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Q6Y5M5

- PMIP_PLEDJ

UniProt

Q6Y5M5 - PMIP_PLEDJ

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Pleurotus djamor (Pink oyster mushroom)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi567 – 5671Zinc; catalyticPROSITE-ProRule annotation
    Active sitei568 – 5681PROSITE-ProRule annotation
    Metal bindingi571 – 5711Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi574 – 5741Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    Synonyms:MIP
    OrganismiPleurotus djamor (Pink oyster mushroom)
    Taxonomic identifieri34470 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPleurotaceaePleurotus

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4343MitochondrionSequence AnalysisAdd
    BLAST
    Chaini44 – 785742Mitochondrial intermediate peptidasePRO_0000343203Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6Y5M5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi390 – 41728Pro-richAdd
    BLAST
    Compositional biasi496 – 4994Poly-Asp

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6Y5M5-1 [UniParc]FASTAAdd to Basket

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    MLTRPAQNAL LKSMQPLFRF RGCLLAKSTS TPRRDISTSS RKLAHPTTVP    50
    IPPSVDDHAL VALLDQPSSF GIVSRLFQTQ GGLFGHKELQ QPSGFITLAE 100
    ATLVRAQILT NRILRARESQ DELRKVVKNL DRLSDMLCGV IDLAELVRNA 150
    HPDRAWVEAA NQAYETLCEF MNVLNTDVGL YDVLKAVLSD PTIVQGMGPE 200
    EYSTAQIFWH DFEKSAINLP PEQRQRFVSL SSEILVLGRE FLQEANTARP 250
    PASIHASELA GLKDKGMGAR LQLQAQFTQK DLLVYPGSLQ AQMIMRCAPA 300
    EEPRRKLYIA ANSSTPSQIE LLERLLRTRA ELARLVGKES FAHMTLSDKM 350
    AKSPENVQYF LDALMDYTRP YARKALRTLS MRKQAHLQTP PFPTIQPWDR 400
    DFYCPPEPPA PPIPLPPLTL GTVFAGLSRL FYHLYGISLR PAECAPGEVW 450
    HPHVHKLEVV DEDAGVIGWI YADLFARRGK PSGAAHYTVR CSRRTDDDDE 500
    AEDGSIPAAE PYVRVSQSFE SSKRHRVRGQ DGEFQLPLVV LVCEFARPSV 550
    SSGPTVLDWH EVMTLFHEMG HAMHSMIGRT EYQNVSGTRC ATDFVELPSI 600
    LMEHFLSSPT VLSLFDVSSS TPSSAWQVGN HHQDPCHSID THSQILLAAM 650
    DQIYHSPSVV DPSFSSTSAL EALHKSRGLI PYVPGTSFQT QFGHLFGYGA 700
    TYYSYLFDRA IASRVWSQVF HANPLNRELG DKYKREVLKF GGGRDPWKMI 750
    SHLLDSPWLE NGNADAMKEV GQWRIEDEVG QPGRH 785
    Length:785
    Mass (Da):87,896
    Last modified:July 5, 2004 - v1
    Checksum:i04FE374000BCB84C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY179563 Genomic DNA. Translation: AAO61502.1.
    AY462111 Genomic DNA. Translation: AAS46738.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY179563 Genomic DNA. Translation: AAO61502.1 .
    AY462111 Genomic DNA. Translation: AAS46738.1 .

    3D structure databases

    ProteinModelPortali Q6Y5M5.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi."
      James T.Y., Kuees U., Rehner S.A., Vilgalys R.
      Fungal Genet. Biol. 41:381-390(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: RV95/957.30.
    2. "The genetic structure and diversity of the A and B mating-type genes from the tropical oyster mushroom, Pleurotus djamor."
      James T.Y., Liou S.-R., Vilgalys R.
      Fungal Genet. Biol. 41:813-825(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: RV95/957.30.

    Entry informationi

    Entry nameiPMIP_PLEDJ
    AccessioniPrimary (citable) accession number: Q6Y5M5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3