Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6Y5M6

- PMIP_COPDI

UniProt

Q6Y5M6 - PMIP_COPDI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Coprinellus disseminatus (Fairy ink cap fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi557 – 5571Zinc; catalyticPROSITE-ProRule annotation
Active sitei558 – 5581PROSITE-ProRule annotation
Metal bindingi561 – 5611Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi564 – 5641Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:MIP
OrganismiCoprinellus disseminatus (Fairy ink cap fungus)
Taxonomic identifieri71703 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinellus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535MitochondrionSequence AnalysisAdd
BLAST
Chaini36 – 773738Mitochondrial intermediate peptidasePRO_0000343200Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6Y5M6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi486 – 4894Poly-Asp

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Y5M6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGRAACKVL HRHALKNPYR FRGCLVAQKE TTRQLATHVQ HHLPASADDR
60 70 80 90 100
LLVDLFDQPG ASTSKSSFAS TGLFGHPTLT HPGALISLAE ATLVRAQLLT
110 120 130 140 150
ERILRARESR DELVKVVKNL DRLSDMLCGV IDLAELVRNA HPERLWMEAA
160 170 180 190 200
NHAYETLCEF MNVLNTHVGL YEVLKVVLSD PSIVKTLSPE AYQTALIFWR
210 220 230 240 250
DFEKSAIDLP PAERQKFVSL SSDILSLGRQ FLENANTPRP PTSIKASHLA
260 270 280 290 300
GLKDQGMGVR LQLQARFTKK DLQVYPGSLQ AQMIMRSAPE EEPRRRIYIA
310 320 330 340 350
SNSSTPEQIS VLEALLRKRA ELAQLIGRPS FAHLTLDDKM AKTPENVSNF
360 370 380 390 400
LDALMDHTRP FARRALHTLA QRKQAHHNLP SLPVVQAWDR DFYCPPDPPA
410 420 430 440 450
PPIPLPPLTL GTVFMGLSRL FRHLYGVSLR PAKSASGETW HADVQKLEVV
460 470 480 490 500
DENQGIIGWI YADLFARRNK ASGAAHYTVR CSRRADDDDE AGDLTLEGEG
510 520 530 540 550
HRIQESQAFE SVKRHRLPNQ DGVYQLPLVV LLTEFARPSI SRGPTVLEWY
560 570 580 590 600
EVLTLFHEMG HAMHSMLGRT EYQNVSGTRC ATDFVELPSI LMEHFLNSPT
610 620 630 640 650
VLSLFDADST TTLRATGNNH ADPCHSIDTY SQILLAAVDQ RYHSPSALDP
660 670 680 690 700
SFDSTAELAN LHNTRGLMPY VPETSFQTQF GHLFGYGATY YSYLFDRAIA
710 720 730 740 750
SRVWSKVFAE NPLDRSRGER LRGEVLMHGG ARDPWHMVSA LMKMPELESG
760 770
DAEAMREVGK WRIEDEVGIS GRH
Length:773
Mass (Da):86,682
Last modified:July 5, 2004 - v1
Checksum:iFA780288468F285A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY179562 Genomic DNA. Translation: AAO61501.1.
DQ056143 Genomic DNA. Translation: AAZ14915.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY179562 Genomic DNA. Translation: AAO61501.1 .
DQ056143 Genomic DNA. Translation: AAZ14915.1 .

3D structure databases

ProteinModelPortali Q6Y5M6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi."
    James T.Y., Kuees U., Rehner S.A., Vilgalys R.
    Fungal Genet. Biol. 41:381-390(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C345.1.
  2. "Evolution of the bipolar mating system of the mushroom Coprinellus disseminatus from its tetrapolar ancestors involves loss of mating-type-specific pheromone receptor function."
    James T.Y., Srivilai P., Kuees U., Vilgalys R.
    Genetics 172:1877-1891(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C345.1.

Entry informationi

Entry nameiPMIP_COPDI
AccessioniPrimary (citable) accession number: Q6Y5M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3