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Q6Y5M6

- PMIP_COPDI

UniProt

Q6Y5M6 - PMIP_COPDI

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Coprinellus disseminatus (Fairy ink cap fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi557 – 5571Zinc; catalyticPROSITE-ProRule annotation
    Active sitei558 – 5581PROSITE-ProRule annotation
    Metal bindingi561 – 5611Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi564 – 5641Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    Synonyms:MIP
    OrganismiCoprinellus disseminatus (Fairy ink cap fungus)
    Taxonomic identifieri71703 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinellus

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3535MitochondrionSequence AnalysisAdd
    BLAST
    Chaini36 – 773738Mitochondrial intermediate peptidasePRO_0000343200Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6Y5M6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi486 – 4894Poly-Asp

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6Y5M6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGRAACKVL HRHALKNPYR FRGCLVAQKE TTRQLATHVQ HHLPASADDR    50
    LLVDLFDQPG ASTSKSSFAS TGLFGHPTLT HPGALISLAE ATLVRAQLLT 100
    ERILRARESR DELVKVVKNL DRLSDMLCGV IDLAELVRNA HPERLWMEAA 150
    NHAYETLCEF MNVLNTHVGL YEVLKVVLSD PSIVKTLSPE AYQTALIFWR 200
    DFEKSAIDLP PAERQKFVSL SSDILSLGRQ FLENANTPRP PTSIKASHLA 250
    GLKDQGMGVR LQLQARFTKK DLQVYPGSLQ AQMIMRSAPE EEPRRRIYIA 300
    SNSSTPEQIS VLEALLRKRA ELAQLIGRPS FAHLTLDDKM AKTPENVSNF 350
    LDALMDHTRP FARRALHTLA QRKQAHHNLP SLPVVQAWDR DFYCPPDPPA 400
    PPIPLPPLTL GTVFMGLSRL FRHLYGVSLR PAKSASGETW HADVQKLEVV 450
    DENQGIIGWI YADLFARRNK ASGAAHYTVR CSRRADDDDE AGDLTLEGEG 500
    HRIQESQAFE SVKRHRLPNQ DGVYQLPLVV LLTEFARPSI SRGPTVLEWY 550
    EVLTLFHEMG HAMHSMLGRT EYQNVSGTRC ATDFVELPSI LMEHFLNSPT 600
    VLSLFDADST TTLRATGNNH ADPCHSIDTY SQILLAAVDQ RYHSPSALDP 650
    SFDSTAELAN LHNTRGLMPY VPETSFQTQF GHLFGYGATY YSYLFDRAIA 700
    SRVWSKVFAE NPLDRSRGER LRGEVLMHGG ARDPWHMVSA LMKMPELESG 750
    DAEAMREVGK WRIEDEVGIS GRH 773
    Length:773
    Mass (Da):86,682
    Last modified:July 5, 2004 - v1
    Checksum:iFA780288468F285A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY179562 Genomic DNA. Translation: AAO61501.1.
    DQ056143 Genomic DNA. Translation: AAZ14915.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY179562 Genomic DNA. Translation: AAO61501.1 .
    DQ056143 Genomic DNA. Translation: AAZ14915.1 .

    3D structure databases

    ProteinModelPortali Q6Y5M6.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi."
      James T.Y., Kuees U., Rehner S.A., Vilgalys R.
      Fungal Genet. Biol. 41:381-390(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C345.1.
    2. "Evolution of the bipolar mating system of the mushroom Coprinellus disseminatus from its tetrapolar ancestors involves loss of mating-type-specific pheromone receptor function."
      James T.Y., Srivilai P., Kuees U., Vilgalys R.
      Genetics 172:1877-1891(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C345.1.

    Entry informationi

    Entry nameiPMIP_COPDI
    AccessioniPrimary (citable) accession number: Q6Y5M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3