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Q6YI21

- CP19A_CAPHI

UniProt

Q6YI21 - CP19A_CAPHI

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Protein
Aromatase
Gene
CYP19A1, CYP19
Organism
Capra hircus (Goat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091Substrate By similarity
Binding sitei374 – 3741Substrate; via amide nitrogen By similarity
Metal bindingi437 – 4371Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiCapra hircus (Goat)
Taxonomic identifieri9925 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Aromatase
PRO_0000051953Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6YI21.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG050750.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6YI21-1 [UniParc]FASTAAdd to Basket

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MLLEVLNPRH YNVTSMVSEV VPIASIAILL LTGFLLLVWN YEDTSSIPGP    50
SYFLGIGPLI SHCRFLWMGI GSACNYYNKM YGEFMRVWVC GEETLIISKS 100
SSMFHVMKHS HYISRFGSKL GLQFIGMHEK GIIFNNNPAL WKAVRPFFTK 150
ALSGPGLVRM VTICADSITK HLDRLEEVCN DLGYVDVLTL MRRIMLDTSN 200
ILFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL CRKYEKSVKD 250
LKDAMEILIE EKRHRISTAE KLEDCIDFAT ELIFAEKRGE LTKENVNQCI 300
LEMLIAAPDT MSVSVFFMLF LIAKHPQVEE AMMREIQTVV GERDIRIDDM 350
QKLKVVENFI NESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNLGR 400
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YIAMVMMKVI 450
LVTLLRRFHV QTLQGRCVEK MQKKNDLSLH PDETSDRLEM IFIPRNSDKC 500
LEC 503
Length:503
Mass (Da):57,970
Last modified:July 5, 2004 - v1
Checksum:iFA9FC7510691B3D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY148883 mRNA. Translation: AAN23836.1.
RefSeqiNP_001272676.1. NM_001285747.1.
UniGeneiChi.38707.

Genome annotation databases

GeneIDi100861413.
KEGGichx:100861413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY148883 mRNA. Translation: AAN23836.1 .
RefSeqi NP_001272676.1. NM_001285747.1.
UniGenei Chi.38707.

3D structure databases

ProteinModelPortali Q6YI21.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100861413.
KEGGi chx:100861413.

Organism-specific databases

CTDi 1588.

Phylogenomic databases

HOVERGENi HBG050750.
KOi K07434.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of goat ovarian aromatase cDNA: assessment of the activity using an intact cell system and placental expression."
    Bobes R.J., Miranda C., Perez-Martinez M., Luu-The V., Romano M.C.
    Theriogenology 62:532-543(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCP19A_CAPHI
AccessioniPrimary (citable) accession number: Q6YI21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi