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Protein

Receptor-type tyrosine-protein phosphatase U

Gene

PTPRU

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1041SubstrateSequence analysis1
Active sitei1073Phosphocysteine intermediateBy similarity1
Binding sitei1117SubstrateBy similarity1
Active sitei1368Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase U (EC:3.1.3.48)
Short name:
R-PTP-U
Alternative name(s):
Receptor-type protein-tyrosine phosphatase psi
Short name:
R-PTP-psi
Short name:
cRPTPPSI
Gene namesi
Name:PTPRU
Synonyms:RPTPPSI
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 748ExtracellularSequence analysisAdd BLAST731
Transmembranei749 – 769HelicalSequence analysisAdd BLAST21
Topological domaini770 – 1434CytoplasmicSequence analysisAdd BLAST665

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000037166018 – 1434Receptor-type tyrosine-protein phosphatase UAdd BLAST1417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi209 ↔ 263PROSITE-ProRule annotation
Glycosylationi409N-linked (GlcNAc...)Sequence analysis1
Glycosylationi684N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6YI48.

Expressioni

Developmental stagei

First observed at HH4 in mesodermal progenitor cells surrounding the area of Hensen node and in the primitive streak. Expressed in the presomitic mesoderm and dynamically expressed in forming somites. Detected in the developing intermediate mesoderm at HH9 and in the mesonephric tubules and ducts by stage HH18. Expressed in the developing nervous system. Also observed in the limb bud and the developing heart.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002193.

Structurei

3D structure databases

ProteinModelPortaliQ6YI48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 187MAMPROSITE-ProRule annotationAdd BLAST163
Domaini189 – 274Ig-like C2-typeAdd BLAST86
Domaini287 – 382Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini385 – 483Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini484 – 590Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST107
Domaini597 – 677Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST81
Domaini876 – 1132Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST257
Domaini1164 – 1427Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1073 – 1079Substrate bindingBy similarity7

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000049029.
InParanoidiQ6YI48.
KOiK16662.
PhylomeDBiQ6YI48.

Family and domain databases

CDDicd00063. FN3. 3 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6YI48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSARALLLA LALRVCALDS ETPSAGCTFE EDDDLNQCEY SQGEDDDFGW
60 70 80 90 100
ELVRSYMMPH LTADLPHGSY LMVNASQHAA GQRAHLLFQA LSENDTHCLQ
110 120 130 140 150
FSYFMYSRDG HSPGTLSAYV RVMGGPVGSA VWNASGSHGR QWHQAELAVS
160 170 180 190 200
LFWPSEYQVL FEAVISSERR GYLGLDDILL LNYPCSKAPH FSRLGDVEVN
210 220 230 240 250
AGQNATFQCV AAGKAAEAER FLMQRQSGEV VPAASVKHIS HRRFLATFQL
260 270 280 290 300
DEVSKGEQDL YRCVTQSSRG SGVSNFAELI VKEPPTPIAP PQLLRAGSTY
310 320 330 340 350
LIIQLNTNSI IGDGPIVRKE IEYRMTSGPW SEVHAVNMQT YKLWHLDPDT
360 370 380 390 400
EYEISVLLTR PGEGGTGKPG PPLISRTKCA EPMRAPKGLA FSEIQSRQLT
410 420 430 440 450
LQWEPLGYNL TRCHTYSVSL CYRYLVGSGL NQTFRECAKM ERNANRYTIK
460 470 480 490 500
NLLPYRNIHV KLILSNPEGR KEGKEVTFQT DEDVPGGIAS ESLTFTPLED
510 520 530 540 550
MIFLKWEEPV EPNGLITQYE ISYQSIESSD PAVNVPGPRR TVSKLRNETY
560 570 580 590 600
HVFSNLHPGT TYLFSVRART GKGFGQTALT EITTNISAPT FDYGDMPSPL
610 620 630 640 650
GESESTITVL LRPAQGRGAP ISTYQVIVEE DRPKRIKREL GGQECFPVPL
660 670 680 690 700
TFDDAMSRGS VHYFGAELPA SSLTEAKPFT VGDNQTYSGY WNPPLEPKKA
710 720 730 740 750
YLIYFQAMSN LKGETRLNCI RIARKAACKE SKRPLEVSQH SEEMGLILGI
760 770 780 790 800
CAGGLVVLII LLGAIIVVIR KGKPVNMTKA TINYRHEKTH MMSAIDRSFT
810 820 830 840 850
DQSTLQEDER LGLSFMDTHN YSNRGDQRSS VVNESSSLLG GSPRRQCGRK
860 870 880 890 900
GSPYHTGQLH PAVRVADLLQ HINQMKTAEG YGFKQEYESF FEGWDASKKK
910 920 930 940 950
DKTKGRQDHV STYDRHRVKL HPLLGDPNSD YINANYIDGY HRSNHFIATQ
960 970 980 990 1000
GPKQEMVYDF WRMVWQEHCS SIVMITKLVE VGRVKCSKYW PDDSEMYGDI
1010 1020 1030 1040 1050
KITLVKSEML AEYAVRTFAL ERRGYSARHE VKQFHFTSWP EHGVPYHATG
1060 1070 1080 1090 1100
LLAFIRRVKA STPPDAGPIV IHCSAGTGRT GCYIVLDVML DMAECEGVVD
1110 1120 1130 1140 1150
IYNCVKTLCS RRINMIQTEE QYIFIHDAIL EACLCGETSI PASEFKPTYK
1160 1170 1180 1190 1200
EMVRIEPQSN SSQLREEFQT LNSVTPHLDV EECSIALLPR NRERNRSMDV
1210 1220 1230 1240 1250
LPPDRCLPFL ISVDGDSNNY INAALTDSYT KSAAFIVTLH PLQNTTTDFW
1260 1270 1280 1290 1300
RLVYDYGCTS IVMLNQLNQS NSAWPCLQYW PEPGLQHYGP MEVEYVSGAA
1310 1320 1330 1340 1350
DEDIVSRLFR VQNITRLQEG HLMVRHFQYL RWSAYRDTPD SKKSFLHLLA
1360 1370 1380 1390 1400
QVERWQKESG DGRTVVHCLN GGGRSGTYCA STMILEMIKC HNMADIFYAA
1410 1420 1430
KTLRNYKPNM VETLEQYHFC YDIALEYLES LETR
Length:1,434
Mass (Da):161,679
Last modified:July 5, 2004 - v1
Checksum:i49E0E609B40555C5
GO

Sequence cautioni

The sequence AAA49016 differs from that shown. Contaminating sequence. Sequence of unknown origin.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti932I → M in AAA49016 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY147868 mRNA. Translation: AAN38300.1.
L20504 mRNA. Translation: AAA49016.1. Sequence problems.
RefSeqiNP_989823.1. NM_204492.1.
UniGeneiGga.43624.

Genome annotation databases

GeneIDi395153.
KEGGigga:395153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY147868 mRNA. Translation: AAN38300.1.
L20504 mRNA. Translation: AAA49016.1. Sequence problems.
RefSeqiNP_989823.1. NM_204492.1.
UniGeneiGga.43624.

3D structure databases

ProteinModelPortaliQ6YI48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002193.

Proteomic databases

PaxDbiQ6YI48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395153.
KEGGigga:395153.

Organism-specific databases

CTDi10076.

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000049029.
InParanoidiQ6YI48.
KOiK16662.
PhylomeDBiQ6YI48.

Miscellaneous databases

PROiQ6YI48.

Family and domain databases

CDDicd00063. FN3. 3 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRU_CHICK
AccessioniPrimary (citable) accession number: Q6YI48
Secondary accession number(s): Q90948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.