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Protein

DnaJ homolog subfamily C member 14

Gene

DNAJC14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 14
Alternative name(s):
DnaJ protein homolog 3
Dopamine receptor-interacting protein of 78 kDa
Short name:
DRIP78
Human DnaJ protein 3
Short name:
hDj-3
Gene namesi
Name:DNAJC14
Synonyms:DRIP78, HDJ3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24581. DNAJC14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence analysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134940402.

Polymorphism and mutation databases

BioMutaiDNAJC14.
DMDMi110808200.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 702702DnaJ homolog subfamily C member 14PRO_0000247493Add
BLAST

Proteomic databases

EPDiQ6Y2X3.
MaxQBiQ6Y2X3.
PaxDbiQ6Y2X3.
PeptideAtlasiQ6Y2X3.
PRIDEiQ6Y2X3.

PTM databases

iPTMnetiQ6Y2X3.
PhosphoSiteiQ6Y2X3.

Expressioni

Tissue specificityi

Highly expressed in pancreas and selectively expressed in brain, lung, liver, skeletal muscle and kidney.1 Publication

Gene expression databases

BgeeiQ6Y2X3.
CleanExiHS_DNAJC14.
ExpressionAtlasiQ6Y2X3. baseline and differential.
GenevisibleiQ6Y2X3. HS.

Organism-specific databases

HPAiHPA017653.

Interactioni

Subunit structurei

Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain.By similarity

Protein-protein interaction databases

BioGridi124515. 6 interactions.
IntActiQ6Y2X3. 1 interaction.
MINTiMINT-1032464.
STRINGi9606.ENSP00000316240.

Structurei

3D structure databases

ProteinModelPortaliQ6Y2X3.
SMRiQ6Y2X3. Positions 445-563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini443 – 50765JPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi673 – 6764Poly-Ala

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0720. Eukaryota.
ENOG410Z2TP. LUCA.
GeneTreeiENSGT00840000129767.
HOGENOMiHOG000290199.
HOVERGENiHBG059561.
InParanoidiQ6Y2X3.
KOiK09534.
OMAiPPGQMSN.
OrthoDBiEOG7HTHGK.
PhylomeDBiQ6Y2X3.
TreeFamiTF105173.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR032843. Jiv.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF14901. Jiv90. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6Y2X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKHPGERG LYGAHHSGGA SLRTLGPSVD PEIPSFSGLR DSAGTAPNGT
60 70 80 90 100
RCLTEHSGPK HTQHPNPAHW LDPSHGPPGG PGPPRDAEDP DQSETSSEEE
110 120 130 140 150
SGVDQELSKE NETGNQKDGN SFLSIPSACN CQGTPGIPEG PYSEGGNGSS
160 170 180 190 200
SNFCHHCTSP ALGEDELEEE YDDEESLKFP SDFSRVSSGK KPPSRRQRHR
210 220 230 240 250
FPTKEDTREG GRRDPRSPGR HRLGRKRSQA DKRKGLGLWG AEELCQLGQA
260 270 280 290 300
GFWWLIELLV LVGEYVETCG HLIYACRQLK SSDLDLFRVW MGVWTGRLGG
310 320 330 340 350
WAQVMFQFLS QGFYCGVGLF TRFLKLLGAL LLLALALFLG FLQLGWRFLV
360 370 380 390 400
GLGDRLGWRD KATWLFSWLD SPALQRCLTL LRDSRPWQRL VRIVQWGWLE
410 420 430 440 450
LPWVKQNINR QGNAPVASGR YCQPEEEVAR LLTMAGVPED ELNPFHVLGV
460 470 480 490 500
EATASDVELK KAYRQLAVMV HPDKNHHPRA EEAFKVLRAA WDIVSNAEKR
510 520 530 540 550
KEYEMKRMAE NELSRSVNEF LSKLQDDLKE AMNTMMCSRC QGKHRRFEMD
560 570 580 590 600
REPKSARYCA ECNRLHPAEE GDFWAESSML GLKITYFALM DGKVYDITEW
610 620 630 640 650
AGCQRVGISP DTHRVPYHIS FGSRIPGTRG RQRATPDAPP ADLQDFLSRI
660 670 680 690 700
FQVPPGQMPN GNFFAAPQPA PGAAAASKPN STVPKGEAKP KRRKKVRRPF

QR
Length:702
Mass (Da):78,569
Last modified:July 25, 2006 - v2
Checksum:iDAECF48B7196C7F2
GO

Sequence cautioni

The sequence BAB71050.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti285 – 2851D → N in AAO73451 (PubMed:12768437).Curated
Sequence conflicti460 – 4601K → R in AAO73451 (PubMed:12768437).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY188447 mRNA. Translation: AAO73451.1.
EF560741 mRNA. Translation: ABQ59051.1.
CH471054 Genomic DNA. Translation: EAW96833.1.
BC080655 mRNA. Translation: AAH80655.1.
BC117146 mRNA. Translation: AAI17147.1.
BC117148 mRNA. Translation: AAI17149.1.
AK055945 mRNA. Translation: BAB71050.1. Different initiation.
AF351784 mRNA. Translation: AAK56241.1.
CCDSiCCDS8894.1.
RefSeqiNP_115740.5. NM_032364.5.
UniGeneiHs.709320.

Genome annotation databases

EnsembliENST00000317269; ENSP00000316240; ENSG00000135392.
ENST00000317287; ENSP00000317500; ENSG00000135392.
ENST00000357606; ENSP00000350223; ENSG00000135392.
GeneIDi85406.
KEGGihsa:85406.
UCSCiuc001shx.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY188447 mRNA. Translation: AAO73451.1.
EF560741 mRNA. Translation: ABQ59051.1.
CH471054 Genomic DNA. Translation: EAW96833.1.
BC080655 mRNA. Translation: AAH80655.1.
BC117146 mRNA. Translation: AAI17147.1.
BC117148 mRNA. Translation: AAI17149.1.
AK055945 mRNA. Translation: BAB71050.1. Different initiation.
AF351784 mRNA. Translation: AAK56241.1.
CCDSiCCDS8894.1.
RefSeqiNP_115740.5. NM_032364.5.
UniGeneiHs.709320.

3D structure databases

ProteinModelPortaliQ6Y2X3.
SMRiQ6Y2X3. Positions 445-563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124515. 6 interactions.
IntActiQ6Y2X3. 1 interaction.
MINTiMINT-1032464.
STRINGi9606.ENSP00000316240.

PTM databases

iPTMnetiQ6Y2X3.
PhosphoSiteiQ6Y2X3.

Polymorphism and mutation databases

BioMutaiDNAJC14.
DMDMi110808200.

Proteomic databases

EPDiQ6Y2X3.
MaxQBiQ6Y2X3.
PaxDbiQ6Y2X3.
PeptideAtlasiQ6Y2X3.
PRIDEiQ6Y2X3.

Protocols and materials databases

DNASUi85406.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317269; ENSP00000316240; ENSG00000135392.
ENST00000317287; ENSP00000317500; ENSG00000135392.
ENST00000357606; ENSP00000350223; ENSG00000135392.
GeneIDi85406.
KEGGihsa:85406.
UCSCiuc001shx.1. human.

Organism-specific databases

CTDi85406.
GeneCardsiDNAJC14.
HGNCiHGNC:24581. DNAJC14.
HPAiHPA017653.
MIMi606092. gene.
neXtProtiNX_Q6Y2X3.
PharmGKBiPA134940402.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0720. Eukaryota.
ENOG410Z2TP. LUCA.
GeneTreeiENSGT00840000129767.
HOGENOMiHOG000290199.
HOVERGENiHBG059561.
InParanoidiQ6Y2X3.
KOiK09534.
OMAiPPGQMSN.
OrthoDBiEOG7HTHGK.
PhylomeDBiQ6Y2X3.
TreeFamiTF105173.

Miscellaneous databases

ChiTaRSiDNAJC14. human.
GeneWikiiDNAJC14.
GenomeRNAii85406.
PROiQ6Y2X3.
SOURCEiSearch...

Gene expression databases

BgeeiQ6Y2X3.
CleanExiHS_DNAJC14.
ExpressionAtlasiQ6Y2X3. baseline and differential.
GenevisibleiQ6Y2X3. HS.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR032843. Jiv.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF14901. Jiv90. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain."
    Chen J., Huang Y., Wu H., Ni X., Cheng H., Fan J., Gu S., Gu X., Cao G., Ying K., Mao Y., Lu Y., Xie Y.
    J. Hum. Genet. 48:217-221(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-702.
  6. "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein."
    Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y.
    Nat. Cell Biol. 3:492-498(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 490-702.

Entry informationi

Entry nameiDJC14_HUMAN
AccessioniPrimary (citable) accession number: Q6Y2X3
Secondary accession number(s): A5YM67
, Q17RY2, Q66K17, Q96N59, Q96T63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 6, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.