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Q6XVN8 (MLP3A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Microtubule-associated proteins 1A/1B light chain 3A
Alternative name(s):
Autophagy-related protein LC3 A
Autophagy-related ubiquitin-like modifier LC3 A
MAP1 light chain 3-like protein 1
MAP1A/MAP1B light chain 3 A
Short name=MAP1A/MAP1B LC3 A
Microtubule-associated protein 1 light chain 3 alpha
Gene names
Name:Map1lc3a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length121 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in formation of autophagosomal vacuoles (autophagosomes) By similarity.

Subunit structure

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins By similarity. Interacts with TP53INP2 By similarity. Interacts with TP53INP1 and SQSTM1. Directly interacts with SQSTM1; this interaction leads to MAP1LC3A recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy By similarity. Ref.4

Subcellular location

Cytoplasmcytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicleautophagosome membrane; Lipid-anchor By similarity. Cytoplasmic vesicleautophagosome By similarity. Note: LC3-II binds to the autophagic membranes By similarity.

Post-translational modification

The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II By similarity.

Sequence similarities

Belongs to the MAP1 LC3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 120120Microtubule-associated proteins 1A/1B light chain 3A
PRO_0000017196
Propeptide1211Removed in mature form Probable
PRO_0000017197

Amino acid modifications

Lipidation1201Phosphatidylethanolamine amidated glycine Probable

Sequences

Sequence LengthMass (Da)Tools
Q6XVN8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 48C1FBE8F7892AF3

FASTA12114,272
        10         20         30         40         50         60 
MPSDRPFKQR RSFADRCKEV QQIRDQHPSK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM 

        70         80         90        100        110        120 
SELVKIIRRR LQLNPTQAFF LLVNQHSMVS VSTPIADIYE QEKDEDGFLY MVYASQETFG 


F 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of rat lc3 orthologs."
Dang Y., Yu L., Wu J., Pei Y.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[3]Lubec G., Kang S.U.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 31-37, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
[4]"TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death."
Seillier M., Peuget S., Gayet O., Gauthier C., N'guessan P., Monte M., Carrier A., Iovanna J.L., Dusetti N.J.
Cell Death Differ. 19:1525-1535(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TP53INP1 AND SQSTM1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY206668 mRNA. Translation: AAP42560.1.
BC086389 mRNA. Translation: AAH86389.1.
IPIIPI00357953.
RefSeqNP_955794.1. NM_199500.2.
UniGeneRn.3135.

3D structure databases

ProteinModelPortalQ6XVN8.
ModBaseSearch...

Protein-protein interaction databases

IntActQ6XVN8. 2 interactions.
STRING10116.ENSRNOP00000032429.

PTM databases

PhosphoSiteQ6XVN8.

Proteomic databases

PaxDbQ6XVN8.
PRIDEQ6XVN8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000035060; ENSRNOP00000032429; ENSRNOG00000025443.
GeneID362245.
KEGGrno:362245.
UCSCRGD:735183. rat.

Organism-specific databases

CTD84557.
RGD735183. Map1lc3a.

Phylogenomic databases

eggNOGNOG264390.
GeneTreeENSGT00390000012937.
HOGENOMHOG000232034.
HOVERGENHBG051706.
InParanoidQ6XVN8.
KOK10435.
OMATPISEIY.
OrthoDBEOG4PC9TJ.

Gene expression databases

GenevestigatorQ6XVN8.
GermOnlineENSRNOG00000025443. Rattus norvegicus.

Family and domain databases

InterProIPR004241. Atg8_ubiquitin-like.
[Graphical view]
PANTHERPTHR10969. PTHR10969. 1 hit.
PfamPF02991. Atg8. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio679168.

Entry information

Entry nameMLP3A_RAT
AccessionPrimary (citable) accession number: Q6XVN8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families