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Protein

CD109 antigen

Gene

CD109

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates negatively TGFB1 signaling in keratinocytes.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-163125. Post-translational modification: synthesis of GPI-anchored proteins.

Protein family/group databases

MEROPSiI39.006.

Names & Taxonomyi

Protein namesi
Recommended name:
CD109 antigen
Alternative name(s):
150 kDa TGF-beta-1-binding protein
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
Platelet-specific Gov antigen
p180
r150
CD_antigen: CD109
Gene namesi
Name:CD109
Synonyms:CPAMD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21685. CD109.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi135228.
MalaCardsiCD109.
OpenTargetsiENSG00000156535.
Orphaneti853. Fetal and neonatal alloimmune thrombocytopenia.
PharmGKBiPA134949237.

Polymorphism and mutation databases

BioMutaiCD109.
DMDMi117949389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000025594522 – 1420CD109 antigenAdd BLAST1399
PropeptideiPRO_00002559461421 – 1445Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi118N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi247N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi513N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi645N-linked (GlcNAc...) asparagineSequence analysis1
Cross-linki921 ↔ 924Isoglutamyl cysteine thioester (Cys-Gln)By similarity
Glycosylationi1086N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1355N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Lipidationi1420GPI-anchor amidated alanineSequence analysis1

Post-translational modificationi

N-glycosylated.5 Publications
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Thioester bond

Proteomic databases

EPDiQ6YHK3.
MaxQBiQ6YHK3.
PaxDbiQ6YHK3.
PeptideAtlasiQ6YHK3.
PRIDEiQ6YHK3.

PTM databases

iPTMnetiQ6YHK3.
PhosphoSitePlusiQ6YHK3.
SwissPalmiQ6YHK3.
UniCarbKBiQ6YHK3.

Expressioni

Tissue specificityi

Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 4 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.3 Publications

Gene expression databases

BgeeiENSG00000156535.
GenevisibleiQ6YHK3. HS.

Organism-specific databases

HPAiHPA009292.
HPA015113.

Interactioni

Subunit structurei

Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner.1 Publication

GO - Molecular functioni

  • transforming growth factor beta binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126424. 49 interactors.
IntActiQ6YHK3. 12 interactors.
STRINGi9606.ENSP00000287097.

Structurei

3D structure databases

ProteinModelPortaliQ6YHK3.
SMRiQ6YHK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni593 – 702Bait region (approximate)By similarityAdd BLAST110

