Reviewed, UniProtKB/Swiss-Prot Q6XVN8 (MLP3A_RAT)

Names and origin

Protein names

Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3A
Alternative name(s):
    Microtubule-associated protein 1 light chain 3 alpha
    MAP1A/1B light chain 3 A
    MAP1A/MAP1B LC3 A
    MAP1 light chain 3-like protein 1
    Autophagy-related protein LC3 A
    Autophagy-related ubiquitin-like modifier LC3 A

Gene names

Name:

Map1lc3a

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	121 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probably involved in formation of autophagosomal vacuoles (autophagosomes) By similarity.
Subunit structure	3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins By similarity.
Subcellular location	Cytoplasm. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle › autophagosome membrane; Lipid-anchor By similarity. Note: LC3-II binds to the autophagic membranes By similarity.
Post-translational modification	The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II By similarity.
Sequence similarities	Belongs to the MAP1 LC3 family.

Ontologies

Keywords
Biological process	Autophagy Ubl conjugation pathway
Cellular component	Cytoplasm Cytoplasmic vesicle Membrane Microtubule
PTM	Lipoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	autophagic vacuole formation Inferred from direct assay. Source: UniProtKB modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell autophagic vacuole membrane Inferred from direct assay. Source: RGD cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 120	120	Microtubule-associated proteins 1A/1B light chain 3A		PRO_0000017196
	Propeptide	121	1	Removed in mature form Probable		PRO_0000017197
Amino acid modifications
	Lipidation	120	1	Phosphatidylethanolamine amidated glycine Probable

Sequences

	Sequence		Length	Mass (Da)
	Q6XVN8-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 48C1FBE8F7892AF3	FASTA	121	14,272
	10 20 30 40 50 60 MPSDRPFKQR RSFADRCKEV QQIRDQHPSK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM 70 80 90 100 110 120 SELVKIIRRR LQLNPTQAFF LLVNQHSMVS VSTPIADIYE QEKDEDGFLY MVYASQETFG F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of rat lc3 orthologs." Dang Y., Yu L., Wu J., Pei Y. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[3]	Lubec G., Kang S.U. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 31-37, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY206668 mRNA. Translation: AAP42560.1. BC086389 mRNA. Translation: AAH86389.1.
IPI	IPI00357953.
RefSeq	NP_955794.1.
UniGene	Rn.3135
3D structure databases
HSSP	HSSP built from PDB template 1KJT based on UniProtKB P60517.
SMR	Q6XVN8. Positions 1-120.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6XVN8.
Proteomic databases
PRIDE	Q6XVN8.
Genome annotation databases
Ensembl	ENSRNOT00000035060; ENSRNOP00000032429; ENSRNOG00000025443; Rattus norvegicus. [Genome view]
GeneID	362245.
KEGG	rno:362245.
UCSC	NM_199500. rat.
Organism-specific databases
CTD	362245.
RGD	735183. Map1lc3a.
Phylogenomic databases
HOVERGEN	Q6XVN8.
OMA	TPISEIY.
Gene expression databases
ArrayExpress	Q6XVN8.
Genevestigator	Q6XVN8.
GermOnline	ENSRNOG00000025443. Rattus norvegicus.
Family and domain databases
InterPro	IPR004241. MAP1_LC3. [Graphical view]
PANTHER	PTHR10969. MAP1_LC3. 1 hit.
Pfam	PF02991. MAP1_LC3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	679168.

Entry information

Entry name

MLP3A_RAT

Accession

Primary (citable) accession number: Q6XVN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)