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Q6YI21 (CP19A_CAPHI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene names
Name:CYP19A1
Synonyms:CYP19
OrganismCapra hircus (Goat)
Taxonomic identifier9925 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

heme binding

Inferred from sequence or structural similarity. Source: UniProtKB

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Aromatase
PRO_0000051953

Sites

Metal binding4371Iron (heme axial ligand) By similarity
Binding site3091Substrate By similarity
Binding site3741Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6YI21 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: FA9FC7510691B3D8

FASTA50357,970
        10         20         30         40         50         60 
MLLEVLNPRH YNVTSMVSEV VPIASIAILL LTGFLLLVWN YEDTSSIPGP SYFLGIGPLI 

        70         80         90        100        110        120 
SHCRFLWMGI GSACNYYNKM YGEFMRVWVC GEETLIISKS SSMFHVMKHS HYISRFGSKL 

       130        140        150        160        170        180 
GLQFIGMHEK GIIFNNNPAL WKAVRPFFTK ALSGPGLVRM VTICADSITK HLDRLEEVCN 

       190        200        210        220        230        240 
DLGYVDVLTL MRRIMLDTSN ILFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL 

       250        260        270        280        290        300 
CRKYEKSVKD LKDAMEILIE EKRHRISTAE KLEDCIDFAT ELIFAEKRGE LTKENVNQCI 

       310        320        330        340        350        360 
LEMLIAAPDT MSVSVFFMLF LIAKHPQVEE AMMREIQTVV GERDIRIDDM QKLKVVENFI 

       370        380        390        400        410        420 
NESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNLGR MHRLEFFPKP NEFTLENFAK 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRACAGK YIAMVMMKVI LVTLLRRFHV QTLQGRCVEK MQKKNDLSLH 

       490        500 
PDETSDRLEM IFIPRNSDKC LEC 

« Hide

References

[1]"Isolation and characterization of goat ovarian aromatase cDNA: assessment of the activity using an intact cell system and placental expression."
Bobes R.J., Miranda C., Perez-Martinez M., Luu-The V., Romano M.C.
Theriogenology 62:532-543(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY148883 mRNA. Translation: AAN23836.1.
RefSeqNP_001272676.1. NM_001285747.1.
UniGeneChi.38707.

3D structure databases

ProteinModelPortalQ6YI21.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100861413.
KEGGchx:100861413.

Organism-specific databases

CTD1588.

Phylogenomic databases

HOVERGENHBG050750.
KOK07434.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP19A_CAPHI
AccessionPrimary (citable) accession number: Q6YI21
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families