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Protein

Nibrin

Gene

nbn

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycleUniRule annotation, DNA damage, DNA repairUniRule annotation, MeiosisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NibrinUniRule annotation
Gene namesi
Name:nbnImported
Synonyms:NBS1Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-943040. nbn.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, NucleusUniRule annotation, TelomereUniRule annotation

Interactioni

Subunit structurei

Component of the MRN complex.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K2WNMR-A215-324[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 8160FHAInterPro annotationAdd
BLAST

Phylogenomic databases

HOVERGENiHBG053070.
KOiK10867.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR013908. DNA-repair_Nbs1_C.
IPR000253. FHA_dom.
IPR032429. Nibrin_BRCT2.
IPR016592. Nibrin_met.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF08599. Nbs1_C. 1 hit.
PF16508. NIBRIN_BRCT_II. 1 hit.
[Graphical view]
PIRSFiPIRSF011869. Nibrin_animal. 1 hit.
SMARTiSM00240. FHA. 1 hit.
SM01348. Nbs1_C. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52113. SSF52113. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XV80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLVAESAA GGTYHFLTGT DYVVGRKNCA ILIPEDQSIS RCHATLSVSH
60 70 80 90 100
PSANLGQTNA ASVLSIKDSS KYGTTVNGDK MNPAVPRNLK SGDKVTFGVF
110 120 130 140 150
NSKYRVEYEP LVVCSSCLDN SEKNSLNQNL IHLGGHVLNN WTEKSTHLVM
160 170 180 190 200
TSIKVTIKTI CALICCKPII KPDYFCELLH AIQEKRPLPD YRSFIPSVDE
210 220 230 240 250
PSLTPESLDL SENVKRKSIF KDKVFLFLNA KQYKKLSPAV LFGGGKTDLL
260 270 280 290 300
MGELKDASVL DNPATCVIDV AMTESQLSES QSTQPWITST LDLLQSKGLR
310 320 330 340 350
TIPEAEIGLA VINVSTEIYC NPRRRAASGT EAGTSKKMNV LSSTLCQGIA
360 370 380 390 400
VDETILPAPT LDITAYAANT EPQDQTGTSW MNISGVREVK ETPGNSSSHS
410 420 430 440 450
RSKGCLQKDP KSGSSSNDLR QTLFREDETD TRKNTPSLLP TKSSARDVTK
460 470 480 490 500
TSQKLQPTKK IDSYFQSLAK KRDRAEDEKE ASSSKLPRVE TLSSQTLEEK
510 520 530 540 550
FPPVTQTLEE ENFDSDLDME LAMSCDQILN DSMGSKAAMP EDSTVKKRKV
560 570 580 590 600
PDDHVVEESD VDSDEGIRAN AEQNDTKSDI NVTKRRKVDS EIEGTKEPTI
610 620 630 640 650
KPREIGTKAQ VKTNSPEMAP AIRKEIEVKK ELDIKKEPKS QWEESKFVPD
660 670 680 690 700
LQGETDALPS RLLLTEFKSL VVSRPVRNNN ATSNSSNGKC HNFKKFKKVA
710 720 730 740 750
YPGAGSFPNI IGGSDLIAHD RKKNAELEQW LRQEVEEQTQ QVREESLAED
760
LFRYNPKPSK RRR
Length:763
Mass (Da):84,614
Last modified:July 5, 2004 - v1
Checksum:i40DAA0A22CAD774A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY207367 mRNA. Translation: AAO34130.1.
AY999019 mRNA. Translation: AAY15242.1.
RefSeqiNP_001084420.1. NM_001090951.1.
UniGeneiXl.9528.

Genome annotation databases

GeneIDi403373.
KEGGixla:403373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY207367 mRNA. Translation: AAO34130.1.
AY999019 mRNA. Translation: AAY15242.1.
RefSeqiNP_001084420.1. NM_001090951.1.
UniGeneiXl.9528.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K2WNMR-A215-324[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403373.
KEGGixla:403373.

Organism-specific databases

CTDi4683.
XenbaseiXB-GENE-943040. nbn.

Phylogenomic databases

HOVERGENiHBG053070.
KOiK10867.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR013908. DNA-repair_Nbs1_C.
IPR000253. FHA_dom.
IPR032429. Nibrin_BRCT2.
IPR016592. Nibrin_met.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF08599. Nbs1_C. 1 hit.
PF16508. NIBRIN_BRCT_II. 1 hit.
[Graphical view]
PIRSFiPIRSF011869. Nibrin_animal. 1 hit.
SMARTiSM00240. FHA. 1 hit.
SM01348. Nbs1_C. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52113. SSF52113. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Xenopus Nijmegen breakage syndrome 1 (nibrin) (xNBS1)."
    Nishiyama A., Ishikawa F.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "ATM activation and its recruitment to damaged DNA require binding to the C-terminus of Nbs1."
    You Z., Chahwan C., Bailis J., Hunter T., Russell P.
    Mol. Cell. Biol. 25:5363-5379(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites."
    Xu C., Wu L., Cui G., Botuyan M.V., Chen J., Mer G.
    J. Mol. Biol. 381:361-372(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 215-324.

Entry informationi

Entry nameiQ6XV80_XENLA
AccessioniPrimary (citable) accession number: Q6XV80
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.