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiENOG410IMYI. Eukaryota.
COG2373. LUCA.
GeneTreeiENSGT00760000118982.
HOVERGENiHBG097839.
InParanoidiQ6YHK3.
KOiK06530.
OMAiNVFFKQH.
OrthoDBiEOG091G00F8.
PhylomeDBiQ6YHK3.
TreeFamiTF313285.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.690. 1 hit.
InterProiView protein in InterPro
IPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
PfamiView protein in Pfam
PF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
SMARTiView protein in SMART
SM01360. A2M. 1 hit.
SM01359. A2M_N_2. 1 hit.
SM01361. A2M_recep. 1 hit.
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiView protein in PROSITE
PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6YHK3-1) [UniParc]FASTAAdd to basket
Also known as: CD109 180-kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE
60 70 80 90 100
HCPSQVTVKA ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE
110 120 130 140 150
IYELRVTGRT QDEILFSNST RLSFETKRIS VFIQTDKALY KPKQEVKFRI
160 170 180 190 200
VTLFSDFKPY KTSLNILIKD PKSNLIQQWL SQQSDLGVIS KTFQLSSHPI
210 220 230 240 250
LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS MNSKHLNGTI
260 270 280 290 300
TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK
310 320 330 340 350
NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI
360 370 380 390 400
IEFFDYTTVL KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE
410 420 430 440 450
YWSGSNSGNQ KMEAVQKINY TVPQSGTFKI EFPILEDSSE LQLKAYFLGS
460 470 480 490 500
KSSMAVHSLF KSPSKTYIQL KTRDENIKVG SPFELVVSGN KRLKELSYMV
510 520 530 540 550
VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG EIISDVLKIP
560 570 580 590 600
VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN
610 620 630 640 650
ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY
660 670 680 690 700
IDGVYDNAEY AERFMEENEG HIVDIHDFSL GSSPHVRKHF PETWIWLDTN
710 720 730 740 750
MGYRIYQEFE VTVPDSITSW VATGFVISED LGLGLTTTPV ELQAFQPFFI
760 770 780 790 800
FLNLPYSVIR GEEFALEITI FNYLKDATEV KVIIEKSDKF DILMTSNEIN
810 820 830 840 850
ATGHQQTLLV PSEDGATVLF PIRPTHLGEI PITVTALSPT ASDAVTQMIL
860 870 880 890 900
VKAEGIEKSY SQSILLDLTD NRLQSTLKTL SFSFPPNTVT GSERVQITAI
910 920 930 940 950
GDVLGPSING LASLIRMPYG CGEQNMINFA PNIYILDYLT KKKQLTDNLK
960 970 980 990 1000
EKALSFMRQG YQRELLYQRE DGSFSAFGNY DPSGSTWLSA FVLRCFLEAD
1010 1020 1030 1040 1050
PYIDIDQNVL HRTYTWLKGH QKSNGEFWDP GRVIHSELQG GNKSPVTLTA
1060 1070 1080 1090 1100
YIVTSLLGYR KYQPNIDVQE SIHFLESEFS RGISDNYTLA LITYALSSVG
1110 1120 1130 1140 1150
SPKAKEALNM LTWRAEQEGG MQFWVSSESK LSDSWQPRSL DIEVAAYALL
1160 1170 1180 1190 1200
SHFLQFQTSE GIPIMRWLSR QRNSLGGFAS TQDTTVALKA LSEFAALMNT
1210 1220 1230 1240 1250
ERTNIQVTVT GPSSPSPVKF LIDTHNRLLL QTAELAVVQP TAVNISANGF
1260 1270 1280 1290 1300
GFAICQLNVV YNVKASGSSR RRRSIQNQEA FDLDVAVKEN KDDLNHVDLN
1310 1320 1330 1340 1350
VCTSFSGPGR SGMALMEVNL LSGFMVPSEA ISLSETVKKV EYDHGKLNLY
1360 1370 1380 1390 1400
LDSVNETQFC VNIPAVRNFK VSNTQDASVS IVDYYEPRRQ AVRSYNSEVK
1410 1420 1430 1440
LSSCDLCSDV QGCRPCEDGA SGSHHHSSVI FIFCFKLLYF MELWL
Length:1,445
Mass (Da):161,689
Last modified:October 31, 2006 - v2
Checksum:i0C5B1C3B8CCAF195
GO
Isoform 2 (identifier: Q6YHK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-169: Missing.

Note: No experimental confirmation available.
Show »
Length:1,368
Mass (Da):152,663
Checksum:i9F326D3F69033813
GO
Isoform 3 (identifier: Q6YHK3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     658-665: AEYAERFM → LFGTQEAL
     666-1445: Missing.

Note: No experimental confirmation available.
Show »
Length:665
Mass (Da):74,411
Checksum:iCC73982C8E88647E
GO
Isoform 4 (identifier: Q6YHK3-4) [UniParc]FASTAAdd to basket
Also known as: CD109S

The sequence of this isoform differs from the canonical sequence as follows:
     1218-1234: Missing.

Show »
Length:1,428
Mass (Da):159,696
Checksum:i9DBA3F0AA03660F5
GO

Sequence cautioni

The sequence BAG53987 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAE46045 differs from that shown. Reason: Frameshift at position 1282.Curated
The sequence CAE46045 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti627M → I in AAN78483 (PubMed:14980714).Curated1
Sequence conflicti789K → E in BAG36395 (PubMed:14702039).Curated1
Sequence conflicti803G → S in AAN78483 (PubMed:14980714).Curated1
Sequence conflicti1046V → A in ABQ66266 (PubMed:17974005).Curated1
Sequence conflicti1418D → N in BAG53987 (PubMed:14702039).Curated1

Polymorphismi

The Gov(b) variant in position 703 defines the Gov alloantigenic determinants.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02887545G → V. Corresponds to variant dbSNP:rs9446983Ensembl.1
Natural variantiVAR_048105377G → D. Corresponds to variant dbSNP:rs7741152Ensembl.1
Natural variantiVAR_048106641L → F. Corresponds to variant dbSNP:rs7742662Ensembl.1
Natural variantiVAR_028876703Y → S in allele Gov(b). 5 PublicationsCorresponds to variant dbSNP:rs10455097Ensembl.1
Natural variantiVAR_074179791D → G1 Publication1
Natural variantiVAR_028877797N → S4 PublicationsCorresponds to variant dbSNP:rs2351528Ensembl.1
Natural variantiVAR_028878845V → I4 PublicationsCorresponds to variant dbSNP:rs5023688Ensembl.1
Natural variantiVAR_0362361007Q → E in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0481071009V → M. Corresponds to variant dbSNP:rs35630075Ensembl.1
Natural variantiVAR_0362371065N → K in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0288791241T → M2 PublicationsCorresponds to variant dbSNP:rs2917862Ensembl.1
Natural variantiVAR_0481081296H → R. Corresponds to variant dbSNP:rs13207595Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02131293 – 169Missing in isoform 2. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_021313658 – 665AEYAERFM → LFGTQEAL in isoform 3. 1 Publication8
Alternative sequenceiVSP_021314666 – 1445Missing in isoform 3. 1 PublicationAdd BLAST780
Alternative sequenceiVSP_0213151218 – 1234Missing in isoform 4. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410459 mRNA. Translation: AAL84159.1.
AY149920 mRNA. Translation: AAN78483.1.
AY788891 mRNA. Translation: AAX14639.1.
AK095888 mRNA. Translation: BAC04642.1.
AK123960 mRNA. Translation: BAG53987.1. Different initiation.
AK313636 mRNA. Translation: BAG36395.1.
AL834478 mRNA. Translation: CAD39137.1.
BX641095 mRNA. Translation: CAE46045.1. Sequence problems.
EF553520 mRNA. Translation: ABQ66266.1.
AL590428, AL591480 Genomic DNA. Translation: CAI15636.1.
AY736555 Genomic DNA. Translation: AAU94642.1.
AY736557 Genomic DNA. Translation: AAU94644.1.
AF410460 Genomic DNA. Translation: AAL84160.1.
CCDSiCCDS4982.1. [Q6YHK3-1]
CCDS55038.1. [Q6YHK3-4]
CCDS55039.1. [Q6YHK3-2]
RefSeqiNP_001153059.1. NM_001159587.2. [Q6YHK3-4]
NP_001153060.1. NM_001159588.2. [Q6YHK3-2]
NP_598000.2. NM_133493.4. [Q6YHK3-1]
XP_005248716.1. XM_005248659.3. [Q6YHK3-1]
UniGeneiHs.399891.

Genome annotation databases

EnsembliENST00000287097; ENSP00000287097; ENSG00000156535. [Q6YHK3-1]
ENST00000422508; ENSP00000404475; ENSG00000156535. [Q6YHK3-2]
ENST00000437994; ENSP00000388062; ENSG00000156535. [Q6YHK3-4]
GeneIDi135228.
KEGGihsa:135228.
UCSCiuc003php.4. human. [Q6YHK3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD109_HUMAN
AccessioniPrimary (citable) accession number: Q6YHK3
Secondary accession number(s): A5YKK4
, B2R948, B3KW25, Q0P6K7, Q5SYA8, Q5XUM7, Q5XUM9, Q6MZI7, Q8N3A7, Q8N915, Q8TDJ2, Q8TDJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: August 30, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families