Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PERQ amino acid-rich with GYF domain-containing protein 2

Gene

GIGYF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PERQ amino acid-rich with GYF domain-containing protein 2
Alternative name(s):
GRB10-interacting GYF protein 2
Trinucleotide repeat-containing gene 15 protein
Gene namesi
Name:GIGYF2
Synonyms:KIAA0642, PERQ2, TNRC15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11960. GIGYF2.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Parkinson disease 11 (PARK11)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
See also OMIM:607688
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561N → S May be associated with PARK11. 1 Publication
Corresponds to variant rs72554080 [ dbSNP | Ensembl ].
VAR_044439
Natural varianti112 – 1121T → A in PARK11. 1 Publication
VAR_044440
Natural varianti278 – 2781I → V in PARK11. 1 Publication
Corresponds to variant rs118203904 [ dbSNP | Ensembl ].
VAR_044441
Natural varianti335 – 3351S → T in PARK11. 1 Publication
Corresponds to variant rs776898936 [ dbSNP | Ensembl ].
VAR_044442
Natural varianti457 – 4571N → T in PARK11. 1 Publication
Corresponds to variant rs116074753 [ dbSNP | Ensembl ].
VAR_044443
Natural varianti606 – 6061D → E in PARK11. 1 Publication
Corresponds to variant rs118203903 [ dbSNP | Ensembl ].
VAR_044445
Natural varianti1242 – 12421V → I in PARK11. 1 Publication
Corresponds to variant rs769022021 [ dbSNP | Ensembl ].
VAR_044449

Keywords - Diseasei

Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism

Organism-specific databases

MalaCardsiGIGYF2.
MIMi607688. phenotype.
Orphaneti2828. Young adult-onset Parkinsonism.
PharmGKBiPA36647.

Chemistry

ChEMBLiCHEMBL2331055.

Polymorphism and mutation databases

BioMutaiGIGYF2.
DMDMi74710467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 12991298PERQ amino acid-rich with GYF domain-containing protein 2PRO_0000270837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei19 – 191PhosphoserineCombined sources
Modified residuei26 – 261PhosphoserineCombined sources
Modified residuei30 – 301PhosphoserineCombined sources
Modified residuei139 – 1391PhosphoserineCombined sources
Modified residuei160 – 1601PhosphoserineCombined sources
Modified residuei189 – 1891PhosphoserineCombined sources
Modified residuei236 – 2361PhosphoserineCombined sources
Modified residuei382 – 3821PhosphothreonineCombined sources
Modified residuei388 – 3881PhosphoserineCombined sources
Modified residuei593 – 5931PhosphoserineCombined sources
Modified residuei993 – 9931PhosphoserineCombined sources
Modified residuei1284 – 12841PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6Y7W6.
MaxQBiQ6Y7W6.
PaxDbiQ6Y7W6.
PeptideAtlasiQ6Y7W6.
PRIDEiQ6Y7W6.

PTM databases

iPTMnetiQ6Y7W6.

Expressioni

Gene expression databases

BgeeiQ6Y7W6.
CleanExiHS_GIGYF2.
ExpressionAtlasiQ6Y7W6. baseline and differential.
GenevisibleiQ6Y7W6. HS.

Organism-specific databases

HPAiHPA050899.
HPA054612.
HPA059918.

Interactioni

Subunit structurei

Interacts with GRB10.By similarity

Protein-protein interaction databases

BioGridi117520. 60 interactions.
IntActiQ6Y7W6. 20 interactions.
MINTiMINT-1365781.
STRINGi9606.ENSP00000387170.

Chemistry

BindingDBiQ6Y7W6.

Structurei

3D structure databases

ProteinModelPortaliQ6Y7W6.
SMRiQ6Y7W6. Positions 530-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini533 – 58149GYFPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni547 – 56317Required for GRB10-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi106 – 1116Poly-Gly
Compositional biasi118 – 272155Arg-richAdd
BLAST
Compositional biasi436 – 47338Pro-richAdd
BLAST
Compositional biasi607 – 1025419Gln-richAdd
BLAST
Compositional biasi738 – 888151Glu-richAdd
BLAST
Compositional biasi1198 – 125255Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the PERQ family.Curated
Contains 1 GYF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1862. Eukaryota.
ENOG4111Q0Y. LUCA.
GeneTreeiENSGT00660000095550.
HOGENOMiHOG000290720.
HOVERGENiHBG082121.
InParanoidiQ6Y7W6.
KOiK18730.
OrthoDBiEOG7RNK1K.
PhylomeDBiQ6Y7W6.
TreeFamiTF325513.

Family and domain databases

Gene3Di3.30.1490.40. 1 hit.
InterProiIPR003169. GYF.
[Graphical view]
PfamiPF02213. GYF. 1 hit.
[Graphical view]
SMARTiSM00444. GYF. 1 hit.
[Graphical view]
SUPFAMiSSF55277. SSF55277. 1 hit.
PROSITEiPS50829. GYF. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6Y7W6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAETQTLNF GPEWLRALSS GGSITSPPLS PALPKYKLAD YRYGREEMLA
60 70 80 90 100
LFLKDNKIPS DLLDKEFLPI LQEEPLPPLA LVPFTEEEQR NFSMSVNSAA
110 120 130 140 150
VLRLTGRGGG GTVVGAPRGR SSSRGRGRGR GECGFYQRSF DEVEGVFGRG
160 170 180 190 200
GGREMHRSQS WEERGDRRFE KPGRKDVGRP NFEEGGPTSV GRKHEFIRSE
210 220 230 240 250
SENWRIFREE QNGEDEDGGW RLAGSRRDGE RWRPHSPDGP RSAGWREHME
260 270 280 290 300
RRRRFEFDFR DRDDERGYRR VRSGSGSIDD DRDSLPEWCL EDAEEEMGTF
310 320 330 340 350
DSSGAFLSLK KVQKEPIPEE QEMDFRPVDE GEECSDSEGS HNEEAKEPDK
360 370 380 390 400
TNKKEGEKTD RVGVEASEET PQTSSSSARP GTPSDHQSQE ASQFERKDEP
410 420 430 440 450
KTEQTEKAEE ETRMENSLPA KVPSRGDEMV ADVQQPLSQI PSDTASPLLI
460 470 480 490 500
LPPPVPNPSP TLRPVETPVV GAPGMGSVST EPDDEEGLKH LEQQAEKMVA
510 520 530 540 550
YLQDSALDDE RLASKLQEHR AKGVSIPLMH EAMQKWYYKD PQGEIQGPFN
560 570 580 590 600
NQEMAEWFQA GYFTMSLLVK RACDESFQPL GDIMKMWGRV PFSPGPAPPP
610 620 630 640 650
HMGELDQERL TRQQELTALY QMQHLQYQQF LIQQQYAQVL AQQQKAALSS
660 670 680 690 700
QQQQQLALLL QQFQTLKMRI SDQNIIPSVT RSVSVPDTGS IWELQPTASQ
710 720 730 740 750
PTVWEGGSVW DLPLDTTTPG PALEQLQQLE KAKAAKLEQE RREAEMRAKR
760 770 780 790 800
EEEERKRQEE LRRQQEEILR RQQEEERKRR EEEELARRKQ EEALRRQREQ
810 820 830 840 850
EIALRRQREE EERQQQEEAL RRLEERRREE EERRKQEELL RKQEEEAAKW
860 870 880 890 900
AREEEEAQRR LEENRLRMEE EAARLRHEEE ERKRKELEVQ RQKELMRQRQ
910 920 930 940 950
QQQEALRRLQ QQQQQQQLAQ MKLPSSSTWG QQSNTTACQS QATLSLAEIQ
960 970 980 990 1000
KLEEERERQL REEQRRQQRE LMKALQQQQQ QQQQKLSGWG NVSKPSGTTK
1010 1020 1030 1040 1050
SLLEIQQEEA RQMQKQQQQQ QQHQQPNRAR NNTHSNLHTS IGNSVWGSIN
1060 1070 1080 1090 1100
TGPPNQWASD LVSSIWSNAD TKNSNMGFWD DAVKEVGPRN STNKNKNNAS
1110 1120 1130 1140 1150
LSKSVGVSNR QNKKVEEEEK LLKLFQGVNK AQDGFTQWCE QMLHALNTAN
1160 1170 1180 1190 1200
NLDVPTFVSF LKEVESPYEV HDYIRAYLGD TSEAKEFAKQ FLERRAKQKA
1210 1220 1230 1240 1250
NQQRQQQQLP QQQQQQPPQQ PPQQPQQQDS VWGMNHSTLH SVFQTNQSNN
1260 1270 1280 1290
QQSNFEAVQS GKKKKKQKMV RADPSLLGFS VNASSERLNM GEIETLDDY
Length:1,299
Mass (Da):150,070
Last modified:July 5, 2004 - v1
Checksum:i2282458102F64B71
GO
Isoform 2 (identifier: Q6Y7W6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-177: V → VGKKNGYYCMYSPVLLLGQPLCQ
     365-365: Missing.

Show »
Length:1,320
Mass (Da):152,399
Checksum:i45DD5F3742C127FF
GO
Isoform 3 (identifier: Q6Y7W6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-243: Missing.
     1205-1211: Missing.

Note: No experimental confirmation available.
Show »
Length:1,286
Mass (Da):148,635
Checksum:iE7FD1ECDDE98DDE1
GO
Isoform 4 (identifier: Q6Y7W6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-243: Missing.

Note: No experimental confirmation available.
Show »
Length:1,293
Mass (Da):149,486
Checksum:iDD5D60E71FFAC884
GO

Sequence cautioni

The sequence BAA31617.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91873.1 differs from that shown.Unlikely isoform.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti565 – 5651M → T in BX538172 (Ref. 4) Curated
Sequence conflicti792 – 7921E → G in CAD98095 (PubMed:17974005).Curated
Sequence conflicti1153 – 11531D → G in CAD98095 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561N → S May be associated with PARK11. 1 Publication
Corresponds to variant rs72554080 [ dbSNP | Ensembl ].
VAR_044439
Natural varianti112 – 1121T → A in PARK11. 1 Publication
VAR_044440
Natural varianti278 – 2781I → V in PARK11. 1 Publication
Corresponds to variant rs118203904 [ dbSNP | Ensembl ].
VAR_044441
Natural varianti335 – 3351S → T in PARK11. 1 Publication
Corresponds to variant rs776898936 [ dbSNP | Ensembl ].
VAR_044442
Natural varianti423 – 4231P → L.
Corresponds to variant rs34845648 [ dbSNP | Ensembl ].
VAR_051268
Natural varianti457 – 4571N → T in PARK11. 1 Publication
Corresponds to variant rs116074753 [ dbSNP | Ensembl ].
VAR_044443
Natural varianti460 – 4601P → T.1 Publication
Corresponds to variant rs2289912 [ dbSNP | Ensembl ].
VAR_044444
Natural varianti606 – 6061D → E in PARK11. 1 Publication
Corresponds to variant rs118203903 [ dbSNP | Ensembl ].
VAR_044445
Natural varianti1171 – 11711H → R.1 Publication
Corresponds to variant rs72554081 [ dbSNP | Ensembl ].
VAR_044446
Natural varianti1211 – 12111Missing .4 Publications
VAR_044447
Natural varianti1212 – 12121Q → QQ.1 Publication
VAR_044448
Natural varianti1242 – 12421V → I in PARK11. 1 Publication
Corresponds to variant rs769022021 [ dbSNP | Ensembl ].
VAR_044449

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei177 – 1771V → VGKKNGYYCMYSPVLLLGQP LCQ in isoform 2. 2 PublicationsVSP_022244
Alternative sequencei238 – 2436Missing in isoform 3 and isoform 4. 1 PublicationVSP_044996
Alternative sequencei365 – 3651Missing in isoform 2. 2 PublicationsVSP_043471
Alternative sequencei1205 – 12117Missing in isoform 3. 1 PublicationVSP_044997

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY176045 mRNA. Translation: AAO46889.1.
AB014542 mRNA. Translation: BAA31617.2. Different initiation.
BX538172 mRNA. No translation available.
AK001739 mRNA. Translation: BAA91873.1. Sequence problems.
BX537885 mRNA. Translation: CAD97881.1.
BX538321 mRNA. Translation: CAD98095.1.
AC016692 Genomic DNA. No translation available.
AC064852 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW71016.1.
BC008072 mRNA. Translation: AAH08072.2.
BC136251 mRNA. Translation: AAI36252.1.
BC146775 mRNA. Translation: AAI46776.1.
CCDSiCCDS33401.1. [Q6Y7W6-1]
CCDS46542.1. [Q6Y7W6-3]
CCDS46543.1. [Q6Y7W6-5]
PIRiT00377.
RefSeqiNP_001096616.1. NM_001103146.1. [Q6Y7W6-1]
NP_001096617.1. NM_001103147.1. [Q6Y7W6-3]
NP_001096618.1. NM_001103148.1. [Q6Y7W6-5]
NP_056390.2. NM_015575.3. [Q6Y7W6-1]
UniGeneiHs.565319.

Genome annotation databases

EnsembliENST00000373563; ENSP00000362664; ENSG00000204120. [Q6Y7W6-1]
ENST00000409196; ENSP00000387070; ENSG00000204120. [Q6Y7W6-5]
ENST00000409451; ENSP00000387170; ENSG00000204120. [Q6Y7W6-3]
ENST00000409547; ENSP00000386537; ENSG00000204120. [Q6Y7W6-1]
GeneIDi26058.
KEGGihsa:26058.
UCSCiuc002vth.6. human. [Q6Y7W6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY176045 mRNA. Translation: AAO46889.1.
AB014542 mRNA. Translation: BAA31617.2. Different initiation.
BX538172 mRNA. No translation available.
AK001739 mRNA. Translation: BAA91873.1. Sequence problems.
BX537885 mRNA. Translation: CAD97881.1.
BX538321 mRNA. Translation: CAD98095.1.
AC016692 Genomic DNA. No translation available.
AC064852 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW71016.1.
BC008072 mRNA. Translation: AAH08072.2.
BC136251 mRNA. Translation: AAI36252.1.
BC146775 mRNA. Translation: AAI46776.1.
CCDSiCCDS33401.1. [Q6Y7W6-1]
CCDS46542.1. [Q6Y7W6-3]
CCDS46543.1. [Q6Y7W6-5]
PIRiT00377.
RefSeqiNP_001096616.1. NM_001103146.1. [Q6Y7W6-1]
NP_001096617.1. NM_001103147.1. [Q6Y7W6-3]
NP_001096618.1. NM_001103148.1. [Q6Y7W6-5]
NP_056390.2. NM_015575.3. [Q6Y7W6-1]
UniGeneiHs.565319.

3D structure databases

ProteinModelPortaliQ6Y7W6.
SMRiQ6Y7W6. Positions 530-579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117520. 60 interactions.
IntActiQ6Y7W6. 20 interactions.
MINTiMINT-1365781.
STRINGi9606.ENSP00000387170.

Chemistry

BindingDBiQ6Y7W6.
ChEMBLiCHEMBL2331055.

PTM databases

iPTMnetiQ6Y7W6.

Polymorphism and mutation databases

BioMutaiGIGYF2.
DMDMi74710467.

Proteomic databases

EPDiQ6Y7W6.
MaxQBiQ6Y7W6.
PaxDbiQ6Y7W6.
PeptideAtlasiQ6Y7W6.
PRIDEiQ6Y7W6.

Protocols and materials databases

DNASUi26058.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373563; ENSP00000362664; ENSG00000204120. [Q6Y7W6-1]
ENST00000409196; ENSP00000387070; ENSG00000204120. [Q6Y7W6-5]
ENST00000409451; ENSP00000387170; ENSG00000204120. [Q6Y7W6-3]
ENST00000409547; ENSP00000386537; ENSG00000204120. [Q6Y7W6-1]
GeneIDi26058.
KEGGihsa:26058.
UCSCiuc002vth.6. human. [Q6Y7W6-1]

Organism-specific databases

CTDi26058.
GeneCardsiGIGYF2.
HGNCiHGNC:11960. GIGYF2.
HPAiHPA050899.
HPA054612.
HPA059918.
MalaCardsiGIGYF2.
MIMi607688. phenotype.
612003. gene.
neXtProtiNX_Q6Y7W6.
Orphaneti2828. Young adult-onset Parkinsonism.
PharmGKBiPA36647.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1862. Eukaryota.
ENOG4111Q0Y. LUCA.
GeneTreeiENSGT00660000095550.
HOGENOMiHOG000290720.
HOVERGENiHBG082121.
InParanoidiQ6Y7W6.
KOiK18730.
OrthoDBiEOG7RNK1K.
PhylomeDBiQ6Y7W6.
TreeFamiTF325513.

Miscellaneous databases

ChiTaRSiGIGYF2. human.
GeneWikiiTNRC15.
GenomeRNAii26058.
PROiQ6Y7W6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6Y7W6.
CleanExiHS_GIGYF2.
ExpressionAtlasiQ6Y7W6. baseline and differential.
GenevisibleiQ6Y7W6. HS.

Family and domain databases

Gene3Di3.30.1490.40. 1 hit.
InterProiIPR003169. GYF.
[Graphical view]
PfamiPF02213. GYF. 1 hit.
[Graphical view]
SMARTiSM00444. GYF. 1 hit.
[Graphical view]
SUPFAMiSSF55277. SSF55277. 1 hit.
PROSITEiPS50829. GYF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling."
    Giovannone B., Lee E., Laviola L., Giorgino F., Cleveland K.A., Smith R.J.
    J. Biol. Chem. 278:31564-31573(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    Tissue: Kidney.
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. Lauber J., Bahr A., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Uterus.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1096 (ISOFORM 1).
    Tissue: Teratocarcinoma.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-1211 DEL.
    Tissue: Fetal kidney and Uterus.
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-1211 DEL.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-1211 DEL.
    Tissue: Lymph and Testis.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-30; SER-160; SER-189 AND THR-382, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-30; SER-139 AND THR-382, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-236; THR-382 AND SER-593, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-30; SER-139 AND SER-236, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-26; SER-30; SER-139; SER-160; SER-189; THR-382; SER-993 AND SER-1284, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-236 AND SER-388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  25. "Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease."
    Lautier C., Goldwurm S., Duerr A., Giovannone B., Tsiaras W.G., Pezzoli G., Brice A., Smith R.J.
    Am. J. Hum. Genet. 82:822-833(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PARK11 ALA-112; VAL-278; THR-335; THR-457; GLU-606 AND ILE-1242, VARIANTS SER-56; THR-460; ARG-1171; GLN-1211 DEL AND GLN-1212 INS.

Entry informationi

Entry nameiPERQ2_HUMAN
AccessioniPrimary (citable) accession number: Q6Y7W6
Secondary accession number(s): A6H8W4
, B9EG55, E9PBB0, O75137, Q7Z2Z8, Q7Z3I2, Q96HU4, Q9NV82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.