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Q6YI48

- PTPRU_CHICK

UniProt

Q6YI48 - PTPRU_CHICK

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Protein

Receptor-type tyrosine-protein phosphatase U

Gene
PTPRU, RPTPPSI
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1041 – 10411Substrate Reviewed prediction
Active sitei1073 – 10731Phosphocysteine intermediate By similarity
Binding sitei1117 – 11171Substrate By similarity
Active sitei1368 – 13681Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase U (EC:3.1.3.48)
Short name:
R-PTP-U
Alternative name(s):
Receptor-type protein-tyrosine phosphatase psi
Short name:
R-PTP-psi
Short name:
cRPTPPSI
Gene namesi
Name:PTPRU
Synonyms:RPTPPSI
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 748731Extracellular Reviewed predictionAdd
BLAST
Transmembranei749 – 76921Helical; Reviewed predictionAdd
BLAST
Topological domaini770 – 1434665Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 14341417Receptor-type tyrosine-protein phosphatase UPRO_0000371660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi209 ↔ 263 Reviewed prediction
Glycosylationi409 – 4091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi684 – 6841N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6YI48.

Expressioni

Developmental stagei

First observed at HH4 in mesodermal progenitor cells surrounding the area of Hensen node and in the primitive streak. Expressed in the presomitic mesoderm and dynamically expressed in forming somites. Detected in the developing intermediate mesoderm at HH9 and in the mesonephric tubules and ducts by stage HH18. Expressed in the developing nervous system. Also observed in the limb bud and the developing heart.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002193.

Structurei

3D structure databases

ProteinModelPortaliQ6YI48.
SMRiQ6YI48. Positions 861-1145.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 187163MAMAdd
BLAST
Domaini189 – 27486Ig-like C2-typeAdd
BLAST
Domaini287 – 38296Fibronectin type-III 1Add
BLAST
Domaini385 – 48399Fibronectin type-III 2Add
BLAST
Domaini484 – 590107Fibronectin type-III 3Add
BLAST
Domaini597 – 67781Fibronectin type-III 4Add
BLAST
Domaini876 – 1132257Tyrosine-protein phosphatase 1Add
BLAST
Domaini1164 – 1427264Tyrosine-protein phosphatase 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1073 – 10797Substrate binding By similarity

Sequence similaritiesi

Contains 1 MAM domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000049029.
InParanoidiQ90948.
KOiK16662.
PhylomeDBiQ6YI48.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6YI48-1 [UniParc]FASTAAdd to Basket

