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Protein

E3 ubiquitin-protein ligase RNF130

Gene

Rnf130

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri264 – 30542RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • programmed cell death Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF130 (EC:6.3.2.-)
Alternative name(s):
Goliath homolog
Short name:
R-goliath
RING finger protein 130
Gene namesi
Name:Rnf130By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1562041. Rnf130.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 194167ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21723HelicalSequence analysisAdd
BLAST
Topological domaini218 – 419202CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 419392E3 ubiquitin-protein ligase RNF130By similarityPRO_0000030720Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Modified residuei341 – 3411PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ6Y290.

Expressioni

Tissue specificityi

In testis sections, expressed in interstitial tissue and seminiferous tubules. In tubules, expression is mainly in postmeiotic germ cells and to a much lesser extent in Sertoli cells (at protein level). Expressed at high levels in liver, lung, stomach, heart and thymus.1 Publication

Inductioni

Regulated by lutenising hormone (LH) in Leydig cells but not in germ cells.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6Y290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 17672PAAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri264 – 30542RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

HOVERGENiHBG057659.
InParanoidiQ6Y290.
KOiK15701.
PhylomeDBiQ6Y290.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Y290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGAARAGPA RLAALALLTC SLWPTRADNA SQEYYTALIN VTVQEPGRGT
60 70 80 90 100
PLTFRIDRGR YGLDSPKAEV RGQVLAPLPI HGVADHLGCD PQTRFFVPPN
110 120 130 140 150
IKQWIALLQR GNCTFKEKIS RAAFHNAVAV VIYNNKSKEE PVTMTHPGTG
160 170 180 190 200
DIIAVMITEL RGKDILSYLE KNISVQMTIA VGTRMPPKNF SRGSLVFVSI
210 220 230 240 250
SFIVLMIISS AWLIFYFIQK IRYTNARDRN QRRLGDAAKK AISKLTTRTV
260 270 280 290 300
KKGDKETDPD FDHCAVCIES YKQNDVVRVL PCKHVFHKSC VDPWLSEHCT
310 320 330 340 350
CPMCKLNILK ALGIVPNLPC TDNVAFDMER LTRTQAVNRR SALGDLANDS
360 370 380 390 400
SLGLEPLRTS GISPLPQDGE LTPRTGEINI AVTKEWFIIA SFGLLSALTL
410
CYMIIRATAS LNANEVEWF
Length:419
Mass (Da):46,449
Last modified:July 5, 2004 - v1
Checksum:iC9FA8EE15B58DD32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190520 mRNA. Translation: AAO31973.1.
RefSeqiNP_001032747.1. NM_001037658.1.
UniGeneiRn.186211.

Genome annotation databases

GeneIDi652955.
KEGGirno:652955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190520 mRNA. Translation: AAO31973.1.
RefSeqiNP_001032747.1. NM_001037658.1.
UniGeneiRn.186211.

3D structure databases

ProteinModelPortaliQ6Y290.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6Y290.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi652955.
KEGGirno:652955.

Organism-specific databases

CTDi55819.
RGDi1562041. Rnf130.

Phylogenomic databases

HOVERGENiHBG057659.
InParanoidiQ6Y290.
KOiK15701.
PhylomeDBiQ6Y290.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi714879.
PROiQ6Y290.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Goliath, a ring-H2 mitochondrial protein, regulated by luteinizing hormone/human chorionic gonadotropin in rat Leydig cells."
    Guais A., Solhonne B., Melaine N., Guellaeen G., Bulle F.
    Biol. Reprod. 70:204-213(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-DawleyImported.
    Tissue: LiverImported.

Entry informationi

Entry nameiGOLI_RAT
AccessioniPrimary (citable) accession number: Q6Y290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.