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Q6Y5M5

- PMIP_PLEDJ

UniProt

Q6Y5M5 - PMIP_PLEDJ

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Protein

Mitochondrial intermediate peptidase

Gene
OCT1, MIP
Organism
Pleurotus djamor (Pink oyster mushroom)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi567 – 5671Zinc; catalytic By similarity
Active sitei568 – 5681 By similarity
Metal bindingi571 – 5711Zinc; catalytic By similarity
Metal bindingi574 – 5741Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:MIP
OrganismiPleurotus djamor (Pink oyster mushroom)
Taxonomic identifieri34470 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPleurotaceaePleurotus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343Mitochondrion Reviewed predictionAdd
BLAST
Chaini44 – 785742Mitochondrial intermediate peptidasePRO_0000343203Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6Y5M5.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi390 – 41728Pro-richAdd
BLAST
Compositional biasi496 – 4994Poly-Asp

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Y5M5-1 [UniParc]FASTAAdd to Basket

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MLTRPAQNAL LKSMQPLFRF RGCLLAKSTS TPRRDISTSS RKLAHPTTVP    50
IPPSVDDHAL VALLDQPSSF GIVSRLFQTQ GGLFGHKELQ QPSGFITLAE 100
ATLVRAQILT NRILRARESQ DELRKVVKNL DRLSDMLCGV IDLAELVRNA 150
HPDRAWVEAA NQAYETLCEF MNVLNTDVGL YDVLKAVLSD PTIVQGMGPE 200
EYSTAQIFWH DFEKSAINLP PEQRQRFVSL SSEILVLGRE FLQEANTARP 250
PASIHASELA GLKDKGMGAR LQLQAQFTQK DLLVYPGSLQ AQMIMRCAPA 300
EEPRRKLYIA ANSSTPSQIE LLERLLRTRA ELARLVGKES FAHMTLSDKM 350
AKSPENVQYF LDALMDYTRP YARKALRTLS MRKQAHLQTP PFPTIQPWDR 400
DFYCPPEPPA PPIPLPPLTL GTVFAGLSRL FYHLYGISLR PAECAPGEVW 450
HPHVHKLEVV DEDAGVIGWI YADLFARRGK PSGAAHYTVR CSRRTDDDDE 500
AEDGSIPAAE PYVRVSQSFE SSKRHRVRGQ DGEFQLPLVV LVCEFARPSV 550
SSGPTVLDWH EVMTLFHEMG HAMHSMIGRT EYQNVSGTRC ATDFVELPSI 600
LMEHFLSSPT VLSLFDVSSS TPSSAWQVGN HHQDPCHSID THSQILLAAM 650
DQIYHSPSVV DPSFSSTSAL EALHKSRGLI PYVPGTSFQT QFGHLFGYGA 700
TYYSYLFDRA IASRVWSQVF HANPLNRELG DKYKREVLKF GGGRDPWKMI 750
SHLLDSPWLE NGNADAMKEV GQWRIEDEVG QPGRH 785
Length:785
Mass (Da):87,896
Last modified:July 5, 2004 - v1
Checksum:i04FE374000BCB84C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY179563 Genomic DNA. Translation: AAO61502.1.
AY462111 Genomic DNA. Translation: AAS46738.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY179563 Genomic DNA. Translation: AAO61502.1 .
AY462111 Genomic DNA. Translation: AAS46738.1 .

3D structure databases

ProteinModelPortali Q6Y5M5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi."
    James T.Y., Kuees U., Rehner S.A., Vilgalys R.
    Fungal Genet. Biol. 41:381-390(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RV95/957.30.
  2. "The genetic structure and diversity of the A and B mating-type genes from the tropical oyster mushroom, Pleurotus djamor."
    James T.Y., Liou S.-R., Vilgalys R.
    Fungal Genet. Biol. 41:813-825(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RV95/957.30.

Entry informationi

Entry nameiPMIP_PLEDJ
AccessioniPrimary (citable) accession number: Q6Y5M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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