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Q6YHK3

- CD109_HUMAN

UniProt

Q6YHK3 - CD109_HUMAN

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Protein

CD109 antigen

Gene
CD109, CPAMD7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Modulates negatively TGFB1 signaling in keratinocytes.1 Publication

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
  2. transforming growth factor beta binding Source: UniProt

GO - Biological processi

  1. negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProt
  2. negative regulation of wound healing Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI39.006.

Names & Taxonomyi

Protein namesi
Recommended name:
CD109 antigen
Alternative name(s):
150 kDa TGF-beta-1-binding protein
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
Platelet-specific Gov antigen
p180
r150
CD_antigen: CD109
Gene namesi
Name:CD109
Synonyms:CPAMD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21685. CD109.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor 2 Publications

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular space Source: InterPro
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti853. Fetal and neonatal alloimmune thrombocytopenia.
PharmGKBiPA134949237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 14201399CD109 antigenPRO_0000255945Add
BLAST
Propeptidei1421 – 144525Removed in mature form Reviewed predictionPRO_0000255946Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)2 Publications
Glycosylationi118 – 1181N-linked (GlcNAc...)2 Publications
Glycosylationi247 – 2471N-linked (GlcNAc...)2 Publications
Glycosylationi279 – 2791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi419 – 4191N-linked (GlcNAc...)2 Publications
Glycosylationi645 – 6451N-linked (GlcNAc...) Reviewed prediction
Cross-linki921 ↔ 924Isoglutamyl cysteine thioester (Cys-Gln) By similarity
Glycosylationi1086 – 10861N-linked (GlcNAc...) Reviewed prediction
Lipidationi1420 – 14201GPI-anchor amidated alanine Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Thioester bond

Proteomic databases

MaxQBiQ6YHK3.
PaxDbiQ6YHK3.
PRIDEiQ6YHK3.

PTM databases

PhosphoSiteiQ6YHK3.

Expressioni

Tissue specificityi

Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.3 Publications

Gene expression databases

ArrayExpressiQ6YHK3.
BgeeiQ6YHK3.
GenevestigatoriQ6YHK3.

Organism-specific databases

HPAiHPA009292.
HPA015113.

Interactioni

Subunit structurei

Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner.1 Publication

Protein-protein interaction databases

IntActiQ6YHK3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6YHK3.
SMRiQ6YHK3. Positions 28-1418.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni593 – 702110Bait region (approximate) By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiCOG2373.
HOVERGENiHBG097839.
InParanoidiQ6YHK3.
KOiK06530.
OMAiRSYNSEV.
OrthoDBiEOG7PGDPR.
PhylomeDBiQ6YHK3.
TreeFamiTF313285.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6YHK3-1) [UniParc]FASTAAdd to Basket

Also known as: CD109 180-kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE     50
HCPSQVTVKA ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE 100
IYELRVTGRT QDEILFSNST RLSFETKRIS VFIQTDKALY KPKQEVKFRI 150
VTLFSDFKPY KTSLNILIKD PKSNLIQQWL SQQSDLGVIS KTFQLSSHPI 200
LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS MNSKHLNGTI 250
TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK 300
NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI 350
IEFFDYTTVL KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE 400
YWSGSNSGNQ KMEAVQKINY TVPQSGTFKI EFPILEDSSE LQLKAYFLGS 450
KSSMAVHSLF KSPSKTYIQL KTRDENIKVG SPFELVVSGN KRLKELSYMV 500
VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG EIISDVLKIP 550
VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN 600
ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY 650
IDGVYDNAEY AERFMEENEG HIVDIHDFSL GSSPHVRKHF PETWIWLDTN 700
MGYRIYQEFE VTVPDSITSW VATGFVISED LGLGLTTTPV ELQAFQPFFI 750
FLNLPYSVIR GEEFALEITI FNYLKDATEV KVIIEKSDKF DILMTSNEIN 800
ATGHQQTLLV PSEDGATVLF PIRPTHLGEI PITVTALSPT ASDAVTQMIL 850
VKAEGIEKSY SQSILLDLTD NRLQSTLKTL SFSFPPNTVT GSERVQITAI 900
GDVLGPSING LASLIRMPYG CGEQNMINFA PNIYILDYLT KKKQLTDNLK 950
EKALSFMRQG YQRELLYQRE DGSFSAFGNY DPSGSTWLSA FVLRCFLEAD 1000
PYIDIDQNVL HRTYTWLKGH QKSNGEFWDP GRVIHSELQG GNKSPVTLTA 1050
YIVTSLLGYR KYQPNIDVQE SIHFLESEFS RGISDNYTLA LITYALSSVG 1100
SPKAKEALNM LTWRAEQEGG MQFWVSSESK LSDSWQPRSL DIEVAAYALL 1150
SHFLQFQTSE GIPIMRWLSR QRNSLGGFAS TQDTTVALKA LSEFAALMNT 1200
ERTNIQVTVT GPSSPSPVKF LIDTHNRLLL QTAELAVVQP TAVNISANGF 1250
GFAICQLNVV YNVKASGSSR RRRSIQNQEA FDLDVAVKEN KDDLNHVDLN 1300
VCTSFSGPGR SGMALMEVNL LSGFMVPSEA ISLSETVKKV EYDHGKLNLY 1350
LDSVNETQFC VNIPAVRNFK VSNTQDASVS IVDYYEPRRQ AVRSYNSEVK 1400
LSSCDLCSDV QGCRPCEDGA SGSHHHSSVI FIFCFKLLYF MELWL 1445
Length:1,445
Mass (Da):161,689
Last modified:October 31, 2006 - v2
Checksum:i0C5B1C3B8CCAF195
GO
Isoform 2 (identifier: Q6YHK3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-169: Missing.

Note: No experimental confirmation available.

Show »
Length:1,368
Mass (Da):152,663
Checksum:i9F326D3F69033813
GO
Isoform 3 (identifier: Q6YHK3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     658-665: AEYAERFM → LFGTQEAL
     666-1445: Missing.

Note: No experimental confirmation available.

Show »
Length:665
Mass (Da):74,411
Checksum:iCC73982C8E88647E
GO
Isoform 4 (identifier: Q6YHK3-4) [UniParc]FASTAAdd to Basket

Also known as: CD109S

The sequence of this isoform differs from the canonical sequence as follows:
     1218-1234: Missing.

Show »
Length:1,428
Mass (Da):159,696
Checksum:i9DBA3F0AA03660F5
GO

Sequence cautioni

The sequence CAE46045.1 differs from that shown. Reason: Frameshift at position 1282.
The sequence BAG53987.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAE46045.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Polymorphismi

The Gov(b) variant in position 703 defines the Gov alloantigenic determinants.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451G → V.
Corresponds to variant rs9446983 [ dbSNP | Ensembl ].
VAR_028875
Natural varianti377 – 3771G → D.
Corresponds to variant rs7741152 [ dbSNP | Ensembl ].
VAR_048105
Natural varianti641 – 6411L → F.
Corresponds to variant rs7742662 [ dbSNP | Ensembl ].
VAR_048106
Natural varianti703 – 7031Y → S in allele Gov(b). 5 Publications
Corresponds to variant rs10455097 [ dbSNP | Ensembl ].
VAR_028876
Natural varianti797 – 7971N → S.4 Publications
Corresponds to variant rs2351528 [ dbSNP | Ensembl ].
VAR_028877
Natural varianti845 – 8451V → I.4 Publications
Corresponds to variant rs5023688 [ dbSNP | Ensembl ].
VAR_028878
Natural varianti1007 – 10071Q → E in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036236
Natural varianti1009 – 10091V → M.
Corresponds to variant rs35630075 [ dbSNP | Ensembl ].
VAR_048107
Natural varianti1065 – 10651N → K in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036237
Natural varianti1241 – 12411T → M.2 Publications
Corresponds to variant rs2917862 [ dbSNP | Ensembl ].
VAR_028879
Natural varianti1296 – 12961H → R.
Corresponds to variant rs13207595 [ dbSNP | Ensembl ].
VAR_048108

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei93 – 16977Missing in isoform 2. VSP_021312Add
BLAST
Alternative sequencei658 – 6658AEYAERFM → LFGTQEAL in isoform 3. VSP_021313
Alternative sequencei666 – 1445780Missing in isoform 3. VSP_021314Add
BLAST
Alternative sequencei1218 – 123417Missing in isoform 4. VSP_021315Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti627 – 6271M → I in AAN78483. 1 Publication
Sequence conflicti789 – 7891K → E in BAG36395. 1 Publication
Sequence conflicti803 – 8031G → S in AAN78483. 1 Publication
Sequence conflicti1046 – 10461V → A in ABQ66266. 1 Publication
Sequence conflicti1418 – 14181D → N in BAG53987. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF410459 mRNA. Translation: AAL84159.1.
AY149920 mRNA. Translation: AAN78483.1.
AY788891 mRNA. Translation: AAX14639.1.
AK095888 mRNA. Translation: BAC04642.1.
AK123960 mRNA. Translation: BAG53987.1. Different initiation.
AK313636 mRNA. Translation: BAG36395.1.
AL834478 mRNA. Translation: CAD39137.1.
BX641095 mRNA. Translation: CAE46045.1. Sequence problems.
EF553520 mRNA. Translation: ABQ66266.1.
AL590428, AL591480 Genomic DNA. Translation: CAI15636.1.
AY736555 Genomic DNA. Translation: AAU94642.1.
AY736557 Genomic DNA. Translation: AAU94644.1.
AF410460 Genomic DNA. Translation: AAL84160.1.
CCDSiCCDS4982.1. [Q6YHK3-1]
CCDS55038.1. [Q6YHK3-4]
CCDS55039.1. [Q6YHK3-2]
RefSeqiNP_001153059.1. NM_001159587.2. [Q6YHK3-4]
NP_001153060.1. NM_001159588.2. [Q6YHK3-2]
NP_598000.2. NM_133493.4. [Q6YHK3-1]
XP_005248716.1. XM_005248659.2. [Q6YHK3-1]
UniGeneiHs.399891.

Genome annotation databases

EnsembliENST00000287097; ENSP00000287097; ENSG00000156535. [Q6YHK3-1]
ENST00000422508; ENSP00000404475; ENSG00000156535. [Q6YHK3-2]
ENST00000437994; ENSP00000388062; ENSG00000156535. [Q6YHK3-4]
GeneIDi135228.
KEGGihsa:135228.
UCSCiuc003php.3. human. [Q6YHK3-1]
uc003phq.3. human. [Q6YHK3-4]
uc010kba.3. human. [Q6YHK3-2]

Polymorphism databases

DMDMi117949389.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF410459 mRNA. Translation: AAL84159.1 .
AY149920 mRNA. Translation: AAN78483.1 .
AY788891 mRNA. Translation: AAX14639.1 .
AK095888 mRNA. Translation: BAC04642.1 .
AK123960 mRNA. Translation: BAG53987.1 . Different initiation.
AK313636 mRNA. Translation: BAG36395.1 .
AL834478 mRNA. Translation: CAD39137.1 .
BX641095 mRNA. Translation: CAE46045.1 . Sequence problems.
EF553520 mRNA. Translation: ABQ66266.1 .
AL590428 , AL591480 Genomic DNA. Translation: CAI15636.1 .
AY736555 Genomic DNA. Translation: AAU94642.1 .
AY736557 Genomic DNA. Translation: AAU94644.1 .
AF410460 Genomic DNA. Translation: AAL84160.1 .
CCDSi CCDS4982.1. [Q6YHK3-1 ]
CCDS55038.1. [Q6YHK3-4 ]
CCDS55039.1. [Q6YHK3-2 ]
RefSeqi NP_001153059.1. NM_001159587.2. [Q6YHK3-4 ]
NP_001153060.1. NM_001159588.2. [Q6YHK3-2 ]
NP_598000.2. NM_133493.4. [Q6YHK3-1 ]
XP_005248716.1. XM_005248659.2. [Q6YHK3-1 ]
UniGenei Hs.399891.

3D structure databases

ProteinModelPortali Q6YHK3.
SMRi Q6YHK3. Positions 28-1418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6YHK3. 1 interaction.

Protein family/group databases

MEROPSi I39.006.

PTM databases

PhosphoSitei Q6YHK3.

Polymorphism databases

DMDMi 117949389.

Proteomic databases

MaxQBi Q6YHK3.
PaxDbi Q6YHK3.
PRIDEi Q6YHK3.

Protocols and materials databases

DNASUi 135228.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000287097 ; ENSP00000287097 ; ENSG00000156535 . [Q6YHK3-1 ]
ENST00000422508 ; ENSP00000404475 ; ENSG00000156535 . [Q6YHK3-2 ]
ENST00000437994 ; ENSP00000388062 ; ENSG00000156535 . [Q6YHK3-4 ]
GeneIDi 135228.
KEGGi hsa:135228.
UCSCi uc003php.3. human. [Q6YHK3-1 ]
uc003phq.3. human. [Q6YHK3-4 ]
uc010kba.3. human. [Q6YHK3-2 ]

Organism-specific databases

CTDi 135228.
GeneCardsi GC06P074462.
H-InvDB HIX0006012.
HGNCi HGNC:21685. CD109.
HPAi HPA009292.
HPA015113.
MIMi 608859. gene.
neXtProti NX_Q6YHK3.
Orphaneti 853. Fetal and neonatal alloimmune thrombocytopenia.
PharmGKBi PA134949237.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2373.
HOVERGENi HBG097839.
InParanoidi Q6YHK3.
KOi K06530.
OMAi RSYNSEV.
OrthoDBi EOG7PGDPR.
PhylomeDBi Q6YHK3.
TreeFami TF313285.

Miscellaneous databases

ChiTaRSi CD109. human.
GeneWikii CD109.
GenomeRNAii 135228.
NextBioi 83469.
PROi Q6YHK3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6YHK3.
Bgeei Q6YHK3.
Genevestigatori Q6YHK3.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProi IPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins."
    Lin M., Sutherland D.R., Horsfall W., Totty N., Yeo E., Nayar R., Wu X.-F., Schuh A.C.
    Blood 99:1683-1691(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 86-98; 127-137; 170-183; 185-196; 355-374; 413-425; 444-451; 465-471; 478-491; 494-510; 573-589; 649-655; 666-672; 677-683; 698-709 AND 791-806, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT MET-1241.
  2. "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family."
    Solomon K.R., Sharma P., Chan M., Morrison P.T., Finberg R.W.
    Gene 327:171-183(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 22-50 (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS SER-703; SER-797 AND ILE-845.
  3. "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes."
    Finnson K.W., Tam B.Y.Y., Liu K., Marcoux A., Lepage P., Roy S., Bizet A.A., Philip A.
    FASEB J. 20:1525-1527(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), PROTEIN SEQUENCE OF 173-191, FUNCTION, INTERACTION WITH TGFB1 AND TGFBR1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PROTEOLYTIC CLEAVAGE, VARIANTS SER-703; SER-797 AND ILE-845.
    Tissue: Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS SER-703; SER-797 AND ILE-845.
    Tissue: Chondrocyte, Trachea and Vascular endothelial cell.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS SER-703; SER-797; ILE-845 AND MET-1241.
    Tissue: Colon endothelium.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "CD109 defines an ancient branch of the alpha2M/C3, C4, C5 family."
    Prosper J.Y.A., Wu X.-F., Sutherland D.R., Irwin D.M., Schuh A.C.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 370-444 AND 922-959.
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 703-741, VARIANT GOV(B) SER-703.
  9. "Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets."
    Sutherland D.R., Yeo E., Ryan A., Mills G.B., Bailey D., Baker M.A.
    Blood 77:84-93(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC CLEAVAGE, GLYCOSYLATION.
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68; ASN-118; ASN-247 AND ASN-419.
    Tissue: Plasma.
  11. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
    Lewandrowski U., Moebius J., Walter U., Sickmann A.
    Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-247.
    Tissue: Platelet.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-419.
    Tissue: Liver.
  13. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68 AND ASN-118.
    Tissue: Leukemic T-cell.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-1007 AND LYS-1065.

Entry informationi

Entry nameiCD109_HUMAN
AccessioniPrimary (citable) accession number: Q6YHK3
Secondary accession number(s): A5YKK4
, B2R948, B3KW25, Q0P6K7, Q5SYA8, Q5XUM7, Q5XUM9, Q6MZI7, Q8N3A7, Q8N915, Q8TDJ2, Q8TDJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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