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Q6XT21

- Q6XT21_9INFA

UniProt

Q6XT21 - Q6XT21_9INFA

Protein
Submitted name:

Membrane ion channel M2

Gene

M

Organism
Influenza A virus (A/Chiba/5/71(H3N2))
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.SAAS annotation

    GO - Molecular functioni

    1. hydrogen ion transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. suppression by virus of host autophagy Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channelSAAS annotation

    Keywords - Biological processi

    Host-virus interaction, Hydrogen ion transportSAAS annotation, Inhibition of host autophagy by virusSAAS annotation, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Membrane ion channel M2Imported
    Gene namesi
    Name:MImported
    OrganismiInfluenza A virus (A/Chiba/5/71(H3N2))Imported
    Taxonomic identifieri221020 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

    Subcellular locationi

    Virion membrane SAAS annotation. Host apical cell membrane SAAS annotation; Single-pass type III membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host membrane, Membrane, VirionSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation, PhosphoproteinSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LY0NMR-A/B/C/D19-49[»]
    ProteinModelPortaliQ6XT21.
    SMRiQ6XT21. Positions 23-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    InterProiIPR002089. Flu_M2.
    [Graphical view]
    PfamiPF00599. Flu_M2. 1 hit.
    [Graphical view]
    ProDomiPD001031. Flu_M2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q6XT21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLLTEVETP IRNEWGCRCN DSSDPLVVAA NIIGILHLIL WILDRLFFKC   50
    IYRFFEHGLK RGPSTEGVPE SMREEYRKEQ QSAVDADDSH FVSIELE 97
    Length:97
    Mass (Da):11,213
    Last modified:July 5, 2004 - v1
    Checksum:i3CDD5C08FD6AF754
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY210265 Genomic RNA. Translation: AAO46704.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY210265 Genomic RNA. Translation: AAO46704.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LY0 NMR - A/B/C/D 19-49 [» ]
    ProteinModelPortali Q6XT21.
    SMRi Q6XT21. Positions 23-60.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002089. Flu_M2.
    [Graphical view ]
    Pfami PF00599. Flu_M2. 1 hit.
    [Graphical view ]
    ProDomi PD001031. Flu_M2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic analysis of human H2N2 and early H3N2 influenza viruses, 1957-1972: evidence for genetic divergence and multiple reassortment events."
      Lindstrom S.E., Cox N.J., Klimov A.
      Virology 328:101-119(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A/Chiba/5/71Imported.
    2. "Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus."
      Wang J., Wu Y., Ma C., Fiorin G., Wang J., Pinto L.H., Lamb R.A., Klein M.L., Degrado W.F.
      Proc. Natl. Acad. Sci. U.S.A. 110:1315-1320(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 19-49.

    Entry informationi

    Entry nameiQ6XT21_9INFA
    AccessioniPrimary (citable) accession number: Q6XT21
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3