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Protein

PERQ amino acid-rich with GYF domain-containing protein 2

Gene

Gigyf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors.1 Publication

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • cellular protein metabolic process Source: MGI
  • feeding behavior Source: MGI
  • homeostasis of number of cells within a tissue Source: MGI
  • insulin-like growth factor receptor signaling pathway Source: MGI
  • mitotic G1 DNA damage checkpoint Source: MGI
  • multicellular organism growth Source: MGI
  • musculoskeletal movement Source: MGI
  • negative regulation of translation Source: MGI
  • neuromuscular process controlling balance Source: MGI
  • post-embryonic development Source: MGI
  • spinal cord motor neuron differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PERQ amino acid-rich with GYF domain-containing protein 2
Alternative name(s):
GRB10-interacting GYF protein 2
Trinucleotide repeat-containing gene 15 protein
Gene namesi
Name:Gigyf2
Synonyms:Kiaa0642, Perq2, Tnrc15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138584. Gigyf2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 12911290PERQ amino acid-rich with GYF domain-containing protein 2PRO_0000270838Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei26 – 261PhosphoserineCombined sources
Modified residuei30 – 301PhosphoserineCombined sources
Modified residuei140 – 1401PhosphoserineBy similarity
Modified residuei161 – 1611PhosphoserineBy similarity
Modified residuei190 – 1901PhosphoserineBy similarity
Modified residuei237 – 2371PhosphoserineBy similarity
Modified residuei383 – 3831PhosphothreonineCombined sources
Modified residuei594 – 5941PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6Y7W8.
MaxQBiQ6Y7W8.
PaxDbiQ6Y7W8.
PRIDEiQ6Y7W8.

PTM databases

iPTMnetiQ6Y7W8.
PhosphoSiteiQ6Y7W8.

Expressioni

Tissue specificityi

Expressed in heart and liver, in kidney and brain as well as in testis.1 Publication

Gene expression databases

BgeeiQ6Y7W8.
CleanExiMM_GIGYF2.
ExpressionAtlasiQ6Y7W8. baseline and differential.
GenevisibleiQ6Y7W8. MM.

Interactioni

Subunit structurei

Interacts with GRB10.1 Publication

Protein-protein interaction databases

BioGridi230615. 1 interaction.
IntActiQ6Y7W8. 1 interaction.
MINTiMINT-266607.
STRINGi10090.ENSMUSP00000027475.

Structurei

3D structure databases

ProteinModelPortaliQ6Y7W8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini534 – 58249GYFPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni548 – 56417Required for GRB10-bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi119 – 273155Arg-richAdd
BLAST
Compositional biasi437 – 47438Pro-richAdd
BLAST
Compositional biasi608 – 1031424Gln-richAdd
BLAST
Compositional biasi739 – 889151Glu-richAdd
BLAST
Compositional biasi1204 – 124441Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the PERQ family.Curated
Contains 1 GYF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1862. Eukaryota.
ENOG4111Q0Y. LUCA.
GeneTreeiENSGT00660000095550.
HOVERGENiHBG082121.
InParanoidiQ6Y7W8.
KOiK18730.
OMAiWGMNHSS.
OrthoDBiEOG7RNK1K.
PhylomeDBiQ6Y7W8.
TreeFamiTF325513.

Family and domain databases

Gene3Di3.30.1490.40. 1 hit.
InterProiIPR003169. GYF.
[Graphical view]
PfamiPF02213. GYF. 1 hit.
[Graphical view]
SMARTiSM00444. GYF. 1 hit.
[Graphical view]
SUPFAMiSSF55277. SSF55277. 1 hit.
PROSITEiPS50829. GYF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6Y7W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAETQTLNF GPEWLRALSS GGSITSPPLS PALPKYKLAD YRYGREEMLA
60 70 80 90 100
LFLKDYKIPF DLLEKEFLPI LQEEPLPPLA LVPFTEEEQR NFSMSVNSAA
110 120 130 140 150
VLRLTGRGGG GGTVVGAPRG RSSSRGRGRG RGECGFYQRS FDEVEGVFGR
160 170 180 190 200
GGGREMHRSQ SWEERGDRRF EKPGRKDVGR PNFEESGPTS VGRKHEFIRS
210 220 230 240 250
ESENWRIFRE EQNGEDEDGG WRLAGSRRDG ERWRPHSPDG PRSTGWREHM
260 270 280 290 300
ERRRRFEFDF RDRDDERGYR RVRSGSGSID DDRDSLPEWC LEDAEEEMGT
310 320 330 340 350
FDSSGAFLSL KKVQKEPIPE EQEMDFRPVE EGEERSDSDS SHNEEAKEPD
360 370 380 390 400
KTNRREGEKT DRAGAEASEE VPQTSLSSAR PGTPSDHQPQ EATQFERKDE
410 420 430 440 450
PKAEQVEKAE EENRSENSLS AKVPSRGDET VPASQQPSTP LPPDTASPLL
460 470 480 490 500
ILSPPVPTPS SASRPVETAA VEAPGMSSVS TEPDDEEGLK HLEQQAEKMV
510 520 530 540 550
AYLQDSALDD ERLTSKLQEH RAKGVSIPLM HEAMQKWYYK DPQGEIQGPF
560 570 580 590 600
NNQEMAEWFQ AGYFTMSLLV KRACDESFQP LGDIMKMWGR VPFSPGPAPP
610 620 630 640 650
PHMGELDQER LTRQQELTAL YQMQHLQYQQ FLIQQQYAQV LAQQQKAALS
660 670 680 690 700
SQQQQQLALL LQQFQALKMR MSDQNIIPSV TRSVSVPDTG SIWELQPAAS
710 720 730 740 750
QPAVWEGGSV WDLPLDTTAP GPSLEQLQQL EKAKAAKLEQ ERREAEMRAK
760 770 780 790 800
REEEERKRQE ELRRQQEEIL RRQQEEERKR REEEELARRK QEEALRRQRE
810 820 830 840 850
QEIALRRQRE EEERQQQEEA LRRLEERRRE EEERRKQEEL LRKQEEEAAK
860 870 880 890 900
WAREEEEAQR RLEENRLRME EEAARLRHEE EERKRKELEL QRQKDLMRQR
910 920 930 940 950
QQQQEALRRL QQQQQQQQLA QMKLPSSSTW GQQSNTATCQ SQATLSLAEI
960 970 980 990 1000
QKLEEERERQ LREEQRRQQR ELMKALQQQQ QQQQQQKLSG WGNVSKPAGT
1010 1020 1030 1040 1050
TKSLLEIQQE EARQMQKQQQ QQQQQQQQHQ QSNRARNSTH SNLHTSLGNS
1060 1070 1080 1090 1100
VWGSINTGPS NQWASELVSS IWSNADTKNS NMGFWDDAVK EVGPRNSTNK
1110 1120 1130 1140 1150
NKNNASLSKS VGVSNRQNKK VEEEEKLLKL FQGVNKAQDG FTQWCEQMLH
1160 1170 1180 1190 1200
ALNTANNLDV PTFVSFLKEV ESPYEVHDYT RAYLGDTSEA KEFAKQFLER
1210 1220 1230 1240 1250
RAKQKVNQQR QQQQQQQQQQ DSVWGMNHST LHSVFQTNQS NNQQSNFEAV
1260 1270 1280 1290
QSGKKKKKQK MVRADPSLLG FSVNASSERL NMGEIETLDD Y
Length:1,291
Mass (Da):149,193
Last modified:January 9, 2007 - v2
Checksum:iD05938427E72580A
GO
Isoform 2 (identifier: Q6Y7W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-868: Missing.

Note: No experimental confirmation available.
Show »
Length:423
Mass (Da):49,140
Checksum:iCEE62BEA76486B59
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131E → G in BAE25675 (PubMed:16141072).Curated
Sequence conflicti549 – 5491P → S in BAC65619 (PubMed:12693553).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 868868Missing in isoform 2. 1 PublicationVSP_022247Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY176043 mRNA. Translation: AAO46887.1.
BC027137 mRNA. Translation: AAH27137.1.
BC030845 mRNA. Translation: AAH30845.1.
BC082811 mRNA. Translation: AAH82811.1.
BC089036 mRNA. Translation: AAH89036.1.
AK144058 mRNA. Translation: BAE25675.1.
AK122337 mRNA. Translation: BAC65619.1.
CCDSiCCDS15133.1. [Q6Y7W8-1]
RefSeqiNP_001103682.1. NM_001110212.2.
NP_666224.3. NM_146112.4. [Q6Y7W8-1]
XP_006529527.1. XM_006529464.1. [Q6Y7W8-1]
XP_006529528.1. XM_006529465.2. [Q6Y7W8-1]
UniGeneiMm.23065.

Genome annotation databases

EnsembliENSMUST00000027475; ENSMUSP00000027475; ENSMUSG00000048000. [Q6Y7W8-1]
ENSMUST00000174501; ENSMUSP00000133327; ENSMUSG00000048000. [Q6Y7W8-1]
GeneIDi227331.
KEGGimmu:227331.
UCSCiuc007bwt.2. mouse. [Q6Y7W8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY176043 mRNA. Translation: AAO46887.1.
BC027137 mRNA. Translation: AAH27137.1.
BC030845 mRNA. Translation: AAH30845.1.
BC082811 mRNA. Translation: AAH82811.1.
BC089036 mRNA. Translation: AAH89036.1.
AK144058 mRNA. Translation: BAE25675.1.
AK122337 mRNA. Translation: BAC65619.1.
CCDSiCCDS15133.1. [Q6Y7W8-1]
RefSeqiNP_001103682.1. NM_001110212.2.
NP_666224.3. NM_146112.4. [Q6Y7W8-1]
XP_006529527.1. XM_006529464.1. [Q6Y7W8-1]
XP_006529528.1. XM_006529465.2. [Q6Y7W8-1]
UniGeneiMm.23065.

3D structure databases

ProteinModelPortaliQ6Y7W8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230615. 1 interaction.
IntActiQ6Y7W8. 1 interaction.
MINTiMINT-266607.
STRINGi10090.ENSMUSP00000027475.

PTM databases

iPTMnetiQ6Y7W8.
PhosphoSiteiQ6Y7W8.

Proteomic databases

EPDiQ6Y7W8.
MaxQBiQ6Y7W8.
PaxDbiQ6Y7W8.
PRIDEiQ6Y7W8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027475; ENSMUSP00000027475; ENSMUSG00000048000. [Q6Y7W8-1]
ENSMUST00000174501; ENSMUSP00000133327; ENSMUSG00000048000. [Q6Y7W8-1]
GeneIDi227331.
KEGGimmu:227331.
UCSCiuc007bwt.2. mouse. [Q6Y7W8-1]

Organism-specific databases

CTDi26058.
MGIiMGI:2138584. Gigyf2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1862. Eukaryota.
ENOG4111Q0Y. LUCA.
GeneTreeiENSGT00660000095550.
HOVERGENiHBG082121.
InParanoidiQ6Y7W8.
KOiK18730.
OMAiWGMNHSS.
OrthoDBiEOG7RNK1K.
PhylomeDBiQ6Y7W8.
TreeFamiTF325513.

Miscellaneous databases

ChiTaRSiGigyf2. mouse.
NextBioi378560.
PROiQ6Y7W8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6Y7W8.
CleanExiMM_GIGYF2.
ExpressionAtlasiQ6Y7W8. baseline and differential.
GenevisibleiQ6Y7W8. MM.

Family and domain databases

Gene3Di3.30.1490.40. 1 hit.
InterProiIPR003169. GYF.
[Graphical view]
PfamiPF02213. GYF. 1 hit.
[Graphical view]
SMARTiSM00444. GYF. 1 hit.
[Graphical view]
SUPFAMiSSF55277. SSF55277. 1 hit.
PROSITEiPS50829. GYF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling."
    Giovannone B., Lee E., Laviola L., Giorgino F., Cleveland K.A., Smith R.J.
    J. Biol. Chem. 278:31564-31573(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH GRB10, FUNCTION.
    Strain: C57BL/6J.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain, Eye and Mammary gland.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-878 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Kidney.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 244-1291 (ISOFORM 1).
    Tissue: Brain.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-30 AND THR-383, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPERQ2_MOUSE
AccessioniPrimary (citable) accession number: Q6Y7W8
Secondary accession number(s): Q0VGQ7
, Q3UNS2, Q63ZU9, Q80TV1, Q8K0R0, Q8R0A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 11, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.