Q6XYB7 (LBX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor LBX2

Alternative name(s):
Ladybird homeobox protein homolog 2

Gene names

Name:	LBX2
ORF Names:	LP3727

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative transcription factor By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6XYB7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6XYB7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MNSGREPRTP...DARALQPSEG → MGKRTSLEVS...NNSQACRPQR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Transcription factor LBX2		PRO_0000311328
Regions
	DNA binding	85 – 144	60	Homeobox
Natural variations
	Alternative sequence	1 – 69	69	MNSGR…QPSEG → MGKRTSLEVSLGELGGEKCR GGRRSFPPLAASRPARPGGW RWARRDLCKTASRAENNSQA CRPQR in isoform 2.		VSP_029522
	Natural variant	158	1	S → F. Corresponds to variant rs17009998 [ dbSNP | Ensembl ].		VAR_037227

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: FF0796EB344F5C26	FASTA	198	21,482
	10 20 30 40 50 60 MNSGREPRTP RTLLSIADIL APRMVPRAPS APQLPESGPG PTSPLCALEE LTSKTFRGLD 70 80 90 100 110 120 ARALQPSEGR AGPDALGPGP FGRKRRKSRT AFTAQQVLEL ERRFVFQKYL APSERDGLAT 130 140 150 160 170 180 RLGLANAQVV TWFQNRRAKL KRDVEEMRAD VASLRALSPE VLCSLALPEG APDPGLCLGP 190 AGPDSRPHLS DEEIQVDD
	Isoform 2 [UniParc]. Checksum: 12F3B61B90422810	FASTA	194	21,356
	10 20 30 40 50 60 MGKRTSLEVS LGELGGEKCR GGRRSFPPLA ASRPARPGGW RWARRDLCKT ASRAENNSQA 70 80 90 100 110 120 CRPQRRAGPD ALGPGPFGRK RRKSRTAFTA QQVLELERRF VFQKYLAPSE RDGLATRLGL 130 140 150 160 170 180 ANAQVVTWFQ NRRAKLKRDV EEMRADVASL RALSPEVLCS LALPEGAPDP GLCLGPAGPD 190 SRPHLSDEEI QVDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Huang C.Q., Wu S.L., Chen Z., Shan Y.X., Liu S., Xiao P.J. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"Characterization of the murine Lbx2 promoter, identification of the human homologue, and evaluation as a candidate for Alstrom syndrome." Chen F., Collin G.B., Liu K.C., Beier D.R., Eccles M., Nishina P.M., Moshang T., Epstein J.A. Genomics 74:219-227(2001) [PubMed: 11386758] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY305861 mRNA. Translation: AAP74384.1. AY203953 mRNA. Translation: AAP34476.1. CH471053 Genomic DNA. Translation: EAW99636.1. BC150517 mRNA. Translation: AAI50518.1.
IPI	IPI00376237. IPI00550811.
RefSeq	NP_001009812.1. NM_001009812.1.
UniGene	Hs.722114.
3D structure databases
HSSP	HSSP built from PDB template 1IG7 based on UniProtKB P13297.
ProteinModelPortal	Q6XYB7.
SMR	Q6XYB7. Positions 92-142.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6XYB7. 1 interaction.
Polymorphism databases
DMDM	74749508.
Proteomic databases
PRIDE	Q6XYB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377566; ENSP00000366789; ENSG00000179528.
GeneID	85474.
KEGG	hsa:85474.
UCSC	uc002slv.2. human. uc002slw.1. human.
Organism-specific databases
CTD	85474.
GeneCards	GC02M074724.
HGNC	HGNC:15525. LBX2.
MIM	607164. gene.
neXtProt	NX_Q6XYB7.
PharmGKB	PA30305.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18131.
GeneTree	ENSGT00600000084095.
HOGENOM	HBG126717.
HOVERGEN	HBG006244.
InParanoid	Q6XYB7.
OMA	MVPRAPS.
PhylomeDB	Q6XYB7.
Gene expression databases
ArrayExpress	Q6XYB7.
Bgee	Q6XYB7.
CleanEx	HS_LBX2.
Genevestigator	Q6XYB7.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09353.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. False negative. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	76128.
SOURCE	Search...

Entry information

Entry name

LBX2_HUMAN

Accession

Primary (citable) accession number: Q6XYB7
Secondary accession number(s): Q7Z5Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.