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Q6Y5M5

- PMIP_PLEDJ

UniProt

Q6Y5M5 - PMIP_PLEDJ

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Pleurotus djamor (Pink oyster mushroom)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi567 – 5671Zinc; catalyticPROSITE-ProRule annotation
Active sitei568 – 5681PROSITE-ProRule annotation
Metal bindingi571 – 5711Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi574 – 5741Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:MIP
OrganismiPleurotus djamor (Pink oyster mushroom)
Taxonomic identifieri34470 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPleurotaceaePleurotus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343MitochondrionSequence AnalysisAdd
BLAST
Chaini44 – 785742Mitochondrial intermediate peptidasePRO_0000343203Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6Y5M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi390 – 41728Pro-richAdd
BLAST
Compositional biasi496 – 4994Poly-Asp

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Y5M5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTRPAQNAL LKSMQPLFRF RGCLLAKSTS TPRRDISTSS RKLAHPTTVP
60 70 80 90 100
IPPSVDDHAL VALLDQPSSF GIVSRLFQTQ GGLFGHKELQ QPSGFITLAE
110 120 130 140 150
ATLVRAQILT NRILRARESQ DELRKVVKNL DRLSDMLCGV IDLAELVRNA
160 170 180 190 200
HPDRAWVEAA NQAYETLCEF MNVLNTDVGL YDVLKAVLSD PTIVQGMGPE
210 220 230 240 250
EYSTAQIFWH DFEKSAINLP PEQRQRFVSL SSEILVLGRE FLQEANTARP
260 270 280 290 300
PASIHASELA GLKDKGMGAR LQLQAQFTQK DLLVYPGSLQ AQMIMRCAPA
310 320 330 340 350
EEPRRKLYIA ANSSTPSQIE LLERLLRTRA ELARLVGKES FAHMTLSDKM
360 370 380 390 400
AKSPENVQYF LDALMDYTRP YARKALRTLS MRKQAHLQTP PFPTIQPWDR
410 420 430 440 450
DFYCPPEPPA PPIPLPPLTL GTVFAGLSRL FYHLYGISLR PAECAPGEVW
460 470 480 490 500
HPHVHKLEVV DEDAGVIGWI YADLFARRGK PSGAAHYTVR CSRRTDDDDE
510 520 530 540 550
AEDGSIPAAE PYVRVSQSFE SSKRHRVRGQ DGEFQLPLVV LVCEFARPSV
560 570 580 590 600
SSGPTVLDWH EVMTLFHEMG HAMHSMIGRT EYQNVSGTRC ATDFVELPSI
610 620 630 640 650
LMEHFLSSPT VLSLFDVSSS TPSSAWQVGN HHQDPCHSID THSQILLAAM
660 670 680 690 700
DQIYHSPSVV DPSFSSTSAL EALHKSRGLI PYVPGTSFQT QFGHLFGYGA
710 720 730 740 750
TYYSYLFDRA IASRVWSQVF HANPLNRELG DKYKREVLKF GGGRDPWKMI
760 770 780
SHLLDSPWLE NGNADAMKEV GQWRIEDEVG QPGRH
Length:785
Mass (Da):87,896
Last modified:July 5, 2004 - v1
Checksum:i04FE374000BCB84C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179563 Genomic DNA. Translation: AAO61502.1.
AY462111 Genomic DNA. Translation: AAS46738.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179563 Genomic DNA. Translation: AAO61502.1 .
AY462111 Genomic DNA. Translation: AAS46738.1 .

3D structure databases

ProteinModelPortali Q6Y5M5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M03.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi."
    James T.Y., Kuees U., Rehner S.A., Vilgalys R.
    Fungal Genet. Biol. 41:381-390(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RV95/957.30.
  2. "The genetic structure and diversity of the A and B mating-type genes from the tropical oyster mushroom, Pleurotus djamor."
    James T.Y., Liou S.-R., Vilgalys R.
    Fungal Genet. Biol. 41:813-825(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RV95/957.30.

Entry informationi

Entry nameiPMIP_PLEDJ
AccessioniPrimary (citable) accession number: Q6Y5M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3