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Protein

Synaptotagmin-10

Gene

SYT10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ca2+ sensor specifically required for the Ca2+-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca2+-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca2+ and phospholipid binding to the C2 domain: Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi262Calcium 1By similarity1
Metal bindingi262Calcium 2By similarity1
Metal bindingi268Calcium 1By similarity1
Metal bindingi320Calcium 1By similarity1
Metal bindingi320Calcium 2By similarity1
Metal bindingi321Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi322Calcium 1By similarity1
Metal bindingi322Calcium 2By similarity1
Metal bindingi322Calcium 3By similarity1
Metal bindingi325Calcium 3By similarity1
Metal bindingi328Calcium 2By similarity1
Metal bindingi328Calcium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-10
Alternative name(s):
Synaptotagmin X
Short name:
SytX
Gene namesi
Name:SYT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:19266. SYT10.

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesicle membrane By similarity; Single-pass membrane protein Sequence analysis

  • Note: Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses. Does not colocalize with synaptic vesicles or with the Golgi apparatus.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55VesicularSequence analysisAdd BLAST55
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 523CytoplasmicSequence analysisAdd BLAST447

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi341359.
OpenTargetsiENSG00000110975.
PharmGKBiPA134866255.

Polymorphism and mutation databases

BioMutaiSYT10.
DMDMi52783447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839651 – 523Synaptotagmin-10Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ6XYQ8.
PaxDbiQ6XYQ8.
PeptideAtlasiQ6XYQ8.
PRIDEiQ6XYQ8.

PTM databases

iPTMnetiQ6XYQ8.
PhosphoSitePlusiQ6XYQ8.

Expressioni

Tissue specificityi

Expressed only in pancreas, lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000110975.
CleanExiHS_SYT10.
ExpressionAtlasiQ6XYQ8. baseline and differential.

Organism-specific databases

HPAiHPA055426.

Interactioni

Subunit structurei

Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT3, SYT6, SYT7 and SYT9.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131131. 4 interactors.
STRINGi9606.ENSP00000228567.

Structurei

3D structure databases

ProteinModelPortaliQ6XYQ8.
SMRiQ6XYQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 334C2 1PROSITE-ProRule annotationAdd BLAST102
Domaini365 – 468C2 2PROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 35Cysteine motifBy similarityAdd BLAST23

Domaini

The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity
The first C2 domain mediates Ca2+-dependent phospholipid binding.By similarity

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XQZ9. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ6XYQ8.
KOiK19910.
OMAiPPENVEQ.
OrthoDBiEOG091G0XMQ.
PhylomeDBiQ6XYQ8.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028677. SYT10.
[Graphical view]
PANTHERiPTHR10024:SF46. PTHR10024:SF46. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XYQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFHKEDGVN SLCQKALHIV TELCFAGQVE WEKCSGIFPR DRGSQGGSST
60 70 80 90 100
DISVSLLAVV VSFCGLALLV VSLFVFWKLC WPCWKSKPVT SNITTLPQSI
110 120 130 140 150
SSAPTEVFET EEKKEIKENE KPAVKAIEPA IKISHTSPDI PAEVQTALKE
160 170 180 190 200
HLIKHARVQR QITEPTSSTR HSSFRRHLPR QMQVSSVDFS MGTEPVLQRG
210 220 230 240 250
ETTTSIGRIK PELYKQKSVD SEGNQNEDVK ICGKLNFTLQ YDYENELLVV
260 270 280 290 300
KIIKALDLPA KDFTGTSDPY VKMYLLPDRK KKFQTRVHRK TLNPLFDETF
310 320 330 340 350
QFPVAYDQLS NRKLHFSVYD FDRFSRHDMI GEVILDNLFE VSDLSREATV
360 370 380 390 400
WKDIHCATTE SIDLGEIMFS LCYLPTAGRM TLTVIKCRNL KAMDITGSSD
410 420 430 440 450
PYVKVSLMCE GRRLKKRKTT TKKNTLNPVY NEAIIFDIPP ENVDQVSLSI
460 470 480 490 500
AVMDYDRVGH NEVIGVCRTG LDAEGLGRDH WNEMLAYHRK PITHWHPLLE
510 520
LPGRATSFDS QGSCPSPKPP STP
Length:523
Mass (Da):59,127
Last modified:July 5, 2004 - v1
Checksum:iD5A10D9A2BA9BF62
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059826172S → I.Corresponds to variant rs12317722dbSNPEnsembl.1
Natural variantiVAR_034529420T → S.Corresponds to variant rs35190376dbSNPEnsembl.1
Natural variantiVAR_034530488H → P.Corresponds to variant rs34190017dbSNPEnsembl.1
Natural variantiVAR_034531505A → V.Corresponds to variant rs34361405dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY198413 mRNA. Translation: AAP37477.1.
BC101024 mRNA. Translation: AAI01025.1.
CCDSiCCDS8732.1.
RefSeqiNP_945343.1. NM_198992.3.
UniGeneiHs.118703.

Genome annotation databases

EnsembliENST00000228567; ENSP00000228567; ENSG00000110975.
GeneIDi341359.
KEGGihsa:341359.
UCSCiuc001rll.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY198413 mRNA. Translation: AAP37477.1.
BC101024 mRNA. Translation: AAI01025.1.
CCDSiCCDS8732.1.
RefSeqiNP_945343.1. NM_198992.3.
UniGeneiHs.118703.

3D structure databases

ProteinModelPortaliQ6XYQ8.
SMRiQ6XYQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131131. 4 interactors.
STRINGi9606.ENSP00000228567.

PTM databases

iPTMnetiQ6XYQ8.
PhosphoSitePlusiQ6XYQ8.

Polymorphism and mutation databases

BioMutaiSYT10.
DMDMi52783447.

Proteomic databases

MaxQBiQ6XYQ8.
PaxDbiQ6XYQ8.
PeptideAtlasiQ6XYQ8.
PRIDEiQ6XYQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228567; ENSP00000228567; ENSG00000110975.
GeneIDi341359.
KEGGihsa:341359.
UCSCiuc001rll.2. human.

Organism-specific databases

CTDi341359.
DisGeNETi341359.
GeneCardsiSYT10.
HGNCiHGNC:19266. SYT10.
HPAiHPA055426.
neXtProtiNX_Q6XYQ8.
OpenTargetsiENSG00000110975.
PharmGKBiPA134866255.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XQZ9. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ6XYQ8.
KOiK19910.
OMAiPPENVEQ.
OrthoDBiEOG091G0XMQ.
PhylomeDBiQ6XYQ8.
TreeFamiTF315600.

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

GenomeRNAii341359.
PROiQ6XYQ8.

Gene expression databases

BgeeiENSG00000110975.
CleanExiHS_SYT10.
ExpressionAtlasiQ6XYQ8. baseline and differential.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028677. SYT10.
[Graphical view]
PANTHERiPTHR10024:SF46. PTHR10024:SF46. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT10_HUMAN
AccessioniPrimary (citable) accession number: Q6XYQ8
Secondary accession number(s): Q495U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.