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Q6XVG2

- CP254_MOUSE

UniProt

Q6XVG2 - CP254_MOUSE

Protein

Cytochrome P450 2C54

Gene

Cyp2c54

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Metabolizes arachidonic acid mainly to 12-hydroxyeicosatetraenoic acid (HETE).1 Publication

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.1 Publication

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. arachidonic acid epoxygenase activity Source: MGI
    2. aromatase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro
    5. linoleic acid epoxygenase activity Source: MGI

    GO - Biological processi

    1. arachidonic acid metabolic process Source: MGI
    2. linoleic acid metabolic process Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C54 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC54
    Gene namesi
    Name:Cyp2c54Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:3642960. Cyp2c54.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Peripheral membrane protein 1 Publication. Microsome membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C54PRO_0000282958Add
    BLAST

    Proteomic databases

    MaxQBiQ6XVG2.
    PaxDbiQ6XVG2.
    PRIDEiQ6XVG2.

    PTM databases

    PhosphoSiteiQ6XVG2.

    Expressioni

    Tissue specificityi

    Expressed in liver.1 Publication

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

    Gene expression databases

    BgeeiQ6XVG2.
    GenevestigatoriQ6XVG2.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1862953.
    STRINGi10090.ENSMUSP00000048284.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6XVG2.
    SMRiQ6XVG2. Positions 27-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00680000099783.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiQ6XVG2.
    KOiK07413.
    OMAiRANFTIS.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiQ6XVG2.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6XVG2-1 [UniParc]FASTAAdd to Basket

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    MDPILVLVLT LSCLFLLSLW RQSYERGKLP PGPTPLPIIG NILQIDVKDI    50
    CQSFTNLSRV YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GDVFAGRGRL 100
    PVFDKATNGM GIGFSNGSVW KNTRHFSLMT LRNLGMGKRS IEDRVQEEAR 150
    CLVEELRKTN GSPCDPTFIL GCAPCNVICS IIFQDRFDYK DRDFLNLLEK 200
    LDEISKILST PWLQVCNTFP ALLDYCPGSH NQFFKNYAYI KNFLLEKIRE 250
    HKESLDVTIP RDFIDYFLIK GAQEDDNHPL KNNFEHLAIT VTDLFIGGTE 300
    SMSTTLRYAL LLLLKYPHVT AKVQEEIEHV IGKHRRPCMQ DRSHMPYTNA 350
    MIHEVQRFID LVPNNLPHEV TCDIKFRNYF IPKGTTVITS LSSVLRDSKE 400
    FPNPEKFDPG HFLDENGKFK KSDYFMPFST GKRICAGEGL ARMELFLFLT 450
    SILQNFNLKP LVHPKDIDIT PMLIGLGSVP PAFQLCFIPS 490
    Length:490
    Mass (Da):55,858
    Last modified:July 5, 2004 - v1
    Checksum:iC226BBBB734DE29D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY206874 mRNA. Translation: AAO52737.1.
    CCDSiCCDS29800.1.
    RefSeqiNP_996260.1. NM_206537.2.
    UniGeneiMm.379575.

    Genome annotation databases

    EnsembliENSMUST00000048959; ENSMUSP00000048284; ENSMUSG00000067225.
    GeneIDi404195.
    KEGGimmu:404195.
    UCSCiuc012bln.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY206874 mRNA. Translation: AAO52737.1 .
    CCDSi CCDS29800.1.
    RefSeqi NP_996260.1. NM_206537.2.
    UniGenei Mm.379575.

    3D structure databases

    ProteinModelPortali Q6XVG2.
    SMRi Q6XVG2. Positions 27-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1862953.
    STRINGi 10090.ENSMUSP00000048284.

    PTM databases

    PhosphoSitei Q6XVG2.

    Proteomic databases

    MaxQBi Q6XVG2.
    PaxDbi Q6XVG2.
    PRIDEi Q6XVG2.

    Protocols and materials databases

    DNASUi 404195.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048959 ; ENSMUSP00000048284 ; ENSMUSG00000067225 .
    GeneIDi 404195.
    KEGGi mmu:404195.
    UCSCi uc012bln.1. mouse.

    Organism-specific databases

    CTDi 404195.
    MGIi MGI:3642960. Cyp2c54.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00680000099783.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi Q6XVG2.
    KOi K07413.
    OMAi RANFTIS.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi Q6XVG2.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Miscellaneous databases

    NextBioi 406406.
    PROi Q6XVG2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6XVG2.
    Genevestigatori Q6XVG2.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities."
      Wang H., Zhao Y., Bradbury J.A., Graves J.P., Foley J., Blaisdell J.A., Goldstein J.A., Zeldin D.C.
      Mol. Pharmacol. 65:1148-1158(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: C57BL/6Imported.
      Tissue: Liver1 Publication.

    Entry informationi

    Entry nameiCP254_MOUSE
    AccessioniPrimary (citable) accession number: Q6XVG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3