SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6Y4S4

- KISS1_MOUSE

UniProt

Q6Y4S4 - KISS1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Metastasis-suppressor KiSS-1
Gene
Kiss1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals.4 Publications

GO - Biological processi

  1. generation of ovulation cycle rhythm Source: Ensembl
  2. negative regulation of cell proliferation Source: Ensembl
  3. positive regulation of MAPK cascade Source: Ensembl
  4. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  5. positive regulation of growth hormone secretion Source: Ensembl
  6. positive regulation of luteinizing hormone secretion Source: Ensembl
  7. positive regulation of synaptic transmission Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-suppressor KiSS-1
Alternative name(s):
Kisspeptin-1
Cleaved into the following 2 chains:
Alternative name(s):
Kisspeptin-52
Alternative name(s):
Metastin45-54
Gene namesi
Name:Kiss1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2663985. Kiss1.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. extracellular space Source: Ensembl
  4. neuron projection Source: Ensembl
  5. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Animals are viable and healthy with no apparent abnormalities but fail to undergo sexual maturation. Mutant female do not progress through the estrous cycle, have thread-like uteri and small ovaries, and do not produce mature Graffian follicles. Mutant males have small testes, and spermatogenesis arrested mainly at the early haploid spermatid stage. Both sexes have low circulating gonadotropin (LH and FSH) and sex steroid (beta-estradiol or testosterone) hormone levels. Migration of GnRH neurons into the hypothalamus appears normal with appropriate axonal connections to the median eminence and total GnRH content. The hypothalamic-pituitary axis is functional, as shown by robust LH secretion after peripheral administration of kisspeptin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 130111Metastasis-suppressor KiSS-1
PRO_0000021552Add
BLAST
Peptidei68 – 11952Metastin
PRO_0000021553Add
BLAST
Peptidei110 – 11910Kisspeptin-10
PRO_0000021554

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 85 Reviewed prediction
Modified residuei110 – 1101Phosphotyrosine By similarity
Modified residuei119 – 1191Tyrosine amide By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiQ6Y4S4.

PTM databases

PhosphoSiteiQ6Y4S4.

Expressioni

Tissue specificityi

Weak in all tissue types with highest levels in lung and 15- 17-day embryos. Expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, including the anteroventral periventricular nucleus, the periventricular nucleus, and the arcuate nucleus.2 Publications

Gene expression databases

BgeeiQ6Y4S4.
GenevestigatoriQ6Y4S4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 11910Essential for receptor binding and receptor activation

Sequence similaritiesi

Belongs to the KISS1 family.

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000008827.
HOVERGENiHBG052261.
OMAiHYITRIH.
OrthoDBiEOG79GT8B.
TreeFamiTF338233.

Family and domain databases

InterProiIPR020207. Metastasis-suppressor_KiSS-1.
[Graphical view]
PfamiPF15152. Kisspeptin. 1 hit.
[Graphical view]
ProDomiPD088121. Metastasis-suppressor_KiSS-1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6Y4S4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MISMASWQLL LLLCVATYGE PLAKVAPLVK PGSTGQQSGP QELVNAWEKE    50
SRYAESKPGS AGLRARRSSP CPPVEGPAGR QRPLCASRSR LIPAPRGAVL 100
VQREKDLSTY NWNSFGLRYG RRQAARAARG 130
Length:130
Mass (Da):14,117
Last modified:March 1, 2005 - v2
Checksum:iAC9D30CF84B4F41B
GO
Isoform 2 (identifier: Q6Y4S4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-28: Missing.

Show »
Length:126
Mass (Da):13,737
Checksum:iA71956212746F37A
GO

Sequence cautioni

The sequence AAO64981.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 284Missing in isoform 2.
VSP_012957

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF472576 mRNA. Translation: AAP13356.1.
AY182231 mRNA. Translation: AAO64981.1. Different initiation.
AB162440 mRNA. Translation: BAD36756.1.
AY707858 mRNA. Translation: AAW34131.1.
BC117046 mRNA. Translation: AAI17047.1.
BC119348 mRNA. Translation: AAI19349.1.
CCDSiCCDS48362.1. [Q6Y4S4-2]
RefSeqiNP_839991.2. NM_178260.3. [Q6Y4S4-2]
XP_006497355.1. XM_006497292.1.
XP_006497356.1. XM_006497293.1. [Q6Y4S4-1]
UniGeneiMm.458301.

Genome annotation databases

EnsembliENSMUST00000007433; ENSMUSP00000007433; ENSMUSG00000091251. [Q6Y4S4-2]
ENSMUST00000178033; ENSMUSP00000136746; ENSMUSG00000091251. [Q6Y4S4-2]
ENSMUST00000183738; ENSMUSP00000138976; ENSMUSG00000091251. [Q6Y4S4-2]
ENSMUST00000185157; ENSMUSP00000139313; ENSMUSG00000091251. [Q6Y4S4-2]
GeneIDi280287.
KEGGimmu:280287.
UCSCiuc007cqd.1. mouse. [Q6Y4S4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF472576 mRNA. Translation: AAP13356.1 .
AY182231 mRNA. Translation: AAO64981.1 . Different initiation.
AB162440 mRNA. Translation: BAD36756.1 .
AY707858 mRNA. Translation: AAW34131.1 .
BC117046 mRNA. Translation: AAI17047.1 .
BC119348 mRNA. Translation: AAI19349.1 .
CCDSi CCDS48362.1. [Q6Y4S4-2 ]
RefSeqi NP_839991.2. NM_178260.3. [Q6Y4S4-2 ]
XP_006497355.1. XM_006497292.1.
XP_006497356.1. XM_006497293.1. [Q6Y4S4-1 ]
UniGenei Mm.458301.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6Y4S4.

Proteomic databases

PRIDEi Q6Y4S4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007433 ; ENSMUSP00000007433 ; ENSMUSG00000091251 . [Q6Y4S4-2 ]
ENSMUST00000178033 ; ENSMUSP00000136746 ; ENSMUSG00000091251 . [Q6Y4S4-2 ]
ENSMUST00000183738 ; ENSMUSP00000138976 ; ENSMUSG00000091251 . [Q6Y4S4-2 ]
ENSMUST00000185157 ; ENSMUSP00000139313 ; ENSMUSG00000091251 . [Q6Y4S4-2 ]
GeneIDi 280287.
KEGGi mmu:280287.
UCSCi uc007cqd.1. mouse. [Q6Y4S4-2 ]

Organism-specific databases

CTDi 3814.
MGIi MGI:2663985. Kiss1.

Phylogenomic databases

GeneTreei ENSGT00390000008827.
HOVERGENi HBG052261.
OMAi HYITRIH.
OrthoDBi EOG79GT8B.
TreeFami TF338233.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 394046.
PROi Q6Y4S4.
SOURCEi Search...

Gene expression databases

Bgeei Q6Y4S4.
Genevestigatori Q6Y4S4.

Family and domain databases

InterProi IPR020207. Metastasis-suppressor_KiSS-1.
[Graphical view ]
Pfami PF15152. Kisspeptin. 1 hit.
[Graphical view ]
ProDomi PD088121. Metastasis-suppressor_KiSS-1. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor."
    Stafford L.J., Xia C., Ma W., Cai Y., Liu M.
    Cancer Res. 62:5399-5404(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, TISSUE SPECIFICITY.
    Strain: 129S6/SvEvTac.
    Tissue: Brain.
  2. "Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta."
    Terao Y., Kumano S., Takatsu Y., Hattori M., Nishimura A., Ohtaki T., Shintani Y.
    Biochim. Biophys. Acta 1678:102-110(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Embryo.
  3. "Identification and characterization of metastin in the mouse spinal cord."
    Ohsawa M., Chi M., Ohtsubo Y., Brailoiu G.C., Yang J., Chang J., Dun N.J.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: ICR.
    Tissue: Brain.
  4. "The genesis of the human KISS1."
    Xie H., Bonaldo M.F., Soares M.B.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Placenta.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: TISSUE SPECIFICITY, ROLE IN THE REGULATION OF GONADOTROPIN SECRETION.
  7. "Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat."
    Irwig M.S., Fraley G.S., Smith J.T., Acohido B.V., Popa S.M., Cunningham M.J., Gottsch M.L., Clifton D.K., Steiner R.A.
    Neuroendocrinology 80:264-272(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN REGULATION OF GONADOTROPIN SECRETION.
  8. "Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54."
    Navarro V.M., Fernandez-Fernandez R., Castellano J.M., Roa J., Mayen A., Barreiro M.L., Gaytan F., Aguilar E., Pinilla L., Dieguez C., Tena-Sempere M.
    J. Physiol. (Lond.) 561:379-386(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54."
    Navarro V.M., Castellano J.M., Fernandez-Fernandez R., Tovar S., Roa J., Mayen A., Nogueiras R., Vazquez M.J., Barreiro M.L., Magni P., Aguilar E., Dieguez C., Pinilla L., Tena-Sempere M.
    Endocrinology 146:156-163(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE IN LUTEINIZING HORMONE SECRETION.
  10. Cited for: DIRECT STIMULATION OF GONADOTROPIN-RELEASING HORMONE RELEASE.
  11. "Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat."
    Navarro V.M., Castellano J.M., Fernandez-Fernandez R., Tovar S., Roa J., Mayen A., Barreiro M.L., Casanueva F.F., Aguilar E., Dieguez C., Pinilla L., Tena-Sempere M.
    Endocrinology 146:1689-1697(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE IN FOLLICLE-STIMULATING HORMONE SECRETION.
  12. Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiKISS1_MOUSE
AccessioniPrimary (citable) accession number: Q6Y4S4
Secondary accession number(s): Q149Z8, Q68Y93, Q80XF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: September 3, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi