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Q6XVG2 (CP254_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C54

EC=1.14.14.1
Alternative name(s):
CYPIIC54
Gene names
Name:Cyp2c54
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Metabolizes arachidonic acid mainly to 12-hydroxyeicosatetraenoic acid (HETE). Ref.1

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. Ref.1

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein Ref.1.

Tissue specificity

Expressed in liver. Ref.1

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C54
PRO_0000282958

Sites

Metal binding4351Iron (heme axial ligand) By similarity UniProtKB P10632

Sequences

Sequence LengthMass (Da)Tools
Q6XVG2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C226BBBB734DE29D

FASTA49055,858
        10         20         30         40         50         60 
MDPILVLVLT LSCLFLLSLW RQSYERGKLP PGPTPLPIIG NILQIDVKDI CQSFTNLSRV 

        70         80         90        100        110        120 
YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GDVFAGRGRL PVFDKATNGM GIGFSNGSVW 

       130        140        150        160        170        180 
KNTRHFSLMT LRNLGMGKRS IEDRVQEEAR CLVEELRKTN GSPCDPTFIL GCAPCNVICS 

       190        200        210        220        230        240 
IIFQDRFDYK DRDFLNLLEK LDEISKILST PWLQVCNTFP ALLDYCPGSH NQFFKNYAYI 

       250        260        270        280        290        300 
KNFLLEKIRE HKESLDVTIP RDFIDYFLIK GAQEDDNHPL KNNFEHLAIT VTDLFIGGTE 

       310        320        330        340        350        360 
SMSTTLRYAL LLLLKYPHVT AKVQEEIEHV IGKHRRPCMQ DRSHMPYTNA MIHEVQRFID 

       370        380        390        400        410        420 
LVPNNLPHEV TCDIKFRNYF IPKGTTVITS LSSVLRDSKE FPNPEKFDPG HFLDENGKFK 

       430        440        450        460        470        480 
KSDYFMPFST GKRICAGEGL ARMELFLFLT SILQNFNLKP LVHPKDIDIT PMLIGLGSVP 

       490 
PAFQLCFIPS 

« Hide

References

[1]"Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities."
Wang H., Zhao Y., Bradbury J.A., Graves J.P., Foley J., Blaisdell J.A., Goldstein J.A., Zeldin D.C.
Mol. Pharmacol. 65:1148-1158(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY206874 mRNA. Translation: AAO52737.1.
RefSeqNP_996260.1. NM_206537.2.
UniGeneMm.379575.

3D structure databases

ProteinModelPortalQ6XVG2.
SMRQ6XVG2. Positions 27-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1862953.
STRING10090.ENSMUSP00000048284.

PTM databases

PhosphoSiteQ6XVG2.

Proteomic databases

PaxDbQ6XVG2.
PRIDEQ6XVG2.

Protocols and materials databases

DNASU404195.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048959; ENSMUSP00000048284; ENSMUSG00000067225.
GeneID404195.
KEGGmmu:404195.
UCSCuc012bln.1. mouse.

Organism-specific databases

CTD404195.
MGIMGI:3642960. Cyp2c54.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00680000099783.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidQ6XVG2.
KOK07413.
OrthoDBEOG7RBZ85.
PhylomeDBQ6XVG2.
TreeFamTF352043.

Gene expression databases

BgeeQ6XVG2.
GenevestigatorQ6XVG2.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio406406.
PROQ6XVG2.
SOURCESearch...

Entry information

Entry nameCP254_MOUSE
AccessionPrimary (citable) accession number: Q6XVG2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot