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Q6Y5M7

- PMIP_COPSC

UniProt

Q6Y5M7 - PMIP_COPSC

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Coprinopsis scobicola (Ink cap fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi556 – 5561Zinc; catalyticPROSITE-ProRule annotation
Active sitei557 – 5571PROSITE-ProRule annotation
Metal bindingi560 – 5601Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi563 – 5631Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:MIP
OrganismiCoprinopsis scobicola (Ink cap fungus)
Taxonomic identifieri71696 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
BLAST
Chaini34 – 772739Mitochondrial intermediate peptidasePRO_0000343201Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6Y5M7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi485 – 4884Poly-Asp

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Y5M7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLARPSTTVL ARRPFFRFRG CLNEPRPTKA RCLATAATHH QIPSTVDDKA
60 70 80 90 100
LVDLFDQPSL SKVRSHFHST GLFGHPSLTH PRSLVSLAES TLVRAQLLTQ
110 120 130 140 150
RILDAKESED ELAHVVKNLD RLSDMLCGVI DLAELVRNAH PDRLWVEAGN
160 170 180 190 200
HAYETLCEFM NVLNTHTGLN DTLKTVLSNP TLVKSLDPEA YQTALIFSRD
210 220 230 240 250
FEKSGIDLPP ATRNKFVSLS SDILILGRQF LENASTPRPP TSVKASELAG
260 270 280 290 300
LKDKGMGVRL QLQAQFTNRD LQVYPGSLQA QMIMRAAPNE EPRRKLYLAA
310 320 330 340 350
NSSTPEQIHV LETLLKKRAE LAQLVGRDSF AHMTLDDKMA KKPEHVTNFL
360 370 380 390 400
DALIDHTRPF ARNALRTLAQ RKQAHHNLPA LPVIQAWDRD FYCPPDPPAP
410 420 430 440 450
PIPLPPLTIG TVFMGLSRLF RHLYGVSLRP AQAASGEVWH PDVQKLEVVD
460 470 480 490 500
EQQGIIGWIY ADLFPRRGKA SGAAHYTVRC SRRTDDDDEA NDGMFEGTEL
510 520 530 540 550
QIQESQQFEA VKRHRLPNQE GVYQLPLVVL LTEFARPSLS KGAAVLEWHE
560 570 580 590 600
VQTLFHEMGH AMHSMLGRTE YQNVSGTRCA TDFVELPSIL MEHFLNSPAV
610 620 630 640 650
LSLFDADNTT SLRQIGNHHN DPCHAIDTYS QIMLAVVDQV YHSPSVLNSS
660 670 680 690 700
FDSTNEFANL VNKRGLIPYV PGTSFQTQFG HLFGYGATYY SYLFDRAIAS
710 720 730 740 750
RVWSKVFSRD PLNRELGEQY KQEVLRWGGA RDPWEMVSTL LDQPELAAGD
760 770
AEAMREVGRW RIEDEVGNSG RH
Length:772
Mass (Da):86,698
Last modified:July 5, 2004 - v1
Checksum:i3ACB37CE292B2ED0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179561 Genomic DNA. Translation: AAO61500.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179561 Genomic DNA. Translation: AAO61500.1 .

3D structure databases

ProteinModelPortali Q6Y5M7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi."
    James T.Y., Kuees U., Rehner S.A., Vilgalys R.
    Fungal Genet. Biol. 41:381-390(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Cb.M8.

Entry informationi

Entry nameiPMIP_COPSC
AccessioniPrimary (citable) accession number: Q6Y5M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3