Q6Y2X3 (DJC14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily C member 14

Alternative name(s):
DnaJ protein homolog 3
Dopamine receptor-interacting protein of 78 kDa
Short name=DRIP78
Human DnaJ protein 3
Short name=hDj-3

Gene names

Name:	DNAJC14
Synonyms:	DRIP78, HDJ3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	702 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface By similarity.
Subunit structure	Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Highly expressed in pancreas and selectively expressed in brain, lung, liver, skeletal muscle and kidney. Ref.1
Sequence similarities	Contains 1 J domain.
Sequence caution	The sequence BAB71050.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleolus Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 702	702	DnaJ homolog subfamily C member 14		PRO_0000247493
Regions
	Transmembrane	250 – 270	21	Helical; Potential
	Transmembrane	300 – 320	21	Helical; Potential
	Transmembrane	326 – 346	21	Helical; Potential
	Domain	443 – 507	65	J
	Compositional bias	673 – 676	4	Poly-Ala
Experimental info
	Sequence conflict	285	1	D → N in AAO73451. Ref.1
	Sequence conflict	460	1	K → R in AAO73451. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6Y2X3 [UniParc]. Last modified July 25, 2006. Version 2. Checksum: DAECF48B7196C7F2	FASTA	702	78,569
	10 20 30 40 50 60 MAQKHPGERG LYGAHHSGGA SLRTLGPSVD PEIPSFSGLR DSAGTAPNGT RCLTEHSGPK 70 80 90 100 110 120 HTQHPNPAHW LDPSHGPPGG PGPPRDAEDP DQSETSSEEE SGVDQELSKE NETGNQKDGN 130 140 150 160 170 180 SFLSIPSACN CQGTPGIPEG PYSEGGNGSS SNFCHHCTSP ALGEDELEEE YDDEESLKFP 190 200 210 220 230 240 SDFSRVSSGK KPPSRRQRHR FPTKEDTREG GRRDPRSPGR HRLGRKRSQA DKRKGLGLWG 250 260 270 280 290 300 AEELCQLGQA GFWWLIELLV LVGEYVETCG HLIYACRQLK SSDLDLFRVW MGVWTGRLGG 310 320 330 340 350 360 WAQVMFQFLS QGFYCGVGLF TRFLKLLGAL LLLALALFLG FLQLGWRFLV GLGDRLGWRD 370 380 390 400 410 420 KATWLFSWLD SPALQRCLTL LRDSRPWQRL VRIVQWGWLE LPWVKQNINR QGNAPVASGR 430 440 450 460 470 480 YCQPEEEVAR LLTMAGVPED ELNPFHVLGV EATASDVELK KAYRQLAVMV HPDKNHHPRA 490 500 510 520 530 540 EEAFKVLRAA WDIVSNAEKR KEYEMKRMAE NELSRSVNEF LSKLQDDLKE AMNTMMCSRC 550 560 570 580 590 600 QGKHRRFEMD REPKSARYCA ECNRLHPAEE GDFWAESSML GLKITYFALM DGKVYDITEW 610 620 630 640 650 660 AGCQRVGISP DTHRVPYHIS FGSRIPGTRG RQRATPDAPP ADLQDFLSRI FQVPPGQMPN 670 680 690 700 GNFFAAPQPA PGAAAASKPN STVPKGEAKP KRRKKVRRPF QR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain." Chen J., Huang Y., Wu H., Ni X., Cheng H., Fan J., Gu S., Gu X., Cao G., Ying K., Mao Y., Lu Y., Xie Y. J. Hum. Genet. 48:217-221(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Skin.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-702.
[6]	"Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein." Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y. Nat. Cell Biol. 3:492-498(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 490-702.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY188447 mRNA. Translation: AAO73451.1. EF560741 mRNA. Translation: ABQ59051.1. CH471054 Genomic DNA. Translation: EAW96833.1. BC080655 mRNA. Translation: AAH80655.1. BC117146 mRNA. Translation: AAI17147.1. BC117148 mRNA. Translation: AAI17149.1. AK055945 mRNA. Translation: BAB71050.1. Different initiation. AF351784 mRNA. Translation: AAK56241.1.
IPI	IPI00158847.
RefSeq	NP_115740.5. NM_032364.5.
UniGene	Hs.709320.
3D structure databases
ProteinModelPortal	Q6Y2X3.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1032464.
STRING	9606.ENSP00000316240.
PTM databases
PhosphoSite	Q6Y2X3.
Polymorphism databases
DMDM	110808200.
Proteomic databases
PaxDb	Q6Y2X3.
PRIDE	Q6Y2X3.
Protocols and materials databases
DNASU	85406.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317269; ENSP00000316240; ENSG00000135392. ENST00000317287; ENSP00000317500; ENSG00000135392. ENST00000357606; ENSP00000350223; ENSG00000135392.
GeneID	85406.
KEGG	hsa:85406.
UCSC	uc001shu.2. human.
Organism-specific databases
CTD	85406.
GeneCards	GC12M056214.
HGNC	HGNC:24581. DNAJC14.
HPA	HPA017653.
MIM	606092. gene.
neXtProt	NX_Q6Y2X3.
PharmGKB	PA134940402.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2214.
HOGENOM	HOG000290199.
HOVERGEN	HBG059561.
InParanoid	Q6Y2X3.
KO	K09534.
OMA	PPGQMSN.
OrthoDB	EOG4RFKS1.
PhylomeDB	Q6Y2X3.
Gene expression databases
ArrayExpress	Q6Y2X3.
Bgee	Q6Y2X3.
CleanEx	HS_DNAJC14.
Genevestigator	Q6Y2X3.
GermOnline	ENSG00000135392. Homo sapiens.
Family and domain databases
Gene3D	1.10.287.110. 1 hit.
InterPro	IPR001623. DnaJ_domain. [Graphical view]
Pfam	PF00226. DnaJ. 1 hit. [Graphical view]
PRINTS	PR00625. JDOMAIN.
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
SUPFAM	SSF46565. DnaJ_N. 1 hit.
PROSITE	PS00636. DNAJ_1. False negative. PS50076. DNAJ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DNAJC14. human.
GenomeRNAi	85406.
NextBio	75966.
SOURCE	Search...

Entry information

Entry name

DJC14_HUMAN

Accession

Primary (citable) accession number: Q6Y2X3
Secondary accession number(s): A5YM67 , Q17RY2, Q66K17, Q96N59, Q96T63

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.