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Protein

Cytochrome P450 2C54

Gene

Cyp2c54

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Metabolizes arachidonic acid mainly to 12-hydroxyeicosatetraenoic acid (HETE).1 Publication

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • arachidonic acid metabolic process Source: MGI
  • epoxygenase P450 pathway Source: GO_Central
  • exogenous drug catabolic process Source: GO_Central
  • linoleic acid metabolic process Source: MGI
  • xenobiotic metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.
REACT_295859. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_300263. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C54 (EC:1.14.14.1)
Alternative name(s):
CYPIIC54
Gene namesi
Name:Cyp2c54Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:3642960. Cyp2c54.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C54PRO_0000282958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei252 – 2521N6-acetyllysineBy similarity
Modified residuei375 – 3751N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6XVG2.
PaxDbiQ6XVG2.
PRIDEiQ6XVG2.

PTM databases

PhosphoSiteiQ6XVG2.

Expressioni

Tissue specificityi

Expressed in liver.1 Publication

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

Gene expression databases

BgeeiQ6XVG2.
GenevestigatoriQ6XVG2.

Interactioni

Protein-protein interaction databases

MINTiMINT-1862953.
STRINGi10090.ENSMUSP00000048284.

Structurei

3D structure databases

ProteinModelPortaliQ6XVG2.
SMRiQ6XVG2. Positions 27-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ6XVG2.
KOiK07413.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ6XVG2.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XVG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPILVLVLT LSCLFLLSLW RQSYERGKLP PGPTPLPIIG NILQIDVKDI
60 70 80 90 100
CQSFTNLSRV YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GDVFAGRGRL
110 120 130 140 150
PVFDKATNGM GIGFSNGSVW KNTRHFSLMT LRNLGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN GSPCDPTFIL GCAPCNVICS IIFQDRFDYK DRDFLNLLEK
210 220 230 240 250
LDEISKILST PWLQVCNTFP ALLDYCPGSH NQFFKNYAYI KNFLLEKIRE
260 270 280 290 300
HKESLDVTIP RDFIDYFLIK GAQEDDNHPL KNNFEHLAIT VTDLFIGGTE
310 320 330 340 350
SMSTTLRYAL LLLLKYPHVT AKVQEEIEHV IGKHRRPCMQ DRSHMPYTNA
360 370 380 390 400
MIHEVQRFID LVPNNLPHEV TCDIKFRNYF IPKGTTVITS LSSVLRDSKE
410 420 430 440 450
FPNPEKFDPG HFLDENGKFK KSDYFMPFST GKRICAGEGL ARMELFLFLT
460 470 480 490
SILQNFNLKP LVHPKDIDIT PMLIGLGSVP PAFQLCFIPS
Length:490
Mass (Da):55,858
Last modified:July 5, 2004 - v1
Checksum:iC226BBBB734DE29D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY206874 mRNA. Translation: AAO52737.1.
CCDSiCCDS29800.1.
RefSeqiNP_996260.1. NM_206537.2.
UniGeneiMm.379575.

Genome annotation databases

EnsembliENSMUST00000048959; ENSMUSP00000048284; ENSMUSG00000067225.
GeneIDi404195.
KEGGimmu:404195.
UCSCiuc012bln.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY206874 mRNA. Translation: AAO52737.1.
CCDSiCCDS29800.1.
RefSeqiNP_996260.1. NM_206537.2.
UniGeneiMm.379575.

3D structure databases

ProteinModelPortaliQ6XVG2.
SMRiQ6XVG2. Positions 27-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1862953.
STRINGi10090.ENSMUSP00000048284.

PTM databases

PhosphoSiteiQ6XVG2.

Proteomic databases

MaxQBiQ6XVG2.
PaxDbiQ6XVG2.
PRIDEiQ6XVG2.

Protocols and materials databases

DNASUi404195.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048959; ENSMUSP00000048284; ENSMUSG00000067225.
GeneIDi404195.
KEGGimmu:404195.
UCSCiuc012bln.1. mouse.

Organism-specific databases

CTDi404195.
MGIiMGI:3642960. Cyp2c54.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ6XVG2.
KOiK07413.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ6XVG2.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.
REACT_295859. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_300263. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Miscellaneous databases

NextBioi406406.
PROiQ6XVG2.
SOURCEiSearch...

Gene expression databases

BgeeiQ6XVG2.
GenevestigatoriQ6XVG2.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities."
    Wang H., Zhao Y., Bradbury J.A., Graves J.P., Foley J., Blaisdell J.A., Goldstein J.A., Zeldin D.C.
    Mol. Pharmacol. 65:1148-1158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6Imported.
    Tissue: Liver1 Publication.

Entry informationi

Entry nameiCP254_MOUSE
AccessioniPrimary (citable) accession number: Q6XVG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.