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Q6Y685 (TACC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transforming acidic coiled-coil-containing protein 1
Gene names
Name:Tacc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length774 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

Subunit structure

Interacts with CH-TOG and YEATS4. Interacts with the AURKA and AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Note: Nucleus during interphase. Weakly concentrated at centrosomes during mitosisand colocalizes with AURKC at the midbody during cytokinesis By similarity.

Sequence similarities

Belongs to the TACC family.

Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6Y685-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6Y685-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     55-55: S → R
     56-461: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 774773Transforming acidic coiled-coil-containing protein 1
PRO_0000179987

Regions

Domain216 – 29479SPAZ 1
Domain354 – 504151SPAZ 2
Region2 – 5655Interaction with LSM7 and SNRPG By similarity
Region153 – 255103Interaction with TDRD7 By similarity
Region207 – 424218Interaction with YEATS4 By similarity
Region670 – 774105Interaction with CH-TOG By similarity
Coiled coil579 – 774196
Motif452 – 46817Bipartite nuclear localization signal Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue41Phosphoserine By similarity
Modified residue101Phosphoserine By similarity
Modified residue2281Phosphoserine; by AURKC By similarity
Modified residue3761Phosphoserine Ref.3

Natural variations

Alternative sequence551S → R in isoform 2.
VSP_012650
Alternative sequence56 – 461406Missing in isoform 2.
VSP_012651

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: AE9D412E63180976

FASTA77483,952
        10         20         30         40         50         60 
MAFSPWQILS PVQWAKWTWS AVRGSGAGED EAGGPEGDPE EEEDSQAETK SLSFSSDSEG 

        70         80         90        100        110        120 
NFETPEAETP IRSPLKESCD SSPGLAEPEA KPQESREADE QLVAEVIEKC SPDTCSRSSE 

       130        140        150        160        170        180 
NEAPQATVDS HPVKDVRGKA EHDVSKISVV RPFSIETRNC TDDPAALGTA AAHGCVPVLP 

       190        200        210        220        230        240 
GMALPSTTPE ATQDEPVMDR GMGVTLEAFT EASLKTGGPC PEPVASRSKL RKPKPVSLRK 

       250        260        270        280        290        300 
KMAPEPEMLM EGSPLPKASS PWLPDGLDQN ANPSVLRGSG AQRSPLNLKE TAGVLSNDTS 

       310        320        330        340        350        360 
DSGVEVAPGS PPLQLEDDFT EDGENVKIRS ALPKQSGRKP SNKLAPSIRK DGVSKPVGVE 

       370        380        390        400        410        420 
QPSDPTVQDA LLDQMSPKLD PSKRSHPPAN FFGSGPILQN SPPLSSKCSH HFDPNNINTD 

       430        440        450        460        470        480 
DSGDPCKPTP ALTSSGFCPA TGNHVNEILD SPKKAKSRLI TSGCKVKKYE AQPLDLDACS 

       490        500        510        520        530        540 
QDEGAVISKI SEIPNRDGHA TDEEKLASTS SCAQKSAGAG VKGIEKETCQ KMEKEELAVH 

       550        560        570        580        590        600 
GLLESSSEKA PVSVACGGES PLDGICLSEA DKTAVLTLIR EEIITKEIEA NEWKKKYEET 

       610        620        630        640        650        660 
REEVLEMRKI VAEYEKTIAQ MIEDEQRTSM SSQKSFQQLT MEKEQALADL NSVERSLSDL 

       670        680        690        700        710        720 
FRRYENLKGV LEGFKKNEEA LKKCAQDYLA RVKQEEQRYQ ALKVHAEEKL DRANEEIAQV 

       730        740        750        760        770 
RSKAKAESAA LHAGLRKEQM KVESLERALQ QKNQEIEELT KICDELIAKL GKTD 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 9F44CC06F0DC8042
Show »

FASTA36841,110

References

« Hide 'large scale' references
[1]"Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms."
Still I.H., Vettaikkorumakankauv A.K., DiMatteo A., Liang P.
BMC Evol. Biol. 4:16-16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6.
Tissue: Spinal cord.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-376, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY177412 mRNA. Translation: AAO53447.1.
AY177413 mRNA. Translation: AAO53448.1.
BC125389 mRNA. Translation: AAI25390.1.
BC145709 mRNA. Translation: AAI45710.1.
CCDSCCDS40302.1. [Q6Y685-2]
RefSeqNP_796063.3. NM_177089.5.
NP_955355.1. NM_199323.3. [Q6Y685-2]
UniGeneMm.308452.

3D structure databases

ProteinModelPortalQ6Y685.
SMRQ6Y685. Positions 582-608.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000081043.

PTM databases

PhosphoSiteQ6Y685.

Proteomic databases

MaxQBQ6Y685.
PaxDbQ6Y685.
PRIDEQ6Y685.

Protocols and materials databases

DNASU320165.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000084512; ENSMUSP00000081560; ENSMUSG00000065954. [Q6Y685-2]
GeneID320165.
KEGGmmu:320165.
UCSCuc009lft.1. mouse. [Q6Y685-2]

Organism-specific databases

CTD6867.
MGIMGI:2443510. Tacc1.

Phylogenomic databases

eggNOGNOG83363.
GeneTreeENSGT00530000063855.
HOGENOMHOG000294120.
HOVERGENHBG105967.
InParanoidQ6Y685.
KOK14281.
PhylomeDBQ6Y685.

Gene expression databases

ArrayExpressQ6Y685.
BgeeQ6Y685.
GenevestigatorQ6Y685.

Family and domain databases

InterProIPR007707. TACC.
[Graphical view]
PANTHERPTHR13924. PTHR13924. 1 hit.
PfamPF05010. TACC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTACC1. mouse.
NextBio396157.
PROQ6Y685.
SOURCESearch...

Entry information

Entry nameTACC1_MOUSE
AccessionPrimary (citable) accession number: Q6Y685
Secondary accession number(s): Q05A66, Q6Y686
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot