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Protein

Dual serine/threonine and tyrosine protein kinase

Gene

Dstyk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei679 – 6791ATPPROSITE-ProRule annotation
Active sitei775 – 7751Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi656 – 6649ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual serine/threonine and tyrosine protein kinase (EC:2.7.12.1)
Alternative name(s):
Dusty protein kinase
Short name:
Dusty PK
Receptor-interacting serine/threonine-protein kinase 5
Gene namesi
Name:Dstyk
Synonyms:Ripk5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi735051. Dstyk.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity
  • Apical cell membrane By similarity
  • Basolateral cell membrane By similarity
  • Cell junction By similarity

  • Note: Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 927927Dual serine/threonine and tyrosine protein kinasePRO_0000233121Add
BLAST

Proteomic databases

PaxDbiQ6XUX2.
PRIDEiQ6XUX2.

Expressioni

Tissue specificityi

Expressed in many regions of the adult brain.1 Publication

Gene expression databases

GenevisibleiQ6XUX2. RN.

Interactioni

Protein-protein interaction databases

BioGridi257980. 1 interaction.
STRINGi10116.ENSRNOP00000004810.

Structurei

3D structure databases

ProteinModelPortaliQ6XUX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini650 – 904255Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili393 – 42937Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 228Poly-Gly

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129948.
HOGENOMiHOG000007092.
InParanoidiQ6XUX2.
KOiK16288.
OMAiPVFFFKV.
OrthoDBiEOG79SDWH.
PhylomeDBiQ6XUX2.
TreeFamiTF331821.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XUX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADGQSWSG ESVSGPGPGG GGMIRELCRG FGRYRRYLGR LRQNLRETQK
60 70 80 90 100
FFRDIKCSHS HSCPSSPAGG GAAELGPAGD VAAAPLPAGQ LSCISFPPME
110 120 130 140 150
EKYLQQIVDH LPCILILGQD CNAKCQLLNL LLAVRVLPTL KLDSDESCKL
160 170 180 190 200
RRLRFTYGTR TQVSLALPGQ YELVHTLASH QDNWETIPEE DLEVQEDSED
210 220 230 240 250
TARVLADLEV TMHHALLQEV DIVVAPCHSH RPAVDVLSDL ANDFLPVITY
260 270 280 290 300
ALHKDELSER DEQELQEIRK YFSFPVFFFK VPTLEIIRSS SGRADSERSP
310 320 330 340 350
LSGQLMDLGY LSSSHRNCMA SDQDCRAQSM LVEQSEKLRQ LSTFSHQLLQ
360 370 380 390 400
TRLVDAAKAL NAVHSHCLDI FINQAFDMQR DLQITPKRLE YTRKKENELY
410 420 430 440 450
ESLMNIANRK QEEMKDMIVE TLNTMKEELL DDAANMEFKD VIVPENGETV
460 470 480 490 500
GTREIKSCIR QIQELIISRL NQAVANKLIS SVDYLRESFV GTLERCLQSL
510 520 530 540 550
EKSQDVSVHI TSNYLKQILN AAYHVEVTFH SGSSVTRMLW EQIKQIIQRI
560 570 580 590 600
TWVNPPTITL EWKRKVAQEA IDSLSASKLA KSICSQFRTR LNSSHEAFAA
610 620 630 640 650
SLRQLEAGHS GRLEKTEDLW LKVRKDHAPR LARLSLESRS LQDVLLHRKP
660 670 680 690 700
KLGQELGRGQ YGVVYLCDNW GGHFPCALKS VVPPDEKHWN DLALEFHYMR
710 720 730 740 750
SLPKHERLVD LHGSVIDYNY GGGSSVAVLL IMERLHRDLY TGLKAGLSLE
760 770 780 790 800
TRLQIALDVV EGIRFLHSQG LVHRDIKLKN VLLDKQNRAK ITDLGFCKPE
810 820 830 840 850
AMMSGSIVGT PIHMAPELFT GKYDNSVDVY AFGILFWYIC SGSIKLPEAF
860 870 880 890 900
ERCASKDHLW NNVRRGTRPE RLPVFDEECW QLMEACWDGD PSKRPLLGIV
910 920
QPILRSIMDR LCKCDSERPS RGLDDST
Length:927
Mass (Da):104,898
Last modified:July 5, 2004 - v1
Checksum:i88C938259D04472C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208851 mRNA. Translation: AAP42419.1.
AY429675 mRNA. Translation: AAS55391.1.
RefSeqiNP_955750.1. NM_199463.2.
UniGeneiRn.32539.

Genome annotation databases

EnsembliENSRNOT00000004810; ENSRNOP00000004810; ENSRNOG00000021298.
GeneIDi304791.
KEGGirno:304791.
UCSCiRGD:735051. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208851 mRNA. Translation: AAP42419.1.
AY429675 mRNA. Translation: AAS55391.1.
RefSeqiNP_955750.1. NM_199463.2.
UniGeneiRn.32539.

3D structure databases

ProteinModelPortaliQ6XUX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi257980. 1 interaction.
STRINGi10116.ENSRNOP00000004810.

Proteomic databases

PaxDbiQ6XUX2.
PRIDEiQ6XUX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004810; ENSRNOP00000004810; ENSRNOG00000021298.
GeneIDi304791.
KEGGirno:304791.
UCSCiRGD:735051. rat.

Organism-specific databases

CTDi25778.
RGDi735051. Dstyk.

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129948.
HOGENOMiHOG000007092.
InParanoidiQ6XUX2.
KOiK16288.
OMAiPVFFFKV.
OrthoDBiEOG79SDWH.
PhylomeDBiQ6XUX2.
TreeFamiTF331821.

Miscellaneous databases

PROiQ6XUX2.

Gene expression databases

GenevisibleiQ6XUX2. RN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain."
    Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H.
    Biochim. Biophys. Acta 1759:562-572(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiDUSTY_RAT
AccessioniPrimary (citable) accession number: Q6XUX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.