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Protein

E3 ubiquitin-protein ligase RNF130

Gene

Rnf130

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri264 – 305RING-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • programmed cell death Source: UniProtKB

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF130 (EC:2.3.2.27By similarity)
Alternative name(s):
Goliath homolog
Short name:
R-goliath
RING finger protein 130
Gene namesi
Name:Rnf130By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1562041. Rnf130.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 194ExtracellularSequence analysisAdd BLAST167
Transmembranei195 – 217HelicalSequence analysisAdd BLAST23
Topological domaini218 – 419CytoplasmicSequence analysisAdd BLAST202

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000003072028 – 419E3 ubiquitin-protein ligase RNF130By similarityAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei341PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ6Y290.

Expressioni

Tissue specificityi

In testis sections, expressed in interstitial tissue and seminiferous tubules. In tubules, expression is mainly in postmeiotic germ cells and to a much lesser extent in Sertoli cells (at protein level). Expressed at high levels in liver, lung, stomach, heart and thymus.1 Publication

Inductioni

Regulated by lutenising hormone (LH) in Leydig cells but not in germ cells.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6Y290.
SMRiQ6Y290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 176PAAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri264 – 305RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

HOVERGENiHBG057659.
InParanoidiQ6Y290.
KOiK15701.
PhylomeDBiQ6Y290.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Y290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGAARAGPA RLAALALLTC SLWPTRADNA SQEYYTALIN VTVQEPGRGT
60 70 80 90 100
PLTFRIDRGR YGLDSPKAEV RGQVLAPLPI HGVADHLGCD PQTRFFVPPN
110 120 130 140 150
IKQWIALLQR GNCTFKEKIS RAAFHNAVAV VIYNNKSKEE PVTMTHPGTG
160 170 180 190 200
DIIAVMITEL RGKDILSYLE KNISVQMTIA VGTRMPPKNF SRGSLVFVSI
210 220 230 240 250
SFIVLMIISS AWLIFYFIQK IRYTNARDRN QRRLGDAAKK AISKLTTRTV
260 270 280 290 300
KKGDKETDPD FDHCAVCIES YKQNDVVRVL PCKHVFHKSC VDPWLSEHCT
310 320 330 340 350
CPMCKLNILK ALGIVPNLPC TDNVAFDMER LTRTQAVNRR SALGDLANDS
360 370 380 390 400
SLGLEPLRTS GISPLPQDGE LTPRTGEINI AVTKEWFIIA SFGLLSALTL
410
CYMIIRATAS LNANEVEWF
Length:419
Mass (Da):46,449
Last modified:July 5, 2004 - v1
Checksum:iC9FA8EE15B58DD32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190520 mRNA. Translation: AAO31973.1.
RefSeqiNP_001032747.1. NM_001037658.1.
UniGeneiRn.186211.

Genome annotation databases

GeneIDi652955.
KEGGirno:652955.

Similar proteinsi

Entry informationi

Entry nameiGOLI_RAT
AccessioniPrimary (citable) accession number: Q6Y290
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways