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Protein

Dynamin-binding protein

Gene

DNMBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-binding protein
Alternative name(s):
Scaffold protein Tuba
Gene namesi
Name:DNMBP
Synonyms:KIAA1010
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:30373. DNMBP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Golgi apparatus, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi23268.
OpenTargetsiENSG00000107554.
PharmGKBiPA134950706.

Polymorphism and mutation databases

BioMutaiDNMBP.
DMDMi56404535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799591 – 1577Dynamin-binding proteinAdd BLAST1577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei684PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6XZF7.
MaxQBiQ6XZF7.
PaxDbiQ6XZF7.
PeptideAtlasiQ6XZF7.
PRIDEiQ6XZF7.

PTM databases

iPTMnetiQ6XZF7.
PhosphoSitePlusiQ6XZF7.

Expressioni

Tissue specificityi

Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000107554.
CleanExiHS_DNMBP.
GenevisibleiQ6XZF7. HS.

Organism-specific databases

HPAiHPA037878.

Interactioni

Subunit structurei

Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WASL, WIRE, CR16, WAVE1 and NAP1L1 (By similarity). Interacts with FASLG.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BIN3Q9NQY02EBI-2483419,EBI-2653038
Dnm1P215753EBI-2483419,EBI-80070From a different organism.

Protein-protein interaction databases

BioGridi116869. 29 interactors.
DIPiDIP-53822N.
IntActiQ6XZF7. 11 interactors.
MINTiMINT-4777306.
STRINGi9606.ENSP00000315659.

Structurei

Secondary structure

11577
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi247 – 252Combined sources6
Beta strandi269 – 275Combined sources7
Beta strandi280 – 285Combined sources6
Beta strandi288 – 293Combined sources6
Helixi294 – 296Combined sources3
Beta strandi297 – 300Combined sources4
Helixi1278 – 1283Combined sources6
Helixi1286 – 1288Combined sources3
Beta strandi1289 – 1294Combined sources6
Beta strandi1300 – 1302Combined sources3
Beta strandi1311 – 1317Combined sources7
Beta strandi1324 – 1330Combined sources7
Beta strandi1332 – 1339Combined sources8
Helixi1340 – 1342Combined sources3
Beta strandi1343 – 1345Combined sources3
Beta strandi1517 – 1522Combined sources6
Beta strandi1528 – 1531Combined sources4
Beta strandi1539 – 1546Combined sources8
Beta strandi1554 – 1559Combined sources6
Beta strandi1562 – 1567Combined sources6
Helixi1568 – 1570Combined sources3
Beta strandi1571 – 1574Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UG1NMR-A1278-1355[»]
1UHCNMR-A1510-1575[»]
4CC2X-ray1.55A/C1513-1577[»]
4CC3X-ray1.97A/C/E/G1513-1577[»]
4CC4X-ray2.60B/D/F1513-1577[»]
4CC7X-ray1.97A/C/E/G/I/K/M1513-1577[»]
4GLMX-ray1.90A/B/C/D246-301[»]
ProteinModelPortaliQ6XZF7.
SMRiQ6XZF7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6XZF7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 61SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini66 – 126SH3 2PROSITE-ProRule annotationAdd BLAST61
Domaini145 – 204SH3 3PROSITE-ProRule annotationAdd BLAST60
Domaini243 – 302SH3 4PROSITE-ProRule annotationAdd BLAST60
Domaini784 – 967DHPROSITE-ProRule annotationAdd BLAST184
Domaini1008 – 1217BARPROSITE-ProRule annotationAdd BLAST210
Domaini1285 – 1348SH3 5PROSITE-ProRule annotationAdd BLAST64
Domaini1513 – 1576SH3 6PROSITE-ProRule annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili693 – 757Sequence analysisAdd BLAST65
Coiled coili1136 – 1173Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi610 – 649Pro-richAdd BLAST40
Compositional biasi1351 – 1449Ser-richAdd BLAST99

Sequence similaritiesi

Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 6 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3519. Eukaryota.
KOG4225. Eukaryota.
ENOG410XT9S. LUCA.
GeneTreeiENSGT00530000063159.
HOGENOMiHOG000112243.
HOVERGENiHBG051383.
InParanoidiQ6XZF7.
KOiK20705.
OMAiEPGWFEG.
OrthoDBiEOG091G01C4.
PhylomeDBiQ6XZF7.
TreeFamiTF330015.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 3 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 6 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 6 hits.
PROSITEiPS51021. BAR. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6XZF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAGSVVRAI FDFCPSVSEE LPLFVGDIIE VLAVVDEFWL LGKKEDVTGQ
60 70 80 90 100
FPSSFVEIVT IPSLKEGERL FVCICEFTSQ ELDNLPLHRG DLVILDGIPT
110 120 130 140 150
AGWLQGRSCW GARGFFPSSC VRELCLSSQS RQWHSQSALF QIPEYSMGQA
160 170 180 190 200
RALMGLSAQL DEELDFREGD VITIIGVPEP GWFEGELEGR RGIFPEGFVE
210 220 230 240 250
LLGPLRTVDE SVSSGNQDDC IVNGEVDTPV GEEEIGPDED EEEPGTYGVA
260 270 280 290 300
LYRFQALEPN ELDFEVGDKI RILATLEDGW LEGSLKGRTG IFPYRFVKLC
310 320 330 340 350
PDTRVEETMA LPQEGSLARI PETSLDCLEN TLGVEEQRHE TSDHEAEEPD
360 370 380 390 400
CIISEAPTSP LGHLTSEYDT DRNSYQDEDT AGGPPRSPGV EWEMPLATDS
410 420 430 440 450
PTSDPTEVVN GISSQPQVPF HPNLQKSQYY STVGGSHPHS EQYPDLLPLE
460 470 480 490 500
ARTRDYASLP PKRMYSQLKT LQKPVLPLYR GSSVSASRVV KPRQSSPQLH
510 520 530 540 550
NLASYTKKHH TSSVYSISER LEMKPGPQAQ GLVMEAATHS QGDGSTDLDS
560 570 580 590 600
KLTQQLIEFE KSLAGPGTEP DKILRHFSIM DFNSEKDIVR GSSKLITEQE
610 620 630 640 650
LPERRKALRP PPPRPCTPVS TSPHLLVDQN LKPAPPLVVR PSRPAPLPPS
660 670 680 690 700
AQQRTNAVSP KLLSRHRPTC ETLEKEGPGH MGRSLDQTSP CPLVLVRIEE
710 720 730 740 750
MERDLDMYSR AQEELNLMLE EKQDESSRAE TLEDLKFCES NIESLNMELQ
760 770 780 790 800
QLREMTLLSS QSSSLVAPSG SVSAENPEQR MLEKRAKVIE ELLQTERDYI
810 820 830 840 850
RDLEMCIERI MVPMQQAQVP NIDFEGLFGN MQMVIKVSKQ LLAALEISDA
860 870 880 890 900
VGPVFLGHRD ELEGTYKIYC QNHDEAIALL EIYEKDEKIQ KHLQDSLADL
910 920 930 940 950
KSLYNEWGCT NYINLGSFLI KPVQRVMRYP LLLMELLNST PESHPDKVPL
960 970 980 990 1000
TNAVLAVKEI NVNINEYKRR KDLVLKYRKG DEDSLMEKIS KLNIHSIIKK
1010 1020 1030 1040 1050
SNRVSSHLKH LTGFAPQIKD EVFEETEKNF RMQERLIKSF IRDLSLYLQH
1060 1070 1080 1090 1100
IRESACVKVV AAVSMWDVCM ERGHRDLEQF ERVHRYISDQ LFTNFKERTE
1110 1120 1130 1140 1150
RLVISPLNQL LSMFTGPHKL VQKRFDKLLD FYNCTERAEK LKDKKTLEEL
1160 1170 1180 1190 1200
QSARNNYEAL NAQLLDELPK FHQYAQGLFT NCVHGYAEAH CDFVHQALEQ
1210 1220 1230 1240 1250
LKPLLSLLKV AGREGNLIAI FHEEHSRVLQ QLQVFTFFPE SLPATKKPFE
1260 1270 1280 1290 1300
RKTIDRQSAR KPLLGLPSYM LQSEELRASL LARYPPEKLF QAERNFNAAQ
1310 1320 1330 1340 1350
DLDVSLLEGD LVGVIKKKDP MGSQNRWLID NGVTKGFVYS SFLKPYNPRR
1360 1370 1380 1390 1400
SHSDASVGSH SSTESEHGSS SPRFPRQNSG STLTFNPSSM AVSFTSGSCQ
1410 1420 1430 1440 1450
KQPQDASPPP KECDQGTLSA SLNPSNSESS PSRCPSDPDS TSQPRSGDSA
1460 1470 1480 1490 1500
DVARDVKQPT ATPRSYRNFR HPEIVGYSVP GRNGQSQDLV KGCARTAQAP
1510 1520 1530 1540 1550
EDRSTEPDGS EAEGNQVYFA VYTFKARNPN ELSVSANQKL KILEFKDVTG
1560 1570
NTEWWLAEVN GKKGYVPSNY IRKTEYT
Length:1,577
Mass (Da):177,347
Last modified:July 5, 2004 - v1
Checksum:i5A1FDCB06124F627
GO
Isoform 2 (identifier: Q6XZF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-754: Missing.

Show »
Length:823
Mass (Da):93,498
Checksum:i535FFA230587539F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti831M → T in AAH41628 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05095581E → D.Corresponds to variant rs12267912dbSNPEnsembl.1
Natural variantiVAR_050956373N → K.Corresponds to variant rs35924554dbSNPEnsembl.1
Natural variantiVAR_050957914N → K.Corresponds to variant rs7919507dbSNPEnsembl.1
Natural variantiVAR_0243391413C → W.1 PublicationCorresponds to variant rs11190305dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0120791 – 754Missing in isoform 2. 1 PublicationAdd BLAST754

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY196211 mRNA. Translation: AAP34307.1.
AB023227 mRNA. Translation: BAA76854.1.
BC041628 mRNA. Translation: AAH41628.1.
CCDSiCCDS7485.1. [Q6XZF7-1]
RefSeqiNP_001305255.1. NM_001318326.1.
NP_001305256.1. NM_001318327.1.
NP_056036.1. NM_015221.3. [Q6XZF7-1]
XP_011537861.1. XM_011539559.2. [Q6XZF7-1]
UniGeneiHs.500771.

Genome annotation databases

EnsembliENST00000324109; ENSP00000315659; ENSG00000107554. [Q6XZF7-1]
GeneIDi23268.
KEGGihsa:23268.
UCSCiuc001kqg.3. human. [Q6XZF7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY196211 mRNA. Translation: AAP34307.1.
AB023227 mRNA. Translation: BAA76854.1.
BC041628 mRNA. Translation: AAH41628.1.
CCDSiCCDS7485.1. [Q6XZF7-1]
RefSeqiNP_001305255.1. NM_001318326.1.
NP_001305256.1. NM_001318327.1.
NP_056036.1. NM_015221.3. [Q6XZF7-1]
XP_011537861.1. XM_011539559.2. [Q6XZF7-1]
UniGeneiHs.500771.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UG1NMR-A1278-1355[»]
1UHCNMR-A1510-1575[»]
4CC2X-ray1.55A/C1513-1577[»]
4CC3X-ray1.97A/C/E/G1513-1577[»]
4CC4X-ray2.60B/D/F1513-1577[»]
4CC7X-ray1.97A/C/E/G/I/K/M1513-1577[»]
4GLMX-ray1.90A/B/C/D246-301[»]
ProteinModelPortaliQ6XZF7.
SMRiQ6XZF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116869. 29 interactors.
DIPiDIP-53822N.
IntActiQ6XZF7. 11 interactors.
MINTiMINT-4777306.
STRINGi9606.ENSP00000315659.

PTM databases

iPTMnetiQ6XZF7.
PhosphoSitePlusiQ6XZF7.

Polymorphism and mutation databases

BioMutaiDNMBP.
DMDMi56404535.

Proteomic databases

EPDiQ6XZF7.
MaxQBiQ6XZF7.
PaxDbiQ6XZF7.
PeptideAtlasiQ6XZF7.
PRIDEiQ6XZF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324109; ENSP00000315659; ENSG00000107554. [Q6XZF7-1]
GeneIDi23268.
KEGGihsa:23268.
UCSCiuc001kqg.3. human. [Q6XZF7-1]

Organism-specific databases

CTDi23268.
DisGeNETi23268.
GeneCardsiDNMBP.
HGNCiHGNC:30373. DNMBP.
HPAiHPA037878.
MIMi611282. gene.
neXtProtiNX_Q6XZF7.
OpenTargetsiENSG00000107554.
PharmGKBiPA134950706.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3519. Eukaryota.
KOG4225. Eukaryota.
ENOG410XT9S. LUCA.
GeneTreeiENSGT00530000063159.
HOGENOMiHOG000112243.
HOVERGENiHBG051383.
InParanoidiQ6XZF7.
KOiK20705.
OMAiEPGWFEG.
OrthoDBiEOG091G01C4.
PhylomeDBiQ6XZF7.
TreeFamiTF330015.

Miscellaneous databases

ChiTaRSiDNMBP. human.
EvolutionaryTraceiQ6XZF7.
GenomeRNAii23268.
PROiQ6XZF7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107554.
CleanExiHS_DNMBP.
GenevisibleiQ6XZF7. HS.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 3 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 6 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 6 hits.
PROSITEiPS51021. BAR. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNMBP_HUMAN
AccessioniPrimary (citable) accession number: Q6XZF7
Secondary accession number(s): Q8IVY3, Q9Y2L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.