Q6XUX0 (DUSTY_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual serine/threonine and tyrosine protein kinase
EC=2.7.12.1

Alternative name(s):
Dusty protein kinase
Short name=Dusty PK
Receptor-interacting serine/threonine-protein kinase 5

Gene names

Name:	DSTYK
Synonyms:	RIPK5

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	930 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May induce both caspase-dependent apoptosis and caspase-independent cell death By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm Probable.
Tissue specificity	Widely expressed with the highest expression in brain and ovary. Ref.1
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine/tyrosine kinase activity Inferred from electronic annotation. Source: EC protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 930	930	Dual serine/threonine and tyrosine protein kinase		PRO_0000233122
Regions
	Domain	653 – 907	255	Protein kinase
	Nucleotide binding	659 – 667	9	ATP By similarity
	Coiled coil	383 – 428	46	Potential
	Compositional bias	69 – 74	6	Poly-Gly
Sites
	Active site	778	1	Proton acceptor By similarity
	Binding site	682	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6XUX0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6FCF8B8073AFFB74	FASTA	930	105,410
	10 20 30 40 50 60 MEGEGAPSWR GGPGGLIREL CRSFGHYNRH LARLQHNLRE TKKFFRDVKY SQGNLFASGA 70 80 90 100 110 120 AIGEGSPSGA GGGGTRDGGQ NFISFPRHEE EHLQQTVSWH PCLLILGQNC NAKCQLLNIL 130 140 150 160 170 180 LGEKLLPTTK ISSEENCKRR RIRFTHGTQT RVSLALPEQY ELVHMMAAHR GHWDTIPEED 190 200 210 220 230 240 LEIRGDSEDP AHRIAELEVV LPYSLLKEVD VVVAPCRGFQ SAEATLEEYM NQVLLIVIFA 250 260 270 280 290 300 ISEAELSSSD ENELREIKEK FSLPIFFFKV PESGVELISP KKTDNEKSSL YCQLMDLEYL 310 320 330 340 350 360 STNHCSCGAP SPDAVAQSML VEQLEKLRLL STFSRQVLQK HLVEAATSLN EVHCRCLNIF 370 380 390 400 410 420 INQAFDMQRD LQITPKRLEY TRRKENELYE SLMNIANRKQ EEMKDMIIET LSNMKEELLE 430 440 450 460 470 480 DAANMEFKDI IIPENGEPVS SKDIKCCIKQ IQELIISRLN QAVANKLISS VDYLRESFVG 490 500 510 520 530 540 TLERCLKSLE ESWEVSVHPA RSLEKSKDVS VHITSNYLKQ ILNAAYHVEV TFHSGSTVTR 550 560 570 580 590 600 MLWEQIKQII QRITWVSPPA ITSDWKRKVA QDAIESLSAS KLAKSICSQF RTRLNSSHEA 610 620 630 640 650 660 FAASLRQLED GHSGRLEKTE DLWLKVRKDH APRLARLSLE SRSLQDVLLH GKPKLGRELG 670 680 690 700 710 720 RGQYGVVYLC DSWGGHFPCA LKSVVPPDEK HWNDLALEFH YMRSLQSHER LVDLHGSVID 730 740 750 760 770 780 YGYGGGSSIA VLLIMERLHR DLYTGLKAGL ELETRLQIAL DVVEGIRYLH SQGLVHRDIK 790 800 810 820 830 840 LKNVLLDKKN RAKITDLGFC KPEAMMSGSI VGTPIHMAPE LFTGKYDNSV DVYAFGILFW 850 860 870 880 890 900 YICSGHVKLP EAFERCASKD HLWNNVRRGV RPERLPVFDE ECWQLMEACW DGDSSQRPLL 910 920 930 GIVQPMLQGI MDRLCKSSSE HPNKGLDDST

References

[1]

"Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain." Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H. Biochim. Biophys. Acta 1759:562-572(2006) [PubMed: 17123648] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY208853 mRNA. Translation: AAP42421.1. AY429677 mRNA. Translation: AAS55393.1.
IPI	IPI00585049.
RefSeq	NP_989837.1. NM_204506.2.
UniGene	Gga.9495.
3D structure databases
ProteinModelPortal	Q6XUX0.
ModBase	Search...
Proteomic databases
PRIDE	Q6XUX0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395171.
KEGG	gga:395171.
Organism-specific databases
CTD	25778.
Phylogenomic databases
eggNOG	veNOG12095.
GeneTree	ENSGT00600000084126.
HOGENOM	HBG713278.
InParanoid	Q6XUX0.
OrthoDB	EOG4CNQQC.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
KO	K08282.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUSTY_CHICK

Accession

Primary (citable) accession number: Q6XUX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program