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Q6YHK3 (CD109_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD109 antigen
Alternative name(s):
150 kDa TGF-beta-1-binding protein
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
Platelet-specific Gov antigen
p180
r150
CD_antigen=CD109
Gene names
Name:CD109
Synonyms:CPAMD7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1445 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Modulates negatively TGFB1 signaling in keratinocytes. Ref.3

Subunit structure

Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner. Ref.3

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Ref.1 Ref.3.

Tissue specificity

Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta. Ref.1 Ref.2 Ref.3

Post-translational modification

N-glycosylated. Ref.9

2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.

Polymorphism

The Gov(b) variant in position 703 defines the Gov alloantigenic determinants.

Sequence similarities

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]

Sequence caution

The sequence BAG53987.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAE46045.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAE46045.1 differs from that shown. Reason: Frameshift at position 1282.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6YHK3-1)

Also known as: CD109 180-kDa;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6YHK3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     93-169: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q6YHK3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     658-665: AEYAERFM → LFGTQEAL
     666-1445: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q6YHK3-4)

Also known as: CD109S;

The sequence of this isoform differs from the canonical sequence as follows:
     1218-1234: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.2
Chain22 – 14201399CD109 antigen
PRO_0000255945
Propeptide1421 – 144525Removed in mature form Potential
PRO_0000255946

Regions

Region593 – 702110Bait region (approximate) By similarity

Amino acid modifications

Lipidation14201GPI-anchor amidated alanine Potential
Glycosylation681N-linked (GlcNAc...) Ref.10 Ref.13
Glycosylation1181N-linked (GlcNAc...) Ref.10 Ref.13
Glycosylation2471N-linked (GlcNAc...) Ref.10 Ref.11
Glycosylation2791N-linked (GlcNAc...) Potential
Glycosylation3651N-linked (GlcNAc...) Potential
Glycosylation4191N-linked (GlcNAc...) Ref.10 Ref.12
Glycosylation6451N-linked (GlcNAc...) Potential
Glycosylation10861N-linked (GlcNAc...) Potential
Cross-link921 ↔ 924Isoglutamyl cysteine thioester (Cys-Gln) By similarity

Natural variations

Alternative sequence93 – 16977Missing in isoform 2.
VSP_021312
Alternative sequence658 – 6658AEYAERFM → LFGTQEAL in isoform 3.
VSP_021313
Alternative sequence666 – 1445780Missing in isoform 3.
VSP_021314
Alternative sequence1218 – 123417Missing in isoform 4.
VSP_021315
Natural variant451G → V.
Corresponds to variant rs9446983 [ dbSNP | Ensembl ].
VAR_028875
Natural variant3771G → D.
Corresponds to variant rs7741152 [ dbSNP | Ensembl ].
VAR_048105
Natural variant6411L → F.
Corresponds to variant rs7742662 [ dbSNP | Ensembl ].
VAR_048106
Natural variant7031Y → S in allele Gov(b). Ref.2 Ref.3 Ref.4 Ref.5 Ref.8
Corresponds to variant rs10455097 [ dbSNP | Ensembl ].
VAR_028876
Natural variant7971N → S. Ref.2 Ref.3 Ref.4 Ref.5
Corresponds to variant rs2351528 [ dbSNP | Ensembl ].
VAR_028877
Natural variant8451V → I. Ref.2 Ref.3 Ref.4 Ref.5
Corresponds to variant rs5023688 [ dbSNP | Ensembl ].
VAR_028878
Natural variant10071Q → E in a colorectal cancer sample; somatic mutation. Ref.15
VAR_036236
Natural variant10091V → M.
Corresponds to variant rs35630075 [ dbSNP | Ensembl ].
VAR_048107
Natural variant10651N → K in a colorectal cancer sample; somatic mutation. Ref.15
VAR_036237
Natural variant12411T → M. Ref.1 Ref.5
Corresponds to variant rs2917862 [ dbSNP | Ensembl ].
VAR_028879
Natural variant12961H → R.
Corresponds to variant rs13207595 [ dbSNP | Ensembl ].
VAR_048108

Experimental info

Sequence conflict6271M → I in AAN78483. Ref.2
Sequence conflict7891K → E in BAG36395. Ref.4
Sequence conflict8031G → S in AAN78483. Ref.2
Sequence conflict10461V → A in ABQ66266. Ref.5
Sequence conflict14181D → N in BAG53987. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (CD109 180-kDa) [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: 0C5B1C3B8CCAF195

FASTA1,445161,689
        10         20         30         40         50         60 
MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE HCPSQVTVKA 

        70         80         90        100        110        120 
ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE IYELRVTGRT QDEILFSNST 

       130        140        150        160        170        180 
RLSFETKRIS VFIQTDKALY KPKQEVKFRI VTLFSDFKPY KTSLNILIKD PKSNLIQQWL 

       190        200        210        220        230        240 
SQQSDLGVIS KTFQLSSHPI LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS 

       250        260        270        280        290        300 
MNSKHLNGTI TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK 

       310        320        330        340        350        360 
NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI IEFFDYTTVL 

       370        380        390        400        410        420 
KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE YWSGSNSGNQ KMEAVQKINY 

       430        440        450        460        470        480 
TVPQSGTFKI EFPILEDSSE LQLKAYFLGS KSSMAVHSLF KSPSKTYIQL KTRDENIKVG 

       490        500        510        520        530        540 
SPFELVVSGN KRLKELSYMV VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG 

       550        560        570        580        590        600 
EIISDVLKIP VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN 

       610        620        630        640        650        660 
ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY IDGVYDNAEY 

       670        680        690        700        710        720 
AERFMEENEG HIVDIHDFSL GSSPHVRKHF PETWIWLDTN MGYRIYQEFE VTVPDSITSW 

       730        740        750        760        770        780 
VATGFVISED LGLGLTTTPV ELQAFQPFFI FLNLPYSVIR GEEFALEITI FNYLKDATEV 

       790        800        810        820        830        840 
KVIIEKSDKF DILMTSNEIN ATGHQQTLLV PSEDGATVLF PIRPTHLGEI PITVTALSPT 

       850        860        870        880        890        900 
ASDAVTQMIL VKAEGIEKSY SQSILLDLTD NRLQSTLKTL SFSFPPNTVT GSERVQITAI 

       910        920        930        940        950        960 
GDVLGPSING LASLIRMPYG CGEQNMINFA PNIYILDYLT KKKQLTDNLK EKALSFMRQG 

       970        980        990       1000       1010       1020 
YQRELLYQRE DGSFSAFGNY DPSGSTWLSA FVLRCFLEAD PYIDIDQNVL HRTYTWLKGH 

      1030       1040       1050       1060       1070       1080 
QKSNGEFWDP GRVIHSELQG GNKSPVTLTA YIVTSLLGYR KYQPNIDVQE SIHFLESEFS 

      1090       1100       1110       1120       1130       1140 
RGISDNYTLA LITYALSSVG SPKAKEALNM LTWRAEQEGG MQFWVSSESK LSDSWQPRSL 

      1150       1160       1170       1180       1190       1200 
DIEVAAYALL SHFLQFQTSE GIPIMRWLSR QRNSLGGFAS TQDTTVALKA LSEFAALMNT 

      1210       1220       1230       1240       1250       1260 
ERTNIQVTVT GPSSPSPVKF LIDTHNRLLL QTAELAVVQP TAVNISANGF GFAICQLNVV 

      1270       1280       1290       1300       1310       1320 
YNVKASGSSR RRRSIQNQEA FDLDVAVKEN KDDLNHVDLN VCTSFSGPGR SGMALMEVNL 

      1330       1340       1350       1360       1370       1380 
LSGFMVPSEA ISLSETVKKV EYDHGKLNLY LDSVNETQFC VNIPAVRNFK VSNTQDASVS 

      1390       1400       1410       1420       1430       1440 
IVDYYEPRRQ AVRSYNSEVK LSSCDLCSDV QGCRPCEDGA SGSHHHSSVI FIFCFKLLYF 


MELWL 

« Hide

Isoform 2 [UniParc].

Checksum: 9F326D3F69033813
Show »

FASTA1,368152,663
Isoform 3 [UniParc].

Checksum: CC73982C8E88647E
Show »

FASTA66574,411
Isoform 4 (CD109S) [UniParc].

Checksum: 9DBA3F0AA03660F5
Show »

FASTA1,428159,696

References

« Hide 'large scale' references
[1]"Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins."
Lin M., Sutherland D.R., Horsfall W., Totty N., Yeo E., Nayar R., Wu X.-F., Schuh A.C.
Blood 99:1683-1691(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 86-98; 127-137; 170-183; 185-196; 355-374; 413-425; 444-451; 465-471; 478-491; 494-510; 573-589; 649-655; 666-672; 677-683; 698-709 AND 791-806, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT MET-1241.
[2]"CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family."
Solomon K.R., Sharma P., Chan M., Morrison P.T., Finberg R.W.
Gene 327:171-183(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 22-50 (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS SER-703; SER-797 AND ILE-845.
[3]"Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes."
Finnson K.W., Tam B.Y.Y., Liu K., Marcoux A., Lepage P., Roy S., Bizet A.A., Philip A.
FASEB J. 20:1525-1527(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), PROTEIN SEQUENCE OF 173-191, FUNCTION, INTERACTION WITH TGFB1 AND TGFBR1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PROTEOLYTIC CLEAVAGE, VARIANTS SER-703; SER-797 AND ILE-845.
Tissue: Placenta.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS SER-703; SER-797 AND ILE-845.
Tissue: Chondrocyte, Trachea and Vascular endothelial cell.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS SER-703; SER-797; ILE-845 AND MET-1241.
Tissue: Colon endothelium.
[6]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"CD109 defines an ancient branch of the alpha2M/C3, C4, C5 family."
Prosper J.Y.A., Wu X.-F., Sutherland D.R., Irwin D.M., Schuh A.C.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 370-444 AND 922-959.
[8]"A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens."
Schuh A.C., Watkins N.A., Nguyen Q., Harmer N.J., Lin M., Prosper J.Y.A., Campbell K., Sutherland D.R., Metcalfe P., Horsfall W., Ouwehand W.H.
Blood 99:1692-1698(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 703-741, VARIANT GOV(B) SER-703.
[9]"Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets."
Sutherland D.R., Yeo E., Ryan A., Mills G.B., Bailey D., Baker M.A.
Blood 77:84-93(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC CLEAVAGE, GLYCOSYLATION.
[10]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68; ASN-118; ASN-247 AND ASN-419.
Tissue: Plasma.
[11]"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U., Moebius J., Walter U., Sickmann A.
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-247.
Tissue: Platelet.
[12]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-419.
Tissue: Liver.
[13]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68 AND ASN-118.
Tissue: Leukemic T-cell.
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-1007 AND LYS-1065.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF410459 mRNA. Translation: AAL84159.1.
AY149920 mRNA. Translation: AAN78483.1.
AY788891 mRNA. Translation: AAX14639.1.
AK095888 mRNA. Translation: BAC04642.1.
AK123960 mRNA. Translation: BAG53987.1. Different initiation.
AK313636 mRNA. Translation: BAG36395.1.
AL834478 mRNA. Translation: CAD39137.1.
BX641095 mRNA. Translation: CAE46045.1. Sequence problems.
EF553520 mRNA. Translation: ABQ66266.1.
AL590428, AL591480 Genomic DNA. Translation: CAI15636.1.
AY736555 Genomic DNA. Translation: AAU94642.1.
AY736557 Genomic DNA. Translation: AAU94644.1.
AF410460 Genomic DNA. Translation: AAL84160.1.
RefSeqNP_001153059.1. NM_001159587.1.
NP_001153060.1. NM_001159588.1.
NP_598000.2. NM_133493.3.
XP_005248716.1. XM_005248659.2.
UniGeneHs.399891.

3D structure databases

ProteinModelPortalQ6YHK3.
SMRQ6YHK3. Positions 27-1418.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6YHK3. 1 interaction.

Protein family/group databases

MEROPSI39.006.

PTM databases

PhosphoSiteQ6YHK3.

Polymorphism databases

DMDM117949389.

Proteomic databases

PaxDbQ6YHK3.
PRIDEQ6YHK3.

Protocols and materials databases

DNASU135228.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000287097; ENSP00000287097; ENSG00000156535. [Q6YHK3-1]
ENST00000422508; ENSP00000404475; ENSG00000156535. [Q6YHK3-2]
ENST00000437994; ENSP00000388062; ENSG00000156535. [Q6YHK3-4]
GeneID135228.
KEGGhsa:135228.
UCSCuc003php.3. human. [Q6YHK3-1]
uc003phq.3. human. [Q6YHK3-4]
uc010kba.3. human. [Q6YHK3-2]

Organism-specific databases

CTD135228.
GeneCardsGC06P074462.
H-InvDBHIX0006012.
HGNCHGNC:21685. CD109.
HPAHPA009292.
HPA015113.
MIM608859. gene.
neXtProtNX_Q6YHK3.
Orphanet853. Fetal and neonatal alloimmune thrombocytopenia.
PharmGKBPA134949237.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2373.
HOVERGENHBG097839.
InParanoidQ6YHK3.
KOK06530.
OMAPENSWAP.
OrthoDBEOG7PGDPR.
PhylomeDBQ6YHK3.
TreeFamTF313285.

Gene expression databases

ArrayExpressQ6YHK3.
BgeeQ6YHK3.
GenevestigatorQ6YHK3.

Family and domain databases

Gene3D1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCD109. human.
GeneWikiCD109.
GenomeRNAi135228.
NextBio83469.
PROQ6YHK3.
SOURCESearch...

Entry information

Entry nameCD109_HUMAN
AccessionPrimary (citable) accession number: Q6YHK3
Secondary accession number(s): A5YKK4 expand/collapse secondary AC list , B2R948, B3KW25, Q0P6K7, Q5SYA8, Q5XUM7, Q5XUM9, Q6MZI7, Q8N3A7, Q8N915, Q8TDJ2, Q8TDJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries