Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dual serine/threonine and tyrosine protein kinase

Gene

DSTYK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei681ATPPROSITE-ProRule annotation1
Active sitei777Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi658 – 666ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • cellular response to fibroblast growth factor stimulus Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of fibroblast growth factor receptor signaling pathway Source: UniProtKB
  • positive regulation of kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS05726-MONOMER.
SignaLinkiQ6XUX3.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual serine/threonine and tyrosine protein kinase (EC:2.7.12.1)
Alternative name(s):
Dusty protein kinase
Short name:
Dusty PK
RIP-homologous kinase
Receptor-interacting serine/threonine-protein kinase 5
Sugen kinase 496
Short name:
SgK496
Gene namesi
Name:DSTYK
Synonyms:KIAA0472, RIP5, RIPK5, SGK496
ORF Names:HDCMD38P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29043. DSTYK.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basolateral plasma membrane Source: UniProtKB
  • cell junction Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • cytosol Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital anomalies of the kidney and urinary tract 1 (CAKUT1)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children.
See also OMIM:610805
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07132429R → Q in CAKUT1. 1 PublicationCorresponds to variant rs200780796dbSNPEnsembl.1
Natural variantiVAR_071325200D → G in CAKUT1. 1 Publication1
Natural variantiVAR_071326843S → L in CAKUT1. 1 PublicationCorresponds to variant rs778586547dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi681K → Q: No change. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi25778.
MalaCardsiDSTYK.
MIMi610805. phenotype.
OpenTargetsiENSG00000133059.
Orphaneti93100. Unilateral renal agenesis.
PharmGKBiPA164718861.

Chemistry databases

ChEMBLiCHEMBL1908386.
GuidetoPHARMACOLOGYi2008.

Polymorphism and mutation databases

BioMutaiDSTYK.
DMDMi296434486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331181 – 929Dual serine/threonine and tyrosine protein kinaseAdd BLAST929

Proteomic databases

EPDiQ6XUX3.
MaxQBiQ6XUX3.
PaxDbiQ6XUX3.
PeptideAtlasiQ6XUX3.
PRIDEiQ6XUX3.

PTM databases

iPTMnetiQ6XUX3.
PhosphoSitePlusiQ6XUX3.

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines.3 Publications

Gene expression databases

BgeeiENSG00000133059.
CleanExiHS_DSTYK.
GenevisibleiQ6XUX3. HS.

Organism-specific databases

HPAiHPA044140.

Interactioni

Protein-protein interaction databases

BioGridi117313. 36 interactors.
IntActiQ6XUX3. 1 interactor.
STRINGi9606.ENSP00000356130.

Chemistry databases

BindingDBiQ6XUX3.

Structurei

3D structure databases

ProteinModelPortaliQ6XUX3.
SMRiQ6XUX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini652 – 906Protein kinasePROSITE-ProRule annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili189 – 215Sequence analysisAdd BLAST27
Coiled coili395 – 431Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 22Poly-Gly8
Compositional biasi69 – 72Poly-Gly4

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129948.
InParanoidiQ6XUX3.
KOiK16288.
OMAiPVFFFKV.
OrthoDBiEOG091G03P4.
PhylomeDBiQ6XUX3.
TreeFamiTF331821.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6XUX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGDGVPWGS EPVSGPGPGG GGMIRELCRG FGRYRRYLGR LRQNLRETQK
60 70 80 90 100
FFRDIKCSHN HTCLSSLTGG GGAERGPAGD VAETGLQAGQ LSCISFPPKE
110 120 130 140 150
EKYLQQIVDC LPCILILGQD CNVKCQLLNL LLGVQVLPTT KLGSEESCKL
160 170 180 190 200
RRLRFTYGTQ TRVSLALPGQ YELVHTLVAH QGNWETIPEE DLEVQENNED
210 220 230 240 250
AAHVLAELEV TMHHALLQEV DVVVAPCQGL RPTVDVLGDL VNDFLPVITY
260 270 280 290 300
ALHKDELSER DEQELQEIRK YFSFPVFFFK VPKLGSEIID SSTRRMESER
310 320 330 340 350
SPLYRQLIDL GYLSSSHWNC GAPGQDTKAQ SMLVEQSEKL RHLSTFSHQV
360 370 380 390 400
LQTRLVDAAK ALNLVHCHCL DIFINQAFDM QRDLQITPKR LEYTRKKENE
410 420 430 440 450
LYESLMNIAN RKQEEMKDMI VETLNTMKEE LLDDATNMEF KDVIVPENGE
460 470 480 490 500
PVGTREIKCC IRQIQELIIS RLNQAVANKL ISSVDYLRES FVGTLERCLQ
510 520 530 540 550
SLEKSQDVSV HITSNYLKQI LNAAYHVEVT FHSGSSVTRM LWEQIKQIIQ
560 570 580 590 600
RITWVSPPAI TLEWKRKVAQ EAIESLSASK LAKSICSQFR TRLNSSHEAF
610 620 630 640 650
AASLRQLEAG HSGRLEKTED LWLRVRKDHA PRLARLSLES CSLQDVLLHR
660 670 680 690 700
KPKLGQELGR GQYGVVYLCD NWGGHFPCAL KSVVPPDEKH WNDLALEFHY
710 720 730 740 750
MRSLPKHERL VDLHGSVIDY NYGGGSSIAV LLIMERLHRD LYTGLKAGLT
760 770 780 790 800
LETRLQIALD VVEGIRFLHS QGLVHRDIKL KNVLLDKQNR AKITDLGFCK
810 820 830 840 850
PEAMMSGSIV GTPIHMAPEL FTGKYDNSVD VYAFGILFWY ICSGSVKLPE
860 870 880 890 900
AFERCASKDH LWNNVRRGAR PERLPVFDEE CWQLMEACWD GDPLKRPLLG
910 920
IVQPMLQGIM NRLCKSNSEQ PNRGLDDST
Length:929
Mass (Da):105,206
Last modified:May 18, 2010 - v2
Checksum:i8DDAAC289DE21EE7
GO
Isoform 2 (identifier: Q6XUX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-868: Missing.

Note: No experimental confirmation available.
Show »
Length:884
Mass (Da):99,968
Checksum:i89E487C2D3CDD2FA
GO
Isoform 3 (identifier: Q6XUX3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-792: Missing.

Note: No experimental confirmation available.
Show »
Length:587
Mass (Da):66,302
Checksum:i6C7E99A983B9BA58
GO
Isoform 4 (identifier: Q6XUX3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-539: Missing.
     703-718: SLPKHERLVDLHGSVI → WVLASFISMRKIQRRI
     719-929: Missing.

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):20,769
Checksum:i67DB6F18452BB99F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247V → A in AAH72406 (PubMed:15489334).Curated1
Sequence conflicti449G → R in AAH60870 (PubMed:15489334).Curated1
Sequence conflicti641C → R in AAP42418 (PubMed:17123648).Curated1
Sequence conflicti641C → R in AAS55390 (PubMed:17123648).Curated1
Sequence conflicti641C → R in AAF65505 (Ref. 2) Curated1
Sequence conflicti641C → R in AAH53627 (PubMed:15489334).Curated1
Sequence conflicti641C → R in AAH72406 (PubMed:15489334).Curated1
Sequence conflicti641C → R in AAI17412 (PubMed:15489334).Curated1
Sequence conflicti641C → R in AAI43604 (PubMed:15489334).Curated1
Sequence conflicti641C → R in BAA32317 (PubMed:9455484).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07132429R → Q in CAKUT1. 1 PublicationCorresponds to variant rs200780796dbSNPEnsembl.1
Natural variantiVAR_071325200D → G in CAKUT1. 1 Publication1
Natural variantiVAR_057101432L → V.Corresponds to variant rs35845538dbSNPEnsembl.1
Natural variantiVAR_071326843S → L in CAKUT1. 1 PublicationCorresponds to variant rs778586547dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0180301 – 539Missing in isoform 4. 1 PublicationAdd BLAST539
Alternative sequenceiVSP_018031451 – 792Missing in isoform 3. 1 PublicationAdd BLAST342
Alternative sequenceiVSP_018032703 – 718SLPKH…HGSVI → WVLASFISMRKIQRRI in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_018033719 – 929Missing in isoform 4. 1 PublicationAdd BLAST211
Alternative sequenceiVSP_018034824 – 868Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208850 mRNA. Translation: AAP42418.1.
AY429674 mRNA. Translation: AAS55390.1.
AF068286 mRNA. Translation: AAF65505.1.
AC093422 Genomic DNA. No translation available.
BC048204 mRNA. Translation: AAH48204.1.
BC053627 mRNA. Translation: AAH53627.1.
BC060870 mRNA. Translation: AAH60870.2.
BC072406 mRNA. Translation: AAH72406.1.
BC117411 mRNA. Translation: AAI17412.1.
BC143603 mRNA. Translation: AAI43604.1.
AB007941 mRNA. Translation: BAA32317.1.
CCDSiCCDS1451.1. [Q6XUX3-1]
CCDS1452.1. [Q6XUX3-2]
RefSeqiNP_056190.1. NM_015375.2. [Q6XUX3-1]
NP_955749.1. NM_199462.2. [Q6XUX3-2]
UniGeneiHs.6874.

