Q6YGU2 (Q6YGU2_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Toll-like receptor PIRNR PIRNR037595

Gene names

Name:	Tlr2 RGD 735138
ORF Names:	rCG_62480 EMBL EDM00832.1

Organism

Rattus norvegicus (Rat) EMBL AAN86525.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	784 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the Toll-like receptor family. PIRNR PIRNR037595 Contains 1 TIR domain. SAAS SAAS000483

Ontologies

Keywords
Biological process	Immunity Inflammatory response PIRNR PIRNR037595 Innate immunity PIRNR PIRNR037595
Cellular component	Membrane
Domain	Leucine-rich repeat SAAS SAAS000483 Repeat SAAS SAAS000483 Transmembrane Transmembrane helix SAAS SAAS000483
Molecular function	Receptor PIRNR PIRNR037595 EMBL AAN86525.1
Gene Ontology (GO)
Biological_process	MyD88-dependent toll-like receptor signaling pathway Inferred from electronic annotation. Source: InterPro central nervous system myelin formation Inferred from direct assay PubMed 21971760. Source: RGD defense response to bacterium Inferred from direct assay PubMed 16973131. Source: RGD inflammatory response Inferred from direct assay PubMed 16154916. Source: RGD innate immune response Inferred from electronic annotation. Source: UniProtKB-KW leukotriene metabolic process Inferred from direct assay PubMed 21765618. Source: RGD microglial cell activation involved in immune response Inferred from direct assay PubMed 16973131. Source: RGD negative regulation of cell proliferation Inferred from direct assay PubMed 21971760. Source: RGD nitric oxide metabolic process Inferred from direct assay PubMed 16973131. Source: RGD pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Inferred from direct assay PubMed 16973131. Source: RGD positive regulation of inflammatory response Inferred from electronic annotation. Source: InterPro positive regulation of interleukin-10 production Inferred from direct assay PubMed 22653369. Source: RGD positive regulation of oligodendrocyte differentiation Inferred from direct assay PubMed 21971760. Source: RGD regulation of cytokine secretion Inferred from electronic annotation. Source: InterPro response to bacterial lipoprotein Inferred from direct assay PubMed 16973131. Source: RGD response to fatty acid Inferred from direct assay PubMed 19144836. Source: RGD response to hypoxia Inferred from expression pattern PubMed 15535030. Source: RGD response to insulin stimulus Inferred from expression pattern PubMed 16740310. Source: RGD response to lipopolysaccharide Inferred from expression pattern PubMed 11028557. Source: RGD response to progesterone stimulus Inferred from expression pattern PubMed 18316784. Source: RGD response to toxic substance Inferred from expression pattern PubMed 15535030. Source: RGD toll-like receptor 2 signaling pathway Inferred from electronic annotation. Source: InterPro toll-like receptor signaling pathway Inferred from direct assay PubMed 16973131. Source: RGD
Cellular_component	cell body Inferred from direct assay PubMed 21971760. Source: RGD cell projection Inferred from direct assay PubMed 21971760. Source: RGD cell surface Inferred from direct assay PubMed 21765618. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lipopeptide binding Inferred from mutant phenotype PubMed 18353287. Source: RGD receptor activity Traceable author statement PubMed 12831613. Source: RGD transmembrane signaling receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6YGU2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B2D22A8998EB77F8	FASTA	784	89,413
	10 20 30 40 50 60 MLQALWLFWI LMAVIGLSRE GHSAQASLSC DAAGVCDGSS RSFTSIPSGL TANTKKLDLS 70 80 90 100 110 120 FNKITYIGHG DLRACVNLRV LTLESSGINT IEGDAFYSLG SLEHLDLSNN HLSSLSSSWF 130 140 150 160 170 180 RPLSSLKYLN LMGNPYRTLG ETSLFSNLTN LQTLRVGNVD TFSEIRRIDF AGLTSLNELE 190 200 210 220 230 240 IQVLSLGNYE SRSLQSIRDI YHLTLHLSES AFLLGIFADI LSSVRYLELR DTNLARFQFS 250 260 270 280 290 300 ELSVDEINSP MKKLAFRNAD LTDKSFNELL KLLRYILELM EVEFDHCTLN GVGNFNPSES 310 320 330 340 350 360 DVVRELGKVE TVTIRSLHIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL VPCSFSQHLK 370 380 390 400 410 420 SLEFLDLSEN LMVEEYLKNS ACEGGWPSLQ SLVLSQNHLR SIRKTAEILL TLKNLTALDI 430 440 450 460 470 480 SKNSFQPMPD SCQWPGKMRF LNLSSTGIQA VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ 490 500 510 520 530 540 ELYISRNKLK TLPEASLFPV LQVMKIRENA ISTFSKDQLG SFPKLETLEA GDNHFICSCE 550 560 570 580 590 600 LLSFILERPA LVHVLVDWPD SYLCDSPPRL HGQRLQDARP SVLECHQAAL VSGVCCALLL 610 620 630 640 650 660 LILLLGALCY HFHGLWYLRM MWAWLRAKRK PKKAPCRDLC YDAFVSYSEQ DSYWVENLMV 670 680 690 700 710 720 QQLENSDPPF KLCLHKRDFV PGKWIIDNII DSIEKSHKTV FVLSENFVRS EWCKYELDFS 730 740 750 760 770 780 HFRLFDENND AAILVLLEPI EKKAIPQRFC KLRKIMNTKT YLEWPLDEGQ REVFWANLRT AIKS

References

[1]	"Molecular cloning and regulation of toll-like receptor 2 mRNA in rat spleen." Li Y., Ji A., Schafer M.K. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar EMBL AAN86525.1. Tissue: Spleen EMBL AAN86525.1.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM00832.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM00832.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY151255 mRNA. Translation: AAN86524.1. AY151256 mRNA. Translation: AAN86525.1. CH473976 Genomic DNA. Translation: EDM00832.1.
IPI	IPI00400619.
RefSeq	NP_942064.1. NM_198769.2.
UniGene	Rn.46387.
3D structure databases
SMR	Q6YGU2. Positions 27-545, 639-784.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000013025.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	310553.
KEGG	rno:310553.
UCSC	RGD:735138. rat.
Organism-specific databases
CTD	7097.
RGD	735138. Tlr2.
Phylogenomic databases
eggNOG	NOG251801.
HOGENOM	HOG000110611.
HOVERGEN	HBG108574.
InParanoid	Q6YGU2.
KO	K10159.
OrthoDB	EOG4SN1N6.
Gene expression databases
Genevestigator	Q6YGU2.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000157. TIR_dom. IPR027185. TLR2. IPR017241. Toll-like_receptor. [Graphical view]
PANTHER	PTHR24365:SF17. PTHR24365:SF17. 1 hit.
Pfam	PF01582. TIR. 1 hit. [Graphical view]
PIRSF	PIRSF037595. Toll-like_receptor. 1 hit.
SMART	SM00369. LRR_TYP. 2 hits. SM00082. LRRCT. 1 hit. SM00255. TIR. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS51450. LRR. 10 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	662149.

Entry information

Entry name

Q6YGU2_RAT

Accession

Primary (citable) accession number: Q6YGU2

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)