Q6YHU6 (THADA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thyroid adenoma-associated protein

Alternative name(s):
Gene inducing thyroid adenomas protein

Gene names

Name:	THADA
Synonyms:	GITA, KIAA1767

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1953 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed in pancreas, adrenal medulla, thyroid, adrenal cortex, testis, thymus, small intestine and stomach. Ref.1
Involvement in disease	Note=Chromosomal aberrations involving THADA have been observed in benign thyroid adenomas. Translocation t(2;3)(p21;p25) and translocation t(2;7)(p21;p15); the sequences derived from chromosomes 3p25 and 7p15 do not appear to include a coding region and the fusion events probably result in truncated THADA proteins.
Sequence similarities	Belongs to the THADA family.
Sequence caution	The sequence BAB15133.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB15162.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB21858.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6YHU6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6YHU6-2)

Also known as: GITA-A2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-290: Missing.
     1249-1279: Missing.

Isoform 3 (identifier: Q6YHU6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1280-1353: Missing.

Isoform 4 (identifier: Q6YHU6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1279: Missing.

Isoform 5 (identifier: Q6YHU6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     937-937: N → K
     938-1953: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1953	1953	Thyroid adenoma-associated protein		PRO_0000344057
Regions
	Coiled coil	886 – 918	33	Potential
	Compositional bias	4 – 7	4	Poly-Lys
	Compositional bias	1322 – 1327	6	Poly-Leu
	Compositional bias	1529 – 1532	4	Poly-Ala
Amino acid modifications
	Modified residue	1031	1	Phosphoserine Ref.8
	Modified residue	1161	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 1279	1279	Missing in isoform 4.		VSP_034730
	Alternative sequence	1 – 290	290	Missing in isoform 2.		VSP_034731
	Alternative sequence	937	1	N → K in isoform 5.		VSP_034732
	Alternative sequence	938 – 1953	1016	Missing in isoform 5.		VSP_034733
	Alternative sequence	1249 – 1279	31	Missing in isoform 2.		VSP_034734
	Alternative sequence	1280 – 1353	74	Missing in isoform 3.		VSP_034735
	Natural variant	63	1	E → G. Corresponds to variant rs10210191 [ dbSNP | Ensembl ].		VAR_054070
	Natural variant	699	1	V → I. Ref.2 Ref.3 Corresponds to variant rs17031056 [ dbSNP | Ensembl ].		VAR_054071
	Natural variant	1187	1	T → A. Corresponds to variant rs7578597 [ dbSNP | Ensembl ].		VAR_054072
	Natural variant	1385	1	T → S. Ref.5 Corresponds to variant rs33979934 [ dbSNP | Ensembl ].		VAR_054073
	Natural variant	1451	1	P → S. Corresponds to variant rs17334247 [ dbSNP | Ensembl ].		VAR_054074
	Natural variant	1605	1	C → Y. Ref.5 Corresponds to variant rs35720761 [ dbSNP | Ensembl ].		VAR_054075
	Natural variant	1668	1	C → R. Corresponds to variant rs17030648 [ dbSNP | Ensembl ].		VAR_054076
Experimental info
	Sequence conflict	245	1	Q → R in BAC86389. Ref.3
	Sequence conflict	1507	1	F → L in BAB15133. Ref.3
	Sequence conflict	1709	1	T → I in BAB15133. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 53099534C8B1D80E	FASTA	1,953	219,607
	10 20 30 40 50 60 MGVKKKKEMQ VAALTICHQD LETLKSFADV EGKNLASLLL HCVQLTDGVS QIHYIKQIVP 70 80 90 100 110 120 LLEKADKNGM CDPTIQSCLD ILAGIYLSLS LKNPLKKVLA SSLNSLPDFF LPEAMHRFTS 130 140 150 160 170 180 RLQEELNTTD LYSYRKVTDN ISSCMENFNL GRASVNNLLK NVLHFLQKSL IEILEENRKC 190 200 210 220 230 240 AGNHIIQTQL MNDLLVGIRV SMMLVQKVQD FQGNLWKTSD SPIWQNMCGL LSIFTKVLSD 250 260 270 280 290 300 DDLLQTVQST SGLAIILFIK TMFHPSEKIP HLISSVLLRS VDCTSVPEWF MSSCRSLCCG 310 320 330 340 350 360 DISQSAVLFL CQGTLAMLDW QNGSMGRSGE ALLLDTAHVL FTLSSQIKEP TLEMFLSRIL 370 380 390 400 410 420 ASWTNSAIQV LESSSPSLTD SLNGNSSIVG RLLEYVYTHW EHPLDALRHQ TKIMFKNLLQ 430 440 450 460 470 480 MHRLTVEGAD FVPDPFFVEL TESLLRLEWH IKGKYTCLGC LVECIGVEHI LAIDKTIPSQ 490 500 510 520 530 540 ILEVMGDQSL VPYASDLLET MFRNHKSHLK SQTAESSWID QWHETWVSPL LFILCEGNLD 550 560 570 580 590 600 QKSYVIDYYL PKLLSYSPES LQYMVKILQT SIDAKTGQEQ SFPSLGSCNS RGALGALMAC 610 620 630 640 650 660 LRIARAHGHL QSATDTWENL VSDARIKQGL IHQHCQVRID TLGLLCESNR STEIVSMEEM 670 680 690 700 710 720 QWIQFFITYN LNSQSPGVRQ QICSLLKKLF CRIQESSQVL YKLEQSKSKR EPENELTKQH 730 740 750 760 770 780 PSVSLQQYKN FMSSICNSLF EALFPGSSYS TRFSALTILG SIAEVFHVPE GRIYTVYQLS 790 800 810 820 830 840 HDIDVGRFQT LMECFTSTFE DVKILAFDLL MKLSKTAVHF QDSGKLQGLF QAALELSTST 850 860 870 880 890 900 KPYDCVTASY LLNFLIWQDA LPSSLSAYLT QQVACDNGDR PAAVVERNTL MVIKCLMENL 910 920 930 940 950 960 EEEVSQAENS LLQAAAAFPM YGRVHCITGA LQKLSLNSLQ LVSEWRPVVE KLLLMSYRLS 970 980 990 1000 1010 1020 TVVSPVIQSS SPEGLIPMDT DSESASRLQM ILNEIQPRDT NDYFNQAKIL KEHDSFDMKD 1030 1040 1050 1060 1070 1080 LNASVVNIDT STEIKGKEVK TCDVTAQMVL VCCWRSMKEV ALLLGMLCQL LPMQPVPESS 1090 1100 1110 1120 1130 1140 DGLLTVEQVK EIGDYFKQHL LQSRHRGAFE LAYTGFVKLT EVLNRCPNVS LQKLPEQWLW 1150 1160 1170 1180 1190 1200 SVLEEIKCSD PSSKLCATRR