Q6YI62 (Q6YI62_9MYCO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase subunit beta HAMAP-Rule MF_01321
Short name=RNAP subunit beta HAMAP-Rule MF_01321
EC=2.7.7.6 HAMAP-Rule MF_01321

Alternative name(s):
RNA polymerase subunit beta HAMAP-Rule MF_01321
Transcriptase subunit beta HAMAP-Rule MF_01321

Gene names

Name:

rpoB HAMAP-Rule MF_01321 EMBL AAN65358.1

Organism

Mycobacterium mucogenicum EMBL AAN65358.1

Taxonomic identifier

56689 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1167 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates By similarity. RuleBase RU000432 HAMAP-Rule MF_01321
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP-Rule MF_01321
Subunit structure	The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity. RuleBase RU000433 HAMAP-Rule MF_01321
Sequence similarities	Belongs to the RNA polymerase beta chain family. RuleBase RU000434 HAMAP-Rule MF_01321

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase HAMAP-Rule MF_01321
Molecular function	Nucleotidyltransferase HAMAP-Rule MF_01321 Transferase
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: HAMAP ribonucleoside binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6YI62 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A1EE5A738A454E4B	FASTA	1,167	128,802
	10 20 30 40 50 60 MLEGRILAVS RESKSVDSNN SVPGAPNRVS FAKLREPLEV PGLLDVQTDS FEWLIGSDRW 70 80 90 100 110 120 RSKAVDRGDI NPVGGLEEVL AELSPIEDFA GTLSLSFSDP RFDEVKAPVD ECKEKDQTYA 130 140 150 160 170 180 APLFVTAEFI NNNTGEIKSQ TVFMGDFPMM TEKGTFIING TERVVVSQLV RSPGVYFDES 190 200 210 220 230 240 IDKATEKTLH SVKVIPGRGA WLEFDVDKRD TVGVRIDRKR RQPVTVLLKA LGWTNEQIRE 250 260 270 280 290 300 RFGFSEIMMG TLEKDPTAGP DEALLDIYRK LRPGEPPTKE SAQTLLENLF FKEKRYDLAR 310 320 330 340 350 360 VGRYKVNKKL GLHDGNPAQV TATTLTEEDI VATIEYLVRL HDGDKTMTAP GGVEVPVEVD 370 380 390 400 410 420 DIDHFGNRRL RTVGELIQNQ IRVGLSRMER VVRERMTTQD VEAITPQTLI NIRPVVAAIK 430 440 450 460 470 480 EFFGTSQLSQ FMDQNNPLSG LTHKRRLSAL GPGGLSRERA GLEVRDVHSS HYGRMCPIET 490 500 510 520 530 540 PEGPNIGLIG SLSVYARVNP FGFIETPYRK VVDGIVTDQI DYLTADEEDR HVVAQANSPL 550 560 570 580 590 600 DANGHFTEEK ILVRRKGGEV EFVSANDVDY MDVSPRQMVS VATAMIPFLE HDDANRALMG 610 620 630 640 650 660 ANMQRQAVPL VRSEAPLVGT GMELRAAIDA GDVVVADKSG VIEEVSADYV TVMADDGSRH 670 680 690 700 710 720 TYRMRKFNRS NHGTCANQRP IVDSGQRVEA GQVIADGPCT ENGEMALGKN LLVAVMPWEG 730 740 750 760 770 780 HNYEDAIILS QRLVEQDVLT SIHIEEHEID ARDTKLGAEE ITRDIPNVSD EVLADLDERG 790 800 810 820 830 840 IVRIGAEVRD GDILVGKVTP KGETELTPEE RLLRAIFGEK AREVRDTSLK VPHGESGKVI 850 860 870 880 890 900 GVRVFSREDD DDLPAGVNEL VRVYVAQKRK ISDGDKLAGR HGNKGVIGKI LPQEDMPFMP 910 920 930 940 950 960 DGTPVDIILN THGVPRRMNI GQILETHLGW VAKAGWNIEG EPEWAANLPE GMRSAPRDSI 970 980 990 1000 1010 1020 VATPVFDGAR ENELQGLLGA TLPNRDGEVM VDADGKSQLF DGRSGEPFPY PVTVGYMYIL 1030 1040 1050 1060 1070 1080 KLHHLVDDKI HARSTGPYSM ITQQPLGGKA QFGGQRFGEM ECWAMQAYGA AYTLQELLTI 1090 1100 1110 1120 1130 1140 KSDDTVGRVK VYEAIVKGEN IPEPGIPESF KVLLKELQSL CLNVEVLSSD GAAIEMRDSD 1150 1160 DEDLERTAAN LGINLSRNES ASVEDLA

References

[1]	"rpoB-based identification of nonpigmented and late-pigmenting rapidly growing mycobacteria." Adekambi T., Colson P., Drancourt M. J. Clin. Microbiol. 41:5699-5708(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 49649 EMBL AAN65358.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY147171 Genomic DNA. Translation: AAN65358.1.
3D structure databases
ProteinModelPortal	Q6YI62.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.30.150.10. 1 hit. 2.40.270.10. 2 hits. 2.40.50.150. 1 hit.
HAMAP	MF_01321. RNApol_bact_RpoB.
InterPro	IPR010243. DNA-dir_RNA_pol_bsu. IPR019462. DNA-dir_RNA_pol_bsu_external_1. IPR015712. DNA-dir_RNA_pol_su2. IPR007120. DNA-dir_RNA_pol_su2_6. IPR007121. RNA_pol_bsu_CS. IPR007644. RNA_pol_bsu_protrusion. IPR007642. RNA_pol_Rpb2_2. IPR007645. RNA_pol_Rpb2_3. IPR007641. RNA_pol_Rpb2_7. IPR014724. RNA_pol_RPB2_OB-fold. [Graphical view]
PANTHER	PTHR20856. PTHR20856. 1 hit. PTHR20856:SF3. PTHR20856:SF3. 1 hit.
Pfam	PF04563. RNA_pol_Rpb2_1. 1 hit. PF04561. RNA_pol_Rpb2_2. 1 hit. PF04565. RNA_pol_Rpb2_3. 1 hit. PF10385. RNA_pol_Rpb2_45. 1 hit. PF00562. RNA_pol_Rpb2_6. 1 hit. PF04560. RNA_pol_Rpb2_7. 1 hit. [Graphical view]
TIGRFAMs	TIGR02013. rpoB. 1 hit.
PROSITE	PS01166. RNA_POL_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6YI62_9MYCO

Accession

Primary (citable) accession number: Q6YI62

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	March 6, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)