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Q6YI48 (PTPRU_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase U

Short name=R-PTP-U
EC=3.1.3.48
Alternative name(s):
Receptor-type protein-tyrosine phosphatase psi
Short name=R-PTP-psi
Short name=cRPTPPSI
Gene names
Name:PTPRU
Synonyms:RPTPPSI
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length1434 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cell junction By similarity. Cell membrane; Single-pass type I membrane protein By similarity.

Developmental stage

First observed at HH4 in mesodermal progenitor cells surrounding the area of Hensen node and in the primitive streak. Expressed in the presomitic mesoderm and dynamically expressed in forming somites. Detected in the developing intermediate mesoderm at HH9 and in the mesonephric tubules and ducts by stage HH18. Expressed in the developing nervous system. Also observed in the limb bud and the developing heart. Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.

Contains 4 fibronectin type-III domains.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 MAM domain.

Contains 2 tyrosine-protein phosphatase domains.

Sequence caution

The sequence AAA49016.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 14341417Receptor-type tyrosine-protein phosphatase U
PRO_0000371660

Regions

Topological domain18 – 748731Extracellular Potential
Transmembrane749 – 76921Helical; Potential
Topological domain770 – 1434665Cytoplasmic Potential
Domain25 – 187163MAM
Domain189 – 27486Ig-like C2-type
Domain287 – 38296Fibronectin type-III 1
Domain385 – 48399Fibronectin type-III 2
Domain484 – 590107Fibronectin type-III 3
Domain597 – 67781Fibronectin type-III 4
Domain876 – 1132257Tyrosine-protein phosphatase 1
Domain1164 – 1427264Tyrosine-protein phosphatase 2
Region1073 – 10797Substrate binding By similarity

Sites

Active site10731Phosphocysteine intermediate By similarity
Active site13681Phosphocysteine intermediate By similarity
Binding site10411Substrate Potential
Binding site11171Substrate By similarity

Amino acid modifications

Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation4091N-linked (GlcNAc...) Potential
Glycosylation6841N-linked (GlcNAc...) Potential
Disulfide bond209 ↔ 263 Potential

Experimental info

Sequence conflict9321I → M in AAA49016. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q6YI48 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 49E0E609B40555C5

FASTA1,434161,679
        10         20         30         40         50         60 
MRSARALLLA LALRVCALDS ETPSAGCTFE EDDDLNQCEY SQGEDDDFGW ELVRSYMMPH 

        70         80         90        100        110        120 
LTADLPHGSY LMVNASQHAA GQRAHLLFQA LSENDTHCLQ FSYFMYSRDG HSPGTLSAYV 

       130        140        150        160        170        180 
RVMGGPVGSA VWNASGSHGR QWHQAELAVS LFWPSEYQVL FEAVISSERR GYLGLDDILL 

       190        200        210        220        230        240 
LNYPCSKAPH FSRLGDVEVN AGQNATFQCV AAGKAAEAER FLMQRQSGEV VPAASVKHIS 

       250        260        270        280        290        300 
HRRFLATFQL DEVSKGEQDL YRCVTQSSRG SGVSNFAELI VKEPPTPIAP PQLLRAGSTY 

       310        320        330        340        350        360 
LIIQLNTNSI IGDGPIVRKE IEYRMTSGPW SEVHAVNMQT YKLWHLDPDT EYEISVLLTR 

       370        380        390        400        410        420 
PGEGGTGKPG PPLISRTKCA EPMRAPKGLA FSEIQSRQLT LQWEPLGYNL TRCHTYSVSL 

       430        440        450        460        470        480 
CYRYLVGSGL NQTFRECAKM ERNANRYTIK NLLPYRNIHV KLILSNPEGR KEGKEVTFQT 

       490        500        510        520        530        540 
DEDVPGGIAS ESLTFTPLED MIFLKWEEPV EPNGLITQYE ISYQSIESSD PAVNVPGPRR 

       550        560        570        580        590        600 
TVSKLRNETY HVFSNLHPGT TYLFSVRART GKGFGQTALT EITTNISAPT FDYGDMPSPL 

       610        620        630        640        650        660 
GESESTITVL LRPAQGRGAP ISTYQVIVEE DRPKRIKREL GGQECFPVPL TFDDAMSRGS 

       670        680        690        700        710        720 
VHYFGAELPA SSLTEAKPFT VGDNQTYSGY WNPPLEPKKA YLIYFQAMSN LKGETRLNCI 

       730        740        750        760        770        780 
RIARKAACKE SKRPLEVSQH SEEMGLILGI CAGGLVVLII LLGAIIVVIR KGKPVNMTKA 

       790        800        810        820        830        840 
TINYRHEKTH MMSAIDRSFT DQSTLQEDER LGLSFMDTHN YSNRGDQRSS VVNESSSLLG 

       850        860        870        880        890        900 
GSPRRQCGRK GSPYHTGQLH PAVRVADLLQ HINQMKTAEG YGFKQEYESF FEGWDASKKK 

       910        920        930        940        950        960 
DKTKGRQDHV STYDRHRVKL HPLLGDPNSD YINANYIDGY HRSNHFIATQ GPKQEMVYDF 

       970        980        990       1000       1010       1020 
WRMVWQEHCS SIVMITKLVE VGRVKCSKYW PDDSEMYGDI KITLVKSEML AEYAVRTFAL 

      1030       1040       1050       1060       1070       1080 
ERRGYSARHE VKQFHFTSWP EHGVPYHATG LLAFIRRVKA STPPDAGPIV IHCSAGTGRT 

      1090       1100       1110       1120       1130       1140 
GCYIVLDVML DMAECEGVVD IYNCVKTLCS RRINMIQTEE QYIFIHDAIL EACLCGETSI 

      1150       1160       1170       1180       1190       1200 
PASEFKPTYK EMVRIEPQSN SSQLREEFQT LNSVTPHLDV EECSIALLPR NRERNRSMDV 

      1210       1220       1230       1240       1250       1260 
LPPDRCLPFL ISVDGDSNNY INAALTDSYT KSAAFIVTLH PLQNTTTDFW RLVYDYGCTS 

      1270       1280       1290       1300       1310       1320 
IVMLNQLNQS NSAWPCLQYW PEPGLQHYGP MEVEYVSGAA DEDIVSRLFR VQNITRLQEG 

      1330       1340       1350       1360       1370       1380 
HLMVRHFQYL RWSAYRDTPD SKKSFLHLLA QVERWQKESG DGRTVVHCLN GGGRSGTYCA 

      1390       1400       1410       1420       1430 
STMILEMIKC HNMADIFYAA KTLRNYKPNM VETLEQYHFC YDIALEYLES LETR 

« Hide

References

[1]"Chick receptor tyrosine phosphatase psi is dynamically expressed during somitogenesis."
Aerne B., Stoker A., Ish-Horowicz D.
Gene Expr. Patterns 3:325-329(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
[2]"Protein tyrosine phosphatases isolated from embryonic chicken lens epithelium."
Potts J.D.
Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 929-986.
Tissue: Lens.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY147868 mRNA. Translation: AAN38300.1.
L20504 mRNA. Translation: AAA49016.1. Sequence problems.
RefSeqNP_989823.1. NM_204492.1.
UniGeneGga.43624.

3D structure databases

ProteinModelPortalQ6YI48.
SMRQ6YI48. Positions 861-1145.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000002193.

Proteomic databases

PaxDbQ6YI48.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395153.
KEGGgga:395153.

Organism-specific databases

CTD10076.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000049029.
InParanoidQ90948.
KOK16662.
PhylomeDBQ6YI48.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815244.
PROQ6YI48.

Entry information

Entry namePTPRU_CHICK
AccessionPrimary (citable) accession number: Q6YI48
Secondary accession number(s): Q90948
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families