Receptor-type tyrosine-protein phosphatase U precursor

Preferred order of sections

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase U
Short name=R-PTP-U
EC=3.1.3.48

Alternative name(s):
Receptor-type protein-tyrosine phosphatase psi
Short name=R-PTP-psi
Short name=cRPTPPSI

Gene names

Name:	PTPRU
Synonyms:	RPTPPSI

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	1434 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity By similarity.
Catalytic activity	Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.
Subcellular location	Cell junction By similarity. Cell membrane; Single-pass type I membrane protein By similarity.
Developmental stage	First observed at HH4 in mesodermal progenitor cells surrounding the area of Hensen node and in the primitive streak. Expressed in the presomitic mesoderm and dynamically expressed in forming somites. Detected in the developing intermediate mesoderm at HH9 and in the mesonephric tubules and ducts by stage HH18. Expressed in the developing nervous system. Also observed in the limb bud and the developing heart. Ref.1
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Contains 4 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 MAM domain. Contains 2 tyrosine-protein phosphatase domains.
Sequence caution	The sequence AAA49016.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin.

Ontologies

Keywords
Biological process	Cell adhesion Differentiation
Cellular component	Cell junction Cell membrane Membrane
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 17

17

Potential

Chain

18 – 1434

1417

Receptor-type tyrosine-protein phosphatase U

PRO_0000371660

Regions

Topological domain

18 – 748

731

Extracellular Potential

Transmembrane

749 – 769

21

Helical; Potential

Topological domain

770 – 1434

665

Cytoplasmic Potential

Domain

25 – 187

163

MAM

Domain

189 – 274

86

Ig-like C2-type

Domain

284 – 376

93

Fibronectin type-III 1

Domain

382 – 480

99

Fibronectin type-III 2

Domain

481 – 584

104

Fibronectin type-III 3

Domain

597 – 677

81

Fibronectin type-III 4

Domain

876 – 1132

257

Tyrosine-protein phosphatase 1

Domain

1164 – 1427

264

Tyrosine-protein phosphatase 2

Region

1073 – 1079

7

Substrate binding By similarity

Sites

Active site

1073

1

Phosphocysteine intermediate By similarity

Active site

1368

1

Phosphocysteine intermediate By similarity

Binding site

1041

1

Substrate Potential

Binding site

1117

1

Substrate By similarity

Amino acid modifications

Glycosylation

74

1

N-linked (GlcNAc...) Potential

Glycosylation

409

1

N-linked (GlcNAc...) Potential

Glycosylation

684

1

N-linked (GlcNAc...) Potential

Disulfide bond

209 ↔ 263

Potential

Experimental info

Sequence conflict

932

1

I → M in AAA49016. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q6YI48 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 49E0E609B40555C5
Show »

FASTA

1,434

161,679

        10         20         30         40         50         60 
MRSARALLLA LALRVCALDS ETPSAGCTFE EDDDLNQCEY SQGEDDDFGW ELVRSYMMPH 

        70         80         90        100        110        120 
LTADLPHGSY LMVNASQHAA GQRAHLLFQA LSENDTHCLQ FSYFMYSRDG HSPGTLSAYV 

       130        140        150        160        170        180 
RVMGGPVGSA VWNASGSHGR QWHQAELAVS LFWPSEYQVL FEAVISSERR GYLGLDDILL 

       190        200        210        220        230        240 
LNYPCSKAPH FSRLGDVEVN AGQNATFQCV AAGKAAEAER FLMQRQSGEV VPAASVKHIS 

       250        260        270        280        290        300 
HRRFLATFQL DEVSKGEQDL YRCVTQSSRG SGVSNFAELI VKEPPTPIAP PQLLRAGSTY 

       310        320        330        340        350        360 
LIIQLNTNSI IGDGPIVRKE IEYRMTSGPW SEVHAVNMQT YKLWHLDPDT EYEISVLLTR 

       370        380        390        400        410        420 
PGEGGTGKPG PPLISRTKCA EPMRAPKGLA FSEIQSRQLT LQWEPLGYNL TRCHTYSVSL 

       430        440        450        460        470        480 
CYRYLVGSGL NQTFRECAKM ERNANRYTIK NLLPYRNIHV KLILSNPEGR KEGKEVTFQT 

       490        500        510        520        530        540 
DEDVPGGIAS ESLTFTPLED MIFLKWEEPV EPNGLITQYE ISYQSIESSD PAVNVPGPRR 

       550        560        570        580        590        600 
TVSKLRNETY HVFSNLHPGT TYLFSVRART GKGFGQTALT EITTNISAPT FDYGDMPSPL 

       610        620        630        640        650        660 
GESESTITVL LRPAQGRGAP ISTYQVIVEE DRPKRIKREL GGQECFPVPL TFDDAMSRGS 

       670        680        690        700        710        720 
VHYFGAELPA SSLTEAKPFT VGDNQTYSGY WNPPLEPKKA YLIYFQAMSN LKGETRLNCI 

       730        740        750        760        770        780 
RIARKAACKE SKRPLEVSQH SEEMGLILGI CAGGLVVLII LLGAIIVVIR KGKPVNMTKA 

       790        800        810        820        830        840 
TINYRHEKTH MMSAIDRSFT DQSTLQEDER LGLSFMDTHN YSNRGDQRSS VVNESSSLLG 

       850        860        870        880        890        900 
GSPRRQCGRK GSPYHTGQLH PAVRVADLLQ HINQMKTAEG YGFKQEYESF FEGWDASKKK 

       910        920        930        940        950        960 
DKTKGRQDHV STYDRHRVKL HPLLGDPNSD YINANYIDGY HRSNHFIATQ GPKQEMVYDF 

       970        980        990       1000       1010       1020 
WRMVWQEHCS SIVMITKLVE VGRVKCSKYW PDDSEMYGDI KITLVKSEML AEYAVRTFAL 

      1030       1040       1050       1060       1070       1080 
ERRGYSARHE VKQFHFTSWP EHGVPYHATG LLAFIRRVKA STPPDAGPIV IHCSAGTGRT 

      1090       1100       1110       1120       1130       1140 
GCYIVLDVML DMAECEGVVD IYNCVKTLCS RRINMIQTEE QYIFIHDAIL EACLCGETSI 

      1150       1160       1170       1180       1190       1200 
PASEFKPTYK EMVRIEPQSN SSQLREEFQT LNSVTPHLDV EECSIALLPR NRERNRSMDV 

      1210       1220       1230       1240       1250       1260 
LPPDRCLPFL ISVDGDSNNY INAALTDSYT KSAAFIVTLH PLQNTTTDFW RLVYDYGCTS 

      1270       1280       1290       1300       1310       1320 
IVMLNQLNQS NSAWPCLQYW PEPGLQHYGP MEVEYVSGAA DEDIVSRLFR VQNITRLQEG 

      1330       1340       1350       1360       1370       1380 
HLMVRHFQYL RWSAYRDTPD SKKSFLHLLA QVERWQKESG DGRTVVHCLN GGGRSGTYCA 

      1390       1400       1410       1420       1430 
STMILEMIKC HNMADIFYAA KTLRNYKPNM VETLEQYHFC YDIALEYLES LETR

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References

[1]	"Chick receptor tyrosine phosphatase psi is dynamically expressed during somitogenesis." Aerne B., Stoker A., Ish-Horowicz D. Gene Expr. Patterns 3:325-329(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
[2]	"Protein tyrosine phosphatases isolated from embryonic chicken lens epithelium." Potts J.D. Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 929-986. Tissue: Lens.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY147868 mRNA. Translation: AAN38300.1. L20504 mRNA. Translation: AAA49016.1. Sequence problems.
IPI	IPI00570728.
RefSeq	NP_989823.1. NM_204492.1.
UniGene	Gga.43624.
3D structure databases
HSSP	HSSP built from PDB template 2C7S based on UniProtKB Q15262.
ProteinModelPortal	Q6YI48.
SMR	Q6YI48. Positions 861-1145.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000002193.
Proteomic databases
PaxDb	Q6YI48.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395153.
KEGG	gga:395153.
Organism-specific databases
CTD	10076.
Phylogenomic databases
eggNOG	COG5599.
HOGENOM	HOG000049029.
InParanoid	Q90948.
KO	K16662.
OrthoDB	EOG4868BM.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR003961. Fibronectin_type3. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR000998. MAM_dom. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00041. fn3. 2 hits. PF00629. MAM. 1 hit. PF00102. Y_phosphatase. 2 hits. [Graphical view]
PRINTS	PR00020. MAMDOMAIN. PR00700. PRTYPHPHTASE.
SMART	SM00060. FN3. 3 hits. SM00409. IG. 1 hit. SM00137. MAM. 1 hit. SM00194. PTPc. 2 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit. SSF49265. FN_III-like. 3 hits.
PROSITE	PS50853. FN3. 3 hits. PS50835. IG_LIKE. 1 hit. PS00740. MAM_1. 1 hit. PS50060. MAM_2. 1 hit. PS00383. TYR_PHOSPHATASE_1. 2 hits. PS50056. TYR_PHOSPHATASE_2. 2 hits. PS50055. TYR_PHOSPHATASE_PTP. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815244.

Entry information

Entry name

PTPRU_CHICK

Accession

Primary (citable) accession number: Q6YI48
Secondary accession number(s): Q90948

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents