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Protein
Submitted name:

PSD-95 alpha

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Biological processi

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering Source: Ensembl
  2. dendritic spine morphogenesis Source: Ensembl
  3. establishment of protein localization Source: Ensembl
  4. negative regulation of receptor internalization Source: Ensembl
  5. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  6. positive regulation of excitatory postsynaptic membrane potential Source: Ensembl
  7. positive regulation of synaptic transmission Source: Ensembl
  8. protein complex assembly Source: Ensembl
  9. receptor localization to synapse Source: Ensembl
  10. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
PSD-95 alphaImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. cortical cytoskeleton Source: Ensembl
  2. dendrite cytoplasm Source: Ensembl
  3. excitatory synapse Source: Ensembl
  4. juxtaparanode region of axon Source: Ensembl
  5. neuronal postsynaptic density Source: Ensembl
  6. postsynaptic membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ6XVF4.
ExpressionAtlasiQ6XVF4. baseline and differential.
GenevestigatoriQ6XVF4.

Structurei

3D structure databases

ProteinModelPortaliQ6XVF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.UniRule annotation

Phylogenomic databases

HOVERGENiHBG104157.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR016313. DLG1.
IPR019590. MAGUK_PEST_N.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR23119. PTHR23119. 1 hit.
PfamiPF10608. MAGUK_N_PEST. 2 hits.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6XVF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCLCIVTTK KYRYQDEDTP PLEHSPAHLP NQANSPPVIV NTDTLEAPGY
60 70 80 90 100
ELQVNGTEGE MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII
110 120 130 140 150
PGGAAAQDGR LRVNDSILFV NEVDVREVTH SAAVEALKEA GSIVRLYVMR
160 170 180 190 200
RKPPAEKIIE IKLIKGPKGL GFSIAGGVGN QHIPGDNSIY VTKIIEGGAA
210 220 230 240 250
HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY LKVAKPSNAY
260
LSDSYAPPDI TT
Length:262
Mass (Da):28,145
Last modified:July 5, 2004 - v1
Checksum:i26EDFD568053A0ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei262 – 2621Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY207049, AY207048 Genomic DNA. Translation: AAQ56705.1.
UniGeneiMm.27256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY207049, AY207048 Genomic DNA. Translation: AAQ56705.1.
UniGeneiMm.27256.

3D structure databases

ProteinModelPortaliQ6XVF4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG104157.

Gene expression databases

BgeeiQ6XVF4.
ExpressionAtlasiQ6XVF4. baseline and differential.
GenevestigatoriQ6XVF4.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR016313. DLG1.
IPR019590. MAGUK_PEST_N.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR23119. PTHR23119. 1 hit.
PfamiPF10608. MAGUK_N_PEST. 2 hits.
PF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analyses of murine postsynaptic density-95 identify novel isoforms and potential translational control elements."
    Bence M., Arbuckle M.I., Dickson K.S., Grant S.G.
    Brain Res. Mol. Brain Res. 133:143-152(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvEvTacfBrImported.

Entry informationi

Entry nameiQ6XVF4_MOUSE
AccessioniPrimary (citable) accession number: Q6XVF4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.