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Protein

Cytochrome c oxidase subunit 6B2

Gene

COX6B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Connects the two COX monomers into the physiological dimeric form.By similarity

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:HS14814-MONOMER.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B2
Alternative name(s):
Cancer/testis antigen 59
Short name:
CT59
Cytochrome c oxidase subunit VIb isoform 2
Short name:
COX VIb-2
Cytochrome c oxidase subunit VIb, testis-specific isoform
Gene namesi
Name:COX6B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24380. COX6B2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial crista Source: MGI
  • mitochondrial intermembrane space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160471.
PharmGKBiPA134869389.

Polymorphism and mutation databases

BioMutaiCOX6B2.
DMDMi74738324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001949211 – 88Cytochrome c oxidase subunit 6B2Add BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 67PROSITE-ProRule annotation
Disulfide bondi42 ↔ 56PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6YFQ2.
PRIDEiQ6YFQ2.

PTM databases

iPTMnetiQ6YFQ2.
PhosphoSitePlusiQ6YFQ2.

Expressioni

Tissue specificityi

Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines.2 Publications

Gene expression databases

BgeeiENSG00000160471.
CleanExiHS_COX6B2.
GenevisibleiQ6YFQ2. HS.

Organism-specific databases

HPAiHPA035014.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FRMD6Q96NE93EBI-10291911,EBI-741729

Protein-protein interaction databases

BioGridi125940. 2 interactors.
IntActiQ6YFQ2. 2 interactors.
STRINGi9606.ENSP00000320672.

Structurei

3D structure databases

ProteinModelPortaliQ6YFQ2.
SMRiQ6YFQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 75CHCHPROSITE-ProRule annotationAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 42Cx9C motifPROSITE-ProRule annotationAdd BLAST11
Motifi56 – 67Cx10C motifPROSITE-ProRule annotationAdd BLAST12

Sequence similaritiesi

Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiQ6YFQ2.
KOiK02267.
OMAiISWVQRW.
OrthoDBiEOG091G0UIB.
PhylomeDBiQ6YFQ2.

Family and domain databases

CDDicd00926. Cyt_c_Oxidase_VIb. 1 hit.
Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6YFQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDVEAQEPP KGKWSTPPFD PRFPSQNQIR NCYQNFLDYH RCLKTRTRRG
60 70 80
KSTQPCEYYF RVYHSLCPIS WVESWNEQIK NGIFAGKI
Length:88
Mass (Da):10,529
Last modified:July 5, 2004 - v1
Checksum:iA1FD936AA6BE3297
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152398 mRNA. Translation: AAN46751.1.
AK057427 mRNA. Translation: BAB71481.2.
BC026123 mRNA. Translation: AAH26123.3.
BC100899 mRNA. Translation: AAI00900.1.
BC100900 mRNA. Translation: AAI00901.1.
BC100901 mRNA. Translation: AAI00902.1.
BC100902 mRNA. Translation: AAI00903.1.
CCDSiCCDS42630.1.
RefSeqiNP_653214.2. NM_144613.4.
UniGeneiHs.550544.

Genome annotation databases

EnsembliENST00000326529; ENSP00000320672; ENSG00000160471.
ENST00000588572; ENSP00000467959; ENSG00000160471.
ENST00000589467; ENSP00000476768; ENSG00000160471.
ENST00000590900; ENSP00000467128; ENSG00000160471.
ENST00000593184; ENSP00000467266; ENSG00000160471.
GeneIDi125965.
KEGGihsa:125965.
UCSCiuc002qkn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152398 mRNA. Translation: AAN46751.1.
AK057427 mRNA. Translation: BAB71481.2.
BC026123 mRNA. Translation: AAH26123.3.
BC100899 mRNA. Translation: AAI00900.1.
BC100900 mRNA. Translation: AAI00901.1.
BC100901 mRNA. Translation: AAI00902.1.
BC100902 mRNA. Translation: AAI00903.1.
CCDSiCCDS42630.1.
RefSeqiNP_653214.2. NM_144613.4.
UniGeneiHs.550544.

3D structure databases

ProteinModelPortaliQ6YFQ2.
SMRiQ6YFQ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125940. 2 interactors.
IntActiQ6YFQ2. 2 interactors.
STRINGi9606.ENSP00000320672.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

iPTMnetiQ6YFQ2.
PhosphoSitePlusiQ6YFQ2.

Polymorphism and mutation databases

BioMutaiCOX6B2.
DMDMi74738324.

Proteomic databases

PaxDbiQ6YFQ2.
PRIDEiQ6YFQ2.

Protocols and materials databases

DNASUi125965.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326529; ENSP00000320672; ENSG00000160471.
ENST00000588572; ENSP00000467959; ENSG00000160471.
ENST00000589467; ENSP00000476768; ENSG00000160471.
ENST00000590900; ENSP00000467128; ENSG00000160471.
ENST00000593184; ENSP00000467266; ENSG00000160471.
GeneIDi125965.
KEGGihsa:125965.
UCSCiuc002qkn.4. human.

Organism-specific databases

CTDi125965.
GeneCardsiCOX6B2.
HGNCiHGNC:24380. COX6B2.
HPAiHPA035014.
neXtProtiNX_Q6YFQ2.
OpenTargetsiENSG00000160471.
PharmGKBiPA134869389.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiQ6YFQ2.
KOiK02267.
OMAiISWVQRW.
OrthoDBiEOG091G0UIB.
PhylomeDBiQ6YFQ2.

Enzyme and pathway databases

BioCyciZFISH:HS14814-MONOMER.

Miscellaneous databases

GenomeRNAii125965.
PROiQ6YFQ2.

Gene expression databases

BgeeiENSG00000160471.
CleanExiHS_COX6B2.
GenevisibleiQ6YFQ2. HS.

Family and domain databases

CDDicd00926. Cyt_c_Oxidase_VIb. 1 hit.
Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCX6B2_HUMAN
AccessioniPrimary (citable) accession number: Q6YFQ2
Secondary accession number(s): Q7L1R4, Q96DL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.