SAGIPFYIQA LLASEPKKGR MDLLKITMKE LISLAGPTDD 1210 1220 1230 1240 1250 1260 IQSTVPQVHA LNILRALFRD TRLGENIIPY VADGAKAAIL GFTSPVWAVR NSSTLLFSAL 1270 1280 1290 1300 1310 1320 ITRIFGVKRA KDEHSKTNRM TGREFFSRFP ELYPFLLKQL ETVANTVDSD MGEPNRHPSM 1330 1340 1350 1360 1370 1380 FLLLLVLERL YASPMDGTSS ALSMGPFVPF IMRCGHSPVY HSREMAARAL VPFVMIDHIP 1390 1400 1410 1420 1430 1440 NTIRTLLSTL PSCTDQCFRQ NHIHGTLLQV FHLLQAYSDS KHGTNSDFQH ELTDITVCTK 1450 1460 1470 1480 1490 1500 AKLWLAKRQN PCLVTRAVYI DILFLLTCCL NRSAKDNQPV LESLGFWEEV RGIISGSELI 1510 1520 1530 1540 1550 1560 TGFPWAFKVP GLPQYLQSLT RLAIAAVWAA AAKSGERETN VPISFSQLLE SAFPEVRSLT 1570 1580 1590 1600 1610 1620 LEALLEKFLA AASGLGEKGV PPLLCNMGEK FLLLAMKENH PECFCKILKI LHCMDPGEWL 1630 1640 1650 1660 1670 1680 PQTEHCVHLT PKEFLIWTMD IASNERSEIQ SVALRLASKV ISHHMQTCVE NRELIAAELK 1690 1700 1710 1720 1730 1740 QWVQLVILSC EDHLPTESRL AVVEVLTSTT PLFLTNPHPI LELQDTLALW KCVLTLLQSE 1750 1760 1770 1780 1790 1800 EQAVRDAATE TVTTAMSQEN TCQSTEFAFC QVDASIALAL ALAVLCDLLQ QWDQLAPGLP 1810 1820 1830 1840 1850 1860 ILLGWLLGES DDLVACVESM HQVEEDYLFE KAEVNFWAET LIFVKYLCKH LFCLLSKSGW 1870 1880 1890 1900 1910 1920 RPPSPEMLCH LQRMVSEQCH LLSQFFRELP PAAEFVKTVE FTRLRIQEER TLACLRLLAF 1930 1940 1950 LEGKEGEDTL VLSVWDSYAE SRQLTLPRTE AAC
	Isoform 2 (GITA-A2) [UniParc]. Checksum: B08341A3BA07CDC2	FASTA	1,632	183,444
	10 20 30 40 50 60 MSSCRSLCCG DISQSAVLFL CQGTLAMLDW QNGSMGRSGE ALLLDTAHVL FTLSSQIKEP 70 80 90 100 110 120 TLEMFLSRIL ASWTNSAIQV LESSSPSLTD SLNGNSSIVG RLLEYVYTHW EHPLDALRHQ 130 140 150 160 170 180 TKIMFKNLLQ MHRLTVEGAD FVPDPFFVEL TESLLRLEWH IKGKYTCLGC LVECIGVEHI 190 200 210 220 230 240 LAIDKTIPSQ ILEVMGDQSL VPYASDLLET MFRNHKSHLK SQTAESSWID QWHETWVSPL 250 260 270 280 290 300 LFILCEGNLD QKSYVIDYYL PKLLSYSPES LQYMVKILQT SIDAKTGQEQ SFPSLGSCNS 310 320 330 340 350 360 RGALGALMAC LRIARAHGHL QSATDTWENL VSDARIKQGL IHQHCQVRID TLGLLCESNR 370 380 390 400 410 420 STEIVSMEEM QWIQFFITYN LNSQSPGVRQ QICSLLKKLF CRIQESSQVL YKLEQSKSKR 430 440 450 460 470 480 EPENELTKQH PSVSLQQYKN FMSSICNSLF EALFPGSSYS TRFSALTILG SIAEVFHVPE 490 500 510 520 530 540 GRIYTVYQLS HDIDVGRFQT LMECFTSTFE DVKILAFDLL MKLSKTAVHF QDSGKLQGLF 550 560 570 580 590 600 QAALELSTST KPYDCVTASY LLNFLIWQDA LPSSLSAYLT QQVACDNGDR PAAVVERNTL 610 620 630 640 650 660 MVIKCLMENL EEEVSQAENS LLQAAAAFPM YGRVHCITGA LQKLSLNSLQ LVSEWRPVVE 670 680 690 700 710 720 KLLLMSYRLS TVVSPVIQSS SPEGLIPMDT DSESASRLQM ILNEIQPRDT NDYFNQAKIL 730 740 750 760 770 780 KEHDSFDMKD LNASVVNIDT STEIKGKEVK TCDVTAQMVL VCCWRSMKEV ALLLGMLCQL 790 800 810 820 830 840 LPMQPVPESS DGLLTVEQVK EIGDYFKQHL LQSRHRGAFE LAYTGFVKLT EVLNRCPNVS 850 860 870 880 890 900 LQKLPEQWLW SVLEEIKCSD PSSKLCATRR SAGIPFYIQA LLASEPKKGR MDLLKITMKE 910 920 930 940 950 960 LISLAGPTDD IQSTVPQVHA LNILRALFRD TRLGENIIPY VADGAKAAIL GFTSPVWAMT 970 980 990 1000 1010 1020 GREFFSRFPE LYPFLLKQLE TVANTVDSDM GEPNRHPSMF LLLLVLERLY ASPMDGTSSA 1030 1040 1050 1060 1070 1080 LSMGPFVPFI MRCGHSPVYH SREMAARALV PFVMIDHIPN TIRTLLSTLP SCTDQCFRQN 1090 1100 1110 1120 1130 1140 HIHGTLLQVF HLLQAYSDSK HGTNSDFQHE LTDITVCTKA KLWLAKRQNP CLVTRAVYID 1150 1160 1170 1180 1190 1200 ILFLLTCCLN RSAKDNQPVL ESLGFWEEVR GIISGSELIT GFPWAFKVPG LPQYLQSLTR 1210 1220 1230 1240 1250 1260 LAIAAVWAAA AKSGERETNV PISFSQLLES AFPEVRSLTL EALLEKFLAA ASGLGEKGVP 1270 1280 1290 1300 1310 1320 PLLCNMGEKF LLLAMKENHP ECFCKILKIL HCMDPGEWLP QTEHCVHLTP KEFLIWTMDI 1330 1340 1350 1360 1370 1380 ASNERSEIQS VALRLASKVI SHHMQTCVEN RELIAAELKQ WVQLVILSCE DHLPTESRLA 1390 1400 1410 1420 1430 1440 VVEVLTSTTP LFLTNPHPIL ELQDTLALWK CVLTLLQSEE QAVRDAATET VTTAMSQENT 1450 1460 1470 1480 1490 1500 CQSTEFAFCQ VDASIALALA LAVLCDLLQQ WDQLAPGLPI LLGWLLGESD DLVACVESMH 1510 1520 1530 1540 1550 1560 QVEEDYLFEK AEVNFWAETL IFVKYLCKHL FCLLSKSGWR PPSPEMLCHL QRMVSEQCHL 1570 1580 1590 1600 1610 1620 LSQFFRELPP AAEFVKTVEF TRLRIQEERT LACLRLLAFL EGKEGEDTLV LSVWDSYAES 1630 RQLTLPRTEA AC
	Isoform 3 [UniParc]. Checksum: 4FF939966B462137	FASTA	1,879	211,180
	10 20 30 40 50 60 MGVKKKKEMQ VAALTICHQD LETLKSFADV EGKNLASLLL HCVQLTDGVS QIHYIKQIVP 70 80 90 100 110 120 LLEKADKNGM CDPTIQSCLD ILAGIYLSLS LKNPLKKVLA SSLNSLPDFF LPEAMHRFTS 130 140 150 160 170 180 RLQEELNTTD LYSYRKVTDN ISSCMENFNL GRASVNNLLK NVLHFLQKSL IEILEENRKC 190 200 210 220 230 240 AGNHIIQTQL MNDLLVGIRV SMMLVQKVQD FQGNLWKTSD SPIWQNMCGL LSIFTKVLSD 250 260 270 280 290 300 DDLLQTVQST SGLAIILFIK TMFHPSEKIP HLISSVLLRS VDCTSVPEWF MSSCRSLCCG 310 320 330 340 350 360 DISQSAVLFL CQGTLAMLDW QNGSMGRSGE ALLLDTAHVL FTLSSQIKEP TLEMFLSRIL 370 380 390 400 410 420 ASWTNSAIQV LESSSPSLTD SLNGNSSIVG RLLEYVYTHW EHPLDALRHQ TKIMFKNLLQ 430 440 450 460 470 480 MHRLTVEGAD FVPDPFFVEL TESLLRLEWH IKGKYTCLGC LVECIGVEHI LAIDKTIPSQ 490 500 510 520 530 540 ILEVMGDQSL VPYASDLLET MFRNHKSHLK SQTAESSWID QWHETWVSPL LFILCEGNLD 550 560 570 580 590 600 QKSYVIDYYL PKLLSYSPES LQYMVKILQT SIDAKTGQEQ SFPSLGSCNS RGALGALMAC 610 620 630 640 650 660 LRIARAHGHL QSATDTWENL VSDARIKQGL IHQHCQVRID TLGLLCESNR STEIVSMEEM 670 680 690 700 710 720 QWIQFFITYN LNSQSPGVRQ QICSLLKKLF CRIQESSQVL YKLEQSKSKR EPENELTKQH 730 740 750 760 770 780 PSVSLQQYKN FMSSICNSLF EALFPGSSYS TRFSALTILG SIAEVFHVPE GRIYTVYQLS 790 800 810 820 830 840 HDIDVGRFQT LMECFTSTFE DVKILAFDLL MKLSKTAVHF QDSGKLQGLF QAALELSTST 850 860 870 880 890 900 KPYDCVTASY LLNFLIWQDA LPSSLSAYLT QQVACDNGDR PAAVVERNTL MVIKCLMENL 910 920 930 940 950 960 EEEVSQAENS LLQAAAAFPM YGRVHCITGA LQKLSLNSLQ LVSEWRPVVE KLLLMSYRLS 970 980 990 1000 1010 1020 TVVSPVIQSS SPEGLIPMDT DSESASRLQM ILNEIQPRDT NDYFNQAKIL KEHDSFDMKD 1030 1040 1050 1060 1070 1080 LNASVVNIDT STEIKGKEVK TCDVTAQMVL VCCWRSMKEV ALLLGMLCQL LPMQPVPESS 1090 1100 1110 1120 1130 1140 DGLLTVEQVK EIGDYFKQHL LQSRHRGAFE LAYTGFVKLT EVLNRCPNVS LQKLPEQWLW 1150 1160 1170 1180 1190 1200 SVLEEIKCSD PSSKLCATRR SAGIPFYIQA LLASEPKKGR MDLLKITMKE LISLAGPTDD 1210 1220 1230 1240 1250 1260 IQSTVPQVHA LNILRALFRD TRLGENIIPY VADGAKAAIL GFTSPVWAVR NSSTLLFSAL 1270 1280 1290 1300 1310 1320 ITRIFGVKRA KDEHSKTNRC GHSPVYHSRE MAARALVPFV MIDHIPNTIR TLLSTLPSCT 1330 1340 1350 1360 1370 1380 DQCFRQNHIH GTLLQVFHLL QAYSDSKHGT NSDFQHELTD ITVCTKAKLW LAKRQNPCLV 1390 1400 1410 1420 1430 1440 TRAVYIDILF LLTCCLNRSA KDNQPVLESL GFWEEVRGII SGSELITGFP WAFKVPGLPQ 1450 1460 1470 1480 1490 1500 YLQSLTRLAI AAVWAAAAKS GERETNVPIS FSQLLESAFP EVRSLTLEAL LEKFLAAASG 1510 1520 1530 1540 1550 1560 LGEKGVPPLL CNMGEKFLLL AMKENHPECF CKILKILHCM DPGEWLPQTE HCVHLTPKEF 1570 1580 1590 1600 1610 1620 LIWTMDIASN ERSEIQSVAL RLASKVISHH MQTCVENREL IAAELKQWVQ LVILSCEDHL 1630 1640 1650 1660 1670 1680 PTESRLAVVE VLTSTTPLFL TNPHPILELQ DTLALWKCVL TLLQSEEQAV RDAATETVTT 1690 1700 1710 1720 1730 1740 AMSQENTCQS TEFAFCQVDA SIALALALAV LCDLLQQWDQ LAPGLPILLG WLLGESDDLV 1750 1760 1770 1780 1790 1800 ACVESMHQVE EDYLFEKAEV NFWAETLIFV KYLCKHLFCL LSKSGWRPPS PEMLCHLQRM 1810 1820 1830 1840 1850 1860 VSEQCHLLSQ FFRELPPAAE FVKTVEFTRL RIQEERTLAC LRLLAFLEGK EGEDTLVLSV 1870 WDSYAESRQL TLPRTEAAC
	Isoform 4 [UniParc]. Checksum: E1AFFD757D82C1AA	FASTA	674	75,966
	10 20 30 40 50 60 MTGREFFSRF PELYPFLLKQ LETVANTVDS DMGEPNRHPS MFLLLLVLER LYASPMDGTS 70 80 90 100 110 120 SALSMGPFVP FIMRCGHSPV YHSREMAARA LVPFVMIDHI PNTIRTLLST LPSCTDQCFR 130 140 150 160 170 180 QNHIHGTLLQ VFHLLQAYSD SKHGTNSDFQ HELTDITVCT KAKLWLAKRQ NPCLVTRAVY 190 200 210 220 230 240 IDILFLLTCC LNRSAKDNQP VLESLGFWEE VRGIISGSEL ITGFPWAFKV PGLPQYLQSL 250 260 270 280 290 300 TRLAIAAVWA AAAKSGERET NVPISFSQLL ESAFPEVRSL TLEALLEKFL AAASGLGEKG 310 320 330 340 350 360 VPPLLCNMGE KFLLLAMKEN HPECFCKILK ILHCMDPGEW LPQTEHCVHL TPKEFLIWTM 370 380 390 400 410 420 DIASNERSEI QSVALRLASK VISHHMQTCV ENRELIAAEL KQWVQLVILS CEDHLPTESR 430 440 450 460 470 480 LAVVEVLTST TPLFLTNPHP ILELQDTLAL WKCVLTLLQS EEQAVRDAAT ETVTTAMSQE 490 500 510 520 530 540 NTCQSTEFAF CQVDASIALA LALAVLCDLL QQWDQLAPGL PILLGWLLGE SDDLVACVES 550 560 570 580 590 600 MHQVEEDYLF EKAEVNFWAE TLIFVKYLCK HLFCLLSKSG WRPPSPEMLC HLQRMVSEQC 610 620 630 640 650 660 HLLSQFFREL PPAAEFVKTV EFTRLRIQEE RTLACLRLLA FLEGKEGEDT LVLSVWDSYA 670 ESRQLTLPRT EAAC
	Isoform 5 [UniParc]. Checksum: D2093158F2BFBE6B	FASTA	937	105,383
	10 20 30 40 50 60 MGVKKKKEMQ VAALTICHQD LETLKSFADV EGKNLASLLL HCVQLTDGVS QIHYIKQIVP 70 80 90 100 110 120 LLEKADKNGM CDPTIQSCLD ILAGIYLSLS LKNPLKKVLA SSLNSLPDFF LPEAMHRFTS 130 140 150 160 170 180 RLQEELNTTD LYSYRKVTDN ISSCMENFNL GRASVNNLLK NVLHFLQKSL IEILEENRKC 190 200 210 220 230 240 AGNHIIQTQL MNDLLVGIRV SMMLVQKVQD FQGNLWKTSD SPIWQNMCGL LSIFTKVLSD 250 260 270 280 290 300 DDLLQTVQST SGLAIILFIK TMFHPSEKIP HLISSVLLRS VDCTSVPEWF MSSCRSLCCG 310 320 330 340 350 360 DISQSAVLFL CQGTLAMLDW QNGSMGRSGE ALLLDTAHVL FTLSSQIKEP TLEMFLSRIL 370 380 390 400 410 420 ASWTNSAIQV LESSSPSLTD SLNGNSSIVG RLLEYVYTHW EHPLDALRHQ TKIMFKNLLQ 430 440 450 460 470 480 MHRLTVEGAD FVPDPFFVEL TESLLRLEWH IKGKYTCLGC LVECIGVEHI LAIDKTIPSQ 490 500 510 520 530 540 ILEVMGDQSL VPYASDLLET MFRNHKSHLK SQTAESSWID QWHETWVSPL LFILCEGNLD 550 560 570 580 590 600 QKSYVIDYYL PKLLSYSPES LQYMVKILQT SIDAKTGQEQ SFPSLGSCNS RGALGALMAC 610 620 630 640 650 660 LRIARAHGHL QSATDTWENL VSDARIKQGL IHQHCQVRID TLGLLCESNR STEIVSMEEM 670 680 690 700 710 720 QWIQFFITYN LNSQSPGVRQ QICSLLKKLF CRIQESSQVL YKLEQSKSKR EPENELTKQH 730 740 750 760 770 780 PSVSLQQYKN FMSSICNSLF EALFPGSSYS TRFSALTILG SIAEVFHVPE GRIYTVYQLS 790 800 810 820 830 840 HDIDVGRFQT LMECFTSTFE DVKILAFDLL MKLSKTAVHF QDSGKLQGLF QAALELSTST 850 860 870 880 890 900 KPYDCVTASY LLNFLIWQDA LPSSLSAYLT QQVACDNGDR PAAVVERNTL MVIKCLMENL 910 920 930 EEEVSQAENS LLQAAAAFPM YGRVHCITGA LQKLSLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas." Rippe V., Drieschner N., Meiboom M., Murua Escobar H., Bonk U., Belge G., Bullerdiek J. Oncogene 22:6111-6114(2003) [PubMed: 12955091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATIONS.
[2]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed: 11214970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-699. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 688-1953 (ISOFORM 3), VARIANT ILE-699. Tissue: Testis.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1118-1953 (ISOFORM 1), VARIANTS SER-1385 AND TYR-1605. Tissue: Brain, Pancreas and Skin.
[6]	"Novel protein interacting with death receptor." Puduvalli V.K., Ridgway L. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1311-1953.