Genome annotation databases

EnsembliENST00000367161; ENSP00000356129; ENSG00000133059. [Q6XUX3-2]
ENST00000367162; ENSP00000356130; ENSG00000133059. [Q6XUX3-1]
ENST00000615388; ENSP00000478016; ENSG00000133059. [Q6XUX3-4]
GeneIDi25778.
KEGGihsa:25778.
UCSCiuc001hbw.4. human. [Q6XUX3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208850 mRNA. Translation: AAP42418.1.
AY429674 mRNA. Translation: AAS55390.1.
AF068286 mRNA. Translation: AAF65505.1.
AC093422 Genomic DNA. No translation available.
BC048204 mRNA. Translation: AAH48204.1.
BC053627 mRNA. Translation: AAH53627.1.
BC060870 mRNA. Translation: AAH60870.2.
BC072406 mRNA. Translation: AAH72406.1.
BC117411 mRNA. Translation: AAI17412.1.
BC143603 mRNA. Translation: AAI43604.1.
AB007941 mRNA. Translation: BAA32317.1.
CCDSiCCDS1451.1. [Q6XUX3-1]
CCDS1452.1. [Q6XUX3-2]
RefSeqiNP_056190.1. NM_015375.2. [Q6XUX3-1]
NP_955749.1. NM_199462.2. [Q6XUX3-2]
UniGeneiHs.6874.

3D structure databases

ProteinModelPortaliQ6XUX3.
SMRiQ6XUX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117313. 36 interactors.
IntActiQ6XUX3. 1 interactor.
STRINGi9606.ENSP00000356130.

Chemistry databases

BindingDBiQ6XUX3.
ChEMBLiCHEMBL1908386.
GuidetoPHARMACOLOGYi2008.

PTM databases

iPTMnetiQ6XUX3.
PhosphoSitePlusiQ6XUX3.

Polymorphism and mutation databases

BioMutaiDSTYK.
DMDMi296434486.

Proteomic databases

EPDiQ6XUX3.
MaxQBiQ6XUX3.
PaxDbiQ6XUX3.
PeptideAtlasiQ6XUX3.
PRIDEiQ6XUX3.

Protocols and materials databases

DNASUi25778.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367161; ENSP00000356129; ENSG00000133059. [Q6XUX3-2]
ENST00000367162; ENSP00000356130; ENSG00000133059. [Q6XUX3-1]
ENST00000615388; ENSP00000478016; ENSG00000133059. [Q6XUX3-4]
GeneIDi25778.
KEGGihsa:25778.
UCSCiuc001hbw.4. human. [Q6XUX3-1]

Organism-specific databases

CTDi25778.
DisGeNETi25778.
GeneCardsiDSTYK.
H-InvDBHIX0018906.
HGNCiHGNC:29043. DSTYK.
HPAiHPA044140.
MalaCardsiDSTYK.
MIMi610805. phenotype.
612666. gene.
neXtProtiNX_Q6XUX3.
OpenTargetsiENSG00000133059.
Orphaneti93100. Unilateral renal agenesis.
PharmGKBiPA164718861.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129948.
InParanoidiQ6XUX3.
KOiK16288.
OMAiPVFFFKV.
OrthoDBiEOG091G03P4.
PhylomeDBiQ6XUX3.
TreeFamiTF331821.

Enzyme and pathway databases

BioCyciZFISH:HS05726-MONOMER.
SignaLinkiQ6XUX3.

Miscellaneous databases

ChiTaRSiDSTYK. human.
GeneWikiiRIPK5.
GenomeRNAii25778.
PROiQ6XUX3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133059.
CleanExiHS_DSTYK.
GenevisibleiQ6XUX3. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUSTY_HUMAN
AccessioniPrimary (citable) accession number: Q6XUX3
Secondary accession number(s): B7ZL64
, O75060, Q17R94, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.