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Protein

Transcription factor LBX2

Gene

LBX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transcription factor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi85 – 144HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor LBX2
Alternative name(s):
Ladybird homeobox protein homolog 2
Gene namesi
Name:LBX2
ORF Names:LP3727
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:15525. LBX2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi85474.
OpenTargetsiENSG00000179528.
PharmGKBiPA30305.

Polymorphism and mutation databases

DMDMi74749508.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113281 – 198Transcription factor LBX2Add BLAST198

Proteomic databases

EPDiQ6XYB7.
PaxDbiQ6XYB7.
PRIDEiQ6XYB7.

Expressioni

Gene expression databases

BgeeiENSG00000179528.
CleanExiHS_LBX2.
ExpressionAtlasiQ6XYB7. baseline and differential.

Organism-specific databases

HPAiHPA044257.
HPA050414.

Interactioni

Protein-protein interaction databases

IntActiQ6XYB7. 2 interactors.
STRINGi9606.ENSP00000417116.

Structurei

3D structure databases

ProteinModelPortaliQ6XYB7.
SMRiQ6XYB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000007247.
HOVERGENiHBG006244.
InParanoidiQ6XYB7.
KOiK09353.
OMAiDILAPRM.
OrthoDBiEOG091G09CY.
PhylomeDBiQ6XYB7.
TreeFamiTF325047.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6XYB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSGREPRTP RTLLSIADIL APRMVPRAPS APQLPESGPG PTSPLCALEE
60 70 80 90 100
LTSKTFRGLD ARALQPSEGR AGPDALGPGP FGRKRRKSRT AFTAQQVLEL
110 120 130 140 150
ERRFVFQKYL APSERDGLAT RLGLANAQVV TWFQNRRAKL KRDVEEMRAD
160 170 180 190
VASLRALSPE VLCSLALPEG APDPGLCLGP AGPDSRPHLS DEEIQVDD
Length:198
Mass (Da):21,482
Last modified:July 5, 2004 - v1
Checksum:iFF0796EB344F5C26
GO
Isoform 2 (identifier: Q6XYB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MNSGREPRTP...DARALQPSEG → MGKRTSLEVS...NNSQACRPQR

Note: No experimental confirmation available.
Show »
Length:194
Mass (Da):21,356
Checksum:i12F3B61B90422810
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037227158S → F.Corresponds to variant rs17009998dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0295221 – 69MNSGR…QPSEG → MGKRTSLEVSLGELGGEKCR GGRRSFPPLAASRPARPGGW RWARRDLCKTASRAENNSQA CRPQR in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305861 mRNA. Translation: AAP74384.1.
AY203953 mRNA. Translation: AAP34476.1.
CH471053 Genomic DNA. Translation: EAW99636.1.
BC150517 mRNA. Translation: AAI50518.1.
CCDSiCCDS33228.1. [Q6XYB7-2]
CCDS62938.1. [Q6XYB7-1]
RefSeqiNP_001009812.1. NM_001009812.1. [Q6XYB7-2]
NP_001269359.1. NM_001282430.1. [Q6XYB7-1]
UniGeneiHs.516124.

Genome annotation databases

EnsembliENST00000377566; ENSP00000366789; ENSG00000179528. [Q6XYB7-1]
ENST00000460508; ENSP00000417116; ENSG00000179528. [Q6XYB7-2]
GeneIDi85474.
KEGGihsa:85474.
UCSCiuc002slv.6. human. [Q6XYB7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305861 mRNA. Translation: AAP74384.1.
AY203953 mRNA. Translation: AAP34476.1.
CH471053 Genomic DNA. Translation: EAW99636.1.
BC150517 mRNA. Translation: AAI50518.1.
CCDSiCCDS33228.1. [Q6XYB7-2]
CCDS62938.1. [Q6XYB7-1]
RefSeqiNP_001009812.1. NM_001009812.1. [Q6XYB7-2]
NP_001269359.1. NM_001282430.1. [Q6XYB7-1]
UniGeneiHs.516124.

3D structure databases

ProteinModelPortaliQ6XYB7.
SMRiQ6XYB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6XYB7. 2 interactors.
STRINGi9606.ENSP00000417116.

Polymorphism and mutation databases

DMDMi74749508.

Proteomic databases

EPDiQ6XYB7.
PaxDbiQ6XYB7.
PRIDEiQ6XYB7.

Protocols and materials databases

DNASUi85474.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377566; ENSP00000366789; ENSG00000179528. [Q6XYB7-1]
ENST00000460508; ENSP00000417116; ENSG00000179528. [Q6XYB7-2]
GeneIDi85474.
KEGGihsa:85474.
UCSCiuc002slv.6. human. [Q6XYB7-1]

Organism-specific databases

CTDi85474.
DisGeNETi85474.
GeneCardsiLBX2.
HGNCiHGNC:15525. LBX2.
HPAiHPA044257.
HPA050414.
MIMi607164. gene.
neXtProtiNX_Q6XYB7.
OpenTargetsiENSG00000179528.
PharmGKBiPA30305.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000007247.
HOVERGENiHBG006244.
InParanoidiQ6XYB7.
KOiK09353.
OMAiDILAPRM.
OrthoDBiEOG091G09CY.
PhylomeDBiQ6XYB7.
TreeFamiTF325047.

Miscellaneous databases

GenomeRNAii85474.
PROiQ6XYB7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179528.
CleanExiHS_LBX2.
ExpressionAtlasiQ6XYB7. baseline and differential.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLBX2_HUMAN
AccessioniPrimary (citable) accession number: Q6XYB7
Secondary accession number(s): Q7Z5Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.