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Q6XT21

- Q6XT21_9INFA

UniProt

Q6XT21 - Q6XT21_9INFA

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Protein
Submitted name: Membrane ion channel M2
Gene
M
Organism
Influenza A virus (A/Chiba/5/71(H3N2))
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation By similarity.SAAS annotations

GO - Molecular functioni

  1. hydrogen ion transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channelSAAS annotations

Keywords - Biological processi

Host-virus interaction, Hydrogen ion transportSAAS annotations, Inhibition of host autophagy by virusSAAS annotations, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Membrane ion channel M2Imported
Gene namesi
Name:MImported
OrganismiInfluenza A virus (A/Chiba/5/71(H3N2))Imported
Taxonomic identifieri221020 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host membrane, Membrane, VirionSAAS annotations

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations, PhosphoproteinSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LY0NMR-A/B/C/D19-49[»]
ProteinModelPortaliQ6XT21.
SMRiQ6XT21. Positions 23-60.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

InterProiIPR002089. Flu_M2.
[Graphical view]
PfamiPF00599. Flu_M2. 1 hit.
[Graphical view]
ProDomiPD001031. Flu_M2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q6XT21-1 [UniParc]FASTAAdd to Basket

« Hide

MSLLTEVETP IRNEWGCRCN DSSDPLVVAA NIIGILHLIL WILDRLFFKC   50
IYRFFEHGLK RGPSTEGVPE SMREEYRKEQ QSAVDADDSH FVSIELE 97
Length:97
Mass (Da):11,213
Last modified:July 5, 2004 - v1
Checksum:i3CDD5C08FD6AF754
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY210265 Genomic RNA. Translation: AAO46704.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY210265 Genomic RNA. Translation: AAO46704.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LY0 NMR - A/B/C/D 19-49 [» ]
ProteinModelPortali Q6XT21.
SMRi Q6XT21. Positions 23-60.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002089. Flu_M2.
[Graphical view ]
Pfami PF00599. Flu_M2. 1 hit.
[Graphical view ]
ProDomi PD001031. Flu_M2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Genetic analysis of human H2N2 and early H3N2 influenza viruses, 1957-1972: evidence for genetic divergence and multiple reassortment events."
    Lindstrom S.E., Cox N.J., Klimov A.
    Virology 328:101-119(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/Chiba/5/71Imported.
  2. "Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus."
    Wang J., Wu Y., Ma C., Fiorin G., Wang J., Pinto L.H., Lamb R.A., Klein M.L., Degrado W.F.
    Proc. Natl. Acad. Sci. U.S.A. 110:1315-1320(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 19-49.

Entry informationi

Entry nameiQ6XT21_9INFA
AccessioniPrimary (citable) accession number: Q6XT21
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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