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Q6XVG2

- CP254_MOUSE

UniProt

Q6XVG2 - CP254_MOUSE

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Protein

Cytochrome P450 2C54

Gene

Cyp2c54

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Metabolizes arachidonic acid mainly to 12-hydroxyeicosatetraenoic acid (HETE).1 Publication

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.1 Publication

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. arachidonic acid epoxygenase activity Source: MGI
  2. aromatase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
  5. linoleic acid epoxygenase activity Source: MGI

GO - Biological processi

  1. arachidonic acid metabolic process Source: MGI
  2. linoleic acid metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C54 (EC:1.14.14.1)
Alternative name(s):
CYPIIC54
Gene namesi
Name:Cyp2c54Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:3642960. Cyp2c54.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Peripheral membrane protein 1 Publication. Microsome membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C54PRO_0000282958Add
BLAST

Proteomic databases

MaxQBiQ6XVG2.
PaxDbiQ6XVG2.
PRIDEiQ6XVG2.

PTM databases

PhosphoSiteiQ6XVG2.

Expressioni

Tissue specificityi

Expressed in liver.1 Publication

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

Gene expression databases

BgeeiQ6XVG2.
GenevestigatoriQ6XVG2.

Interactioni

Protein-protein interaction databases

MINTiMINT-1862953.
STRINGi10090.ENSMUSP00000048284.

Structurei

3D structure databases

ProteinModelPortaliQ6XVG2.
SMRiQ6XVG2. Positions 27-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ6XVG2.
KOiK07413.
OMAiRANFTIS.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ6XVG2.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XVG2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPILVLVLT LSCLFLLSLW RQSYERGKLP PGPTPLPIIG NILQIDVKDI
60 70 80 90 100
CQSFTNLSRV YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GDVFAGRGRL
110 120 130 140 150
PVFDKATNGM GIGFSNGSVW KNTRHFSLMT LRNLGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN GSPCDPTFIL GCAPCNVICS IIFQDRFDYK DRDFLNLLEK
210 220 230 240 250
LDEISKILST PWLQVCNTFP ALLDYCPGSH NQFFKNYAYI KNFLLEKIRE
260 270 280 290 300
HKESLDVTIP RDFIDYFLIK GAQEDDNHPL KNNFEHLAIT VTDLFIGGTE
310 320 330 340 350
SMSTTLRYAL LLLLKYPHVT AKVQEEIEHV IGKHRRPCMQ DRSHMPYTNA
360 370 380 390 400
MIHEVQRFID LVPNNLPHEV TCDIKFRNYF IPKGTTVITS LSSVLRDSKE
410 420 430 440 450
FPNPEKFDPG HFLDENGKFK KSDYFMPFST GKRICAGEGL ARMELFLFLT
460 470 480 490
SILQNFNLKP LVHPKDIDIT PMLIGLGSVP PAFQLCFIPS
Length:490
Mass (Da):55,858
Last modified:July 5, 2004 - v1
Checksum:iC226BBBB734DE29D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY206874 mRNA. Translation: AAO52737.1.
CCDSiCCDS29800.1.
RefSeqiNP_996260.1. NM_206537.2.
UniGeneiMm.379575.

Genome annotation databases

EnsembliENSMUST00000048959; ENSMUSP00000048284; ENSMUSG00000067225.
GeneIDi404195.
KEGGimmu:404195.
UCSCiuc012bln.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY206874 mRNA. Translation: AAO52737.1 .
CCDSi CCDS29800.1.
RefSeqi NP_996260.1. NM_206537.2.
UniGenei Mm.379575.

3D structure databases

ProteinModelPortali Q6XVG2.
SMRi Q6XVG2. Positions 27-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1862953.
STRINGi 10090.ENSMUSP00000048284.

PTM databases

PhosphoSitei Q6XVG2.

Proteomic databases

MaxQBi Q6XVG2.
PaxDbi Q6XVG2.
PRIDEi Q6XVG2.

Protocols and materials databases

DNASUi 404195.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048959 ; ENSMUSP00000048284 ; ENSMUSG00000067225 .
GeneIDi 404195.
KEGGi mmu:404195.
UCSCi uc012bln.1. mouse.

Organism-specific databases

CTDi 404195.
MGIi MGI:3642960. Cyp2c54.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi Q6XVG2.
KOi K07413.
OMAi RANFTIS.
OrthoDBi EOG7RBZ85.
PhylomeDBi Q6XVG2.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Miscellaneous databases

NextBioi 406406.
PROi Q6XVG2.
SOURCEi Search...

Gene expression databases

Bgeei Q6XVG2.
Genevestigatori Q6XVG2.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities."
    Wang H., Zhao Y., Bradbury J.A., Graves J.P., Foley J., Blaisdell J.A., Goldstein J.A., Zeldin D.C.
    Mol. Pharmacol. 65:1148-1158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6Imported.
    Tissue: Liver1 Publication.

Entry informationi

Entry nameiCP254_MOUSE
AccessioniPrimary (citable) accession number: Q6XVG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3