Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 6B2

Gene

COX6B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Connects the two COX monomers into the physiological dimeric form.By similarity

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B2
Alternative name(s):
Cancer/testis antigen 59
Short name:
CT59
Cytochrome c oxidase subunit VIb isoform 2
Short name:
COX VIb-2
Cytochrome c oxidase subunit VIb, testis-specific isoform
Gene namesi
Name:COX6B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24380. COX6B2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial crista Source: MGI
  • mitochondrial intermembrane space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869389.

Polymorphism and mutation databases

BioMutaiCOX6B2.
DMDMi74738324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888Cytochrome c oxidase subunit 6B2PRO_0000194921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 67By similarity
Disulfide bondi42 ↔ 56By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6YFQ2.
PRIDEiQ6YFQ2.

PTM databases

iPTMnetiQ6YFQ2.

Expressioni

Tissue specificityi

Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines.2 Publications

Gene expression databases

BgeeiENSG00000160471.
CleanExiHS_COX6B2.
GenevisibleiQ6YFQ2. HS.

Organism-specific databases

HPAiHPA035014.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FRMD6Q96NE93EBI-10291911,EBI-741729

Protein-protein interaction databases

BioGridi125940. 2 interactions.
IntActiQ6YFQ2. 2 interactions.
STRINGi9606.ENSP00000320672.

Structurei

3D structure databases

ProteinModelPortaliQ6YFQ2.
SMRiQ6YFQ2. Positions 14-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiQ6YFQ2.
KOiK02267.
OMAiISWVQRW.
OrthoDBiEOG091G0UIB.
PhylomeDBiQ6YFQ2.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6YFQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDVEAQEPP KGKWSTPPFD PRFPSQNQIR NCYQNFLDYH RCLKTRTRRG
60 70 80
KSTQPCEYYF RVYHSLCPIS WVESWNEQIK NGIFAGKI
Length:88
Mass (Da):10,529
Last modified:July 5, 2004 - v1
Checksum:iA1FD936AA6BE3297
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152398 mRNA. Translation: AAN46751.1.
AK057427 mRNA. Translation: BAB71481.2.
BC026123 mRNA. Translation: AAH26123.3.
BC100899 mRNA. Translation: AAI00900.1.
BC100900 mRNA. Translation: AAI00901.1.
BC100901 mRNA. Translation: AAI00902.1.
BC100902 mRNA. Translation: AAI00903.1.
CCDSiCCDS42630.1.
RefSeqiNP_653214.2. NM_144613.4.
UniGeneiHs.550544.

Genome annotation databases

EnsembliENST00000326529; ENSP00000320672; ENSG00000160471.
ENST00000588572; ENSP00000467959; ENSG00000160471.
ENST00000589467; ENSP00000476768; ENSG00000160471.
ENST00000590900; ENSP00000467128; ENSG00000160471.
ENST00000593184; ENSP00000467266; ENSG00000160471.
GeneIDi125965.
KEGGihsa:125965.
UCSCiuc002qkn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152398 mRNA. Translation: AAN46751.1.
AK057427 mRNA. Translation: BAB71481.2.
BC026123 mRNA. Translation: AAH26123.3.
BC100899 mRNA. Translation: AAI00900.1.
BC100900 mRNA. Translation: AAI00901.1.
BC100901 mRNA. Translation: AAI00902.1.
BC100902 mRNA. Translation: AAI00903.1.
CCDSiCCDS42630.1.
RefSeqiNP_653214.2. NM_144613.4.
UniGeneiHs.550544.

3D structure databases

ProteinModelPortaliQ6YFQ2.
SMRiQ6YFQ2. Positions 14-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125940. 2 interactions.
IntActiQ6YFQ2. 2 interactions.
STRINGi9606.ENSP00000320672.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

iPTMnetiQ6YFQ2.

Polymorphism and mutation databases

BioMutaiCOX6B2.
DMDMi74738324.

Proteomic databases

PaxDbiQ6YFQ2.
PRIDEiQ6YFQ2.

Protocols and materials databases

DNASUi125965.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326529; ENSP00000320672; ENSG00000160471.
ENST00000588572; ENSP00000467959; ENSG00000160471.
ENST00000589467; ENSP00000476768; ENSG00000160471.
ENST00000590900; ENSP00000467128; ENSG00000160471.
ENST00000593184; ENSP00000467266; ENSG00000160471.
GeneIDi125965.
KEGGihsa:125965.
UCSCiuc002qkn.4. human.

Organism-specific databases

CTDi125965.
GeneCardsiCOX6B2.
HGNCiHGNC:24380. COX6B2.
HPAiHPA035014.
neXtProtiNX_Q6YFQ2.
PharmGKBiPA134869389.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiQ6YFQ2.
KOiK02267.
OMAiISWVQRW.
OrthoDBiEOG091G0UIB.
PhylomeDBiQ6YFQ2.

Miscellaneous databases

GenomeRNAii125965.
PROiQ6YFQ2.

Gene expression databases

BgeeiENSG00000160471.
CleanExiHS_COX6B2.
GenevisibleiQ6YFQ2. HS.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCX6B2_HUMAN
AccessioniPrimary (citable) accession number: Q6YFQ2
Secondary accession number(s): Q7L1R4, Q96DL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.