Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Multidrug resistance-associated protein 9

Gene

Abcc12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transporter.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi514 – 5218ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1161 – 11688ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 9
Alternative name(s):
ATP-binding cassette sub-family C member 12
Gene namesi
Name:Abcc12
Synonyms:Mrp9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735100. Abcc12.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei125 – 14521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei160 – 18021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei235 – 25521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei257 – 27721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei349 – 36921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei377 – 39721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei788 – 80821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei850 – 87021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei943 – 96321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1038 – 105821HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13661366Multidrug resistance-associated protein 9PRO_0000253580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence analysis
Glycosylationi837 – 8371N-linked (GlcNAc...)Sequence analysis
Glycosylationi978 – 9781N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6Y306.
PRIDEiQ6Y306.

PTM databases

iPTMnetiQ6Y306.
PhosphoSiteiQ6Y306.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021095.

Structurei

3D structure databases

ProteinModelPortaliQ6Y306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 404282ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini478 – 702225ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini792 – 1089298ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1127 – 1361235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.
InParanoidiQ6Y306.
KOiK05672.
PhylomeDBiQ6Y306.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030250. MRP9.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF10. PTHR24223:SF10. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6Y306-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGEDPYLIS DLDRRGRRRS FAERYDPSLK TMIPMRPYAR LAPNPVDDAG
60 70 80 90 100
LLSFATFSWL TPVMIRSYKH TLTVDTLPPL SPYDSSDVNA KRLQILWDEE
110 120 130 140 150
IERVGPERAS LGRVVWKFQR TRVLMDVVAN ILCIIMAALG PTVLIHQILQ
160 170 180 190 200
HVTNISSGHI GISICLCLAL FATEFTKVLF RALAWAINYR TAIRLKVALS
210 220 230 240 250
TLIFKNLLSF KTLTHISAGE VLNVLSSDSY SLFEAALFCP LPATIPILMV
260 270 280 290 300
VCAVYAFFIL GSTALVGICV YLIFIPIQMF MAKLNSAFRR SAISVTDKRV
310 320 330 340 350
QTMNEFLTCI KLIKMYAWEK SFMNTIHDIR KREKKLLEKA GYVQSGNSAL
360 370 380 390 400
APIVSTIAIV STFTCHIFLK RTLTAPVAFS VIAMFNVMKF SIAILPFSVK
410 420 430 440 450
AVAEASVSLR RMKKILVAKS PPSYITQPED PDTILLLANA TLTWEQEINR
460 470 480 490 500
KRGPSKTQDQ RRHVFKKQRA ELYSEQSLSD QGVASPERQS GSPKSVLHNI
510 520 530 540 550
SFVVRKGKVL GICGNVGSGK SSLISALLGQ MQLQKGVVAA SGPLAYVSQQ
560 570 580 590 600
AWIFHGNVRE NILFGEKYNH QRYQHTVHVC GLQKDLNSLP YGDLTEIGER
610 620 630 640 650
GVNLSGGQRQ RISLARAVYA NRQLYLLDDP LSAVDAHVGK HVFEECIKKT
660 670 680 690 700
LKGKTVVLVT HQLQFLESCD EVILLEDGEI CEKGTHKELM EERGRYAKLI
710 720 730 740 750
HNLRGLQFKD PEHIYNVAMV ETLKESQAQR DEDAVLASGD ERDEGKEPET
760 770 780 790 800
EEFVDIKAPV HQLIQIESPQ EGIVTWKTYH TYIKASGGYL VSFLVLCLFF
810 820 830 840 850
LMMGSSAFST WWLGLWLDSG SQVICAPQSN ETACNVNQTL QDTKHHMYQL
860 870 880 890 900
VYIASMMSVL TFGIIKGFTF TNTTLMASSS LHNRVFNKIV SSPMSFFDTT
910 920 930 940 950
PTGRLMNRFS KDMDELDVRL PFHAENFLQQ FSMVVFILVI MAASFPVVLV
960 970 980 990 1000
VLAGLAILFF ILLRIFHRGV QELKQVENIS RSPWFSHITS SMQGLGVIHA
1010 1020 1030 1040 1050
YDKKDDCISK FKALNDENSS HLLYFNCALR WFALRMDILM NIVTFVVALL
1060 1070 1080 1090 1100
VTLSFSSISA SSKGLSLSYI IQLSGLLQVC VRTGTETQAK FTSAELMREY
1110 1120 1130 1140 1150
ISTCVPEHTQ SFKVGTCPKD WPSRGEITFK DYRMRYRDNT PLVLDGLNLN
1160 1170 1180 1190 1200
IQSGQTVGIV GRTGSGKSSL GMALFRLVEP ASGTIFIDEV DICTVGLEEL
1210 1220 1230 1240 1250
RTKLTMIPQD PVLFVGTVRY NLDPLGSHTD EMLWHVLERT FMRDTIMKLP
1260 1270 1280 1290 1300
EKLQAEVTEN GENFSVGERQ LLCMARALLR NSKIILLDEA TASMDSKTDT
1310 1320 1330 1340 1350
LVQSTIKEAF KSCTVLTIAH RLNTVLNCDL VLVMENGKVI EFDKPEVLAE
1360
KPDSAFAMLL AAEVGL
Length:1,366
Mass (Da):152,965
Last modified:July 5, 2004 - v1
Checksum:i632672C4565C5C15
GO
Isoform 2 (identifier: Q6Y306-2) [UniParc]FASTAAdd to basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     142-220: Missing.

Show »
Length:1,287
Mass (Da):144,217
Checksum:i575901DCCE720970
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 22079Missing in isoform 2. 1 PublicationVSP_021099Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY188179 mRNA. Translation: AAO74586.1.
AY188180 mRNA. Translation: AAO74587.1.
RefSeqiNP_955409.1. NM_199377.1. [Q6Y306-1]
UniGeneiRn.214958.

Genome annotation databases

GeneIDi291923.
KEGGirno:291923.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY188179 mRNA. Translation: AAO74586.1.
AY188180 mRNA. Translation: AAO74587.1.
RefSeqiNP_955409.1. NM_199377.1. [Q6Y306-1]
UniGeneiRn.214958.

3D structure databases

ProteinModelPortaliQ6Y306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021095.

PTM databases

iPTMnetiQ6Y306.
PhosphoSiteiQ6Y306.

Proteomic databases

PaxDbiQ6Y306.
PRIDEiQ6Y306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi291923.
KEGGirno:291923.

Organism-specific databases

CTDi94160.
RGDi735100. Abcc12.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.
InParanoidiQ6Y306.
KOiK05672.
PhylomeDBiQ6Y306.

Miscellaneous databases

PROiQ6Y306.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030250. MRP9.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF10. PTHR24223:SF10. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Shimizu H., Ishikawa T.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: Sprague-Dawley.
    Tissue: Testis.

Entry informationi

Entry nameiMRP9_RAT
AccessioniPrimary (citable) accession number: Q6Y306
Secondary accession number(s): Q6Y305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.