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Q6XUX3

- DUSTY_HUMAN

UniProt

Q6XUX3 - DUSTY_HUMAN

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Protein

Dual serine/threonine and tyrosine protein kinase

Gene

DSTYK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei681 – 6811ATPPROSITE-ProRule annotation
Active sitei777 – 7771Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi658 – 6669ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
  4. protein tyrosine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to fibroblast growth factor stimulus Source: UniProtKB
  2. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  3. positive regulation of fibroblast growth factor receptor signaling pathway Source: UniProtKB
  4. positive regulation of kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ6XUX3.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual serine/threonine and tyrosine protein kinase (EC:2.7.12.1)
Alternative name(s):
Dusty protein kinase
Short name:
Dusty PK
RIP-homologous kinase
Receptor-interacting serine/threonine-protein kinase 5
Sugen kinase 496
Short name:
SgK496
Gene namesi
Name:DSTYK
Synonyms:KIAA0472, RIP5, RIPK5, SGK496
ORF Names:HDCMD38P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29043. DSTYK.

Subcellular locationi

Cytoplasm 2 Publications. Cell membrane By similarity. Apical cell membrane 1 Publication. Basolateral cell membrane 1 Publication. Cell junction By similarity
Note: Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane By similarity. Detected in basolateral and apical membranes of all tubular epithelia.By similarity1 Publication

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. basolateral plasma membrane Source: UniProtKB
  3. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital anomalies of the kidney and urinary tract (CAKUT) [MIM:610805]: A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. CAKUT is the commonest cause of chronic kidney disease in children.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291R → Q in CAKUT. 1 Publication
VAR_071324
Natural varianti200 – 2001D → G in CAKUT. 1 Publication
VAR_071325
Natural varianti843 – 8431S → L in CAKUT. 1 Publication
VAR_071326

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi681 – 6811K → Q: No change. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi610805. phenotype.
Orphaneti93100. Unilateral renal agenesis.
PharmGKBiPA164718861.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 929929Dual serine/threonine and tyrosine protein kinasePRO_0000233118Add
BLAST

Proteomic databases

MaxQBiQ6XUX3.
PaxDbiQ6XUX3.
PRIDEiQ6XUX3.

PTM databases

PhosphoSiteiQ6XUX3.

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines.3 Publications

Gene expression databases

BgeeiQ6XUX3.
CleanExiHS_DSTYK.
GenevestigatoriQ6XUX3.

Organism-specific databases

HPAiHPA044140.

Interactioni

Protein-protein interaction databases

BioGridi117313. 19 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6XUX3.
SMRiQ6XUX3. Positions 111-136, 549-912.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini652 – 906255Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili189 – 21527Sequence AnalysisAdd
BLAST
Coiled coili395 – 43137Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 228Poly-Gly
Compositional biasi69 – 724Poly-Gly

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119011.
InParanoidiQ6XUX3.
KOiK16288.
OMAiAGQLSCI.
OrthoDBiEOG79SDWH.
PhylomeDBiQ6XUX3.
TreeFamiTF331821.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6XUX3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGDGVPWGS EPVSGPGPGG GGMIRELCRG FGRYRRYLGR LRQNLRETQK
60 70 80 90 100
FFRDIKCSHN HTCLSSLTGG GGAERGPAGD VAETGLQAGQ LSCISFPPKE
110 120 130 140 150
EKYLQQIVDC LPCILILGQD CNVKCQLLNL LLGVQVLPTT KLGSEESCKL
160 170 180 190 200
RRLRFTYGTQ TRVSLALPGQ YELVHTLVAH QGNWETIPEE DLEVQENNED
210 220 230 240 250
AAHVLAELEV TMHHALLQEV DVVVAPCQGL RPTVDVLGDL VNDFLPVITY
260 270 280 290 300
ALHKDELSER DEQELQEIRK YFSFPVFFFK VPKLGSEIID SSTRRMESER
310 320 330 340 350
SPLYRQLIDL GYLSSSHWNC GAPGQDTKAQ SMLVEQSEKL RHLSTFSHQV
360 370 380 390 400
LQTRLVDAAK ALNLVHCHCL DIFINQAFDM QRDLQITPKR LEYTRKKENE
410 420 430 440 450
LYESLMNIAN RKQEEMKDMI VETLNTMKEE LLDDATNMEF KDVIVPENGE
460 470 480 490 500
PVGTREIKCC IRQIQELIIS RLNQAVANKL ISSVDYLRES FVGTLERCLQ
510 520 530 540 550
SLEKSQDVSV HITSNYLKQI LNAAYHVEVT FHSGSSVTRM LWEQIKQIIQ
560 570 580 590 600
RITWVSPPAI TLEWKRKVAQ EAIESLSASK LAKSICSQFR TRLNSSHEAF
610 620 630 640 650
AASLRQLEAG HSGRLEKTED LWLRVRKDHA PRLARLSLES CSLQDVLLHR
660 670 680 690 700
KPKLGQELGR GQYGVVYLCD NWGGHFPCAL KSVVPPDEKH WNDLALEFHY
710 720 730 740 750
MRSLPKHERL VDLHGSVIDY NYGGGSSIAV LLIMERLHRD LYTGLKAGLT
760 770 780 790 800
LETRLQIALD VVEGIRFLHS QGLVHRDIKL KNVLLDKQNR AKITDLGFCK
810 820 830 840 850
PEAMMSGSIV GTPIHMAPEL FTGKYDNSVD VYAFGILFWY ICSGSVKLPE
860 870 880 890 900
AFERCASKDH LWNNVRRGAR PERLPVFDEE CWQLMEACWD GDPLKRPLLG
910 920
IVQPMLQGIM NRLCKSNSEQ PNRGLDDST
Length:929
Mass (Da):105,206
Last modified:May 18, 2010 - v2
Checksum:i8DDAAC289DE21EE7
GO
Isoform 2 (identifier: Q6XUX3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-868: Missing.

Note: No experimental confirmation available.

Show »
Length:884
Mass (Da):99,968
Checksum:i89E487C2D3CDD2FA
GO
Isoform 3 (identifier: Q6XUX3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-792: Missing.

Note: No experimental confirmation available.

Show »
Length:587
Mass (Da):66,302
Checksum:i6C7E99A983B9BA58
GO
Isoform 4 (identifier: Q6XUX3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-539: Missing.
     703-718: SLPKHERLVDLHGSVI → WVLASFISMRKIQRRI
     719-929: Missing.

Note: No experimental confirmation available.

Show »
Length:179
Mass (Da):20,769
Checksum:i67DB6F18452BB99F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti247 – 2471V → A in AAH72406. (PubMed:15489334)Curated
Sequence conflicti449 – 4491G → R in AAH60870. (PubMed:15489334)Curated
Sequence conflicti641 – 6411C → R in AAP42418. (PubMed:17123648)Curated
Sequence conflicti641 – 6411C → R in AAS55390. (PubMed:17123648)Curated
Sequence conflicti641 – 6411C → R in AAF65505. 1 PublicationCurated
Sequence conflicti641 – 6411C → R in AAH53627. (PubMed:15489334)Curated
Sequence conflicti641 – 6411C → R in AAH72406. (PubMed:15489334)Curated
Sequence conflicti641 – 6411C → R in AAI17412. (PubMed:15489334)Curated
Sequence conflicti641 – 6411C → R in AAI43604. (PubMed:15489334)Curated
Sequence conflicti641 – 6411C → R in BAA32317. (PubMed:9455484)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291R → Q in CAKUT. 1 Publication
VAR_071324
Natural varianti200 – 2001D → G in CAKUT. 1 Publication
VAR_071325
Natural varianti432 – 4321L → V.
Corresponds to variant rs35845538 [ dbSNP | Ensembl ].
VAR_057101
Natural varianti843 – 8431S → L in CAKUT. 1 Publication
VAR_071326

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 539539Missing in isoform 4. 1 PublicationVSP_018030Add
BLAST
Alternative sequencei451 – 792342Missing in isoform 3. 1 PublicationVSP_018031Add
BLAST
Alternative sequencei703 – 71816SLPKH…HGSVI → WVLASFISMRKIQRRI in isoform 4. 1 PublicationVSP_018032Add
BLAST
Alternative sequencei719 – 929211Missing in isoform 4. 1 PublicationVSP_018033Add
BLAST
Alternative sequencei824 – 86845Missing in isoform 2. 1 PublicationVSP_018034Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY208850 mRNA. Translation: AAP42418.1.
AY429674 mRNA. Translation: AAS55390.1.
AF068286 mRNA. Translation: AAF65505.1.
AC093422 Genomic DNA. No translation available.
BC048204 mRNA. Translation: AAH48204.1.
BC053627 mRNA. Translation: AAH53627.1.
BC060870 mRNA. Translation: AAH60870.2.
BC072406 mRNA. Translation: AAH72406.1.
BC117411 mRNA. Translation: AAI17412.1.
BC143603 mRNA. Translation: AAI43604.1.
AB007941 mRNA. Translation: BAA32317.1.
CCDSiCCDS1451.1. [Q6XUX3-1]
CCDS1452.1. [Q6XUX3-2]
RefSeqiNP_056190.1. NM_015375.2. [Q6XUX3-1]
NP_955749.1. NM_199462.2. [Q6XUX3-2]
UniGeneiHs.6874.

Genome annotation databases

EnsembliENST00000367161; ENSP00000356129; ENSG00000133059. [Q6XUX3-2]
ENST00000367162; ENSP00000356130; ENSG00000133059. [Q6XUX3-1]
ENST00000615388; ENSP00000478016; ENSG00000133059. [Q6XUX3-4]
GeneIDi25778.
KEGGihsa:25778.
UCSCiuc001hbw.3. human. [Q6XUX3-1]
uc001hbx.3. human. [Q6XUX3-2]
uc001hby.1. human. [Q6XUX3-4]

Polymorphism databases

DMDMi296434486.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY208850 mRNA. Translation: AAP42418.1 .
AY429674 mRNA. Translation: AAS55390.1 .
AF068286 mRNA. Translation: AAF65505.1 .
AC093422 Genomic DNA. No translation available.
BC048204 mRNA. Translation: AAH48204.1 .
BC053627 mRNA. Translation: AAH53627.1 .
BC060870 mRNA. Translation: AAH60870.2 .
BC072406 mRNA. Translation: AAH72406.1 .
BC117411 mRNA. Translation: AAI17412.1 .
BC143603 mRNA. Translation: AAI43604.1 .
AB007941 mRNA. Translation: BAA32317.1 .
CCDSi CCDS1451.1. [Q6XUX3-1 ]
CCDS1452.1. [Q6XUX3-2 ]
RefSeqi NP_056190.1. NM_015375.2. [Q6XUX3-1 ]
NP_955749.1. NM_199462.2. [Q6XUX3-2 ]
UniGenei Hs.6874.

3D structure databases

ProteinModelPortali Q6XUX3.
SMRi Q6XUX3. Positions 111-136, 549-912.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117313. 19 interactions.

Chemistry

BindingDBi Q6XUX3.
ChEMBLi CHEMBL1908386.
GuidetoPHARMACOLOGYi 2008.

PTM databases

PhosphoSitei Q6XUX3.

Polymorphism databases

DMDMi 296434486.

Proteomic databases

MaxQBi Q6XUX3.
PaxDbi Q6XUX3.
PRIDEi Q6XUX3.

Protocols and materials databases

DNASUi 25778.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367161 ; ENSP00000356129 ; ENSG00000133059 . [Q6XUX3-2 ]
ENST00000367162 ; ENSP00000356130 ; ENSG00000133059 . [Q6XUX3-1 ]
ENST00000615388 ; ENSP00000478016 ; ENSG00000133059 . [Q6XUX3-4 ]
GeneIDi 25778.
KEGGi hsa:25778.
UCSCi uc001hbw.3. human. [Q6XUX3-1 ]
uc001hbx.3. human. [Q6XUX3-2 ]
uc001hby.1. human. [Q6XUX3-4 ]

Organism-specific databases

CTDi 25778.
GeneCardsi GC01M205111.
H-InvDB HIX0018906.
HGNCi HGNC:29043. DSTYK.
HPAi HPA044140.
MIMi 610805. phenotype.
612666. gene.
neXtProti NX_Q6XUX3.
Orphaneti 93100. Unilateral renal agenesis.
PharmGKBi PA164718861.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119011.
InParanoidi Q6XUX3.
KOi K16288.
OMAi AGQLSCI.
OrthoDBi EOG79SDWH.
PhylomeDBi Q6XUX3.
TreeFami TF331821.

Enzyme and pathway databases

SignaLinki Q6XUX3.

Miscellaneous databases

ChiTaRSi DSTYK. human.
GeneWikii RIPK5.
GenomeRNAii 25778.
NextBioi 46924.
PROi Q6XUX3.
SOURCEi Search...

Gene expression databases

Bgeei Q6XUX3.
CleanExi HS_DSTYK.
Genevestigatori Q6XUX3.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain."
    Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H.
    Biochim. Biophys. Acta 1759:562-572(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "A novel gene from human dendritic cell."
    Zhao Z., Huang X., Li N., Zhu X., Cao X.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Dendritic cell.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain, Eye, Muscle, Placenta and Skin.
  5. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 565-929 (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-681.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: INVOLVEMENT IN CAKUT, VARIANTS CAKUT GLN-29; GLY-200 AND LEU-843, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDUSTY_HUMAN
AccessioniPrimary (citable) accession number: Q6XUX3
Secondary accession number(s): B7ZL64
, O75060, Q17R94, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3