##gff-version 3 Q6XR72 UniProtKB Chain 1 485 . . . ID=PRO_0000312580;Note=Calcium/manganese antiporter SLC30A10 Q6XR72 UniProtKB Topological domain 1 10 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Transmembrane 11 31 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Topological domain 32 40 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Transmembrane 41 61 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Topological domain 62 81 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Transmembrane 82 102 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Topological domain 103 113 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Transmembrane 114 134 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Topological domain 135 244 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Transmembrane 245 265 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Topological domain 266 278 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Transmembrane 279 299 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Topological domain 300 485 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6XR72 UniProtKB Region 167 196 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6XR72 UniProtKB Region 308 485 . . . Note=Required for plasma membrane localization;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25319704;Dbxref=PMID:25319704 Q6XR72 UniProtKB Site 43 43 . . . Note=Important for coupling of manganese to calcium transport;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30755481;Dbxref=PMID:30755481 Q6XR72 UniProtKB Alternative sequence 1 245 . . . ID=VSP_029863;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 Q6XR72 UniProtKB Alternative sequence 214 223 . . . ID=VSP_029864;Note=In isoform 3. GDSFNTQNEP->ELIHNTRFLL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q6XR72 UniProtKB Alternative sequence 224 485 . . . ID=VSP_029865;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q6XR72 UniProtKB Natural variant 89 89 . . . ID=VAR_072573;Note=In HMNDYT1%3B loss of localization to the plasma membrane%3B retained in the endoplasmic reticulum%3B increased proteasomal degradation%3B loss of function in intracellular manganese ion homeostasis. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22341972,ECO:0000269|PubMed:25319704;Dbxref=dbSNP:rs281860284,PMID:22341972,PMID:25319704 Q6XR72 UniProtKB Natural variant 105 107 . . . ID=VAR_072574;Note=In HMNDYT1%3B loss of localization to the plasma membrane%3B retained in the endoplasmic reticulum%3B increased proteasomal degradation%3B decreased function in intracellular manganese ion homeostasis. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22341972,ECO:0000269|PubMed:25319704;Dbxref=PMID:22341972,PMID:25319704 Q6XR72 UniProtKB Natural variant 167 167 . . . ID=VAR_072575;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22341971;Dbxref=dbSNP:rs281860286,PMID:22341971 Q6XR72 UniProtKB Natural variant 256 256 . . . ID=VAR_072576;Note=In HMNDYT1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22341972;Dbxref=PMID:22341972 Q6XR72 UniProtKB Natural variant 349 349 . . . ID=VAR_072577;Note=In HMNDYT1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22341972;Dbxref=dbSNP:rs281860291,PMID:22341972 Q6XR72 UniProtKB Mutagenesis 4 4 . . . Note=Decreased interaction with SLC30A3. No effect on self-association. Decreased zinc ion transmembrane transporter activity. Decreased EGF-induced ERK1/2 phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26728129;Dbxref=PMID:26728129 Q6XR72 UniProtKB Mutagenesis 25 25 . . . Note=No effect on localization to the plasma membrane. Loss of calcium:manganese antiporter activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27307044;Dbxref=PMID:27307044 Q6XR72 UniProtKB Mutagenesis 40 40 . . . Note=No effect on localization to the plasma membrane. Loss of calcium:manganese antiporter activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27307044;Dbxref=PMID:27307044 Q6XR72 UniProtKB Mutagenesis 43 43 . . . Note=No effect on localization to the plasma membrane. Changed calcium:manganese antiporter activity. Enhanced coupling between manganese and calcium exchange. N->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27307044,ECO:0000269|PubMed:30755481;Dbxref=PMID:27307044,PMID:30755481 Q6XR72 UniProtKB Mutagenesis 43 43 . . . Note=Loss of calcium:manganese antiporter activity. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30755481;Dbxref=PMID:30755481 Q6XR72 UniProtKB Mutagenesis 43 43 . . . Note=No effect on localization to the plasma membrane. Loss of calcium:manganese antiporter activity. Loss of calcium:manganese antiporter activity and increased zinc ion transmembrane transporter activity%3B when associated with V-52 and F-242. N->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27226609,ECO:0000269|PubMed:30755481;Dbxref=PMID:27226609,PMID:30755481 Q6XR72 UniProtKB Mutagenesis 43 43 . . . Note=Loss of calcium:manganese antiporter activity. Uncoupling between manganese and calcium exchange. N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30755481;Dbxref=PMID:30755481 Q6XR72 UniProtKB Mutagenesis 47 47 . . . Note=No effect on localization to the plasma membrane. No effect on calcium:manganese antiporter activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27307044;Dbxref=PMID:27307044 Q6XR72 UniProtKB Mutagenesis 47 47 . . . Note=Loss of calcium:manganese antiporter activity. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30755481;Dbxref=PMID:30755481 Q6XR72 UniProtKB Mutagenesis 52 52 . . . Note=Loss of calcium:manganese antiporter activity and increased zinc ion transmembrane transporter activity%3B when associated with H-43 and F-242. C->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27226609;Dbxref=PMID:27226609 Q6XR72 UniProtKB Mutagenesis 127 127 . . . Note=No effect on localization to the plasma membrane. No effect on localization to the plasma membrane and decreased calcium:manganese antiporter activity%3B when associated with A-244. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27307044;Dbxref=PMID:27307044 Q6XR72 UniProtKB Mutagenesis 196 196 . . . Note=Loss of localization to the plasma membrane. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25319704;Dbxref=PMID:25319704 Q6XR72 UniProtKB Mutagenesis 242 242 . . . Note=Loss of calcium:manganese antiporter activity and increased zinc ion transmembrane transporter activity%3B when associated with H-43 and V-52. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27226609;Dbxref=PMID:27226609 Q6XR72 UniProtKB Mutagenesis 244 244 . . . Note=No effect on localization to the plasma membrane. No effect on localization to the plasma membrane and decreased calcium:manganese antiporter activity%3B when associated with A-127. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27307044;Dbxref=PMID:27307044 Q6XR72 UniProtKB Mutagenesis 244 244 . . . Note=Loss of calcium:manganese antiporter activity. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30755481;Dbxref=PMID:30755481 Q6XR72 UniProtKB Mutagenesis 248 248 . . . Note=No effect on localization to the plasma membrane. Loss of manganese ion export across plasma membrane. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27307044;Dbxref=PMID:27307044 Q6XR72 UniProtKB Mutagenesis 333 333 . . . Note=Decreased calcium:manganese antiporter activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27307044;Dbxref=PMID:27307044 Q6XR72 UniProtKB Mutagenesis 350 350 . . . Note=Decreased calcium:manganese antiporter activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27307044;Dbxref=PMID:27307044