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Q6XZF7

- DNMBP_HUMAN

UniProt

Q6XZF7 - DNMBP_HUMAN

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Protein
Dynamin-binding protein
Gene
DNMBP, KIAA1010
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi By similarity.

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
  2. protein binding Source: IntAct

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-binding protein
Alternative name(s):
Scaffold protein Tuba
Gene namesi
Name:DNMBP
Synonyms:KIAA1010
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:30373. DNMBP.

Subcellular locationi

Cytoplasm By similarity. Golgi apparatusGolgi stack By similarity. Cytoplasmcytoskeleton By similarity. Cell junctionsynapse By similarity
Note: Localized to synapses and Golgi stacks By similarity.

GO - Cellular componenti

  1. Golgi stack Source: UniProtKB-SubCell
  2. cell junction Source: UniProtKB-KW
  3. cytoskeleton Source: UniProtKB-SubCell
  4. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Golgi apparatus, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950706.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15771577Dynamin-binding protein
PRO_0000079959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6XZF7.
PaxDbiQ6XZF7.
PRIDEiQ6XZF7.

PTM databases

PhosphoSiteiQ6XZF7.

Expressioni

Tissue specificityi

Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

ArrayExpressiQ6XZF7.
BgeeiQ6XZF7.
CleanExiHS_DNMBP.
GenevestigatoriQ6XZF7.

Organism-specific databases

HPAiHPA037878.

Interactioni

Subunit structurei

Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WASL, WIRE, CR16, WAVE1 and NAP1L1 By similarity. Interacts with FASLG.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BIN3Q9NQY02EBI-2483419,EBI-2653038
Dnm1P215753EBI-2483419,EBI-80070From a different organism.

Protein-protein interaction databases

BioGridi116869. 23 interactions.
DIPiDIP-53822N.
IntActiQ6XZF7. 5 interactions.
MINTiMINT-4777306.
STRINGi9606.ENSP00000315659.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi247 – 2526
Beta strandi269 – 2757
Beta strandi280 – 2856
Beta strandi288 – 2936
Helixi294 – 2963
Beta strandi297 – 3004
Helixi1278 – 12836
Helixi1286 – 12883
Beta strandi1289 – 12946
Beta strandi1300 – 13023
Beta strandi1311 – 13177
Beta strandi1324 – 13307
Beta strandi1332 – 13398
Helixi1340 – 13423
Beta strandi1343 – 13453
Beta strandi1517 – 15226
Beta strandi1528 – 15314
Beta strandi1539 – 15468
Beta strandi1554 – 15596
Beta strandi1562 – 15676
Helixi1568 – 15703
Beta strandi1571 – 15744

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UG1NMR-A1278-1355[»]
1UHCNMR-A1510-1575[»]
4CC2X-ray1.55A/C1513-1577[»]
4CC3X-ray1.97A/C/E/G1513-1577[»]
4CC4X-ray2.60B/D/F1513-1577[»]
4CC7X-ray1.97A/C/E/G/I/K/M1513-1577[»]
4GLMX-ray1.90A/B/C/D246-301[»]
ProteinModelPortaliQ6XZF7.
SMRiQ6XZF7. Positions 3-59, 69-124, 151-301, 777-1008, 1013-1172, 1283-1361, 1513-1576.

Miscellaneous databases

EvolutionaryTraceiQ6XZF7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 6160SH3 1
Add
BLAST
Domaini66 – 12661SH3 2
Add
BLAST
Domaini145 – 20460SH3 3
Add
BLAST
Domaini243 – 30260SH3 4
Add
BLAST
Domaini784 – 967184DH
Add
BLAST
Domaini1008 – 1217210BAR
Add
BLAST
Domaini1285 – 134864SH3 5
Add
BLAST
Domaini1513 – 157664SH3 6
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili693 – 75765 Reviewed prediction
Add
BLAST
Coiled coili1136 – 117338 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi610 – 64940Pro-rich
Add
BLAST
Compositional biasi1351 – 144999Ser-rich
Add
BLAST

Sequence similaritiesi

Contains 1 BAR domain.
Contains 6 SH3 domains.

