Q6Y1I9 (Q6Y1I9_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lactase-phlorizin hydrolase-1 EMBL AAP12677.1

Gene names

Name:

LCT EMBL AAP12677.1

Organism

Homo sapiens (Human) EMBL AAP12677.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1003 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the glycosyl hydrolase 1 family. RuleBase RU003690

Ontologies

Keywords
Molecular function	Glycosidase RuleBase RU004468 Hydrolase
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAP12677.1

Sequences

	Sequence		Length	Mass (Da)
	Q6Y1I9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 77FBCABDA91E43B6	FASTA	1,003	115,174
	10 20 30 40 50 60 KVAHLVLKAH ARTWHHYNSH HRPQQQGHVG IVLNSDWAEP LSPERPEDLR ASERFLHFML 70 80 90 100 110 120 GWFAHPVFVD GDYPATLRTQ IQQMNRQCSH PVAQLPEFTE AEKQLLKGSA DFLGLSHYTS 130 140 150 160 170 180 RLISNAPQNT CIPSYDTIGG FSQHVNHVWP QTSSSWIRVV PWGIRRLLQF VSLEYTRGKV 190 200 210 220 230 240 PIYLAGNGMP IGESENLFDD SLRVDYFNQY INEVLKAIKE DSVDVRSYIA RSLIDGFEGP 250 260 270 280 290 300 SGYSQRFGLH HVNFSDSSKS RTPRKSAYFF TSIIEKNGFL TKGAKRLLPP NTVNLPSKVR 310 320 330 340 350 360 AFTFPSEVPS KAKVVWEKFS SQPKFERDLF YHGTFRDDFL WGVSSSAYQI EGAWDADGKG 370 380 390 400 410 420 PSIWDNFTHT PGSNVKDNAT GDIACDSYHQ LDADLNMLRA LKVKAYRFSI SWSRIFPTGR 430 440 450 460 470 480 NSSINSHGVD YYNRLINGLV ASNIFPMVTL FHWDLPQALQ DIGGWENPAL IDLFDSYADF 490 500 510 520 530 540 CFQTFGDRVK FWMTFNEPMY LAWLGYGSGE FPPGVKDPGW APYRIAHTVI KAHARVYHTY 550 560 570 580 590 600 DEKYRQEQKG VISLSLSTHW AEPKSPGVPR DVEAADRMLQ FSLGWFAHPI FRNGDYPDTM 610 620 630 640 650 660 KWKVGNRSEL QHLATSRLPS FTEEEKRFIR ATADVFCLNT YYSRIVQHKT PRLNPPSYED 670 680 690 700 710 720 DQEMAEEEDP SWPSTAMNRA APWGTRRLLN WIKEEYGDIP IYITENGVGL TNPNTEDTDR 730 740 750 760 770 780 IFYHKTYINE ALKAYRLDGI DLRGYVAWSL MDNFEWLNGY TVKFGLYHVD FNNTNRPRTA 790 800 810 820 830 840 RASARYYTEV ITNNGMPLAR EDEFLYGRFP EGFIWSAASA AYQIEGAWRA DGKGLSIWDT 850 860 870 880 890 900 FSHTPLRVEN DAIGDVACDS YHKIAEDLVT LQNLGVSHYR FSISWSRILP DGTTRYINEA 910 920 930 940 950 960 GLNYYVRLID TLLAASIQPQ VTIYHWDLPQ TLQDVGGWEN ETIVQRFKEY ADVLFQRLGD 970 980 990 1000 KVKFWITLNE PFVIAYQGYG YGTAAPVHGR LVCTSYFQEW RLQ

References

[1]

"Alternative mRNA and membrane anchor-less human lactase-phlorizin hydrolase-1 (hLPH-1) in premature Caucasian intestinal tract." Chen C.-M., Lin C.-C., Lin Y.-J., Tsai T.C., Lin C.-J., Hung C.-M., Cheng W.T.K., Chen H.-L. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Small intestine EMBL AAP12677.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY191611 mRNA. Translation: AAP12677.1.
IPI	IPI00916950.
3D structure databases
ProteinModelPortal	Q6Y1I9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000024957.
HOVERGEN	HBG006290.
Family and domain databases
Gene3D	3.20.20.80. 3 hits.
InterPro	IPR001360. Glyco_hydro_1. IPR018120. Glyco_hydro_1_AS. IPR013781. Glyco_hydro_catalytic_dom. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
PANTHER	PTHR10353. PTHR10353. 1 hit.
Pfam	PF00232. Glyco_hydro_1. 3 hits. [Graphical view]
PRINTS	PR00131. GLHYDRLASE1.
SUPFAM	SSF51445. Glyco_hydro_cat. 3 hits.
PROSITE	PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit. PS00653. GLYCOSYL_HYDROL_F1_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LCT. human.

Entry information

Entry name

Q6Y1I9_HUMAN

Accession

Primary (citable) accession number: Q6Y1I9

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.