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Protein

Thyroid adenoma-associated protein

Gene

THADA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid adenoma-associated protein
Alternative name(s):
Gene inducing thyroid adenomas protein
Gene namesi
Name:THADA
Synonyms:GITA, KIAA1767
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:19217. THADA.

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving THADA have been observed in benign thyroid adenomas. Translocation t(2;3)(p21;p25) and translocation t(2;7)(p21;p15); the sequences derived from chromosomes 3p25 and 7p15 do not appear to include a coding region and the fusion events probably result in truncated THADA proteins.

Organism-specific databases

DisGeNETi63892.
OpenTargetsiENSG00000115970.
PharmGKBiPA134882460.

Polymorphism and mutation databases

BioMutaiTHADA.
DMDMi74749519.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003440571 – 1953Thyroid adenoma-associated proteinAdd BLAST1953

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1015PhosphoserineCombined sources1
Modified residuei1024PhosphoserineCombined sources1
Modified residuei1161PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6YHU6.
MaxQBiQ6YHU6.
PaxDbiQ6YHU6.
PeptideAtlasiQ6YHU6.
PRIDEiQ6YHU6.

PTM databases

iPTMnetiQ6YHU6.
PhosphoSitePlusiQ6YHU6.

Expressioni

Tissue specificityi

Expressed in pancreas, adrenal medulla, thyroid, adrenal cortex, testis, thymus, small intestine and stomach.1 Publication

Gene expression databases

BgeeiENSG00000115970.
ExpressionAtlasiQ6YHU6. baseline and differential.
GenevisibleiQ6YHU6. HS.

Organism-specific databases

HPAiHPA035191.
HPA035192.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
USHBP1Q8N6Y03EBI-2824523,EBI-739895

Protein-protein interaction databases

BioGridi121972. 36 interactors.
IntActiQ6YHU6. 4 interactors.
STRINGi9606.ENSP00000385995.

Structurei

3D structure databases

ProteinModelPortaliQ6YHU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili886 – 918Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 7Poly-Lys4
Compositional biasi1322 – 1327Poly-Leu6
Compositional biasi1529 – 1532Poly-Ala4

Sequence similaritiesi

Belongs to the THADA family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1810. Eukaryota.
COG5543. LUCA.
GeneTreeiENSGT00390000015500.
HOGENOMiHOG000074082.
HOVERGENiHBG108565.
InParanoidiQ6YHU6.
OMAiEIKCSDP.
OrthoDBiEOG091G084B.
PhylomeDBiQ6YHU6.
TreeFamiTF319713.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR019442. DUF2428_death-receptor-like.
[Graphical view]
PfamiPF10350. DUF2428. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 7 hits.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6YHU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVKKKKEMQ VAALTICHQD LETLKSFADV EGKNLASLLL HCVQLTDGVS
60 70 80 90 100
QIHYIKQIVP LLEKADKNGM CDPTIQSCLD ILAGIYLSLS LKNPLKKVLA
110 120 130 140 150
SSLNSLPDFF LPEAMHRFTS RLQEELNTTD LYSYRKVTDN ISSCMENFNL
160 170 180 190 200
GRASVNNLLK NVLHFLQKSL IEILEENRKC AGNHIIQTQL MNDLLVGIRV
210 220 230 240 250
SMMLVQKVQD FQGNLWKTSD SPIWQNMCGL LSIFTKVLSD DDLLQTVQST
260 270 280 290 300
SGLAIILFIK TMFHPSEKIP HLISSVLLRS VDCTSVPEWF MSSCRSLCCG
310 320 330 340 350
DISQSAVLFL CQGTLAMLDW QNGSMGRSGE ALLLDTAHVL FTLSSQIKEP
360 370 380 390 400
TLEMFLSRIL ASWTNSAIQV LESSSPSLTD SLNGNSSIVG RLLEYVYTHW
410 420 430 440 450
EHPLDALRHQ TKIMFKNLLQ MHRLTVEGAD FVPDPFFVEL TESLLRLEWH
460 470 480 490 500
IKGKYTCLGC LVECIGVEHI LAIDKTIPSQ ILEVMGDQSL VPYASDLLET
510 520 530 540 550
MFRNHKSHLK SQTAESSWID QWHETWVSPL LFILCEGNLD QKSYVIDYYL
560 570 580 590 600
PKLLSYSPES LQYMVKILQT SIDAKTGQEQ SFPSLGSCNS RGALGALMAC
610 620 630 640 650
LRIARAHGHL QSATDTWENL VSDARIKQGL IHQHCQVRID TLGLLCESNR
660 670 680 690 700
STEIVSMEEM QWIQFFITYN LNSQSPGVRQ QICSLLKKLF CRIQESSQVL
710 720 730 740 750
YKLEQSKSKR EPENELTKQH PSVSLQQYKN FMSSICNSLF EALFPGSSYS
760 770 780 790 800
TRFSALTILG SIAEVFHVPE GRIYTVYQLS HDIDVGRFQT LMECFTSTFE
810 820 830 840 850
DVKILAFDLL MKLSKTAVHF QDSGKLQGLF QAALELSTST KPYDCVTASY
860 870 880 890 900
LLNFLIWQDA LPSSLSAYLT QQVACDNGDR PAAVVERNTL MVIKCLMENL
910 920 930 940 950
EEEVSQAENS LLQAAAAFPM YGRVHCITGA LQKLSLNSLQ LVSEWRPVVE
960 970 980 990 1000
KLLLMSYRLS TVVSPVIQSS SPEGLIPMDT DSESASRLQM ILNEIQPRDT
1010 1020 1030 1040 1050
NDYFNQAKIL KEHDSFDMKD LNASVVNIDT STEIKGKEVK TCDVTAQMVL
1060 1070 1080 1090 1100
VCCWRSMKEV ALLLGMLCQL LPMQPVPESS DGLLTVEQVK EIGDYFKQHL
1110 1120 1130 1140 1150
LQSRHRGAFE LAYTGFVKLT EVLNRCPNVS LQKLPEQWLW SVLEEIKCSD
1160 1170 1180 1190 1200
PSSKLCATRR SAGIPFYIQA LLASEPKKGR MDLLKITMKE LISLAGPTDD
1210 1220 1230 1240 1250
IQSTVPQVHA LNILRALFRD TRLGENIIPY VADGAKAAIL GFTSPVWAVR
1260 1270 1280 1290 1300
NSSTLLFSAL ITRIFGVKRA KDEHSKTNRM TGREFFSRFP ELYPFLLKQL
1310 1320 1330 1340 1350
ETVANTVDSD MGEPNRHPSM FLLLLVLERL YASPMDGTSS ALSMGPFVPF
1360 1370 1380 1390 1400
IMRCGHSPVY HSREMAARAL VPFVMIDHIP NTIRTLLSTL PSCTDQCFRQ
1410 1420 1430 1440 1450
NHIHGTLLQV FHLLQAYSDS KHGTNSDFQH ELTDITVCTK AKLWLAKRQN
1460 1470 1480 1490 1500
PCLVTRAVYI DILFLLTCCL NRSAKDNQPV LESLGFWEEV RGIISGSELI
1510 1520 1530 1540 1550
TGFPWAFKVP GLPQYLQSLT RLAIAAVWAA AAKSGERETN VPISFSQLLE
1560 1570 1580 1590 1600
SAFPEVRSLT LEALLEKFLA AASGLGEKGV PPLLCNMGEK FLLLAMKENH
1610 1620 1630 1640 1650
PECFCKILKI LHCMDPGEWL PQTEHCVHLT PKEFLIWTMD IASNERSEIQ
1660 1670 1680 1690 1700
SVALRLASKV ISHHMQTCVE NRELIAAELK QWVQLVILSC EDHLPTESRL
1710 1720 1730 1740 1750
AVVEVLTSTT PLFLTNPHPI LELQDTLALW KCVLTLLQSE EQAVRDAATE
1760 1770 1780 1790 1800
TVTTAMSQEN TCQSTEFAFC QVDASIALAL ALAVLCDLLQ QWDQLAPGLP
1810 1820 1830 1840 1850
ILLGWLLGES DDLVACVESM HQVEEDYLFE KAEVNFWAET LIFVKYLCKH
1860 1870 1880 1890 1900
LFCLLSKSGW RPPSPEMLCH LQRMVSEQCH LLSQFFRELP PAAEFVKTVE
1910 1920 1930 1940 1950
FTRLRIQEER TLACLRLLAF LEGKEGEDTL VLSVWDSYAE SRQLTLPRTE

AAC
Length:1,953
Mass (Da):219,607
Last modified:July 5, 2004 - v1
Checksum:i53099534C8B1D80E
GO
Isoform 2 (identifier: Q6YHU6-2) [UniParc]FASTAAdd to basket
Also known as: GITA-A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-290: Missing.
     1249-1279: Missing.

Show »
Length:1,632
Mass (Da):183,444
Checksum:iB08341A3BA07CDC2
GO
Isoform 3 (identifier: Q6YHU6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1280-1353: Missing.

Show »
Length:1,879
Mass (Da):211,180
Checksum:i4FF939966B462137
GO
Isoform 4 (identifier: Q6YHU6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1279: Missing.

Show »
Length:674
Mass (Da):75,966
Checksum:iE1AFFD757D82C1AA
GO
Isoform 5 (identifier: Q6YHU6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     937-937: N → K
     938-1953: Missing.

Show »
Length:937
Mass (Da):105,383
Checksum:iD2093158F2BFBE6B
GO
Isoform 6 (identifier: Q6YHU6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     892-894: VIK → GLY
     895-1953: Missing.

Note: No experimental confirmation available.
Show »
Length:894
Mass (Da):100,685
Checksum:iE94748967CE07F50
GO

Sequence cautioni

The sequence BAB15133 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15162 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB21858 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti245Q → R in BAC86389 (PubMed:14702039).Curated1
Sequence conflicti1507F → L in BAB15133 (PubMed:14702039).Curated1
Sequence conflicti1709T → I in BAB15133 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05407063E → G.Corresponds to variant rs10210191dbSNPEnsembl.1
Natural variantiVAR_054071699V → I.2 PublicationsCorresponds to variant rs17031056dbSNPEnsembl.1
Natural variantiVAR_0540721187T → A.Corresponds to variant rs7578597dbSNPEnsembl.1
Natural variantiVAR_0540731385T → S.1 PublicationCorresponds to variant rs33979934dbSNPEnsembl.1
Natural variantiVAR_0540741451P → S.Corresponds to variant rs17334247dbSNPEnsembl.1
Natural variantiVAR_0540751605C → Y.1 PublicationCorresponds to variant rs35720761dbSNPEnsembl.1
Natural variantiVAR_0540761668C → R.Corresponds to variant rs17030648dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0347301 – 1279Missing in isoform 4. 1 PublicationAdd BLAST1279
Alternative sequenceiVSP_0347311 – 290Missing in isoform 2. 1 PublicationAdd BLAST290
Alternative sequenceiVSP_054421892 – 894VIK → GLY in isoform 6. 1 Publication3
Alternative sequenceiVSP_054422895 – 1953Missing in isoform 6. 1 PublicationAdd BLAST1059
Alternative sequenceiVSP_034732937N → K in isoform 5. 1 Publication1
Alternative sequenceiVSP_034733938 – 1953Missing in isoform 5. 1 PublicationAdd BLAST1016
Alternative sequenceiVSP_0347341249 – 1279Missing in isoform 2. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0347351280 – 1353Missing in isoform 3. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149629 mRNA. Translation: AAO46785.1.
AY149633 mRNA. Translation: AAO46789.1.
AB051554 mRNA. Translation: BAB21858.2. Different initiation.
AK025530 mRNA. Translation: BAB15162.1. Different initiation.
AK025445 mRNA. Translation: BAB15133.1. Different initiation.
AK126004 mRNA. Translation: BAC86389.1.
AK290023 mRNA. Translation: BAF82712.1.
AC010883 Genomic DNA. Translation: AAY14994.1.
AC092615 Genomic DNA. Translation: AAX93152.1.
AC092838 Genomic DNA. Translation: AAX93154.1.
AC104138 Genomic DNA. No translation available.
BC007743 mRNA. Translation: AAH07743.1.
BC025773 mRNA. Translation: AAH25773.1.
BC037990 mRNA. Translation: AAH37990.1.
BC105976 mRNA. Translation: AAI05977.1.
AF323176 mRNA. Translation: AAK11318.1.
CCDSiCCDS46268.1. [Q6YHU6-1]
CCDS62901.1. [Q6YHU6-6]
CCDS62902.1. [Q6YHU6-5]
RefSeqiNP_001077422.1. NM_001083953.1. [Q6YHU6-1]
NP_001258572.1. NM_001271643.1. [Q6YHU6-5]
NP_001258573.1. NM_001271644.1. [Q6YHU6-6]
NP_071348.3. NM_022065.4. [Q6YHU6-1]
XP_006712128.1. XM_006712065.1. [Q6YHU6-3]
UniGeneiHs.369592.

