneous databases

ChiTaRSiHSDL2. human.
EvolutionaryTraceiQ6YN16.
GenomeRNAii84263.
PROiQ6YN16.

Gene expression databases

BgeeiENSG00000119471.
CleanExiHS_HSDL2.
ExpressionAtlasiQ6YN16. baseline and differential.
GenevisibleiQ6YN16. HS.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR003033. SCP2_sterol-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
PF02036. SCP2. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF55718. SSF55718. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSDL2_HUMAN
AccessioniPrimary (citable) accession number: Q6YN16
Secondary accession number(s): A8K1L4
, A8K8X1, A8MSV3, Q658M8, Q9BT58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.