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Protein

Matrix protein 2

Gene

M

Organism
Influenza A virus (A/Chiba/5/71(H3N2))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme regulationi

The M2 protein from most influenza A strains is inhibited by amantadine and rimantadine, resulting in viral uncoating incapacity. Emergence of amantadine-resistant variants is usually rapid.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Host-virus interaction, Hydrogen ion transportUniRule annotationSAAS annotation, Inhibition of host autophagy by virusSAAS annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix protein 2UniRule annotationSAAS annotation
Gene namesi
Name:MImported
OrganismiInfluenza A virus (A/Chiba/5/71(H3N2))Imported
Taxonomic identifieri221020 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

  • Host apical cell membrane SAAS annotation; Single-pass type III membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4319HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host membrane, Membrane, VirionUniRule annotationSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Homotetramer; composed of two disulfide-linked dimers held together by non-covalent interactions. May interact with matrix protein 1.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LY0NMR-A/B/C/D19-49[»]
ProteinModelPortaliQ6XT21.
SMRiQ6XT21. Positions 23-60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Cytoplasmic tail plays an important role in virion assembly and morphogenesis.UniRule annotation

Sequence similaritiesi

Belongs to the influenza viruses matrix protein M2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

InterProiIPR002089. Flu_M2.
[Graphical view]
PfamiPF00599. Flu_M2. 1 hit.
[Graphical view]
ProDomiPD001031. Flu_M2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q6XT21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLTEVETP IRNEWGCRCN DSSDPLVVAA NIIGILHLIL WILDRLFFKC
60 70 80 90
IYRFFEHGLK RGPSTEGVPE SMREEYRKEQ QSAVDADDSH FVSIELE
Length:97
Mass (Da):11,213
Last modified:July 5, 2004 - v1
Checksum:i3CDD5C08FD6AF754
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY210265 Genomic RNA. Translation: AAO46704.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY210265 Genomic RNA. Translation: AAO46704.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LY0NMR-A/B/C/D19-49[»]
ProteinModelPortaliQ6XT21.
SMRiQ6XT21. Positions 23-60.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR002089. Flu_M2.
[Graphical view]
PfamiPF00599. Flu_M2. 1 hit.
[Graphical view]
ProDomiPD001031. Flu_M2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Genetic analysis of human H2N2 and early H3N2 influenza viruses, 1957-1972: evidence for genetic divergence and multiple reassortment events."
    Lindstrom S.E., Cox N.J., Klimov A.
    Virology 328:101-119(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/Chiba/5/71Imported.
  2. "Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus."
    Wang J., Wu Y., Ma C., Fiorin G., Wang J., Pinto L.H., Lamb R.A., Klein M.L., Degrado W.F.
    Proc. Natl. Acad. Sci. U.S.A. 110:1315-1320(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 19-49.

Entry informationi

Entry nameiQ6XT21_9INFA
AccessioniPrimary (citable) accession number: Q6XT21
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.