Genome annotation databases

EnsembliENST00000402360; ENSP00000385441; ENSG00000115970. [Q6YHU6-5]
ENST00000404790; ENSP00000384266; ENSG00000115970. [Q6YHU6-6]
ENST00000405006; ENSP00000385995; ENSG00000115970. [Q6YHU6-1]
ENST00000405975; ENSP00000386088; ENSG00000115970. [Q6YHU6-1]
GeneIDi63892.
KEGGihsa:63892.
UCSCiuc002rsw.5. human. [Q6YHU6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149629 mRNA. Translation: AAO46785.1.
AY149633 mRNA. Translation: AAO46789.1.
AB051554 mRNA. Translation: BAB21858.2. Different initiation.
AK025530 mRNA. Translation: BAB15162.1. Different initiation.
AK025445 mRNA. Translation: BAB15133.1. Different initiation.
AK126004 mRNA. Translation: BAC86389.1.
AK290023 mRNA. Translation: BAF82712.1.
AC010883 Genomic DNA. Translation: AAY14994.1.
AC092615 Genomic DNA. Translation: AAX93152.1.
AC092838 Genomic DNA. Translation: AAX93154.1.
AC104138 Genomic DNA. No translation available.
BC007743 mRNA. Translation: AAH07743.1.
BC025773 mRNA. Translation: AAH25773.1.
BC037990 mRNA. Translation: AAH37990.1.
BC105976 mRNA. Translation: AAI05977.1.
AF323176 mRNA. Translation: AAK11318.1.
CCDSiCCDS46268.1. [Q6YHU6-1]
CCDS62901.1. [Q6YHU6-6]
CCDS62902.1. [Q6YHU6-5]
RefSeqiNP_001077422.1. NM_001083953.1. [Q6YHU6-1]
NP_001258572.1. NM_001271643.1. [Q6YHU6-5]
NP_001258573.1. NM_001271644.1. [Q6YHU6-6]
NP_071348.3. NM_022065.4. [Q6YHU6-1]
XP_006712128.1. XM_006712065.1. [Q6YHU6-3]
UniGeneiHs.369592.

3D structure databases

ProteinModelPortaliQ6YHU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121972. 36 interactors.
IntActiQ6YHU6. 4 interactors.
STRINGi9606.ENSP00000385995.

PTM databases

iPTMnetiQ6YHU6.
PhosphoSitePlusiQ6YHU6.

Polymorphism and mutation databases

BioMutaiTHADA.
DMDMi74749519.

Proteomic databases

EPDiQ6YHU6.
MaxQBiQ6YHU6.
PaxDbiQ6YHU6.
PeptideAtlasiQ6YHU6.
PRIDEiQ6YHU6.

Protocols and materials databases

DNASUi63892.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402360; ENSP00000385441; ENSG00000115970. [Q6YHU6-5]
ENST00000404790; ENSP00000384266; ENSG00000115970. [Q6YHU6-6]
ENST00000405006; ENSP00000385995; ENSG00000115970. [Q6YHU6-1]
ENST00000405975; ENSP00000386088; ENSG00000115970. [Q6YHU6-1]
GeneIDi63892.
KEGGihsa:63892.
UCSCiuc002rsw.5. human. [Q6YHU6-1]

Organism-specific databases

CTDi63892.
DisGeNETi63892.
GeneCardsiTHADA.
HGNCiHGNC:19217. THADA.
HPAiHPA035191.
HPA035192.
MIMi611800. gene.
neXtProtiNX_Q6YHU6.
OpenTargetsiENSG00000115970.
PharmGKBiPA134882460.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1810. Eukaryota.
COG5543. LUCA.
GeneTreeiENSGT00390000015500.
HOGENOMiHOG000074082.
HOVERGENiHBG108565.
InParanoidiQ6YHU6.
OMAiEIKCSDP.
OrthoDBiEOG091G084B.
PhylomeDBiQ6YHU6.
TreeFamiTF319713.

Miscellaneous databases

ChiTaRSiTHADA. human.
GenomeRNAii63892.
PROiQ6YHU6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115970.
ExpressionAtlasiQ6YHU6. baseline and differential.
GenevisibleiQ6YHU6. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR019442. DUF2428_death-receptor-like.
[Graphical view]
PfamiPF10350. DUF2428. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 7 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTHADA_HUMAN
AccessioniPrimary (citable) accession number: Q6YHU6
Secondary accession number(s): A8K1V8
, B7WNS6, Q3KR04, Q53RC6, Q53TB2, Q6YHU2, Q6ZU38, Q8IY32, Q8TAU8, Q96I88, Q9BZF7, Q9C096, Q9H6U0, Q9H6W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.