Q6YI21 (CP19A_CAPHI) Reviewed, UniProtKB/Swiss-Prot
Last modified
March 6, 2013.
Version 52.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cytochrome P450 19A1 EC=1.14.14.1 Alternative name(s): Aromatase CYPXIX Cytochrome P-450AROM Estrogen synthase | ||||
| Gene names |
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| Organism | Capra hircus (Goat) | ||||
| Taxonomic identifier | 9925 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Capra![]() |
Protein attributes
| Sequence length | 503 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the formation of aromatic C18 estrogens from C19 androgens. |
| Catalytic activity | RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. |
| Cofactor | Heme group By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Ligand | Heme Iron Metal-binding |
| Molecular function | Monooxygenase Oxidoreductase |
| Gene Ontology (GO) | |
| Cellular_component | membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | aromatase activity Inferred from sequence or structural similarity. Source: UniProtKB electron carrier activityInferred from electronic annotation. Source: InterPro heme bindingInferred from sequence or structural similarity. Source: UniProtKB iron ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 503 | 503 | Cytochrome P450 19A1 | PRO_0000051953 | |||||
Sites | |||||||||
| Metal binding | 437 | 1 | Iron (heme axial ligand) By similarity | ||||||
| Binding site | 309 | 1 | Substrate By similarity | ||||||
| Binding site | 374 | 1 | Substrate; via amide nitrogen By similarity | ||||||
Sequences
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References
| [1] | "Isolation and characterization of goat ovarian aromatase cDNA: assessment of the activity using an intact cell system and placental expression." Bobes R.J., Miranda C., Perez-Martinez M., Luu-The V., Romano M.C. Theriogenology 62:532-543(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY148883 mRNA. Translation: AAN23836.1. |
| UniGene | Chi.38707. |
3D structure databases | |
| ProteinModelPortal | Q6YI21. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG050750. |
Family and domain databases | |
| Gene3D | 1.10.630.10. 1 hit. |
| InterPro | IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view] |
| Pfam | PF00067. p450. 1 hit. [Graphical view] |
| PRINTS | PR00463. EP450I. PR00385. P450. |
| SUPFAM | SSF48264. Cytochrome_P450. 1 hit. |
| PROSITE | PS00086. CYTOCHROME_P450. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CP19A_CAPHI | ||||||||
| Accession | Primary (citable) accession number: Q6YI21 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
