Neuraminidase - Influenza A virus (A/mink/Sweden/E12665/84(H10N4))

Preferred order of sections

Names and origin

Protein names

Submitted name:
Neuraminidase EMBL AAO62044.1

Gene names

Name:

NA EMBL AAO62044.1

Organism

Influenza A virus (A/mink/Sweden/E12665/84(H10N4)) EMBL AAO62044.1

Taxonomic identifier

222742 [NCBI]

Taxonomic lineage

Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. SAAS SAAS011040
Subunit structure	Homotetramer By similarity. SAAS SAAS011040

Ontologies

Keywords
Cellular component	Host cell membrane SAAS SAAS011040 Host membrane Membrane Virion SAAS SAAS011040
Domain	Transmembrane Transmembrane helix SAAS SAAS011040
Ligand	Calcium PDB 2HTV Metal-binding PDB 2HTV
Molecular function	Glycosidase SAAS SAAS011040 Hydrolase
PTM	Disulfide bond SAAS SAAS011040
Technical term	3D-structure PDB 2HTV PDB 2HTW
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW virion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	exo-alpha-sialidase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

293

1

Calcium; via carbonyl oxygen PDB 2HTV

Metal binding

297

1

Calcium; via carbonyl oxygen PDB 2HTV

Metal binding

323

1

Calcium PDB 2HTV

Metal binding

343

1

Calcium; via carbonyl oxygen PDB 2HTV

Metal binding

344

1

Calcium; via carbonyl oxygen PDB 2HTV

Metal binding

345

1

Calcium; via carbonyl oxygen PDB 2HTV

Binding site

145

1

N-acetyl-D-glucosamine PDB 2HTV

Sequences

Sequence

Length

Mass (Da)

Tools

Q6XV46 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B63040295F04643C
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FASTA

470

51,848

        10         20         30         40         50         60 
MNPNQKIITI GSVSIVLTTI GLLLQITSLC SIWFSHYNQV TQTNEQPCSN NTTNYYNETF 

        70         80         90        100        110        120 
VNVTNVQNNY TTITDPSTSQ VIHYSSGKDL CPVKGWAPLS KDNGIRIGSR GEVFVIREPF 

       130        140        150        160        170        180 
ISCSINECRT FFLTQGALLN DKHSNGTVKD RSPFRTLMSC PIGVAPSPSN SRFESVAWSA 

       190        200        210        220        230        240 
TACSDGPGWL TIGITGPDAT AVAVLKYNGI ITDTLKSWKG NIMRTQESEC VCQDEFCYTL 

       250        260        270        280        290        300 
ITDGPSDAQA FYKILKIKKG KIVSVKDVDA PGFHFEECSC YPSGENVECV CRDNWRGSNR 

       310        320        330        340        350        360 
PWIRFNSDLD YQIGYVCSGV FGDNPRPMDS TGSCNSPINN GKGRYGVKGF SFRYGDGVWI 

       370        380        390        400        410        420 
GRTKSLESRS GFEMVWDANG WVSTDKDSNG VQDIIDNDNW SGYSGSFSIR GETTGRNCTV 

       430        440        450        460        470 
PCFWVEMIRG QPKEKTIWTS GSSIAFCGVN SDTTGWSWPD GALLPFDIDK

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References

[1]	"Genetic analysis of multiple N3, N4, and N6 influenza A virus neuraminidase genes." Webby R.J., Humberd J.L., Krauss S.L. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A/mink/Sweden/E12665/84 EMBL AAO62044.1.
[2]	"The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design." Russell R.J., Haire L.F., Stevens D.J., Collins P.J., Lin Y.P., Blackburn G.M., Hay A.J., Gamblin S.J., Skehel J.J. Nature 443:45-49(2006) [PubMed: 16915235] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 81-470 IN COMPLEX WITH CALCIUM AND N-ACETYL-D-GLUCOSAMINE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY207530 Genomic DNA. Translation: AAO62044.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HTV	X-ray	2.80	A/B	81-470	[»]
2HTW	X-ray	3.50	A	81-470	[»]

ProteinModelPortal

Q6XV46.

SMR

Q6XV46. Positions 81-468.

ModBase

Search...

Protein family/group databases

CAZy

GH34. Glycoside Hydrolase Family 34.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR001860. Glyco_hydro_34.
IPR011040. Neuraminidase.
[Graphical view]

Gene3D

G3DSA:2.120.10.10. Neuraminidase. 1 hit.

Pfam

PF00064. Neur. 1 hit.
[Graphical view]

SUPFAM

SSF50939. Sialidase. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q6XV46_9INFA

Accession

Primary (citable) accession number: Q6XV46

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)