Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6Y685

- TACC1_MOUSE

UniProt

Q6Y685 - TACC1_MOUSE

Protein

Transforming acidic coiled-coil-containing protein 1

Gene

Tacc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

    GO - Molecular functioni

    1. protein domain specific binding Source: MGI

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. cell proliferation Source: MGI
    4. cerebral cortex development Source: MGI
    5. interkinetic nuclear migration Source: MGI
    6. microtubule cytoskeleton organization Source: MGI
    7. neurogenesis Source: MGI
    8. regulation of microtubule-based process Source: MGI

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transforming acidic coiled-coil-containing protein 1
    Gene namesi
    Name:Tacc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2443510. Tacc1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
    Note: Nucleus during interphase. Weakly concentrated at centrosomes during mitosisand colocalizes with AURKC at the midbody during cytokinesis By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. microtubule organizing center Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 774773Transforming acidic coiled-coil-containing protein 1PRO_0000179987Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei4 – 41PhosphoserineBy similarity
    Modified residuei10 – 101PhosphoserineBy similarity
    Modified residuei228 – 2281Phosphoserine; by AURKCBy similarity
    Modified residuei376 – 3761Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ6Y685.
    PaxDbiQ6Y685.
    PRIDEiQ6Y685.

    PTM databases

    PhosphoSiteiQ6Y685.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6Y685.
    BgeeiQ6Y685.
    GenevestigatoriQ6Y685.

    Interactioni

    Subunit structurei

    Interacts with CH-TOG and YEATS4. Interacts with the AURKA and AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000081043.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6Y685.
    SMRiQ6Y685. Positions 582-608.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini216 – 29479SPAZ 1Add
    BLAST
    Domaini354 – 504151SPAZ 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 5655Interaction with LSM7 and SNRPGBy similarityAdd
    BLAST
    Regioni153 – 255103Interaction with TDRD7By similarityAdd
    BLAST
    Regioni207 – 424218Interaction with YEATS4By similarityAdd
    BLAST
    Regioni670 – 774105Interaction with CH-TOGBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili579 – 774196Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi452 – 46817Bipartite nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TACC family.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG83363.
    GeneTreeiENSGT00530000063855.
    HOGENOMiHOG000294120.
    HOVERGENiHBG105967.
    InParanoidiQ6Y685.
    KOiK14281.
    PhylomeDBiQ6Y685.

    Family and domain databases

    InterProiIPR007707. TACC.
    [Graphical view]
    PANTHERiPTHR13924. PTHR13924. 1 hit.
    PfamiPF05010. TACC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6Y685-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFSPWQILS PVQWAKWTWS AVRGSGAGED EAGGPEGDPE EEEDSQAETK    50
    SLSFSSDSEG NFETPEAETP IRSPLKESCD SSPGLAEPEA KPQESREADE 100
    QLVAEVIEKC SPDTCSRSSE NEAPQATVDS HPVKDVRGKA EHDVSKISVV 150
    RPFSIETRNC TDDPAALGTA AAHGCVPVLP GMALPSTTPE ATQDEPVMDR 200
    GMGVTLEAFT EASLKTGGPC PEPVASRSKL RKPKPVSLRK KMAPEPEMLM 250
    EGSPLPKASS PWLPDGLDQN ANPSVLRGSG AQRSPLNLKE TAGVLSNDTS 300
    DSGVEVAPGS PPLQLEDDFT EDGENVKIRS ALPKQSGRKP SNKLAPSIRK 350
    DGVSKPVGVE QPSDPTVQDA LLDQMSPKLD PSKRSHPPAN FFGSGPILQN 400
    SPPLSSKCSH HFDPNNINTD DSGDPCKPTP ALTSSGFCPA TGNHVNEILD 450
    SPKKAKSRLI TSGCKVKKYE AQPLDLDACS QDEGAVISKI SEIPNRDGHA 500
    TDEEKLASTS SCAQKSAGAG VKGIEKETCQ KMEKEELAVH GLLESSSEKA 550
    PVSVACGGES PLDGICLSEA DKTAVLTLIR EEIITKEIEA NEWKKKYEET 600
    REEVLEMRKI VAEYEKTIAQ MIEDEQRTSM SSQKSFQQLT MEKEQALADL 650
    NSVERSLSDL FRRYENLKGV LEGFKKNEEA LKKCAQDYLA RVKQEEQRYQ 700
    ALKVHAEEKL DRANEEIAQV RSKAKAESAA LHAGLRKEQM KVESLERALQ 750
    QKNQEIEELT KICDELIAKL GKTD 774
    Length:774
    Mass (Da):83,952
    Last modified:July 5, 2004 - v1
    Checksum:iAE9D412E63180976
    GO
    Isoform 2 (identifier: Q6Y685-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         55-55: S → R
         56-461: Missing.

    Show »
    Length:368
    Mass (Da):41,110
    Checksum:i9F44CC06F0DC8042
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei55 – 551S → R in isoform 2. 2 PublicationsVSP_012650
    Alternative sequencei56 – 461406Missing in isoform 2. 2 PublicationsVSP_012651Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY177412 mRNA. Translation: AAO53447.1.
    AY177413 mRNA. Translation: AAO53448.1.
    BC125389 mRNA. Translation: AAI25390.1.
    BC145709 mRNA. Translation: AAI45710.1.
    CCDSiCCDS40302.1. [Q6Y685-2]
    RefSeqiNP_796063.3. NM_177089.5.
    NP_955355.1. NM_199323.3. [Q6Y685-2]
    UniGeneiMm.308452.

    Genome annotation databases

    EnsembliENSMUST00000084512; ENSMUSP00000081560; ENSMUSG00000065954. [Q6Y685-2]
    GeneIDi320165.
    KEGGimmu:320165.
    UCSCiuc009lft.1. mouse. [Q6Y685-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY177412 mRNA. Translation: AAO53447.1 .
    AY177413 mRNA. Translation: AAO53448.1 .
    BC125389 mRNA. Translation: AAI25390.1 .
    BC145709 mRNA. Translation: AAI45710.1 .
    CCDSi CCDS40302.1. [Q6Y685-2 ]
    RefSeqi NP_796063.3. NM_177089.5.
    NP_955355.1. NM_199323.3. [Q6Y685-2 ]
    UniGenei Mm.308452.

    3D structure databases

    ProteinModelPortali Q6Y685.
    SMRi Q6Y685. Positions 582-608.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000081043.

    PTM databases

    PhosphoSitei Q6Y685.

    Proteomic databases

    MaxQBi Q6Y685.
    PaxDbi Q6Y685.
    PRIDEi Q6Y685.

    Protocols and materials databases

    DNASUi 320165.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084512 ; ENSMUSP00000081560 ; ENSMUSG00000065954 . [Q6Y685-2 ]
    GeneIDi 320165.
    KEGGi mmu:320165.
    UCSCi uc009lft.1. mouse. [Q6Y685-2 ]

    Organism-specific databases

    CTDi 6867.
    MGIi MGI:2443510. Tacc1.

    Phylogenomic databases

    eggNOGi NOG83363.
    GeneTreei ENSGT00530000063855.
    HOGENOMi HOG000294120.
    HOVERGENi HBG105967.
    InParanoidi Q6Y685.
    KOi K14281.
    PhylomeDBi Q6Y685.

    Miscellaneous databases

    ChiTaRSi TACC1. mouse.
    NextBioi 396157.
    PROi Q6Y685.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6Y685.
    Bgeei Q6Y685.
    Genevestigatori Q6Y685.

    Family and domain databases

    InterProi IPR007707. TACC.
    [Graphical view ]
    PANTHERi PTHR13924. PTHR13924. 1 hit.
    Pfami PF05010. TACC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms."
      Still I.H., Vettaikkorumakankauv A.K., DiMatteo A., Liang P.
      BMC Evol. Biol. 4:16-16(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
      Tissue: Spinal cord.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-376, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTACC1_MOUSE
    AccessioniPrimary (citable) accession number: Q6Y685
    Secondary accession number(s): Q05A66, Q6Y686
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3