[7]	"A domain of the thyroid adenoma associated gene (THADA) conserved in vertebrates becomes destroyed by chromosomal rearrangements observed in thyroid adenomas." Drieschner N., Kerschling S., Soller J.T., Rippe V., Belge G., Bullerdiek J., Nimzyk R. Gene 403:110-117(2007) [PubMed: 17889454] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATIONS.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1031 AND SER-1161, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY149629 mRNA. Translation: AAO46785.1. AY149633 mRNA. Translation: AAO46789.1. AB051554 mRNA. Translation: BAB21858.2. Different initiation. AK025530 mRNA. Translation: BAB15162.1. Different initiation. AK025445 mRNA. Translation: BAB15133.1. Different initiation. AK126004 mRNA. Translation: BAC86389.1. AK290023 mRNA. Translation: BAF82712.1. AC010883 Genomic DNA. Translation: AAY14994.1. AC092838 Genomic DNA. Translation: AAX93154.1. BC007743 mRNA. Translation: AAH07743.1. BC025773 mRNA. Translation: AAH25773.1. BC105976 mRNA. Translation: AAI05977.1. AF323176 mRNA. Translation: AAK11318.1.
IPI	IPI00894197. IPI00900266. IPI00900350. IPI00917435. IPI01019074.
RefSeq	NP_001077422.1. NM_001083953.1. NP_071348.3. NM_022065.4.
UniGene	Hs.369592.
3D structure databases
ProteinModelPortal	Q6YHU6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6YHU6. 2 interactions.
STRING	Q6YHU6.
Polymorphism databases
DMDM	74749519.
Proteomic databases
PRIDE	Q6YHU6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000402360; ENSP00000385441; ENSG00000115970. ENST00000405006; ENSP00000385995; ENSG00000115970. ENST00000405975; ENSP00000386088; ENSG00000115970. ENST00000409142; ENSP00000387029; ENSG00000115970.
GeneID	63892.
KEGG	hsa:63892.
UCSC	uc002rsw.2. human.
Organism-specific databases
CTD	63892.
GeneCards	GC02M043393.
H-InvDB	HIX0002009.
HGNC	HGNC:19217. THADA.
HPA	HPA035191.
MIM	611800. gene.
neXtProt	NX_Q6YHU6.
PharmGKB	PA134882460.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000015500.
HOVERGEN	HBG108565.
OrthoDB	EOG4MPHP9.
PhylomeDB	Q6YHU6.
Gene expression databases
ArrayExpress	Q6YHU6.
Bgee	Q6YHU6.
Genevestigator	Q6YHU6.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR019442. DUF2428_death-receptor-like. [Graphical view]
Pfam	PF10350. DUF2428. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	65572.
SOURCE	Search...

Entry information

Entry name

THADA_HUMAN

Accession

Primary (citable) accession number: Q6YHU6
Secondary accession number(s): A8K1V8 , B7WNS6, Q3KR04, Q53RC6, Q53TB2, Q6YHU2, Q6ZU38, Q8TAU8, Q96I88, Q9BZF7, Q9C096, Q9H6U0, Q9H6W7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.