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Q6Y685

- TACC1_MOUSE

UniProt

Q6Y685 - TACC1_MOUSE

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Protein

Transforming acidic coiled-coil-containing protein 1

Gene
Tacc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

GO - Molecular functioni

  1. protein domain specific binding Source: MGI

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell proliferation Source: MGI
  4. cerebral cortex development Source: MGI
  5. interkinetic nuclear migration Source: MGI
  6. microtubule cytoskeleton organization Source: MGI
  7. neurogenesis Source: MGI
  8. regulation of microtubule-based process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming acidic coiled-coil-containing protein 1
Gene namesi
Name:Tacc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2443510. Tacc1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Nucleus during interphase. Weakly concentrated at centrosomes during mitosisand colocalizes with AURKC at the midbody during cytokinesis By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. microtubule organizing center Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 774773Transforming acidic coiled-coil-containing protein 1PRO_0000179987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei4 – 41Phosphoserine By similarity
Modified residuei10 – 101Phosphoserine By similarity
Modified residuei228 – 2281Phosphoserine; by AURKC By similarity
Modified residuei376 – 3761Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6Y685.
PaxDbiQ6Y685.
PRIDEiQ6Y685.

PTM databases

PhosphoSiteiQ6Y685.

Expressioni

Gene expression databases

ArrayExpressiQ6Y685.
BgeeiQ6Y685.
GenevestigatoriQ6Y685.

Interactioni

Subunit structurei

Interacts with CH-TOG and YEATS4. Interacts with the AURKA and AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081043.

Structurei

3D structure databases

ProteinModelPortaliQ6Y685.
SMRiQ6Y685. Positions 582-608.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini216 – 29479SPAZ 1Add
BLAST
Domaini354 – 504151SPAZ 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 5655Interaction with LSM7 and SNRPG By similarityAdd
BLAST
Regioni153 – 255103Interaction with TDRD7 By similarityAdd
BLAST
Regioni207 – 424218Interaction with YEATS4 By similarityAdd
BLAST
Regioni670 – 774105Interaction with CH-TOG By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili579 – 774196Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi452 – 46817Bipartite nuclear localization signal Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the TACC family.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG83363.
GeneTreeiENSGT00530000063855.
HOGENOMiHOG000294120.
HOVERGENiHBG105967.
InParanoidiQ6Y685.
KOiK14281.
PhylomeDBiQ6Y685.

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PANTHERiPTHR13924. PTHR13924. 1 hit.
PfamiPF05010. TACC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6Y685-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAFSPWQILS PVQWAKWTWS AVRGSGAGED EAGGPEGDPE EEEDSQAETK    50
SLSFSSDSEG NFETPEAETP IRSPLKESCD SSPGLAEPEA KPQESREADE 100
QLVAEVIEKC SPDTCSRSSE NEAPQATVDS HPVKDVRGKA EHDVSKISVV 150
RPFSIETRNC TDDPAALGTA AAHGCVPVLP GMALPSTTPE ATQDEPVMDR 200
GMGVTLEAFT EASLKTGGPC PEPVASRSKL RKPKPVSLRK KMAPEPEMLM 250
EGSPLPKASS PWLPDGLDQN ANPSVLRGSG AQRSPLNLKE TAGVLSNDTS 300
DSGVEVAPGS PPLQLEDDFT EDGENVKIRS ALPKQSGRKP SNKLAPSIRK 350
DGVSKPVGVE QPSDPTVQDA LLDQMSPKLD PSKRSHPPAN FFGSGPILQN 400
SPPLSSKCSH HFDPNNINTD DSGDPCKPTP ALTSSGFCPA TGNHVNEILD 450
SPKKAKSRLI TSGCKVKKYE AQPLDLDACS QDEGAVISKI SEIPNRDGHA 500
TDEEKLASTS SCAQKSAGAG VKGIEKETCQ KMEKEELAVH GLLESSSEKA 550
PVSVACGGES PLDGICLSEA DKTAVLTLIR EEIITKEIEA NEWKKKYEET 600
REEVLEMRKI VAEYEKTIAQ MIEDEQRTSM SSQKSFQQLT MEKEQALADL 650
NSVERSLSDL FRRYENLKGV LEGFKKNEEA LKKCAQDYLA RVKQEEQRYQ 700
ALKVHAEEKL DRANEEIAQV RSKAKAESAA LHAGLRKEQM KVESLERALQ 750
QKNQEIEELT KICDELIAKL GKTD 774
Length:774
Mass (Da):83,952
Last modified:July 5, 2004 - v1
Checksum:iAE9D412E63180976
GO
Isoform 2 (identifier: Q6Y685-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     55-55: S → R
     56-461: Missing.

Show »
Length:368
Mass (Da):41,110
Checksum:i9F44CC06F0DC8042
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 551S → R in isoform 2. VSP_012650
Alternative sequencei56 – 461406Missing in isoform 2. VSP_012651Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY177412 mRNA. Translation: AAO53447.1.
AY177413 mRNA. Translation: AAO53448.1.
BC125389 mRNA. Translation: AAI25390.1.
BC145709 mRNA. Translation: AAI45710.1.
CCDSiCCDS40302.1. [Q6Y685-2]
RefSeqiNP_796063.3. NM_177089.5.
NP_955355.1. NM_199323.3. [Q6Y685-2]
UniGeneiMm.308452.

Genome annotation databases

EnsembliENSMUST00000084512; ENSMUSP00000081560; ENSMUSG00000065954. [Q6Y685-2]
GeneIDi320165.
KEGGimmu:320165.
UCSCiuc009lft.1. mouse. [Q6Y685-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY177412 mRNA. Translation: AAO53447.1 .
AY177413 mRNA. Translation: AAO53448.1 .
BC125389 mRNA. Translation: AAI25390.1 .
BC145709 mRNA. Translation: AAI45710.1 .
CCDSi CCDS40302.1. [Q6Y685-2 ]
RefSeqi NP_796063.3. NM_177089.5.
NP_955355.1. NM_199323.3. [Q6Y685-2 ]
UniGenei Mm.308452.

3D structure databases

ProteinModelPortali Q6Y685.
SMRi Q6Y685. Positions 582-608.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000081043.

PTM databases

PhosphoSitei Q6Y685.

Proteomic databases

MaxQBi Q6Y685.
PaxDbi Q6Y685.
PRIDEi Q6Y685.

Protocols and materials databases

DNASUi 320165.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084512 ; ENSMUSP00000081560 ; ENSMUSG00000065954 . [Q6Y685-2 ]
GeneIDi 320165.
KEGGi mmu:320165.
UCSCi uc009lft.1. mouse. [Q6Y685-2 ]

Organism-specific databases

CTDi 6867.
MGIi MGI:2443510. Tacc1.

Phylogenomic databases

eggNOGi NOG83363.
GeneTreei ENSGT00530000063855.
HOGENOMi HOG000294120.
HOVERGENi HBG105967.
InParanoidi Q6Y685.
KOi K14281.
PhylomeDBi Q6Y685.

Miscellaneous databases

ChiTaRSi TACC1. mouse.
NextBioi 396157.
PROi Q6Y685.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6Y685.
Bgeei Q6Y685.
Genevestigatori Q6Y685.

Family and domain databases

InterProi IPR007707. TACC.
[Graphical view ]
PANTHERi PTHR13924. PTHR13924. 1 hit.
Pfami PF05010. TACC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms."
    Still I.H., Vettaikkorumakankauv A.K., DiMatteo A., Liang P.
    BMC Evol. Biol. 4:16-16(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-376, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTACC1_MOUSE
AccessioniPrimary (citable) accession number: Q6Y685
Secondary accession number(s): Q05A66, Q6Y686
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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