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MRSARALLLA LALRVCALDS ETPSAGCTFE EDDDLNQCEY SQGEDDDFGW     50
ELVRSYMMPH LTADLPHGSY LMVNASQHAA GQRAHLLFQA LSENDTHCLQ 100
FSYFMYSRDG HSPGTLSAYV RVMGGPVGSA VWNASGSHGR QWHQAELAVS 150
LFWPSEYQVL FEAVISSERR GYLGLDDILL LNYPCSKAPH FSRLGDVEVN 200
AGQNATFQCV AAGKAAEAER FLMQRQSGEV VPAASVKHIS HRRFLATFQL 250
DEVSKGEQDL YRCVTQSSRG SGVSNFAELI VKEPPTPIAP PQLLRAGSTY 300
LIIQLNTNSI IGDGPIVRKE IEYRMTSGPW SEVHAVNMQT YKLWHLDPDT 350
EYEISVLLTR PGEGGTGKPG PPLISRTKCA EPMRAPKGLA FSEIQSRQLT 400
LQWEPLGYNL TRCHTYSVSL CYRYLVGSGL NQTFRECAKM ERNANRYTIK 450
NLLPYRNIHV KLILSNPEGR KEGKEVTFQT DEDVPGGIAS ESLTFTPLED 500
MIFLKWEEPV EPNGLITQYE ISYQSIESSD PAVNVPGPRR TVSKLRNETY 550
HVFSNLHPGT TYLFSVRART GKGFGQTALT EITTNISAPT FDYGDMPSPL 600
GESESTITVL LRPAQGRGAP ISTYQVIVEE DRPKRIKREL GGQECFPVPL 650
TFDDAMSRGS VHYFGAELPA SSLTEAKPFT VGDNQTYSGY WNPPLEPKKA 700
YLIYFQAMSN LKGETRLNCI RIARKAACKE SKRPLEVSQH SEEMGLILGI 750
CAGGLVVLII LLGAIIVVIR KGKPVNMTKA TINYRHEKTH MMSAIDRSFT 800
DQSTLQEDER LGLSFMDTHN YSNRGDQRSS VVNESSSLLG GSPRRQCGRK 850
GSPYHTGQLH PAVRVADLLQ HINQMKTAEG YGFKQEYESF FEGWDASKKK 900
DKTKGRQDHV STYDRHRVKL HPLLGDPNSD YINANYIDGY HRSNHFIATQ 950
GPKQEMVYDF WRMVWQEHCS SIVMITKLVE VGRVKCSKYW PDDSEMYGDI 1000
KITLVKSEML AEYAVRTFAL ERRGYSARHE VKQFHFTSWP EHGVPYHATG 1050
LLAFIRRVKA STPPDAGPIV IHCSAGTGRT GCYIVLDVML DMAECEGVVD 1100
IYNCVKTLCS RRINMIQTEE QYIFIHDAIL EACLCGETSI PASEFKPTYK 1150
EMVRIEPQSN SSQLREEFQT LNSVTPHLDV EECSIALLPR NRERNRSMDV 1200
LPPDRCLPFL ISVDGDSNNY INAALTDSYT KSAAFIVTLH PLQNTTTDFW 1250
RLVYDYGCTS IVMLNQLNQS NSAWPCLQYW PEPGLQHYGP MEVEYVSGAA 1300
DEDIVSRLFR VQNITRLQEG HLMVRHFQYL RWSAYRDTPD SKKSFLHLLA 1350
QVERWQKESG DGRTVVHCLN GGGRSGTYCA STMILEMIKC HNMADIFYAA 1400
KTLRNYKPNM VETLEQYHFC YDIALEYLES LETR 1434
Length:1,434
Mass (Da):161,679
Last modified:July 5, 2004 - v1
Checksum:i49E0E609B40555C5
GO

Sequence cautioni

The sequence AAA49016.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti932 – 9321I → M in AAA49016. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY147868 mRNA. Translation: AAN38300.1.
L20504 mRNA. Translation: AAA49016.1. Sequence problems.
RefSeqiNP_989823.1. NM_204492.1.
UniGeneiGga.43624.

Genome annotation databases

GeneIDi395153.
KEGGigga:395153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY147868 mRNA. Translation: AAN38300.1 .
L20504 mRNA. Translation: AAA49016.1 . Sequence problems.
RefSeqi NP_989823.1. NM_204492.1.
UniGenei Gga.43624.

3D structure databases

ProteinModelPortali Q6YI48.
SMRi Q6YI48. Positions 861-1145.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000002193.

Proteomic databases

PaxDbi Q6YI48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395153.
KEGGi gga:395153.

Organism-specific databases

CTDi 10076.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000049029.
InParanoidi Q90948.
KOi K16662.
PhylomeDBi Q6YI48.

Miscellaneous databases

NextBioi 20815244.
PROi Q6YI48.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chick receptor tyrosine phosphatase psi is dynamically expressed during somitogenesis."
    Aerne B., Stoker A., Ish-Horowicz D.
    Gene Expr. Patterns 3:325-329(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  2. "Protein tyrosine phosphatases isolated from embryonic chicken lens epithelium."
    Potts J.D.
    Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 929-986.
    Tissue: Lens.

Entry informationi

Entry nameiPTPRU_CHICK
AccessioniPrimary (citable) accession number: Q6YI48
Secondary accession number(s): Q90948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi