ID   DJC14_HUMAN             Reviewed;         702 AA.
AC   Q6Y2X3; Q17RY2; Q66K17; Q96N59; Q96T63;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 2.
DT   03-NOV-2009, entry version 52.
DE   RecName: Full=DnaJ homolog subfamily C member 14;
DE   AltName: Full=Dopamine receptor-interacting protein of 78 kDa;
DE            Short=DRiP78;
DE   AltName: Full=DnaJ protein homolog 3;
DE   AltName: Full=HDJ-3;
GN   Name=DNAJC14; Synonyms=DRIP78, HDJ3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Fetal brain;
RX   PubMed=12768437; DOI=10.1007/s10038-003-0012-8;
RA   Chen J., Huang Y., Wu H., Ni X., Cheng H., Fan J., Gu S., Gu X.,
RA   Cao G., Ying K., Mao Y., Lu Y., Xie Y.;
RT   "Molecular cloning and characterization of a novel human J-domain
RT   protein gene (HDJ3) from the fetal brain.";
RL   J. Hum. Genet. 48:217-221(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-702.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 490-702.
RX   MEDLINE=21231375; PubMed=11331877; DOI=10.1038/35074561;
RA   Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y.;
RT   "Regulation of transport of the dopamine D1 receptor by a new
RT   membrane-associated ER protein.";
RL   Nat. Cell Biol. 3:492-498(2001).
CC   -!- FUNCTION: Regulates the export of target proteins, such as DRD1,
CC       from the endoplasmic reticulum to the cell surface (By
CC       similarity).
CC   -!- SUBUNIT: Interacts with the FxxxFxxxF motif of DRD1 via its C-
CC       terminal domain (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- TISSUE SPECIFICITY: Highly expressed in pancreas and selectively
CC       expressed in brain, lung, liver, skeletal muscle and kidney.
CC   -!- SIMILARITY: Contains 1 J domain.
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DR   EMBL; AY188447; AAO73451.1; -; mRNA.
DR   EMBL; BC080655; AAH80655.1; -; mRNA.
DR   EMBL; BC117146; AAI17147.1; -; mRNA.
DR   EMBL; BC117148; AAI17149.1; -; mRNA.
DR   EMBL; AK055945; BAB71050.1; ALT_INIT; mRNA.
DR   EMBL; AF351784; AAK56241.1; -; mRNA.
DR   IPI; IPI00158847; -.
DR   RefSeq; NP_115740.5; -.
DR   UniGene; Hs.709320; -.
DR   HSSP; P25685; 1HDJ.
DR   STRING; Q6Y2X3; -.
DR   PRIDE; Q6Y2X3; -.
DR   Ensembl; ENST00000317269; ENSP00000316240; ENSG00000135392; Homo sapiens.
DR   Ensembl; ENST00000317287; ENSP00000317500; ENSG00000135392; Homo sapiens.
DR   Ensembl; ENST00000357606; ENSP00000350223; ENSG00000135392; Homo sapiens.
DR   GeneID; 85406; -.
DR   KEGG; hsa:85406; -.
DR   NMPDR; fig|9606.3.peg.7707; -.
DR   UCSC; uc001shx.1; human.
DR   CTD; 85406; -.
DR   GeneCards; GC12M054501; -.
DR   HGNC; HGNC:24581; DNAJC14.
DR   HPA; HPA017653; -.
DR   MIM; 606092; gene.
DR   PharmGKB; PA134940402; -.
DR   HOGENOM; Q6Y2X3; -.
DR   HOVERGEN; Q6Y2X3; -.
DR   OMA; WQQLVRI; -.
DR   NextBio; 75966; -.
DR   ArrayExpress; Q6Y2X3; -.
DR   Bgee; Q6Y2X3; -.
DR   CleanEx; HS_DNAJC14; -.
DR   Genevestigator; Q6Y2X3; -.
DR   GermOnline; ENSG00000135392; Homo sapiens.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001623; DnaJ_N.
DR   InterPro; IPR018253; Heat_shock_DnaJ_CS.
DR   InterPro; IPR015609; Hsp40/DnaJ_Rel.
DR   InterPro; IPR003095; Hsp_DnaJ.
DR   Gene3D; G3DSA:1.10.287.110; DnaJ_N; 1.
DR   PANTHER; PTHR11821; Hsp40/DnaJ_Rel; 1.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; DNAJPROTEIN.
DR   SMART; SM00271; DnaJ; 1.
DR   PROSITE; PS00636; DNAJ_1; FALSE_NEG.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Complete proteome; Endoplasmic reticulum; Membrane;
KW   Protein transport; Transmembrane; Transport.
FT   CHAIN         1    702       DnaJ homolog subfamily C member 14.
FT                                /FTId=PRO_0000247493.
FT   TRANSMEM    250    270       Potential.
FT   TRANSMEM    300    320       Potential.
FT   TRANSMEM    326    346       Potential.
FT   DOMAIN      443    507       J.
FT   COMPBIAS    673    676       Poly-Ala.
FT   CONFLICT    285    285       D -> N (in Ref. 1; AAO73451).
FT   CONFLICT    460    460       K -> R (in Ref. 1; AAO73451).
SQ   SEQUENCE   702 AA;  78569 MW;  DAECF48B7196C7F2 CRC64;
     MAQKHPGERG LYGAHHSGGA SLRTLGPSVD PEIPSFSGLR DSAGTAPNGT RCLTEHSGPK
     HTQHPNPAHW LDPSHGPPGG PGPPRDAEDP DQSETSSEEE SGVDQELSKE NETGNQKDGN
     SFLSIPSACN CQGTPGIPEG PYSEGGNGSS SNFCHHCTSP ALGEDELEEE YDDEESLKFP
     SDFSRVSSGK KPPSRRQRHR FPTKEDTREG GRRDPRSPGR HRLGRKRSQA DKRKGLGLWG
     AEELCQLGQA GFWWLIELLV LVGEYVETCG HLIYACRQLK SSDLDLFRVW MGVWTGRLGG
     WAQVMFQFLS QGFYCGVGLF TRFLKLLGAL LLLALALFLG FLQLGWRFLV GLGDRLGWRD
     KATWLFSWLD SPALQRCLTL LRDSRPWQRL VRIVQWGWLE LPWVKQNINR QGNAPVASGR
     YCQPEEEVAR LLTMAGVPED ELNPFHVLGV EATASDVELK KAYRQLAVMV HPDKNHHPRA
     EEAFKVLRAA WDIVSNAEKR KEYEMKRMAE NELSRSVNEF LSKLQDDLKE AMNTMMCSRC
     QGKHRRFEMD REPKSARYCA ECNRLHPAEE GDFWAESSML GLKITYFALM DGKVYDITEW
     AGCQRVGISP DTHRVPYHIS FGSRIPGTRG RQRATPDAPP ADLQDFLSRI FQVPPGQMPN
     GNFFAAPQPA PGAAAASKPN STVPKGEAKP KRRKKVRRPF QR
//