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG5422.
HOGENOMiHOG000112243.
HOVERGENiHBG051383.
OrthoDBiEOG7M3J14.
PhylomeDBiQ6XZF7.
TreeFamiTF330015.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 6 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 6 hits.
PROSITEiPS51021. BAR. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6XZF7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEAGSVVRAI FDFCPSVSEE LPLFVGDIIE VLAVVDEFWL LGKKEDVTGQ     50
FPSSFVEIVT IPSLKEGERL FVCICEFTSQ ELDNLPLHRG DLVILDGIPT 100
AGWLQGRSCW GARGFFPSSC VRELCLSSQS RQWHSQSALF QIPEYSMGQA 150
RALMGLSAQL DEELDFREGD VITIIGVPEP GWFEGELEGR RGIFPEGFVE 200
LLGPLRTVDE SVSSGNQDDC IVNGEVDTPV GEEEIGPDED EEEPGTYGVA 250
LYRFQALEPN ELDFEVGDKI RILATLEDGW LEGSLKGRTG IFPYRFVKLC 300
PDTRVEETMA LPQEGSLARI PETSLDCLEN TLGVEEQRHE TSDHEAEEPD 350
CIISEAPTSP LGHLTSEYDT DRNSYQDEDT AGGPPRSPGV EWEMPLATDS 400
PTSDPTEVVN GISSQPQVPF HPNLQKSQYY STVGGSHPHS EQYPDLLPLE 450
ARTRDYASLP PKRMYSQLKT LQKPVLPLYR GSSVSASRVV KPRQSSPQLH 500
NLASYTKKHH TSSVYSISER LEMKPGPQAQ GLVMEAATHS QGDGSTDLDS 550
KLTQQLIEFE KSLAGPGTEP DKILRHFSIM DFNSEKDIVR GSSKLITEQE 600
LPERRKALRP PPPRPCTPVS TSPHLLVDQN LKPAPPLVVR PSRPAPLPPS 650
AQQRTNAVSP KLLSRHRPTC ETLEKEGPGH MGRSLDQTSP CPLVLVRIEE 700
MERDLDMYSR AQEELNLMLE EKQDESSRAE TLEDLKFCES NIESLNMELQ 750
QLREMTLLSS QSSSLVAPSG SVSAENPEQR MLEKRAKVIE ELLQTERDYI 800
RDLEMCIERI MVPMQQAQVP NIDFEGLFGN MQMVIKVSKQ LLAALEISDA 850
VGPVFLGHRD ELEGTYKIYC QNHDEAIALL EIYEKDEKIQ KHLQDSLADL 900
KSLYNEWGCT NYINLGSFLI KPVQRVMRYP LLLMELLNST PESHPDKVPL 950
TNAVLAVKEI NVNINEYKRR KDLVLKYRKG DEDSLMEKIS KLNIHSIIKK 1000
SNRVSSHLKH LTGFAPQIKD EVFEETEKNF RMQERLIKSF IRDLSLYLQH 1050
IRESACVKVV AAVSMWDVCM ERGHRDLEQF ERVHRYISDQ LFTNFKERTE 1100
RLVISPLNQL LSMFTGPHKL VQKRFDKLLD FYNCTERAEK LKDKKTLEEL 1150
QSARNNYEAL NAQLLDELPK FHQYAQGLFT NCVHGYAEAH CDFVHQALEQ 1200
LKPLLSLLKV AGREGNLIAI FHEEHSRVLQ QLQVFTFFPE SLPATKKPFE 1250
RKTIDRQSAR KPLLGLPSYM LQSEELRASL LARYPPEKLF QAERNFNAAQ 1300
DLDVSLLEGD LVGVIKKKDP MGSQNRWLID NGVTKGFVYS SFLKPYNPRR 1350
SHSDASVGSH SSTESEHGSS SPRFPRQNSG STLTFNPSSM AVSFTSGSCQ 1400
KQPQDASPPP KECDQGTLSA SLNPSNSESS PSRCPSDPDS TSQPRSGDSA 1450
DVARDVKQPT ATPRSYRNFR HPEIVGYSVP GRNGQSQDLV KGCARTAQAP 1500
EDRSTEPDGS EAEGNQVYFA VYTFKARNPN ELSVSANQKL KILEFKDVTG 1550
NTEWWLAEVN GKKGYVPSNY IRKTEYT 1577
Length:1,577
Mass (Da):177,347
Last modified:July 5, 2004 - v1
Checksum:i5A1FDCB06124F627
GO
Isoform 2 (identifier: Q6XZF7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-754: Missing.

Show »
Length:823
Mass (Da):93,498
Checksum:i535FFA230587539F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811E → D.
Corresponds to variant rs12267912 [ dbSNP | Ensembl ].
VAR_050955
Natural varianti373 – 3731N → K.
Corresponds to variant rs35924554 [ dbSNP | Ensembl ].
VAR_050956
Natural varianti914 – 9141N → K.
Corresponds to variant rs7919507 [ dbSNP | Ensembl ].
VAR_050957
Natural varianti1413 – 14131C → W.1 Publication
Corresponds to variant rs11190305 [ dbSNP | Ensembl ].
VAR_024339

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 754754Missing in isoform 2.
VSP_012079Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti831 – 8311M → T in AAH41628. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY196211 mRNA. Translation: AAP34307.1.
AB023227 mRNA. Translation: BAA76854.1.
BC041628 mRNA. Translation: AAH41628.1.
CCDSiCCDS7485.1. [Q6XZF7-1]
RefSeqiNP_056036.1. NM_015221.2. [Q6XZF7-1]
UniGeneiHs.500771.

Genome annotation databases

EnsembliENST00000324109; ENSP00000315659; ENSG00000107554. [Q6XZF7-1]
ENST00000543621; ENSP00000443657; ENSG00000107554. [Q6XZF7-2]
GeneIDi23268.
KEGGihsa:23268.
UCSCiuc001kqg.2. human. [Q6XZF7-1]

Polymorphism databases

DMDMi56404535.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY196211 mRNA. Translation: AAP34307.1 .
AB023227 mRNA. Translation: BAA76854.1 .
BC041628 mRNA. Translation: AAH41628.1 .
CCDSi CCDS7485.1. [Q6XZF7-1 ]
RefSeqi NP_056036.1. NM_015221.2. [Q6XZF7-1 ]
UniGenei Hs.500771.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UG1 NMR - A 1278-1355 [» ]
1UHC NMR - A 1510-1575 [» ]
4CC2 X-ray 1.55 A/C 1513-1577 [» ]
4CC3 X-ray 1.97 A/C/E/G 1513-1577 [» ]
4CC4 X-ray 2.60 B/D/F 1513-1577 [» ]
4CC7 X-ray 1.97 A/C/E/G/I/K/M 1513-1577 [» ]
4GLM X-ray 1.90 A/B/C/D 246-301 [» ]
ProteinModelPortali Q6XZF7.
SMRi Q6XZF7. Positions 3-59, 69-124, 151-301, 777-1008, 1013-1172, 1283-1361, 1513-1576.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116869. 23 interactions.
DIPi DIP-53822N.
IntActi Q6XZF7. 5 interactions.
MINTi MINT-4777306.
STRINGi 9606.ENSP00000315659.

PTM databases

PhosphoSitei Q6XZF7.

Polymorphism databases

DMDMi 56404535.

Proteomic databases

MaxQBi Q6XZF7.
PaxDbi Q6XZF7.
PRIDEi Q6XZF7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324109 ; ENSP00000315659 ; ENSG00000107554 . [Q6XZF7-1 ]
ENST00000543621 ; ENSP00000443657 ; ENSG00000107554 . [Q6XZF7-2 ]
GeneIDi 23268.
KEGGi hsa:23268.
UCSCi uc001kqg.2. human. [Q6XZF7-1 ]

Organism-specific databases

CTDi 23268.
GeneCardsi GC10M101625.
HGNCi HGNC:30373. DNMBP.
HPAi HPA037878.
MIMi 611282. gene.
neXtProti NX_Q6XZF7.
PharmGKBi PA134950706.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5422.
HOGENOMi HOG000112243.
HOVERGENi HBG051383.
OrthoDBi EOG7M3J14.
PhylomeDBi Q6XZF7.
TreeFami TF330015.

Miscellaneous databases

ChiTaRSi DNMBP. human.
EvolutionaryTracei Q6XZF7.
GenomeRNAii 23268.
NextBioi 45022.
PROi Q6XZF7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6XZF7.
Bgeei Q6XZF7.
CleanExi HS_DNMBP.
Genevestigatori Q6XZF7.

Family and domain databases

Gene3Di 1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProi IPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view ]
SMARTi SM00721. BAR. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 6 hits.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 6 hits.
PROSITEi PS51021. BAR. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton."
    Salazar M.A., Kwiatkowski A.V., Pellegrini L., Cestra G., Butler M.H., Rossman K.L., Serna D.M., Sondek J., Gertler F.B., De Camilli P.
    J. Biol. Chem. 278:49031-49043(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Brain and Skeletal muscle.
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 263-1577 (ISOFORM 1).
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT TRP-1413.
    Tissue: Uterus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "NMR structure of SH3 domain of hypothetical protein BAA76854.1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (DEC-2003) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1278-1353 AND 1510-1575.

Entry informationi

Entry nameiDNMBP_HUMAN
AccessioniPrimary (citable) accession number: Q6XZF7
Secondary accession number(s): Q8IVY3, Q9Y2L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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