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Q6Y5M6

- PMIP_COPDI

UniProt

Q6Y5M6 - PMIP_COPDI

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Protein

Mitochondrial intermediate peptidase

Gene
OCT1, MIP
Organism
Coprinellus disseminatus (Fairy ink cap fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi557 – 5571Zinc; catalytic By similarity
Active sitei558 – 5581 By similarity
Metal bindingi561 – 5611Zinc; catalytic By similarity
Metal bindingi564 – 5641Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:MIP
OrganismiCoprinellus disseminatus (Fairy ink cap fungus)
Taxonomic identifieri71703 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinellus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535Mitochondrion Reviewed predictionAdd
BLAST
Chaini36 – 773738Mitochondrial intermediate peptidasePRO_0000343200Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6Y5M6.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi486 – 4894Poly-Asp

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Y5M6-1 [UniParc]FASTAAdd to Basket

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MLGRAACKVL HRHALKNPYR FRGCLVAQKE TTRQLATHVQ HHLPASADDR    50
LLVDLFDQPG ASTSKSSFAS TGLFGHPTLT HPGALISLAE ATLVRAQLLT 100
ERILRARESR DELVKVVKNL DRLSDMLCGV IDLAELVRNA HPERLWMEAA 150
NHAYETLCEF MNVLNTHVGL YEVLKVVLSD PSIVKTLSPE AYQTALIFWR 200
DFEKSAIDLP PAERQKFVSL SSDILSLGRQ FLENANTPRP PTSIKASHLA 250
GLKDQGMGVR LQLQARFTKK DLQVYPGSLQ AQMIMRSAPE EEPRRRIYIA 300
SNSSTPEQIS VLEALLRKRA ELAQLIGRPS FAHLTLDDKM AKTPENVSNF 350
LDALMDHTRP FARRALHTLA QRKQAHHNLP SLPVVQAWDR DFYCPPDPPA 400
PPIPLPPLTL GTVFMGLSRL FRHLYGVSLR PAKSASGETW HADVQKLEVV 450
DENQGIIGWI YADLFARRNK ASGAAHYTVR CSRRADDDDE AGDLTLEGEG 500
HRIQESQAFE SVKRHRLPNQ DGVYQLPLVV LLTEFARPSI SRGPTVLEWY 550
EVLTLFHEMG HAMHSMLGRT EYQNVSGTRC ATDFVELPSI LMEHFLNSPT 600
VLSLFDADST TTLRATGNNH ADPCHSIDTY SQILLAAVDQ RYHSPSALDP 650
SFDSTAELAN LHNTRGLMPY VPETSFQTQF GHLFGYGATY YSYLFDRAIA 700
SRVWSKVFAE NPLDRSRGER LRGEVLMHGG ARDPWHMVSA LMKMPELESG 750
DAEAMREVGK WRIEDEVGIS GRH 773
Length:773
Mass (Da):86,682
Last modified:July 5, 2004 - v1
Checksum:iFA780288468F285A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY179562 Genomic DNA. Translation: AAO61501.1.
DQ056143 Genomic DNA. Translation: AAZ14915.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY179562 Genomic DNA. Translation: AAO61501.1 .
DQ056143 Genomic DNA. Translation: AAZ14915.1 .

3D structure databases

ProteinModelPortali Q6Y5M6.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi."
    James T.Y., Kuees U., Rehner S.A., Vilgalys R.
    Fungal Genet. Biol. 41:381-390(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C345.1.
  2. "Evolution of the bipolar mating system of the mushroom Coprinellus disseminatus from its tetrapolar ancestors involves loss of mating-type-specific pheromone receptor function."
    James T.Y., Srivilai P., Kuees U., Vilgalys R.
    Genetics 172:1877-1891(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C345.1.

Entry informationi

Entry nameiPMIP_COPDI
AccessioniPrimary (citable) accession number: Q6Y5M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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