Q6YHK3 (CD109_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CD109 antigen

Alternative name(s):
150 kDa TGF-beta-1-binding protein
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
Platelet-specific Gov antigen
p180
r150
CD_antigen=CD109

Gene names

Name:	CD109
Synonyms:	CPAMD7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1445 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Modulates negatively TGFB1 signaling in keratinocytes. Ref.3
Subunit structure	Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner. Ref.3
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Ref.1 Ref.3.
Tissue specificity	Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta. Ref.1 Ref.2 Ref.3
Post-translational modification	N-glycosylated. Ref.9 2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.
Polymorphism	The Gov(b) variant in position 703 defines the Gov alloantigenic determinants.
Sequence similarities	Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]
Sequence caution	The sequence BAG53987.1 differs from that shown. Reason: Erroneous initiation. The sequence CAE46045.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAE46045.1 differs from that shown. Reason: Frameshift at position 1282.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Bait region Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein Thioester bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of endopeptidase activity Inferred from electronic annotation. Source: GOC
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW extracellular space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6YHK3-1)

Also known as: CD109 180-kDa;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6YHK3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     93-169: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6YHK3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     658-665: AEYAERFM → LFGTQEAL
     666-1445: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6YHK3-4)

Also known as: CD109S;

The sequence of this isoform differs from the canonical sequence as follows:
     1218-1234: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.2
	Chain	22 – 1420	1399	CD109 antigen		PRO_0000255945
	Propeptide	1421 – 1445	25	Removed in mature form Potential		PRO_0000255946
Regions
	Region	593 – 702	110	Bait region (approximate) By similarity
Amino acid modifications
	Lipidation	1420	1	GPI-anchor amidated alanine Potential
	Glycosylation	68	1	N-linked (GlcNAc...) Ref.10 Ref.13
	Glycosylation	118	1	N-linked (GlcNAc...) Ref.10 Ref.13
	Glycosylation	247	1	N-linked (GlcNAc...) Ref.10 Ref.11
	Glycosylation	279	1	N-linked (GlcNAc...) Potential
	Glycosylation	365	1	N-linked (GlcNAc...) Potential
	Glycosylation	419	1	N-linked (GlcNAc...) Ref.10 Ref.12
	Glycosylation	645	1	N-linked (GlcNAc...) Potential
	Glycosylation	1086	1	N-linked (GlcNAc...) Potential
	Cross-link	921 ↔ 924		Isoglutamyl cysteine thioester (Cys-Gln) By similarity
Natural variations
	Alternative sequence	93 – 169	77	Missing in isoform 2.		VSP_021312
	Alternative sequence	658 – 665	8	AEYAERFM → LFGTQEAL in isoform 3.		VSP_021313
	Alternative sequence	666 – 1445	780	Missing in isoform 3.		VSP_021314
	Alternative sequence	1218 – 1234	17	Missing in isoform 4.		VSP_021315
	Natural variant	45	1	G → V. Corresponds to variant rs9446983 [ dbSNP | Ensembl ].		VAR_028875
	Natural variant	377	1	G → D. Corresponds to variant rs7741152 [ dbSNP | Ensembl ].		VAR_048105
	Natural variant	641	1	L → F. Corresponds to variant rs7742662 [ dbSNP | Ensembl ].		VAR_048106
	Natural variant	703	1	Y → S in allele Gov(b). Ref.2 Ref.3 Ref.4 Ref.5 Ref.8 Corresponds to variant rs10455097 [ dbSNP | Ensembl ].		VAR_028876
	Natural variant	797	1	N → S. Ref.2 Ref.3 Ref.4 Ref.5 Corresponds to variant rs2351528 [ dbSNP | Ensembl ].		VAR_028877
	Natural variant	845	1	V → I. Ref.2 Ref.3 Ref.4 Ref.5 Corresponds to variant rs5023688 [ dbSNP | Ensembl ].		VAR_028878
	Natural variant	1007	1	Q → E in a colorectal cancer sample; somatic mutation. Ref.15		VAR_036236
	Natural variant	1009	1	V → M. Corresponds to variant rs35630075 [ dbSNP | Ensembl ].		VAR_048107
	Natural variant	1065	1	N → K in a colorectal cancer sample; somatic mutation. Ref.15		VAR_036237
	Natural variant	1241	1	T → M. Ref.1 Ref.5 Corresponds to variant rs2917862 [ dbSNP | Ensembl ].		VAR_028879
	Natural variant	1296	1	H → R. Corresponds to variant rs13207595 [ dbSNP | Ensembl ].		VAR_048108
Experimental info
	Sequence conflict	627	1	M → I in AAN78483. Ref.2
	Sequence conflict	789	1	K → E in BAG36395. Ref.4
	Sequence conflict	803	1	G → S in AAN78483. Ref.2
	Sequence conflict	1046	1	V → A in ABQ66266. Ref.5
	Sequence conflict	1418	1	D → N in BAG53987. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (CD109 180-kDa) [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 0C5B1C3B8CCAF195	FASTA	1,445	161,689
	10 20 30 40 50 60 MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE HCPSQVTVKA 70 80 90 100 110 120 ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE IYELRVTGRT QDEILFSNST 130 140 150 160 170 180 RLSFETKRIS VFIQTDKALY KPKQEVKFRI VTLFSDFKPY KTSLNILIKD PKSNLIQQWL 190 200 210 220 230 240 SQQSDLGVIS KTFQLSSHPI LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS 250 260 270 280 290 300 MNSKHLNGTI TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK 310 320 330 340 350 360 NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI IEFFDYTTVL 370 380 390 400 410 420 KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE YWSGSNSGNQ KMEAVQKINY 430 440 450 460 470 480 TVPQSGTFKI EFPILEDSSE LQLKAYFLGS KSSMAVHSLF KSPSKTYIQL KTRDENIKVG 490 500 510 520 530 540 SPFELVVSGN KRLKELSYMV VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG 550 560 570 580 590 600 EIISDVLKIP VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN 610 620 630 640 650 660 ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY IDGVYDNAEY 670 680 690 700 710 720 AERFMEENEG HIVDIHDFSL GSSPHVRKHF PETWIWLDTN MGYRIYQEFE VTVPDSITSW 730 740 750 760 770 780 VATGFVISED LGLGLTTTPV ELQAFQPFFI FLNLPYSVIR GEEFALEITI FNYLKDATEV 790 800 810 820 830 840 KVIIEKSDKF DILMTSNEIN ATGHQQTLLV PSEDGATVLF PIRPTHLGEI PITVTALSPT 850 860 870 880 890 900 ASDAVTQMIL VKAEGIEKSY SQSILLDLTD NRLQSTLKTL SFSFPPNTVT GSERVQITAI 910 920 930 940 950 960 GDVLGPSING LASLIRMPYG CGEQNMINFA PNIYILDYLT KKKQLTDNLK EKALSFMRQG 970 980 990 1000 1010 1020 YQRELLYQRE DGSFSAFGNY DPSGSTWLSA FVLRCFLEAD PYIDIDQNVL HRTYTWLKGH 1030 1040 1050 1060 1070 1080 QKSNGEFWDP GRVIHSELQG GNKSPVTLTA YIVTSLLGYR KYQPNIDVQE SIHFLESEFS 1090 1100 1110 1120 1130 1140 RGISDNYTLA LITYALSSVG SPKAKEALNM LTWRAEQEGG MQFWVSSESK LSDSWQPRSL 1150 1160 1170 1180 1190 1200 DIEVAAYALL SHFLQFQTSE GIPIMRWLSR QRNSLGGFAS TQDTTVALKA LSEFAALMNT 1210 1220 1230 1240 1250 1260 ERTNIQVTVT GPSSPSPVKF LIDTHNRLLL QTAELAVVQP TAVNISANGF GFAICQLNVV 1270 1280 1290 1300 1310 1320 YNVKASGSSR RRRSIQNQEA FDLDVAVKEN KDDLNHVDLN VCTSFSGPGR SGMALMEVNL 1330 1340 1350 1360 1370 1380 LSGFMVPSEA ISLSETVKKV EYDHGKLNLY LDSVNETQFC VNIPAVRNFK VSNTQDASVS 1390 1400 1410 1420 1430 1440 IVDYYEPRRQ AVRSYNSEVK LSSCDLCSDV QGCRPCEDGA SGSHHHSSVI FIFCFKLLYF MELWL
	Isoform 2 [UniParc]. Checksum: 9F326D3F69033813	FASTA	1,368	152,663
	10 20 30 40 50 60 MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE HCPSQVTVKA 70 80 90 100 110 120 ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSDPKSNLIQ QWLSQQSDLG VISKTFQLSS 130 140 150 160 170 180 HPILGDWSIQ VQVNDQTYYQ SFQVSEYVLP KFEVTLQTPL YCSMNSKHLN GTITAKYTYG 190 200 210 220 230 240 KPVKGDVTLT FLPLSFWGKK KNITKTFKIN GSANFSFNDE EMKNVMDSSN GLSEYLDLSS 250 260 270 280 290 300 PGPVEILTTV TESVTGISRN VSTNVFFKQH DYIIEFFDYT TVLKPSLNFT ATVKVTRADG 310 320 330 340 350 360 NQLTLEERRN NVVITVTQRN YTEYWSGSNS GNQKMEAVQK INYTVPQSGT FKIEFPILED 370 380 390 400 410 420 SSELQLKAYF LGSKSSMAVH SLFKSPSKTY IQLKTRDENI KVGSPFELVV SGNKRLKELS 430 440 450 460 470 480 YMVVSRGQLV AVGKQNSTMF SLTPENSWTP KACVIVYYIE DDGEIISDVL KIPVQLVFKN 490 500 510 520 530 540 KIKLYWSKVK AEPSEKVSLR ISVTQPDSIV GIVAVDKSVN LMNASNDITM ENVVHELELY 550 560 570 580 590 600 NTGYYLGMFM NSFAVFQECG LWVLTDANLT KDYIDGVYDN AEYAERFMEE NEGHIVDIHD 610 620 630 640 650 660 FSLGSSPHVR KHFPETWIWL DTNMGYRIYQ EFEVTVPDSI TSWVATGFVI SEDLGLGLTT 670 680 690 700 710 720 TPVELQAFQP FFIFLNLPYS VIRGEEFALE ITIFNYLKDA TEVKVIIEKS DKFDILMTSN 730 740 750 760 770 780 EINATGHQQT LLVPSEDGAT VLFPIRPTHL GEIPITVTAL SPTASDAVTQ MILVKAEGIE 790 800 810 820 830 840 KSYSQSILLD LTDNRLQSTL KTLSFSFPPN TVTGSERVQI TAIGDVLGPS INGLASLIRM 850 860 870 880 890 900 PYGCGEQNMI NFAPNIYILD YLTKKKQLTD NLKEKALSFM RQGYQRELLY QREDGSFSAF 910 920 930 940 950 960 GNYDPSGSTW LSAFVLRCFL EADPYIDIDQ NVLHRTYTWL KGHQKSNGEF WDPGRVIHSE 970 980 990 1000 1010 1020 LQGGNKSPVT LTAYIVTSLL GYRKYQPNID VQESIHFLES EFSRGISDNY TLALITYALS 1030 1040 1050 1060 1070 1080 SVGSPKAKEA LNMLTWRAEQ EGGMQFWVSS ESKLSDSWQP RSLDIEVAAY ALLSHFLQFQ 1090 1100 1110 1120 1130 1140 TSEGIPIMRW LSRQRNSLGG FASTQDTTVA LKALSEFAAL MNTERTNIQV TVTGPSSPSP 1150 1160 1170 1180 1190 1200 VKFLIDTHNR LLLQTAELAV VQPTAVNISA NGFGFAICQL NVVYNVKASG SSRRRRSIQN 1210 1220 1230 1240 1250 1260 QEAFDLDVAV KENKDDLNHV DLNVCTSFSG PGRSGMALME VNLLSGFMVP SEAISLSETV 1270 1280 1290 1300 1310 1320 KKVEYDHGKL NLYLDSVNET QFCVNIPAVR NFKVSNTQDA SVSIVDYYEP RRQAVRSYNS 1330 1340 1350 1360 EVKLSSCDLC SDVQGCRPCE DGASGSHHHS SVIFIFCFKL LYFMELWL
	Isoform 3 [UniParc]. Checksum: CC73982C8E88647E	FASTA	665	74,411
	10 20 30 40 50 60 MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE HCPSQVTVKA 70 80 90 100 110 120 ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE IYELRVTGRT QDEILFSNST 130 140 150 160 170 180 RLSFETKRIS VFIQTDKALY KPKQEVKFRI VTLFSDFKPY KTSLNILIKD PKSNLIQQWL 190 200 210 220 230 240 SQQSDLGVIS KTFQLSSHPI LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS 250 260 270 280 290 300 MNSKHLNGTI TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK 310 320 330 340 350 360 NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI IEFFDYTTVL 370 380 390 400 410 420 KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE YWSGSNSGNQ KMEAVQKINY 430 440 450 460 470 480 TVPQSGTFKI EFPILEDSSE LQLKAYFLGS KSSMAVHSLF KSPSKTYIQL KTRDENIKVG 490 500 510 520 530 540 SPFELVVSGN KRLKELSYMV VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG 550 560 570 580 590 600 EIISDVLKIP VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN 610 620 630 640 650 660 ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY IDGVYDNLFG TQEAL
	Isoform 4 (CD109S) [UniParc]. Checksum: 9DBA3F0AA03660F5	FASTA	1,428	159,696
	10 20 30 40 50 60 MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE HCPSQVTVKA 70 80 90 100 110 120 ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE IYELRVTGRT QDEILFSNST 130 140 150 160 170 180 RLSFETKRIS VFIQTDKALY KPKQEVKFRI VTLFSDFKPY KTSLNILIKD PKSNLIQQWL 190 200 210 220 230 240 SQQSDLGVIS KTFQLSSHPI LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS 250 260 270 280 290 300 MNSKHLNGTI TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK 310 320 330 340 350 360 NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI IEFFDYTTVL 370 380 390 400 410 420 KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE YWSGSNSGNQ KMEAVQKINY 430 440 450 460 470 480 TVPQSGTFKI EFPILEDSSE LQLKAYFLGS KSSMAVHSLF KSPSKTYIQL KTRDENIKVG 490 500 510 520 530 540 SPFELVVSGN KRLKELSYMV VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG 550 560 570 580 590 600 EIISDVLKIP VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN 610 620 630 640 650 660 ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY IDGVYDNAEY 670 680 690 700 710 720 AERFMEENEG HIVDIHDFSL GSSPHVRKHF PETWIWLDTN MGYRIYQEFE VTVPDSITSW 730 740 750 760 770 780 VATGFVISED LGLGLTTTPV ELQAFQPFFI FLNLPYSVIR GEEFALEITI FNYLKDATEV 790 800 810 820 830 840 KVIIEKSDKF DILMTSNEIN ATGHQQTLLV PSEDGATVLF PIRPTHLGEI PITVTALSPT 850 860 870 880 890 900 ASDAVTQMIL VKAEGIEKSY SQSILLDLTD NRLQSTLKTL SFSFPPNTVT GSERVQITAI 910 920 930 940 950 960 GDVLGPSING LASLIRMPYG CGEQNMINFA PNIYILDYLT KKKQLTDNLK EKALSFMRQG 970 980 990 1000 1010 1020 YQRELLYQRE DGSFSAFGNY DPSGSTWLSA FVLRCFLEAD PYIDIDQNVL HRTYTWLKGH 1030 1040 1050 1060 1070 1080 QKSNGEFWDP GRVIHSELQG GNKSPVTLTA YIVTSLLGYR KYQPNIDVQE SIHFLESEFS 1090 1100 1110 1120 1130 1140 RGISDNYTLA LITYALSSVG SPKAKEALNM LTWRAEQEGG MQFWVSSESK LSDSWQPRSL 1150 1160 1170 1180 1190 1200 DIEVAAYALL SHFLQFQTSE GIPIMRWLSR QRNSLGGFAS TQDTTVALKA LSEFAALMNT 1210 1220 1230 1240 1250 1260 ERTNIQVTVT GPSSPSPLAV VQPTAVNISA NGFGFAICQL NVVYNVKASG SSRRRRSIQN 1270 1280 1290 1300 1310 1320 QEAFDLDVAV KENKDDLNHV DLNVCTSFSG PGRSGMALME VNLLSGFMVP SEAISLSETV 1330 1340 1350 1360 1370 1380 KKVEYDHGKL NLYLDSVNET QFCVNIPAVR NFKVSNTQDA SVSIVDYYEP RRQAVRSYNS 1390 1400 1410 1420 EVKLSSCDLC SDVQGCRPCE DGASGSHHHS SVIFIFCFKL LYFMELWL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins." Lin M., Sutherland D.R., Horsfall W., Totty N., Yeo E., Nayar R., Wu X.-F., Schuh A.C. Blood 99:1683-1691(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 86-98; 127-137; 170-183; 185-196; 355-374; 413-425; 444-451; 465-471; 478-491; 494-510; 573-589; 649-655; 666-672; 677-683; 698-709 AND 791-806, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT MET-1241.
[2]	"CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family." Solomon K.R., Sharma P., Chan M., Morrison P.T., Finberg R.W. Gene 327:171-183(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 22-50 (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS SER-703; SER-797 AND ILE-845.
[3]	"Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes." Finnson K.W., Tam B.Y.Y., Liu K., Marcoux A., Lepage P., Roy S., Bizet A.A., Philip A. FASEB J. 20:1525-1527(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), PROTEIN SEQUENCE OF 173-191, FUNCTION, INTERACTION WITH TGFB1 AND TGFBR1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PROTEOLYTIC CLEAVAGE, VARIANTS SER-703; SER-797 AND ILE-845. Tissue: Placenta.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS SER-703; SER-797 AND ILE-845. Tissue: Chondrocyte, Trachea and Vascular endothelial cell.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS SER-703; SER-797; ILE-845 AND MET-1241. Tissue: Colon endothelium.
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"CD109 defines an ancient branch of the alpha2M/C3, C4, C5 family." Prosper J.Y.A., Wu X.-F., Sutherland D.R., Irwin D.M., Schuh A.C. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 370-444 AND 922-959.
[8]	"A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens." Schuh A.C., Watkins N.A., Nguyen Q., Harmer N.J., Lin M., Prosper J.Y.A., Campbell K., Sutherland D.R., Metcalfe P., Horsfall W., Ouwehand W.H. Blood 99:1692-1698(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 703-741, VARIANT GOV(B) SER-703.
[9]	"Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets." Sutherland D.R., Yeo E., Ryan A., Mills G.B., Bailey D., Baker M.A. Blood 77:84-93(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEOLYTIC CLEAVAGE, GLYCOSYLATION.
[10]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68; ASN-118; ASN-247 AND ASN-419, MASS SPECTROMETRY. Tissue: Plasma.
[11]	"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach." Lewandrowski U., Moebius J., Walter U., Sickmann A. Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-247, MASS SPECTROMETRY. Tissue: Platelet.
[12]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-419, MASS SPECTROMETRY. Tissue: Liver.
[13]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68 AND ASN-118, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-1007 AND LYS-1065.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF410459 mRNA. Translation: AAL84159.1. AY149920 mRNA. Translation: AAN78483.1. AY788891 mRNA. Translation: AAX14639.1. AK095888 mRNA. Translation: BAC04642.1. AK123960 mRNA. Translation: BAG53987.1. Different initiation. AK313636 mRNA. Translation: BAG36395.1. AL834478 mRNA. Translation: CAD39137.1. BX641095 mRNA. Translation: CAE46045.1. Sequence problems. EF553520 mRNA. Translation: ABQ66266.1. AL590428, AL591480 Genomic DNA. Translation: CAI15636.1. AY736555 Genomic DNA. Translation: AAU94642.1. AY736557 Genomic DNA. Translation: AAU94644.1. AF410460 Genomic DNA. Translation: AAL84160.1.
IPI	IPI00152540. IPI00788676. IPI00795327. IPI00795801.
RefSeq	NP_001153059.1. NM_001159587.1. NP_001153060.1. NM_001159588.1. NP_598000.2. NM_133493.3.
UniGene	Hs.399891.
3D structure databases
HSSP	HSSP built from PDB template 2A73 based on UniProtKB P01024.
ProteinModelPortal	Q6YHK3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6YHK3. 1 interaction.
Protein family/group databases
MEROPS	I39.006.
PTM databases
PhosphoSite	Q6YHK3.
Polymorphism databases
DMDM	117949389.
Proteomic databases
PaxDb	Q6YHK3.
PRIDE	Q6YHK3.
Protocols and materials databases
DNASU	135228.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000287097; ENSP00000287097; ENSG00000156535. ENST00000422508; ENSP00000404475; ENSG00000156535. ENST00000437994; ENSP00000388062; ENSG00000156535.
GeneID	135228.
KEGG	hsa:135228.
UCSC	uc003php.3. human. uc003phq.3. human. uc010kba.3. human.
Organism-specific databases
CTD	135228.
GeneCards	GC06P074462.
H-InvDB	HIX0006012.
HGNC	HGNC:21685. CD109.
HPA	HPA009292. HPA015113.
MIM	608859. gene.
neXtProt	NX_Q6YHK3.
PharmGKB	PA134949237.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2373.
HOVERGEN	HBG097839.
InParanoid	Q6YHK3.
KO	K06530.
OMA	KPYKTSL.
OrthoDB	EOG4548XZ.
PhylomeDB	Q6YHK3.
Gene expression databases
ArrayExpress	Q6YHK3.
Bgee	Q6YHK3.
Genevestigator	Q6YHK3.
GermOnline	ENSG00000156535. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.690. 1 hit.
InterPro	IPR009048. A-macroglobulin_rcpt-bd. IPR011626. A2M_comp. IPR002890. A2M_N. IPR011625. A2M_N_2. IPR001599. Macroglobln_a2. IPR019742. MacrogloblnA2_CS. IPR019565. MacrogloblnA2_thiol-ester-bond. IPR008930. Terpenoid_cyclase/PrenylTrfase. [Graphical view]
Pfam	PF00207. A2M. 1 hit. PF07678. A2M_comp. 1 hit. PF01835. A2M_N. 1 hit. PF07703. A2M_N_2. 1 hit. PF07677. A2M_recep. 1 hit. PF10569. Thiol-ester_cl. 1 hit. [Graphical view]
SUPFAM	SSF49410. AM_receptor_bind. 1 hit. SSF48239. Terp_cyc_toroid. 1 hit.
PROSITE	PS00477. ALPHA_2_MACROGLOBULIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CD109. human.
GenomeRNAi	135228.
NextBio	83469.
SOURCE	Search...

Entry information

Entry name

CD109_HUMAN

Accession

Primary (citable) accession number: Q6YHK3
Secondary accession number(s): A5YKK4 , B2R948, B3KW25, Q0P6K7, Q5SYA8, Q5XUM7, Q5XUM9, Q6MZI7, Q8N3A7, Q8N915, Q8TDJ2, Q8TDJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	May 1, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.