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Protein

5-hydroxytryptamine receptor 1B

Gene

HTR1B

Organism
Vulpes vulpes (Red fox)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei354 – 3541Important for species-specific agonist sensitivityBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1B
Short name:
5-HT-1B
Short name:
5-HT1B
Short name:
5-HTR1B
Alternative name(s):
Serotonin receptor 1B
Gene namesi
Name:HTR1B
OrganismiVulpes vulpes (Red fox)
Taxonomic identifieri9627 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeVulpes

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848ExtracellularBy similarityAdd
BLAST
Transmembranei49 – 7426Helical; Name=1By similarityAdd
BLAST
Topological domaini75 – 839CytoplasmicBy similarity
Transmembranei84 – 10926Helical; Name=2By similarityAdd
BLAST
Topological domaini110 – 12213ExtracellularBy similarityAdd
BLAST
Transmembranei123 – 14422Helical; Name=3By similarityAdd
BLAST
Topological domaini145 – 16420CytoplasmicBy similarityAdd
BLAST
Transmembranei165 – 18622Helical; Name=4By similarityAdd
BLAST
Topological domaini187 – 20418ExtracellularBy similarityAdd
BLAST
Transmembranei205 – 22723Helical; Name=5By similarityAdd
BLAST
Topological domaini228 – 31487CytoplasmicBy similarityAdd
BLAST
Transmembranei315 – 33521Helical; Name=6By similarityAdd
BLAST
Topological domaini336 – 34813ExtracellularBy similarityAdd
BLAST
Transmembranei349 – 37022Helical; Name=7By similarityAdd
BLAST
Topological domaini371 – 38919CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3893895-hydroxytryptamine receptor 1BPRO_0000068923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
Lipidationi387 – 3871S-palmitoyl cysteineSequence analysis

Post-translational modificationi

Phosphorylated.By similarity
Palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Subunit structurei

Homodimer. Heterodimer with HTR1D (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6XXX8.
SMRiQ6XXX8. Positions 133-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 13310Agonist bindingBy similarity
Regioni326 – 3305Agonist bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi145 – 1473DRY motif; important for ligand-induced conformation changes and signalingBy similarity
Motifi364 – 3685NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity

Domaini

Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962.

Family and domain databases

InterProiIPR002147. 5HT1B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF16. PTHR24247:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00513. 5HT1BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XXX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDAGTPCAP PPPAGSQTGA PPANLSSAPH NCSAEGYIYQ DSIALPWKVL
60 70 80 90 100
LAILLALLTL ATTLSNAFVI ATVYRTRKLH TPANYLIASL AVTDLLVSIL
110 120 130 140 150
VMPISTMYAV TGRWTLGQVV CDLWLSSDIT CCTASILHLC VIALDRYWAI
160 170 180 190 200
TDAVEYSAKR TPKRAAVMIA LVWVFSISIS LPPFFWRQAK AEEEVSDCVV
210 220 230 240 250
NTDHILYTVY STVGAFYFPT LLLIALYGRI YVEARSRILK QTPNRTGKRL
260 270 280 290 300
TRAQLITDSP GSTSSVTSVN SRAPDVPSES GSPVYVNQVK VRVSDALLEK
310 320 330 340 350
KKLMAARERK ATKTLGIILG AFIVCWLPFF IISLVMPICK DACWFHLAIF
360 370 380
DFFTWLGYLN SLINPIIYTM SNEDFKQAFH KLIRFKCAS
Length:389
Mass (Da):42,990
Last modified:July 5, 2004 - v1
Checksum:i43080C597CCB39E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204571 Genomic DNA. Translation: AAP12468.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204571 Genomic DNA. Translation: AAP12468.1.

3D structure databases

ProteinModelPortaliQ6XXX8.
SMRiQ6XXX8. Positions 133-164.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106962.

Family and domain databases

InterProiIPR002147. 5HT1B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF16. PTHR24247:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00513. 5HT1BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5HT1B_VULVU
AccessioniPrimary (citable) accession number: Q6XXX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

A residue in the 7th transmembrane region ('Thr-355' in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.By similarity

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.