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Q6XR72 (ZNT10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter 10

Short name=ZnT-10
Alternative name(s):
Solute carrier family 30 member 10
Gene names
Name:SLC30A10
Synonyms:ZNT10, ZNT8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in zinc transport out of the cell, being a zinc-efflux transporter By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Tissue specificity

Specifically expressed in fetal liver and fetal brain. Ref.5

Sequence similarities

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Sequence caution

The sequence AAP44332.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in position 427.

Ontologies

Keywords
   Biological processIon transport
Transport
Zinc transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandZinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processzinc ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncation transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6XR72-4)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6XR72-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 3 (identifier: Q6XR72-3)

The sequence of this isoform differs from the canonical sequence as follows:
     214-223: GDSFNTQNEP → ELIHNTRFLL
     224-485: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485Zinc transporter 10
PRO_0000312580

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 409Extracellular Potential
Transmembrane41 – 6121Helical; Potential
Topological domain62 – 8120Cytoplasmic Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 11311Extracellular Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 244110Cytoplasmic Potential
Transmembrane245 – 26521Helical; Potential
Topological domain266 – 27813Extracellular Potential
Transmembrane279 – 29921Helical; Potential
Topological domain300 – 485186Cytoplasmic Potential
Compositional bias253 – 2564Poly-Val
Compositional bias396 – 3994Poly-Leu

Natural variations

Alternative sequence1 – 245245Missing in isoform 2.
VSP_029863
Alternative sequence214 – 22310GDSFNTQNEP → ELIHNTRFLL in isoform 3.
VSP_029864
Alternative sequence224 – 485262Missing in isoform 3.
VSP_029865

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 2, 2010. Version 2.
Checksum: 96A3495EF026DE94

FASTA48552,684
        10         20         30         40         50         60 
MGRYSGKTCR LLFMLVLTVA FFVAELVSGY LGNSIALLSD SFNMLSDLIS LCVGLSAGYI 

        70         80         90        100        110        120 
ARRPTRGFSA TYGYARAEVV GALSNAVFLT ALCFTIFVEA VLRLARPERI DDPELVLIVG 

       130        140        150        160        170        180 
VLGLLVNVVG LLIFQDCAAW FACCLRGRSR RLQQRQQLAE GCVPGAFGGP QGAEDPRRAA 

       190        200        210        220        230        240 
DPTAPGSDSA VTLRGTSVER KREKGATVFA NVAGDSFNTQ NEPEDMMKKE KKSEALNIRG 

       250        260        270        280        290        300 
VLLHVMGDAL GSVVVVITAI IFYVLPLKSE DPCNWQCYID PSLTVLMVII ILSSAFPLIK 

       310        320        330        340        350        360 
ETAAILLQMV PKGVNMEELM SKLSAVPGIS SVHEVHIWEL VSGKIIATLH IKYPKDRGYQ 

       370        380        390        400        410        420 
DASTKIREIF HHAGIHNVTI QFENVDLKEP LEQKDLLLLC NSPCISKGCA KQLCCPPGAL 

       430        440        450        460        470        480 
PLAHVNGCAE HNGGPSLDTY GSDGLSRRDA REVAIEVSLD SCLSDHGQSL NKTQEDQCYV 


NRTHF 

« Hide

Isoform 2 [UniParc].

Checksum: 8D3C17D391E719E6
Show »

FASTA24026,289
Isoform 3 [UniParc].

Checksum: 3A7FDB2E11FF9459
Show »

FASTA22324,009

References

« Hide 'large scale' references
[1]"Characterization of a novel mammalian zinc transporter, ZNT8."
Huang L., Zhou B., Gitschier J.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-485 (ISOFORM 3).
Tissue: Brain.
[5]"In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression."
Seve M., Chimienti F., Devergnas S., Favier A.
BMC Genomics 5:32-32(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY212919 mRNA. Translation: AAP44332.1. Sequence problems.
AL359609 mRNA. Translation: CAB94880.1.
AC093562 Genomic DNA. No translation available.
BC036078 mRNA. Translation: AAH36078.1.
CCDSCCDS31026.1. [Q6XR72-4]
PIRT50628.
RefSeqNP_061183.2. NM_018713.2. [Q6XR72-4]
UniGeneHs.284450.

3D structure databases

ProteinModelPortalQ6XR72.
SMRQ6XR72. Positions 27-107.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000355893.

Protein family/group databases

TCDB2.A.4.2.5. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSiteQ6XR72.

Polymorphism databases

DMDM311033506.

Proteomic databases

MaxQBQ6XR72.
PaxDbQ6XR72.
PRIDEQ6XR72.

Protocols and materials databases

DNASU55532.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356609; ENSP00000349018; ENSG00000196660. [Q6XR72-3]
ENST00000366926; ENSP00000355893; ENSG00000196660. [Q6XR72-4]
ENST00000536446; ENSP00000439489; ENSG00000196660. [Q6XR72-2]
ENST00000536992; ENSP00000440627; ENSG00000196660. [Q6XR72-3]
GeneID55532.
KEGGhsa:55532.
UCSCuc001hlv.3. human. [Q6XR72-2]
uc001hlw.3. human. [Q6XR72-4]

Organism-specific databases

CTD55532.
GeneCardsGC01M219858.
GeneReviewsSLC30A10.
H-InvDBHIX0001600.
HGNCHGNC:25355. SLC30A10.
HPAHPA017989.
MIM611146. gene.
neXtProtNX_Q6XR72.
Orphanet309854. Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome.
PharmGKBPA142670903.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1230.
HOGENOMHOG000166089.
HOVERGENHBG000588.
InParanoidQ6XR72.
KOK14697.
OMAGYQDAST.
OrthoDBEOG7034GQ.
PhylomeDBQ6XR72.
TreeFamTF313924.

Gene expression databases

ArrayExpressQ6XR72.
BgeeQ6XR72.
CleanExHS_SLC30A10.
GenevestigatorQ6XR72.

Family and domain databases

Gene3D1.20.1510.10. 2 hits.
InterProIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERPTHR11562. PTHR11562. 1 hit.
PfamPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsTIGR01297. CDF. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi55532.
NextBio59970.
PROQ6XR72.
SOURCESearch...

Entry information

Entry nameZNT10_HUMAN
AccessionPrimary (citable) accession number: Q6XR72
Secondary accession number(s): Q49AL9, Q9NPW0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM