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Q6XUX3

- DUSTY_HUMAN

UniProt

Q6XUX3 - DUSTY_HUMAN

Protein

Dual serine/threonine and tyrosine protein kinase

Gene

DSTYK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    May induce both caspase-dependent apoptosis and caspase-independent cell death.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei681 – 6811ATPPROSITE-ProRule annotation
    Active sitei777 – 7771Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi658 – 6669ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
    3. protein serine/threonine kinase activity Source: UniProtKB-KW
    4. protein tyrosine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ6XUX3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual serine/threonine and tyrosine protein kinase (EC:2.7.12.1)
    Alternative name(s):
    Dusty protein kinase
    Short name:
    Dusty PK
    RIP-homologous kinase
    Receptor-interacting serine/threonine-protein kinase 5
    Sugen kinase 496
    Short name:
    SgK496
    Gene namesi
    Name:DSTYK
    Synonyms:KIAA0472, RIP5, RIPK5, SGK496
    ORF Names:HDCMD38P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29043. DSTYK.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi681 – 6811K → Q: No change. 1 Publication

    Organism-specific databases

    PharmGKBiPA164718861.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 929929Dual serine/threonine and tyrosine protein kinasePRO_0000233118Add
    BLAST

    Proteomic databases

    MaxQBiQ6XUX3.
    PaxDbiQ6XUX3.
    PRIDEiQ6XUX3.

    PTM databases

    PhosphoSiteiQ6XUX3.

    Expressioni

    Tissue specificityi

    Predominantly expressed in skeletal muscle and testis. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines.2 Publications

    Gene expression databases

    ArrayExpressiQ6XUX3.
    BgeeiQ6XUX3.
    CleanExiHS_DSTYK.
    GenevestigatoriQ6XUX3.

    Organism-specific databases

    HPAiHPA044140.

    Interactioni

    Protein-protein interaction databases

    BioGridi117313. 13 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6XUX3.
    SMRiQ6XUX3. Positions 646-912.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini652 – 906255Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili189 – 21527Sequence AnalysisAdd
    BLAST
    Coiled coili395 – 43137Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 228Poly-Gly
    Compositional biasi69 – 724Poly-Gly

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0515.
    InParanoidiQ6XUX3.
    KOiK16288.
    OMAiAGQLSCI.
    OrthoDBiEOG79SDWH.
    PhylomeDBiQ6XUX3.
    TreeFamiTF331821.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6XUX3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGDGVPWGS EPVSGPGPGG GGMIRELCRG FGRYRRYLGR LRQNLRETQK    50
    FFRDIKCSHN HTCLSSLTGG GGAERGPAGD VAETGLQAGQ LSCISFPPKE 100
    EKYLQQIVDC LPCILILGQD CNVKCQLLNL LLGVQVLPTT KLGSEESCKL 150
    RRLRFTYGTQ TRVSLALPGQ YELVHTLVAH QGNWETIPEE DLEVQENNED 200
    AAHVLAELEV TMHHALLQEV DVVVAPCQGL RPTVDVLGDL VNDFLPVITY 250
    ALHKDELSER DEQELQEIRK YFSFPVFFFK VPKLGSEIID SSTRRMESER 300
    SPLYRQLIDL GYLSSSHWNC GAPGQDTKAQ SMLVEQSEKL RHLSTFSHQV 350
    LQTRLVDAAK ALNLVHCHCL DIFINQAFDM QRDLQITPKR LEYTRKKENE 400
    LYESLMNIAN RKQEEMKDMI VETLNTMKEE LLDDATNMEF KDVIVPENGE 450
    PVGTREIKCC IRQIQELIIS RLNQAVANKL ISSVDYLRES FVGTLERCLQ 500
    SLEKSQDVSV HITSNYLKQI LNAAYHVEVT FHSGSSVTRM LWEQIKQIIQ 550
    RITWVSPPAI TLEWKRKVAQ EAIESLSASK LAKSICSQFR TRLNSSHEAF 600
    AASLRQLEAG HSGRLEKTED LWLRVRKDHA PRLARLSLES CSLQDVLLHR 650
    KPKLGQELGR GQYGVVYLCD NWGGHFPCAL KSVVPPDEKH WNDLALEFHY 700
    MRSLPKHERL VDLHGSVIDY NYGGGSSIAV LLIMERLHRD LYTGLKAGLT 750
    LETRLQIALD VVEGIRFLHS QGLVHRDIKL KNVLLDKQNR AKITDLGFCK 800
    PEAMMSGSIV GTPIHMAPEL FTGKYDNSVD VYAFGILFWY ICSGSVKLPE 850
    AFERCASKDH LWNNVRRGAR PERLPVFDEE CWQLMEACWD GDPLKRPLLG 900
    IVQPMLQGIM NRLCKSNSEQ PNRGLDDST 929
    Length:929
    Mass (Da):105,206
    Last modified:May 18, 2010 - v2
    Checksum:i8DDAAC289DE21EE7
    GO
    Isoform 2 (identifier: Q6XUX3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         824-868: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:884
    Mass (Da):99,968
    Checksum:i89E487C2D3CDD2FA
    GO
    Isoform 3 (identifier: Q6XUX3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         451-792: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:587
    Mass (Da):66,302
    Checksum:i6C7E99A983B9BA58
    GO
    Isoform 4 (identifier: Q6XUX3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-539: Missing.
         703-718: SLPKHERLVDLHGSVI → WVLASFISMRKIQRRI
         719-929: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:179
    Mass (Da):20,769
    Checksum:i67DB6F18452BB99F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti247 – 2471V → A in AAH72406. (PubMed:15489334)Curated
    Sequence conflicti449 – 4491G → R in AAH60870. (PubMed:15489334)Curated
    Sequence conflicti641 – 6411C → R in AAP42418. (PubMed:17123648)Curated
    Sequence conflicti641 – 6411C → R in AAS55390. (PubMed:17123648)Curated
    Sequence conflicti641 – 6411C → R in AAF65505. 1 PublicationCurated
    Sequence conflicti641 – 6411C → R in AAH53627. (PubMed:15489334)Curated
    Sequence conflicti641 – 6411C → R in AAH72406. (PubMed:15489334)Curated
    Sequence conflicti641 – 6411C → R in AAI17412. (PubMed:15489334)Curated
    Sequence conflicti641 – 6411C → R in AAI43604. (PubMed:15489334)Curated
    Sequence conflicti641 – 6411C → R in BAA32317. (PubMed:9455484)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti432 – 4321L → V.
    Corresponds to variant rs35845538 [ dbSNP | Ensembl ].
    VAR_057101

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 539539Missing in isoform 4. 1 PublicationVSP_018030Add
    BLAST
    Alternative sequencei451 – 792342Missing in isoform 3. 1 PublicationVSP_018031Add
    BLAST
    Alternative sequencei703 – 71816SLPKH…HGSVI → WVLASFISMRKIQRRI in isoform 4. 1 PublicationVSP_018032Add
    BLAST
    Alternative sequencei719 – 929211Missing in isoform 4. 1 PublicationVSP_018033Add
    BLAST
    Alternative sequencei824 – 86845Missing in isoform 2. 1 PublicationVSP_018034Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY208850 mRNA. Translation: AAP42418.1.
    AY429674 mRNA. Translation: AAS55390.1.
    AF068286 mRNA. Translation: AAF65505.1.
    AC093422 Genomic DNA. No translation available.
    BC048204 mRNA. Translation: AAH48204.1.
    BC053627 mRNA. Translation: AAH53627.1.
    BC060870 mRNA. Translation: AAH60870.2.
    BC072406 mRNA. Translation: AAH72406.1.
    BC117411 mRNA. Translation: AAI17412.1.
    BC143603 mRNA. Translation: AAI43604.1.
    AB007941 mRNA. Translation: BAA32317.1.
    CCDSiCCDS1451.1. [Q6XUX3-1]
    CCDS1452.1. [Q6XUX3-2]
    RefSeqiNP_056190.1. NM_015375.2. [Q6XUX3-1]
    NP_955749.1. NM_199462.2. [Q6XUX3-2]
    UniGeneiHs.6874.

    Genome annotation databases

    EnsembliENST00000367161; ENSP00000356129; ENSG00000133059. [Q6XUX3-2]
    ENST00000367162; ENSP00000356130; ENSG00000133059. [Q6XUX3-1]
    GeneIDi25778.
    KEGGihsa:25778.
    UCSCiuc001hbw.3. human. [Q6XUX3-1]
    uc001hbx.3. human. [Q6XUX3-2]
    uc001hby.1. human. [Q6XUX3-4]

    Polymorphism databases

    DMDMi296434486.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY208850 mRNA. Translation: AAP42418.1 .
    AY429674 mRNA. Translation: AAS55390.1 .
    AF068286 mRNA. Translation: AAF65505.1 .
    AC093422 Genomic DNA. No translation available.
    BC048204 mRNA. Translation: AAH48204.1 .
    BC053627 mRNA. Translation: AAH53627.1 .
    BC060870 mRNA. Translation: AAH60870.2 .
    BC072406 mRNA. Translation: AAH72406.1 .
    BC117411 mRNA. Translation: AAI17412.1 .
    BC143603 mRNA. Translation: AAI43604.1 .
    AB007941 mRNA. Translation: BAA32317.1 .
    CCDSi CCDS1451.1. [Q6XUX3-1 ]
    CCDS1452.1. [Q6XUX3-2 ]
    RefSeqi NP_056190.1. NM_015375.2. [Q6XUX3-1 ]
    NP_955749.1. NM_199462.2. [Q6XUX3-2 ]
    UniGenei Hs.6874.

    3D structure databases

    ProteinModelPortali Q6XUX3.
    SMRi Q6XUX3. Positions 646-912.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117313. 13 interactions.

    Chemistry

    BindingDBi Q6XUX3.
    ChEMBLi CHEMBL1908386.
    GuidetoPHARMACOLOGYi 2008.

    PTM databases

    PhosphoSitei Q6XUX3.

    Polymorphism databases

    DMDMi 296434486.

    Proteomic databases

    MaxQBi Q6XUX3.
    PaxDbi Q6XUX3.
    PRIDEi Q6XUX3.

    Protocols and materials databases

    DNASUi 25778.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367161 ; ENSP00000356129 ; ENSG00000133059 . [Q6XUX3-2 ]
    ENST00000367162 ; ENSP00000356130 ; ENSG00000133059 . [Q6XUX3-1 ]
    GeneIDi 25778.
    KEGGi hsa:25778.
    UCSCi uc001hbw.3. human. [Q6XUX3-1 ]
    uc001hbx.3. human. [Q6XUX3-2 ]
    uc001hby.1. human. [Q6XUX3-4 ]

    Organism-specific databases

    CTDi 25778.
    GeneCardsi GC01M205111.
    H-InvDB HIX0018906.
    HGNCi HGNC:29043. DSTYK.
    HPAi HPA044140.
    MIMi 612666. gene.
    neXtProti NX_Q6XUX3.
    PharmGKBi PA164718861.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    InParanoidi Q6XUX3.
    KOi K16288.
    OMAi AGQLSCI.
    OrthoDBi EOG79SDWH.
    PhylomeDBi Q6XUX3.
    TreeFami TF331821.

    Enzyme and pathway databases

    SignaLinki Q6XUX3.

    Miscellaneous databases

    ChiTaRSi DSTYK. human.
    GeneWikii RIPK5.
    GenomeRNAii 25778.
    NextBioi 46924.
    PROi Q6XUX3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6XUX3.
    Bgeei Q6XUX3.
    CleanExi HS_DSTYK.
    Genevestigatori Q6XUX3.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain."
      Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H.
      Biochim. Biophys. Acta 1759:562-572(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "A novel gene from human dendritic cell."
      Zhao Z., Huang X., Li N., Zhu X., Cao X.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Dendritic cell.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Brain, Eye, Muscle, Placenta and Skin.
    5. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
      Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
      DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 565-929 (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-681.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDUSTY_HUMAN
    AccessioniPrimary (citable) accession number: Q6XUX3
    Secondary accession number(s): B7ZL64
    , O75060, Q17R94, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3