Q6YI67 (Q6YI67_MYCPR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase subunit beta HAMAP-Rule MF_01321
Short name=RNAP subunit beta HAMAP-Rule MF_01321
EC=2.7.7.6 HAMAP-Rule MF_01321

Alternative name(s):
RNA polymerase subunit beta HAMAP-Rule MF_01321
Transcriptase subunit beta HAMAP-Rule MF_01321

Gene names

Name:

rpoB HAMAP-Rule MF_01321 EMBL AAN65353.1

Organism

Mycobacterium peregrinum EMBL AAN65353.1

Taxonomic identifier

43304 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1169 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates By similarity. HAMAP-Rule MF_01321 RuleBase RU000432
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP-Rule MF_01321
Subunit structure	The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity. HAMAP-Rule MF_01321 RuleBase RU000433
Sequence similarities	Belongs to the RNA polymerase beta chain family. HAMAP-Rule MF_01321 RuleBase RU000434

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase HAMAP-Rule MF_01321
Molecular function	Nucleotidyltransferase HAMAP-Rule MF_01321 Transferase
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: HAMAP ribonucleoside binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6YI67 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F6A32466A9963955	FASTA	1,169	128,429
	10 20 30 40 50 60 MLEGCILAVS SQSTANANTN NSVPGAPNRV SFAKLREPLE VPGLLDVQTD SFDWLVGADG 70 80 90 100 110 120 WRQKAVDRGE TDPKGGLEEV LEELSPIEDF SGSMSLSFSD PRFDEVKAPV DECKDKDMTY 130 140 150 160 170 180 AAPLFVTAEF INNNTGEIKS QTVFMGDFPM MTEKGTFIIN GTERVVVSQL VRSPGVYFDE 190 200 210 220 230 240 SIDKSTEKTL HSVKVIPGRG AWLEFDVDKR DTVGVRIDRK RRQPVTVLLK ALGWTSEQIT 250 260 270 280 290 300 ERFGFSEIMM GTLEKDSTAG PDEALLDIYR KLRPGEPPTK ESAQTLLENL FFKEKRYDLA 310 320 330 340 350 360 RVGRYKVNKK LGLNAGQPIT SSTLTEEDVV ATIEYLVRLH EGQTSMTVPG GVEVPVEVDD 370 380 390 400 410 420 IDHFGNRRLR TVGELIQNQI RVGLSRMERV VRERMTTQDV EAITPQTLIN IRPVVAAIKE 430 440 450 460 470 480 FFGTSQLSQF MDQNNPLSGL THKRRLSALG PGGLSRERAG LEVRDVHSSH YGRMCPIETP 490 500 510 520 530 540 EGPNIGLIGS LSVYARVNPF GFIETPYRKV VDGVVSDQID YLTADEEDRH VVAQANSPID 550 560 570 580 590 600 TDGRFTEDRV MVRRKGGEVE NVAPSDVDYM DVSPRQMVSV ATAMIPFLEH DDANRALMGA 610 620 630 640 650 660 NMQRQAVPLV RSEAPLVGTG MELRAAIDAG DVIVSEKAGV VEEVSADYIT VMADDGSRHT 670 680 690 700 710 720 YRMRKFARSN HGTCANQRPI VDAGQRVEAG QVVADGPCTE NGEMALGKNL LVAIMPWEGH 730 740 750 760 770 780 NYEDAIILSN RLVEEDVLTS IHIEEHEIDA RDTKLGAEEI TRDIPNVSDE VLADLDERGI 790 800 810 820 830 840 VRIGAEVRDG DILVGKVTPK GETELTPEER LLRAIFGEKA REVRDTSLKV PHGESGKVIG 850 860 870 880 890 900 IRVFSREDDD ELPAGVNELV RVYVAQKRKI SDGDKLAGRH GNKGVIGKIL PVEDMPFMPD 910 920 930 940 950 960 GTPVDIILNT HGVPRRMNIG QILETHLGWV AKAGWNIDVA EGTPEWASRL PDGLHSAPVD 970 980 990 1000 1010 1020 SIVSTPVFDG AREEELAGLL GSTLPNRDGD VMVNADGKAT LFDGRSGEPF PYPVTVGYMY 1030 1040 1050 1060 1070 1080 ILKLHHLVDD KIHARSTGPY SMITQQPLGG KAQFGGQRFG EMECWAMQAY GAAYTLQELL 1090 1100 1110 1120 1130 1140 TIKSDDTVGR VKVYEAIVKG ENIPEPGIPE SFKVLLKELQ SLCLNVEVLS SDGAAIEMRD 1150 1160 GDDEDLDRAA ANLGINLSRN ESASVEDLA

References

[1]	"rpoB-based identification of nonpigmented and late-pigmenting rapidly growing mycobacteria." Adekambi T., Colson P., Drancourt M. J. Clin. Microbiol. 41:5699-5708(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: CIP 105382T EMBL AAN65353.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY147166 Genomic DNA. Translation: AAN65353.1.
3D structure databases
ProteinModelPortal	Q6YI67.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.30.150.10. 1 hit. 2.40.270.10. 2 hits. 2.40.50.150. 1 hit.
HAMAP	MF_01321. RNApol_bact_RpoB.
InterPro	IPR010243. DNA-dir_RNA_pol_bsu. IPR019462. DNA-dir_RNA_pol_bsu_external_1. IPR015712. DNA-dir_RNA_pol_su2. IPR007120. DNA-dir_RNA_pol_su2_6. IPR007121. RNA_pol_bsu_CS. IPR007644. RNA_pol_bsu_protrusion. IPR007642. RNA_pol_Rpb2_2. IPR007645. RNA_pol_Rpb2_3. IPR007641. RNA_pol_Rpb2_7. IPR014724. RNA_pol_RPB2_OB-fold. [Graphical view]
PANTHER	PTHR20856. PTHR20856. 1 hit. PTHR20856:SF3. PTHR20856:SF3. 1 hit.
Pfam	PF04563. RNA_pol_Rpb2_1. 1 hit. PF04561. RNA_pol_Rpb2_2. 1 hit. PF04565. RNA_pol_Rpb2_3. 1 hit. PF10385. RNA_pol_Rpb2_45. 1 hit. PF00562. RNA_pol_Rpb2_6. 1 hit. PF04560. RNA_pol_Rpb2_7. 1 hit. [Graphical view]
TIGRFAMs	TIGR02013. rpoB. 1 hit.
PROSITE	PS01166. RNA_POL_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6YI67_MYCPR

Accession

Primary (citable) accession number: Q6YI67

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	March 6, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)