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Protein

Epsilon-sarcoglycan

Gene

Sgce

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.By similarity

GO - Biological processi

  • brain development Source: RGD
  • kidney development Source: RGD
  • skeletal muscle tissue development Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Epsilon-sarcoglycanImported
Short name:
Epsilon-SGBy similarity
Gene namesi
Name:SgceImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303201. Sgce.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 317317ExtracellularSequence analysisBy similarityAdd
BLAST
Transmembranei318 – 33821HelicalSequence analysisAdd
BLAST
Topological domaini339 – 43799CytoplasmicSequence analysisBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Epsilon-sarcoglycanPRO_0000378624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity
Ubiquitinated, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6YAT4.
PRIDEiQ6YAT4.

Expressioni

Tissue specificityi

In both neural tissues including cerebellar cortex, striatum, cerebral cortex, thalamus and hippocampus, and non-neural tissues including quadriceps muscle, liver, kidney, spleen, lung, testis and heart. Widely distributed in the brain, with a robust signal obtained from regions with dense neuronal packing such as the pyramidal cell layer of the hippocampus, cerebellar molecular layer, and cerebral cortex. Levels are highest in kidney, moderate in brain and lung, and low in skeletal muscle, liver, spleen and testis.1 Publication

Developmental stagei

Expressed at embryonic day 20, postnatal days 1, 7, 14, 36, six months and one and a half years. Highest level at E20. In muscle, expression is over 10 times higher at E20 and during the early postnatal period than in adults. In adults, expression levels are several-fold higher in brain, particularly in the cerebellar cortex, than in muscle.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064432.

Family & Domainsi

Sequence similaritiesi

Belongs to the sarcoglycan alpha/epsilon family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4482. Eukaryota.
ENOG4110FPC. LUCA.
InParanoidiQ6YAT4.
PhylomeDBiQ6YAT4.

Family and domain databases

InterProiIPR006644. Cadg.
IPR008908. Sarcoglycan_alpha/epsilon.
IPR030775. SGCE.
[Graphical view]
PANTHERiPTHR10132. PTHR10132. 1 hit.
PTHR10132:SF17. PTHR10132:SF17. 1 hit.
PfamiPF05510. Sarcoglycan_2. 1 hit.
[Graphical view]
SMARTiSM00736. CADG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6YAT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFWWWELG DPCAWTGKGR GTLKMSPATT GTFLLTVYTL FSKVHSDRNV
60 70 80 90 100
YPSAGVLFVH VLEREYFKGE FPPYPKPGEV SNDPITFNTN LMGYPDRPGW
110 120 130 140 150
LRYIQRTPYS DGVLYGSPTA ENVGKPTIIE ITAYNRRTFE TARHNLIINI
160 170 180 190 200
MSAEEFPLPY QAEFFIKNMN VEEMLASEVL GDFLGAVKNV WQPERLNAIN
210 220 230 240 250
ITSALDRGGR VPLPIKDMKE GVYVMVGADV AFSSCLREVE NPQNQLRCSQ
260 270 280 290 300
EMEPVITCDK KFRTQFYIDW CKISLVDKTK QVSTYQEVVR GEGILPDGGE
310 320 330 340 350
YKPPSDSLKS RDYYTDFLVT LAVPSAVALV LFLILAYIMC CRREGVEKRN
360 370 380 390 400
MQTPDIQLVH HSSIQKSTKE LRDMSKNREI AWPLSTLPVF HPVTGEIIPP
410 420 430
MHTDNYDSTN MPLMQTQPNL PHQTQIPQQQ TTGKWYP
Length:437
Mass (Da):49,840
Last modified:July 5, 2004 - v1
Checksum:i04D6F1F5469E7112
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164274 mRNA. Translation: AAO37579.1.
BC089947 mRNA. Translation: AAH89947.1.
RefSeqiNP_001002023.1. NM_001002023.2.
UniGeneiRn.185815.

Genome annotation databases

GeneIDi432360.
KEGGirno:432360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164274 mRNA. Translation: AAO37579.1.
BC089947 mRNA. Translation: AAH89947.1.
RefSeqiNP_001002023.1. NM_001002023.2.
UniGeneiRn.185815.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064432.

Proteomic databases

PaxDbiQ6YAT4.
PRIDEiQ6YAT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi432360.
KEGGirno:432360.

Organism-specific databases

CTDi8910.
RGDi1303201. Sgce.

Phylogenomic databases

eggNOGiKOG4482. Eukaryota.
ENOG4110FPC. LUCA.
InParanoidiQ6YAT4.
PhylomeDBiQ6YAT4.

Miscellaneous databases

NextBioi696841.
PROiQ6YAT4.

Family and domain databases

InterProiIPR006644. Cadg.
IPR008908. Sarcoglycan_alpha/epsilon.
IPR030775. SGCE.
[Graphical view]
PANTHERiPTHR10132. PTHR10132. 1 hit.
PTHR10132:SF17. PTHR10132:SF17. 1 hit.
PfamiPF05510. Sarcoglycan_2. 1 hit.
[Graphical view]
SMARTiSM00736. CADG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, developmental regulation and neural localization of rat epsilon-sarcoglycan."
    Xiao J., LeDoux M.S.
    Brain Res. Mol. Brain Res. 119:132-143(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Sprague-DawleyImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiSGCE_RAT
AccessioniPrimary (citable) accession number: Q6YAT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.