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Q6YI48

- PTPRU_CHICK

UniProt

Q6YI48 - PTPRU_CHICK

Protein

Receptor-type tyrosine-protein phosphatase U

Gene

PTPRU

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1041 – 10411SubstrateSequence Analysis
    Active sitei1073 – 10731Phosphocysteine intermediateBy similarity
    Binding sitei1117 – 11171SubstrateBy similarity
    Active sitei1368 – 13681Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Keywords - Biological processi

    Cell adhesion, Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase U (EC:3.1.3.48)
    Short name:
    R-PTP-U
    Alternative name(s):
    Receptor-type protein-tyrosine phosphatase psi
    Short name:
    R-PTP-psi
    Short name:
    cRPTPPSI
    Gene namesi
    Name:PTPRU
    Synonyms:RPTPPSI
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cell junction By similarity. Cell membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 14341417Receptor-type tyrosine-protein phosphatase UPRO_0000371660Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi209 ↔ 263PROSITE-ProRule annotation
    Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi684 – 6841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6YI48.

    Expressioni

    Developmental stagei

    First observed at HH4 in mesodermal progenitor cells surrounding the area of Hensen node and in the primitive streak. Expressed in the presomitic mesoderm and dynamically expressed in forming somites. Detected in the developing intermediate mesoderm at HH9 and in the mesonephric tubules and ducts by stage HH18. Expressed in the developing nervous system. Also observed in the limb bud and the developing heart.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000002193.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6YI48.
    SMRiQ6YI48. Positions 861-1145.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 748731ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini770 – 1434665CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei749 – 76921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 187163MAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini189 – 27486Ig-like C2-typeAdd
    BLAST
    Domaini287 – 38296Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini385 – 48399Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 590107Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini597 – 67781Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini876 – 1132257Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1164 – 1427264Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1073 – 10797Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 MAM domain.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000049029.
    InParanoidiQ90948.
    KOiK16662.
    PhylomeDBiQ6YI48.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR000998. MAM_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF00629. MAM. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00020. MAMDOMAIN.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00137. MAM. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6YI48-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSARALLLA LALRVCALDS ETPSAGCTFE EDDDLNQCEY SQGEDDDFGW     50
    ELVRSYMMPH LTADLPHGSY LMVNASQHAA GQRAHLLFQA LSENDTHCLQ 100
    FSYFMYSRDG HSPGTLSAYV RVMGGPVGSA VWNASGSHGR QWHQAELAVS 150
    LFWPSEYQVL FEAVISSERR GYLGLDDILL LNYPCSKAPH FSRLGDVEVN 200
    AGQNATFQCV AAGKAAEAER FLMQRQSGEV VPAASVKHIS HRRFLATFQL 250
    DEVSKGEQDL YRCVTQSSRG SGVSNFAELI VKEPPTPIAP PQLLRAGSTY 300
    LIIQLNTNSI IGDGPIVRKE IEYRMTSGPW SEVHAVNMQT YKLWHLDPDT 350
    EYEISVLLTR PGEGGTGKPG PPLISRTKCA EPMRAPKGLA FSEIQSRQLT 400
    LQWEPLGYNL TRCHTYSVSL CYRYLVGSGL NQTFRECAKM ERNANRYTIK 450
    NLLPYRNIHV KLILSNPEGR KEGKEVTFQT DEDVPGGIAS ESLTFTPLED 500
    MIFLKWEEPV EPNGLITQYE ISYQSIESSD PAVNVPGPRR TVSKLRNETY 550
    HVFSNLHPGT TYLFSVRART GKGFGQTALT EITTNISAPT FDYGDMPSPL 600
    GESESTITVL LRPAQGRGAP ISTYQVIVEE DRPKRIKREL GGQECFPVPL 650
    TFDDAMSRGS VHYFGAELPA SSLTEAKPFT VGDNQTYSGY WNPPLEPKKA 700
    YLIYFQAMSN LKGETRLNCI RIARKAACKE SKRPLEVSQH SEEMGLILGI 750
    CAGGLVVLII LLGAIIVVIR KGKPVNMTKA TINYRHEKTH MMSAIDRSFT 800
    DQSTLQEDER LGLSFMDTHN YSNRGDQRSS VVNESSSLLG GSPRRQCGRK 850
    GSPYHTGQLH PAVRVADLLQ HINQMKTAEG YGFKQEYESF FEGWDASKKK 900
    DKTKGRQDHV STYDRHRVKL HPLLGDPNSD YINANYIDGY HRSNHFIATQ 950
    GPKQEMVYDF WRMVWQEHCS SIVMITKLVE VGRVKCSKYW PDDSEMYGDI 1000
    KITLVKSEML AEYAVRTFAL ERRGYSARHE VKQFHFTSWP EHGVPYHATG 1050
    LLAFIRRVKA STPPDAGPIV IHCSAGTGRT GCYIVLDVML DMAECEGVVD 1100
    IYNCVKTLCS RRINMIQTEE QYIFIHDAIL EACLCGETSI PASEFKPTYK 1150
    EMVRIEPQSN SSQLREEFQT LNSVTPHLDV EECSIALLPR NRERNRSMDV 1200
    LPPDRCLPFL ISVDGDSNNY INAALTDSYT KSAAFIVTLH PLQNTTTDFW 1250
    RLVYDYGCTS IVMLNQLNQS NSAWPCLQYW PEPGLQHYGP MEVEYVSGAA 1300
    DEDIVSRLFR VQNITRLQEG HLMVRHFQYL RWSAYRDTPD SKKSFLHLLA 1350
    QVERWQKESG DGRTVVHCLN GGGRSGTYCA STMILEMIKC HNMADIFYAA 1400
    KTLRNYKPNM VETLEQYHFC YDIALEYLES LETR 1434
    Length:1,434
    Mass (Da):161,679
    Last modified:July 5, 2004 - v1
    Checksum:i49E0E609B40555C5
    GO

    Sequence cautioni

    The sequence AAA49016.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti932 – 9321I → M in AAA49016. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY147868 mRNA. Translation: AAN38300.1.
    L20504 mRNA. Translation: AAA49016.1. Sequence problems.
    RefSeqiNP_989823.1. NM_204492.1.
    UniGeneiGga.43624.

    Genome annotation databases

    GeneIDi395153.
    KEGGigga:395153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY147868 mRNA. Translation: AAN38300.1 .
    L20504 mRNA. Translation: AAA49016.1 . Sequence problems.
    RefSeqi NP_989823.1. NM_204492.1.
    UniGenei Gga.43624.

    3D structure databases

    ProteinModelPortali Q6YI48.
    SMRi Q6YI48. Positions 861-1145.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000002193.

    Proteomic databases

    PaxDbi Q6YI48.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395153.
    KEGGi gga:395153.

    Organism-specific databases

    CTDi 10076.

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000049029.
    InParanoidi Q90948.
    KOi K16662.
    PhylomeDBi Q6YI48.

    Miscellaneous databases

    NextBioi 20815244.
    PROi Q6YI48.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR000998. MAM_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF00629. MAM. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00020. MAMDOMAIN.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00137. MAM. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chick receptor tyrosine phosphatase psi is dynamically expressed during somitogenesis."
      Aerne B., Stoker A., Ish-Horowicz D.
      Gene Expr. Patterns 3:325-329(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    2. "Protein tyrosine phosphatases isolated from embryonic chicken lens epithelium."
      Potts J.D.
      Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 929-986.
      Tissue: Lens.

    Entry informationi

    Entry nameiPTPRU_CHICK
    AccessioniPrimary (citable) accession number: Q6YI48
    Secondary accession number(s): Q90948
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3