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Protein

2-oxoglutarate receptor 1

Gene

Oxgr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-373076. Class A/1 (Rhodopsin-like receptors).
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate receptor 1
Alternative name(s):
Alpha-ketoglutarate receptor 1
G-protein coupled receptor 80
P2Y purinoceptor 15
Short name:
P2Y15
Gene namesi
Name:Oxgr1
Synonyms:Gpr80, P2y15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1303155. Oxgr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularSequence analysisAdd
BLAST
Transmembranei38 – 5821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini59 – 6911CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 11626ExtracellularSequence analysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 15114CytoplasmicSequence analysisAdd
BLAST
Transmembranei152 – 17221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini173 – 20028ExtracellularSequence analysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini222 – 24221CytoplasmicSequence analysisAdd
BLAST
Transmembranei243 – 26321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini264 – 28421ExtracellularSequence analysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini306 – 33732CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3373372-oxoglutarate receptor 1PRO_0000069996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6Y1R5.

PTM databases

PhosphoSiteiQ6Y1R5.

Expressioni

Tissue specificityi

Highly expressed in mast cells and is found predominantly in the tissues of the respiratory tract and kidneys.1 Publication

Gene expression databases

BgeeiENSRNOG00000037884.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054374.

Chemistry

BindingDBiQ6Y1R5.

Structurei

3D structure databases

ProteinModelPortaliQ6Y1R5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHYM. Eukaryota.
ENOG410YD7Q. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG106870.
InParanoidiQ6Y1R5.
KOiK08419.
OMAiCKFIRFG.
OrthoDBiEOG091G0A94.
PhylomeDBiQ6Y1R5.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6Y1R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIETLDSPAN DSDFLDYITA LENCTDEQIS FKMQYLPVIY SIIFLVGFPG
60 70 80 90 100
NTVAISIYVF KMRPWKSSTI IMLNLALTDL LYLTSLPFLI HYYASGENWI
110 120 130 140 150
FGDFMCKFIR FGFHFNLYSS ILFLTCFSLF RYIVIIHPMS CFSIQKTRWA
160 170 180 190 200
VVACAGVWVI SLVAVMPMTF LITSTTRTNR SACLDLTSSD DLTTIKWYNL
210 220 230 240 250
ILTATTFCLP LLIVTLCYTT IISTLTHGPR THSCFKQKAR RLTILLLLVF
260 270 280 290 300
YVCFLPFHIL RVIRIESRLL SISCSIESHI HEAYIVSRPL AALNTFGNLL
310 320 330
LYVVVSNNFQ QAFCSAVRCK AIGDLEQAKK DSCSNNP
Length:337
Mass (Da):38,377
Last modified:July 5, 2004 - v1
Checksum:i9899E80DE0531CB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191367 mRNA. Translation: AAP32736.1.
RefSeqiNP_997471.1. NM_207588.1.
XP_006252533.1. XM_006252471.2.
UniGeneiRn.115325.

Genome annotation databases

EnsembliENSRNOT00000057564; ENSRNOP00000054374; ENSRNOG00000037884.
GeneIDi290493.
KEGGirno:290493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191367 mRNA. Translation: AAP32736.1.
RefSeqiNP_997471.1. NM_207588.1.
XP_006252533.1. XM_006252471.2.
UniGeneiRn.115325.

3D structure databases

ProteinModelPortaliQ6Y1R5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054374.

Chemistry

BindingDBiQ6Y1R5.
ChEMBLiCHEMBL2325.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ6Y1R5.

Proteomic databases

PaxDbiQ6Y1R5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057564; ENSRNOP00000054374; ENSRNOG00000037884.
GeneIDi290493.
KEGGirno:290493.

Organism-specific databases

CTDi27199.
RGDi1303155. Oxgr1.

Phylogenomic databases

eggNOGiENOG410IHYM. Eukaryota.
ENOG410YD7Q. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG106870.
InParanoidiQ6Y1R5.
KOiK08419.
OMAiCKFIRFG.
OrthoDBiEOG091G0A94.
PhylomeDBiQ6Y1R5.
TreeFamiTF330775.

Enzyme and pathway databases

ReactomeiR-RNO-373076. Class A/1 (Rhodopsin-like receptors).
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ6Y1R5.

Gene expression databases

BgeeiENSRNOG00000037884.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOXGR1_RAT
AccessioniPrimary (citable) accession number: Q6Y1R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be a P2Y receptor.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.