Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Coprinopsis scobicola (Ink cap fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi556Zinc; catalyticPROSITE-ProRule annotation1
Active sitei557PROSITE-ProRule annotation1
Metal bindingi560Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi563Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:MIP
OrganismiCoprinopsis scobicola (Ink cap fungus)
Taxonomic identifieri71696 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionSequence analysisAdd BLAST33
ChainiPRO_000034320134 – 772Mitochondrial intermediate peptidaseAdd BLAST739

Structurei

3D structure databases

ProteinModelPortaliQ6Y5M7
SMRiQ6Y5M7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi485 – 488Poly-Asp4

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 1 hit
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Y5M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARPSTTVL ARRPFFRFRG CLNEPRPTKA RCLATAATHH QIPSTVDDKA
60 70 80 90 100
LVDLFDQPSL SKVRSHFHST GLFGHPSLTH PRSLVSLAES TLVRAQLLTQ
110 120 130 140 150
RILDAKESED ELAHVVKNLD RLSDMLCGVI DLAELVRNAH PDRLWVEAGN
160 170 180 190 200
HAYETLCEFM NVLNTHTGLN DTLKTVLSNP TLVKSLDPEA YQTALIFSRD
210 220 230 240 250
FEKSGIDLPP ATRNKFVSLS SDILILGRQF LENASTPRPP TSVKASELAG
260 270 280 290 300
LKDKGMGVRL QLQAQFTNRD LQVYPGSLQA QMIMRAAPNE EPRRKLYLAA
310 320 330 340 350
NSSTPEQIHV LETLLKKRAE LAQLVGRDSF AHMTLDDKMA KKPEHVTNFL
360 370 380 390 400
DALIDHTRPF ARNALRTLAQ RKQAHHNLPA LPVIQAWDRD FYCPPDPPAP
410 420 430 440 450
PIPLPPLTIG TVFMGLSRLF RHLYGVSLRP AQAASGEVWH PDVQKLEVVD
460 470 480 490 500
EQQGIIGWIY ADLFPRRGKA SGAAHYTVRC SRRTDDDDEA NDGMFEGTEL
510 520 530 540 550
QIQESQQFEA VKRHRLPNQE GVYQLPLVVL LTEFARPSLS KGAAVLEWHE
560 570 580 590 600
VQTLFHEMGH AMHSMLGRTE YQNVSGTRCA TDFVELPSIL MEHFLNSPAV
610 620 630 640 650
LSLFDADNTT SLRQIGNHHN DPCHAIDTYS QIMLAVVDQV YHSPSVLNSS
660 670 680 690 700
FDSTNEFANL VNKRGLIPYV PGTSFQTQFG HLFGYGATYY SYLFDRAIAS
710 720 730 740 750
RVWSKVFSRD PLNRELGEQY KQEVLRWGGA RDPWEMVSTL LDQPELAAGD
760 770
AEAMREVGRW RIEDEVGNSG RH
Length:772
Mass (Da):86,698
Last modified:July 5, 2004 - v1
Checksum:i3ACB37CE292B2ED0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179561 Genomic DNA Translation: AAO61500.1

Similar proteinsi

Entry informationi

Entry nameiPMIP_COPSC
AccessioniPrimary (citable) accession number: Q6Y5M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health