Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6Y5M7

- PMIP_COPSC

UniProt

Q6Y5M7 - PMIP_COPSC

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Coprinopsis scobicola (Ink cap fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi556 – 5561Zinc; catalyticPROSITE-ProRule annotation
    Active sitei557 – 5571PROSITE-ProRule annotation
    Metal bindingi560 – 5601Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi563 – 5631Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    Synonyms:MIP
    OrganismiCoprinopsis scobicola (Ink cap fungus)
    Taxonomic identifieri71696 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
    BLAST
    Chaini34 – 772739Mitochondrial intermediate peptidasePRO_0000343201Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6Y5M7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi485 – 4884Poly-Asp

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6Y5M7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLARPSTTVL ARRPFFRFRG CLNEPRPTKA RCLATAATHH QIPSTVDDKA    50
    LVDLFDQPSL SKVRSHFHST GLFGHPSLTH PRSLVSLAES TLVRAQLLTQ 100
    RILDAKESED ELAHVVKNLD RLSDMLCGVI DLAELVRNAH PDRLWVEAGN 150
    HAYETLCEFM NVLNTHTGLN DTLKTVLSNP TLVKSLDPEA YQTALIFSRD 200
    FEKSGIDLPP ATRNKFVSLS SDILILGRQF LENASTPRPP TSVKASELAG 250
    LKDKGMGVRL QLQAQFTNRD LQVYPGSLQA QMIMRAAPNE EPRRKLYLAA 300
    NSSTPEQIHV LETLLKKRAE LAQLVGRDSF AHMTLDDKMA KKPEHVTNFL 350
    DALIDHTRPF ARNALRTLAQ RKQAHHNLPA LPVIQAWDRD FYCPPDPPAP 400
    PIPLPPLTIG TVFMGLSRLF RHLYGVSLRP AQAASGEVWH PDVQKLEVVD 450
    EQQGIIGWIY ADLFPRRGKA SGAAHYTVRC SRRTDDDDEA NDGMFEGTEL 500
    QIQESQQFEA VKRHRLPNQE GVYQLPLVVL LTEFARPSLS KGAAVLEWHE 550
    VQTLFHEMGH AMHSMLGRTE YQNVSGTRCA TDFVELPSIL MEHFLNSPAV 600
    LSLFDADNTT SLRQIGNHHN DPCHAIDTYS QIMLAVVDQV YHSPSVLNSS 650
    FDSTNEFANL VNKRGLIPYV PGTSFQTQFG HLFGYGATYY SYLFDRAIAS 700
    RVWSKVFSRD PLNRELGEQY KQEVLRWGGA RDPWEMVSTL LDQPELAAGD 750
    AEAMREVGRW RIEDEVGNSG RH 772
    Length:772
    Mass (Da):86,698
    Last modified:July 5, 2004 - v1
    Checksum:i3ACB37CE292B2ED0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY179561 Genomic DNA. Translation: AAO61500.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY179561 Genomic DNA. Translation: AAO61500.1 .

    3D structure databases

    ProteinModelPortali Q6Y5M7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi."
      James T.Y., Kuees U., Rehner S.A., Vilgalys R.
      Fungal Genet. Biol. 41:381-390(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Cb.M8.

    Entry informationi

    Entry nameiPMIP_COPSC
    AccessioniPrimary (citable) accession number: Q6Y5M7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3