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Q6YI21

- CP19A_CAPHI

UniProt

Q6YI21 - CP19A_CAPHI

Protein

Aromatase

Gene

CYP19A1

Organism
Capra hircus (Goat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei309 – 3091SubstrateBy similarity
    Binding sitei374 – 3741Substrate; via amide nitrogenBy similarity
    Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:CYP19A1
    Synonyms:CYP19
    OrganismiCapra hircus (Goat)
    Taxonomic identifieri9925 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503AromatasePRO_0000051953Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6YI21.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG050750.
    KOiK07434.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6YI21-1 [UniParc]FASTAAdd to Basket

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    MLLEVLNPRH YNVTSMVSEV VPIASIAILL LTGFLLLVWN YEDTSSIPGP    50
    SYFLGIGPLI SHCRFLWMGI GSACNYYNKM YGEFMRVWVC GEETLIISKS 100
    SSMFHVMKHS HYISRFGSKL GLQFIGMHEK GIIFNNNPAL WKAVRPFFTK 150
    ALSGPGLVRM VTICADSITK HLDRLEEVCN DLGYVDVLTL MRRIMLDTSN 200
    ILFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL CRKYEKSVKD 250
    LKDAMEILIE EKRHRISTAE KLEDCIDFAT ELIFAEKRGE LTKENVNQCI 300
    LEMLIAAPDT MSVSVFFMLF LIAKHPQVEE AMMREIQTVV GERDIRIDDM 350
    QKLKVVENFI NESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNLGR 400
    MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YIAMVMMKVI 450
    LVTLLRRFHV QTLQGRCVEK MQKKNDLSLH PDETSDRLEM IFIPRNSDKC 500
    LEC 503
    Length:503
    Mass (Da):57,970
    Last modified:July 5, 2004 - v1
    Checksum:iFA9FC7510691B3D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY148883 mRNA. Translation: AAN23836.1.
    RefSeqiNP_001272676.1. NM_001285747.1.
    UniGeneiChi.38707.

    Genome annotation databases

    GeneIDi100861413.
    KEGGichx:100861413.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY148883 mRNA. Translation: AAN23836.1 .
    RefSeqi NP_001272676.1. NM_001285747.1.
    UniGenei Chi.38707.

    3D structure databases

    ProteinModelPortali Q6YI21.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100861413.
    KEGGi chx:100861413.

    Organism-specific databases

    CTDi 1588.

    Phylogenomic databases

    HOVERGENi HBG050750.
    KOi K07434.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of goat ovarian aromatase cDNA: assessment of the activity using an intact cell system and placental expression."
      Bobes R.J., Miranda C., Perez-Martinez M., Luu-The V., Romano M.C.
      Theriogenology 62:532-543(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiCP19A_CAPHI
    AccessioniPrimary (citable) accession number: Q6YI21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3