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Q6YI48

- PTPRU_CHICK

UniProt

Q6YI48 - PTPRU_CHICK

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Protein

Receptor-type tyrosine-protein phosphatase U

Gene

PTPRU

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1041 – 10411SubstrateSequence Analysis
Active sitei1073 – 10731Phosphocysteine intermediateBy similarity
Binding sitei1117 – 11171SubstrateBy similarity
Active sitei1368 – 13681Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase U (EC:3.1.3.48)
Short name:
R-PTP-U
Alternative name(s):
Receptor-type protein-tyrosine phosphatase psi
Short name:
R-PTP-psi
Short name:
cRPTPPSI
Gene namesi
Name:PTPRU
Synonyms:RPTPPSI
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell junction By similarity. Cell membrane By similarity; Single-pass type I membrane protein By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 14341417Receptor-type tyrosine-protein phosphatase UPRO_0000371660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi209 ↔ 263PROSITE-ProRule annotation
Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi684 – 6841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6YI48.

Expressioni

Developmental stagei

First observed at HH4 in mesodermal progenitor cells surrounding the area of Hensen node and in the primitive streak. Expressed in the presomitic mesoderm and dynamically expressed in forming somites. Detected in the developing intermediate mesoderm at HH9 and in the mesonephric tubules and ducts by stage HH18. Expressed in the developing nervous system. Also observed in the limb bud and the developing heart.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002193.

Structurei

3D structure databases

ProteinModelPortaliQ6YI48.
SMRiQ6YI48. Positions 861-1145.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 748731ExtracellularSequence AnalysisAdd
BLAST
Topological domaini770 – 1434665CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei749 – 76921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 187163MAMPROSITE-ProRule annotationAdd
BLAST
Domaini189 – 27486Ig-like C2-typeAdd
BLAST
Domaini287 – 38296Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini385 – 48399Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini484 – 590107Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini597 – 67781Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini876 – 1132257Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1164 – 1427264Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1073 – 10797Substrate bindingBy similarity

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000049029.
InParanoidiQ6YI48.
KOiK16662.
PhylomeDBiQ6YI48.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6YI48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSARALLLA LALRVCALDS ETPSAGCTFE EDDDLNQCEY SQGEDDDFGW
60 70 80 90 100
ELVRSYMMPH LTADLPHGSY LMVNASQHAA GQRAHLLFQA LSENDTHCLQ
110 120 130 140 150
FSYFMYSRDG HSPGTLSAYV RVMGGPVGSA VWNASGSHGR QWHQAELAVS
160 170 180 190 200
LFWPSEYQVL FEAVISSERR GYLGLDDILL LNYPCSKAPH FSRLGDVEVN
210 220 230 240 250
AGQNATFQCV AAGKAAEAER FLMQRQSGEV VPAASVKHIS HRRFLATFQL
260 270 280 290 300
DEVSKGEQDL YRCVTQSSRG SGVSNFAELI VKEPPTPIAP PQLLRAGSTY
310 320 330 340 350
LIIQLNTNSI IGDGPIVRKE IEYRMTSGPW SEVHAVNMQT YKLWHLDPDT
360 370 380 390 400
EYEISVLLTR PGEGGTGKPG PPLISRTKCA EPMRAPKGLA FSEIQSRQLT
410 420 430 440 450
LQWEPLGYNL TRCHTYSVSL CYRYLVGSGL NQTFRECAKM ERNANRYTIK
460 470 480 490 500
NLLPYRNIHV KLILSNPEGR KEGKEVTFQT DEDVPGGIAS ESLTFTPLED
510 520 530 540 550
MIFLKWEEPV EPNGLITQYE ISYQSIESSD PAVNVPGPRR TVSKLRNETY
560 570 580 590 600
HVFSNLHPGT TYLFSVRART GKGFGQTALT EITTNISAPT FDYGDMPSPL
610 620 630 640 650
GESESTITVL LRPAQGRGAP ISTYQVIVEE DRPKRIKREL GGQECFPVPL
660 670 680 690 700
TFDDAMSRGS VHYFGAELPA SSLTEAKPFT VGDNQTYSGY WNPPLEPKKA
710 720 730 740 750
YLIYFQAMSN LKGETRLNCI RIARKAACKE SKRPLEVSQH SEEMGLILGI
760 770 780 790 800
CAGGLVVLII LLGAIIVVIR KGKPVNMTKA TINYRHEKTH MMSAIDRSFT
810 820 830 840 850
DQSTLQEDER LGLSFMDTHN YSNRGDQRSS VVNESSSLLG GSPRRQCGRK
860 870 880 890 900
GSPYHTGQLH PAVRVADLLQ HINQMKTAEG YGFKQEYESF FEGWDASKKK
910 920 930 940 950
DKTKGRQDHV STYDRHRVKL HPLLGDPNSD YINANYIDGY HRSNHFIATQ
960 970 980 990 1000
GPKQEMVYDF WRMVWQEHCS SIVMITKLVE VGRVKCSKYW PDDSEMYGDI
1010 1020 1030 1040 1050
KITLVKSEML AEYAVRTFAL ERRGYSARHE VKQFHFTSWP EHGVPYHATG
1060 1070 1080 1090 1100
LLAFIRRVKA STPPDAGPIV IHCSAGTGRT GCYIVLDVML DMAECEGVVD
1110 1120 1130 1140 1150
IYNCVKTLCS RRINMIQTEE QYIFIHDAIL EACLCGETSI PASEFKPTYK
1160 1170 1180 1190 1200
EMVRIEPQSN SSQLREEFQT LNSVTPHLDV EECSIALLPR NRERNRSMDV
1210 1220 1230 1240 1250
LPPDRCLPFL ISVDGDSNNY INAALTDSYT KSAAFIVTLH PLQNTTTDFW
1260 1270 1280 1290 1300
RLVYDYGCTS IVMLNQLNQS NSAWPCLQYW PEPGLQHYGP MEVEYVSGAA
1310 1320 1330 1340 1350
DEDIVSRLFR VQNITRLQEG HLMVRHFQYL RWSAYRDTPD SKKSFLHLLA
1360 1370 1380 1390 1400
QVERWQKESG DGRTVVHCLN GGGRSGTYCA STMILEMIKC HNMADIFYAA
1410 1420 1430
KTLRNYKPNM VETLEQYHFC YDIALEYLES LETR
Length:1,434
Mass (Da):161,679
Last modified:July 5, 2004 - v1
Checksum:i49E0E609B40555C5
GO

Sequence cautioni

The sequence AAA49016.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti932 – 9321I → M in AAA49016. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY147868 mRNA. Translation: AAN38300.1.
L20504 mRNA. Translation: AAA49016.1. Sequence problems.
RefSeqiNP_989823.1. NM_204492.1.
UniGeneiGga.43624.

Genome annotation databases

GeneIDi395153.
KEGGigga:395153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY147868 mRNA. Translation: AAN38300.1 .
L20504 mRNA. Translation: AAA49016.1 . Sequence problems.
RefSeqi NP_989823.1. NM_204492.1.
UniGenei Gga.43624.

3D structure databases

ProteinModelPortali Q6YI48.
SMRi Q6YI48. Positions 861-1145.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000002193.

Proteomic databases

PaxDbi Q6YI48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395153.
KEGGi gga:395153.

Organism-specific databases

CTDi 10076.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000049029.
InParanoidi Q6YI48.
KOi K16662.
PhylomeDBi Q6YI48.

Miscellaneous databases

NextBioi 20815244.
PROi Q6YI48.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chick receptor tyrosine phosphatase psi is dynamically expressed during somitogenesis."
    Aerne B., Stoker A., Ish-Horowicz D.
    Gene Expr. Patterns 3:325-329(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  2. "Protein tyrosine phosphatases isolated from embryonic chicken lens epithelium."
    Potts J.D.
    Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 929-986.
    Tissue: Lens.

Entry informationi

Entry nameiPTPRU_CHICK
AccessioniPrimary (citable) accession number: Q6YI48
Secondary accession number(s): Q90948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3