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Q6XT21 (Q6XT21_9INFA) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Membrane ion channel M2 EMBL AAO46704.1
Gene names
Name:M EMBL AAO46704.1
OrganismInfluenza A virus (A/Chiba/5/71(H3N2)) EMBL AAO46704.1
Taxonomic identifier221020 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A ›

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation By similarity. SAAS SAAS002089

Sequences

Sequence LengthMass (Da)Tools
Q6XT21 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 3CDD5C08FD6AF754

FASTA9711,213
        10         20         30         40         50         60 
MSLLTEVETP IRNEWGCRCN DSSDPLVVAA NIIGILHLIL WILDRLFFKC IYRFFEHGLK 

        70         80         90 
RGPSTEGVPE SMREEYRKEQ QSAVDADDSH FVSIELE

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References

[1]"Genetic analysis of human H2N2 and early H3N2 influenza viruses, 1957-1972: evidence for genetic divergence and multiple reassortment events."
Lindstrom S.E., Cox N.J., Klimov A.
Virology 328:101-119(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A/Chiba/5/71 EMBL AAO46704.1.
[2]"Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus."
Wang J., Wu Y., Ma C., Fiorin G., Wang J., Pinto L.H., Lamb R.A., Klein M.L., Degrado W.F.
Proc. Natl. Acad. Sci. U.S.A. 110:1315-1320(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 20-49.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY210265 Genomic RNA. Translation: AAO46704.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2LY0NMR-A/B/C/D20-49[»]
ProteinModelPortalQ6XT21.
SMRQ6XT21. Positions 23-60.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002089. Flu_M2.
[Graphical view]
PfamPF00599. Flu_M2. 1 hit.
[Graphical view]
ProDomPD001031. Flu_M2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameQ6XT21_9INFA
AccessionPrimary (citable) accession number: Q6XT21
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info