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Q6XZF7 (DNMBP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dynamin-binding protein
Alternative name(s):
Scaffold protein Tuba
Gene names
Name:DNMBP
Synonyms:KIAA1010
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1577 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi By similarity.

Subunit structure

Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WASL, WIRE, CR16, WAVE1 and NAP1L1 By similarity. Interacts with FASLG. Ref.5

Subcellular location

Cytoplasm By similarity. Golgi apparatusGolgi stack By similarity. Cytoplasmcytoskeleton By similarity. Cell junctionsynapse By similarity. Note: Localized to synapses and Golgi stacks By similarity.

Tissue specificity

Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Ref.1

Sequence similarities

Contains 1 BAR domain.

Contains 1 DH (DBL-homology) domain.

Contains 6 SH3 domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BIN3Q9NQY02EBI-2483419,EBI-2653038
Dnm1P215753EBI-2483419,EBI-80070From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6XZF7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6XZF7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-754: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15771577Dynamin-binding protein
PRO_0000079959

Regions

Domain2 – 6160SH3 1
Domain66 – 12661SH3 2
Domain145 – 20460SH3 3
Domain243 – 30260SH3 4
Domain784 – 967184DH
Domain1008 – 1217210BAR
Domain1285 – 134864SH3 5
Domain1513 – 157664SH3 6
Coiled coil693 – 75765 Potential
Coiled coil1136 – 117338 Potential
Compositional bias610 – 64940Pro-rich
Compositional bias1351 – 144999Ser-rich

Amino acid modifications

Modified residue11N-acetylmethionine Ref.8

Natural variations

Alternative sequence1 – 754754Missing in isoform 2.
VSP_012079
Natural variant811E → D.
Corresponds to variant rs12267912 [ dbSNP | Ensembl ].
VAR_050955
Natural variant3731N → K.
Corresponds to variant rs35924554 [ dbSNP | Ensembl ].
VAR_050956
Natural variant9141N → K.
Corresponds to variant rs7919507 [ dbSNP | Ensembl ].
VAR_050957
Natural variant14131C → W. Ref.3
Corresponds to variant rs11190305 [ dbSNP | Ensembl ].
VAR_024339

Experimental info

Sequence conflict8311M → T in AAH41628. Ref.3

Secondary structure

...................................... 1577
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5A1FDCB06124F627

FASTA1,577177,347
        10         20         30         40         50         60 
MEAGSVVRAI FDFCPSVSEE LPLFVGDIIE VLAVVDEFWL LGKKEDVTGQ FPSSFVEIVT 

        70         80         90        100        110        120 
IPSLKEGERL FVCICEFTSQ ELDNLPLHRG DLVILDGIPT AGWLQGRSCW GARGFFPSSC 

       130        140        150        160        170        180 
VRELCLSSQS RQWHSQSALF QIPEYSMGQA RALMGLSAQL DEELDFREGD VITIIGVPEP 

       190        200        210        220        230        240 
GWFEGELEGR RGIFPEGFVE LLGPLRTVDE SVSSGNQDDC IVNGEVDTPV GEEEIGPDED 

       250        260        270        280        290        300 
EEEPGTYGVA LYRFQALEPN ELDFEVGDKI RILATLEDGW LEGSLKGRTG IFPYRFVKLC 

       310        320        330        340        350        360 
PDTRVEETMA LPQEGSLARI PETSLDCLEN TLGVEEQRHE TSDHEAEEPD CIISEAPTSP 

       370        380        390        400        410        420 
LGHLTSEYDT DRNSYQDEDT AGGPPRSPGV EWEMPLATDS PTSDPTEVVN GISSQPQVPF 

       430        440        450        460        470        480 
HPNLQKSQYY STVGGSHPHS EQYPDLLPLE ARTRDYASLP PKRMYSQLKT LQKPVLPLYR 

       490        500        510        520        530        540 
GSSVSASRVV KPRQSSPQLH NLASYTKKHH TSSVYSISER LEMKPGPQAQ GLVMEAATHS 

       550        560        570        580        590        600 
QGDGSTDLDS KLTQQLIEFE KSLAGPGTEP DKILRHFSIM DFNSEKDIVR GSSKLITEQE 

       610        620        630        640        650        660 
LPERRKALRP PPPRPCTPVS TSPHLLVDQN LKPAPPLVVR PSRPAPLPPS AQQRTNAVSP 

       670        680        690        700        710        720 
KLLSRHRPTC ETLEKEGPGH MGRSLDQTSP CPLVLVRIEE MERDLDMYSR AQEELNLMLE 

       730        740        750        760        770        780 
EKQDESSRAE TLEDLKFCES NIESLNMELQ QLREMTLLSS QSSSLVAPSG SVSAENPEQR 

       790        800        810        820        830        840 
MLEKRAKVIE ELLQTERDYI RDLEMCIERI MVPMQQAQVP NIDFEGLFGN MQMVIKVSKQ 

       850        860        870        880        890        900 
LLAALEISDA VGPVFLGHRD ELEGTYKIYC QNHDEAIALL EIYEKDEKIQ KHLQDSLADL 

       910        920        930        940        950        960 
KSLYNEWGCT NYINLGSFLI KPVQRVMRYP LLLMELLNST PESHPDKVPL TNAVLAVKEI 

       970        980        990       1000       1010       1020 
NVNINEYKRR KDLVLKYRKG DEDSLMEKIS KLNIHSIIKK SNRVSSHLKH LTGFAPQIKD 

      1030       1040       1050       1060       1070       1080 
EVFEETEKNF RMQERLIKSF IRDLSLYLQH IRESACVKVV AAVSMWDVCM ERGHRDLEQF 

      1090       1100       1110       1120       1130       1140 
ERVHRYISDQ LFTNFKERTE RLVISPLNQL LSMFTGPHKL VQKRFDKLLD FYNCTERAEK 

      1150       1160       1170       1180       1190       1200 
LKDKKTLEEL QSARNNYEAL NAQLLDELPK FHQYAQGLFT NCVHGYAEAH CDFVHQALEQ 

      1210       1220       1230       1240       1250       1260 
LKPLLSLLKV AGREGNLIAI FHEEHSRVLQ QLQVFTFFPE SLPATKKPFE RKTIDRQSAR 

      1270       1280       1290       1300       1310       1320 
KPLLGLPSYM LQSEELRASL LARYPPEKLF QAERNFNAAQ DLDVSLLEGD LVGVIKKKDP 

      1330       1340       1350       1360       1370       1380 
MGSQNRWLID NGVTKGFVYS SFLKPYNPRR SHSDASVGSH SSTESEHGSS SPRFPRQNSG 

      1390       1400       1410       1420       1430       1440 
STLTFNPSSM AVSFTSGSCQ KQPQDASPPP KECDQGTLSA SLNPSNSESS PSRCPSDPDS 

      1450       1460       1470       1480       1490       1500 
TSQPRSGDSA DVARDVKQPT ATPRSYRNFR HPEIVGYSVP GRNGQSQDLV KGCARTAQAP 

      1510       1520       1530       1540       1550       1560 
EDRSTEPDGS EAEGNQVYFA VYTFKARNPN ELSVSANQKL KILEFKDVTG NTEWWLAEVN 

      1570 
GKKGYVPSNY IRKTEYT 

« Hide

Isoform 2 [UniParc].

Checksum: 535FFA230587539F
Show »

FASTA82393,498

References

« Hide 'large scale' references
[1]"Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton."
Salazar M.A., Kwiatkowski A.V., Pellegrini L., Cestra G., Butler M.H., Rossman K.L., Serna D.M., Sondek J., Gertler F.B., De Camilli P.
J. Biol. Chem. 278:49031-49043(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
Tissue: Brain and Skeletal muscle.
[2]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 263-1577 (ISOFORM 1).
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT TRP-1413.
Tissue: Uterus.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
Voss M., Lettau M., Janssen O.
BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FASLG.
[6]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"NMR structure of SH3 domain of hypothetical protein BAA76854.1."
RIKEN structural genomics initiative (RSGI)
Submitted (DEC-2003) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 1278-1353 AND 1510-1575.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY196211 mRNA. Translation: AAP34307.1.
AB023227 mRNA. Translation: BAA76854.1.
BC041628 mRNA. Translation: AAH41628.1.
RefSeqNP_056036.1. NM_015221.2.
UniGeneHs.500771.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UG1NMR-A1278-1356[»]
1UHCNMR-A1509-1575[»]
4CC2X-ray1.55A/C1513-1577[»]
4CC3X-ray1.97A/C/E/G1513-1577[»]
4CC4X-ray2.60B/D/F1513-1577[»]
4CC7X-ray1.97A/C/E/G/I/K/M1513-1577[»]
4GLMX-ray1.90A/B/C/D246-301[»]
ProteinModelPortalQ6XZF7.
SMRQ6XZF7. Positions 2-301, 777-1008, 1013-1204, 1283-1361, 1513-1576.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116869. 23 interactions.
IntActQ6XZF7. 5 interactions.
MINTMINT-4777306.
STRING9606.ENSP00000315659.

PTM databases

PhosphoSiteQ6XZF7.

Polymorphism databases

DMDM56404535.

Proteomic databases

PaxDbQ6XZF7.
PRIDEQ6XZF7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000324109; ENSP00000315659; ENSG00000107554. [Q6XZF7-1]
ENST00000543621; ENSP00000443657; ENSG00000107554. [Q6XZF7-2]
GeneID23268.
KEGGhsa:23268.
UCSCuc001kqg.2. human. [Q6XZF7-1]

Organism-specific databases

CTD23268.
GeneCardsGC10M101625.
HGNCHGNC:30373. DNMBP.
HPAHPA037878.
MIM611282. gene.
neXtProtNX_Q6XZF7.
PharmGKBPA134950706.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5422.
HOGENOMHOG000112243.
HOVERGENHBG051383.
OrthoDBEOG7M3J14.
PhylomeDBQ6XZF7.
TreeFamTF330015.

Gene expression databases

ArrayExpressQ6XZF7.
BgeeQ6XZF7.
CleanExHS_DNMBP.
GenevestigatorQ6XZF7.

Family and domain databases

Gene3D1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTSM00721. BAR. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 6 hits.
[Graphical view]
SUPFAMSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 6 hits.
PROSITEPS51021. BAR. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDNMBP. human.
EvolutionaryTraceQ6XZF7.
GenomeRNAi23268.
NextBio45022.
PROQ6XZF7.
SOURCESearch...

Entry information

Entry nameDNMBP_HUMAN
AccessionPrimary (citable) accession number: Q6XZF7
Secondary accession number(s): Q8IVY3, Q9Y2L3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM