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Q6XR72

- ZNT10_HUMAN

UniProt

Q6XR72 - ZNT10_HUMAN

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Protein
Zinc transporter 10
Gene
SLC30A10, ZNT10, ZNT8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in zinc transport out of the cell, being a zinc-efflux transporter By similarity.

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. zinc ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.4.2.5. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 10
Short name:
ZnT-10
Alternative name(s):
Solute carrier family 30 member 10
Gene namesi
Synonyms:ZNT10, ZNT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25355. SLC30A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Cytoplasmic Reviewed prediction
Transmembranei11 – 3121Helical; Reviewed prediction
Add
BLAST
Topological domaini32 – 409Extracellular Reviewed prediction
Transmembranei41 – 6121Helical; Reviewed prediction
Add
BLAST
Topological domaini62 – 8120Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Topological domaini103 – 11311Extracellular Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Topological domaini135 – 244110Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei245 – 26521Helical; Reviewed prediction
Add
BLAST
Topological domaini266 – 27813Extracellular Reviewed prediction
Add
BLAST
Transmembranei279 – 29921Helical; Reviewed prediction
Add
BLAST
Topological domaini300 – 485186Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti309854. Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome.
PharmGKBiPA142670903.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Zinc transporter 10
PRO_0000312580Add
BLAST

Proteomic databases

MaxQBiQ6XR72.
PaxDbiQ6XR72.
PRIDEiQ6XR72.

PTM databases

PhosphoSiteiQ6XR72.

Expressioni

Tissue specificityi

Specifically expressed in fetal liver and fetal brain.1 Publication

Gene expression databases

ArrayExpressiQ6XR72.
BgeeiQ6XR72.
CleanExiHS_SLC30A10.
GenevestigatoriQ6XR72.

Organism-specific databases

HPAiHPA017989.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355893.

Structurei

3D structure databases

ProteinModelPortaliQ6XR72.
SMRiQ6XR72. Positions 27-107.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi253 – 2564Poly-Val
Compositional biasi396 – 3994Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ6XR72.
KOiK14697.
OMAiGYQDAST.
OrthoDBiEOG7034GQ.
PhylomeDBiQ6XR72.
TreeFamiTF313924.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6XR72-4) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGRYSGKTCR LLFMLVLTVA FFVAELVSGY LGNSIALLSD SFNMLSDLIS    50
LCVGLSAGYI ARRPTRGFSA TYGYARAEVV GALSNAVFLT ALCFTIFVEA 100
VLRLARPERI DDPELVLIVG VLGLLVNVVG LLIFQDCAAW FACCLRGRSR 150
RLQQRQQLAE GCVPGAFGGP QGAEDPRRAA DPTAPGSDSA VTLRGTSVER 200
KREKGATVFA NVAGDSFNTQ NEPEDMMKKE KKSEALNIRG VLLHVMGDAL 250
GSVVVVITAI IFYVLPLKSE DPCNWQCYID PSLTVLMVII ILSSAFPLIK 300
ETAAILLQMV PKGVNMEELM SKLSAVPGIS SVHEVHIWEL VSGKIIATLH 350
IKYPKDRGYQ DASTKIREIF HHAGIHNVTI QFENVDLKEP LEQKDLLLLC 400
NSPCISKGCA KQLCCPPGAL PLAHVNGCAE HNGGPSLDTY GSDGLSRRDA 450
REVAIEVSLD SCLSDHGQSL NKTQEDQCYV NRTHF 485
Length:485
Mass (Da):52,684
Last modified:November 2, 2010 - v2
Checksum:i96A3495EF026DE94
GO
Isoform 2 (identifier: Q6XR72-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:240
Mass (Da):26,289
Checksum:i8D3C17D391E719E6
GO
Isoform 3 (identifier: Q6XR72-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-223: GDSFNTQNEP → ELIHNTRFLL
     224-485: Missing.

Note: No experimental confirmation available.

Show »
Length:223
Mass (Da):24,009
Checksum:i3A7FDB2E11FF9459
GO

Sequence cautioni

The sequence AAP44332.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in position 427.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 245245Missing in isoform 2.
VSP_029863Add
BLAST
Alternative sequencei214 – 22310GDSFNTQNEP → ELIHNTRFLL in isoform 3.
VSP_029864
Alternative sequencei224 – 485262Missing in isoform 3.
VSP_029865Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY212919 mRNA. Translation: AAP44332.1. Sequence problems.
AL359609 mRNA. Translation: CAB94880.1.
AC093562 Genomic DNA. No translation available.
BC036078 mRNA. Translation: AAH36078.1.
CCDSiCCDS31026.1. [Q6XR72-4]
PIRiT50628.
RefSeqiNP_061183.2. NM_018713.2. [Q6XR72-4]
UniGeneiHs.284450.

Genome annotation databases

EnsembliENST00000356609; ENSP00000349018; ENSG00000196660. [Q6XR72-3]
ENST00000366926; ENSP00000355893; ENSG00000196660. [Q6XR72-4]
ENST00000536446; ENSP00000439489; ENSG00000196660. [Q6XR72-2]
ENST00000536992; ENSP00000440627; ENSG00000196660. [Q6XR72-3]
GeneIDi55532.
KEGGihsa:55532.
UCSCiuc001hlv.3. human. [Q6XR72-2]
uc001hlw.3. human. [Q6XR72-4]

Polymorphism databases

DMDMi311033506.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY212919 mRNA. Translation: AAP44332.1 . Sequence problems.
AL359609 mRNA. Translation: CAB94880.1 .
AC093562 Genomic DNA. No translation available.
BC036078 mRNA. Translation: AAH36078.1 .
CCDSi CCDS31026.1. [Q6XR72-4 ]
PIRi T50628.
RefSeqi NP_061183.2. NM_018713.2. [Q6XR72-4 ]
UniGenei Hs.284450.

3D structure databases

ProteinModelPortali Q6XR72.
SMRi Q6XR72. Positions 27-107.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000355893.

Protein family/group databases

TCDBi 2.A.4.2.5. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSitei Q6XR72.

Polymorphism databases

DMDMi 311033506.

Proteomic databases

MaxQBi Q6XR72.
PaxDbi Q6XR72.
PRIDEi Q6XR72.

Protocols and materials databases

DNASUi 55532.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356609 ; ENSP00000349018 ; ENSG00000196660 . [Q6XR72-3 ]
ENST00000366926 ; ENSP00000355893 ; ENSG00000196660 . [Q6XR72-4 ]
ENST00000536446 ; ENSP00000439489 ; ENSG00000196660 . [Q6XR72-2 ]
ENST00000536992 ; ENSP00000440627 ; ENSG00000196660 . [Q6XR72-3 ]
GeneIDi 55532.
KEGGi hsa:55532.
UCSCi uc001hlv.3. human. [Q6XR72-2 ]
uc001hlw.3. human. [Q6XR72-4 ]

Organism-specific databases

CTDi 55532.
GeneCardsi GC01M219858.
GeneReviewsi SLC30A10.
H-InvDB HIX0001600.
HGNCi HGNC:25355. SLC30A10.
HPAi HPA017989.
MIMi 611146. gene.
neXtProti NX_Q6XR72.
Orphaneti 309854. Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome.
PharmGKBi PA142670903.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1230.
HOGENOMi HOG000166089.
HOVERGENi HBG000588.
InParanoidi Q6XR72.
KOi K14697.
OMAi GYQDAST.
OrthoDBi EOG7034GQ.
PhylomeDBi Q6XR72.
TreeFami TF313924.

Miscellaneous databases

GenomeRNAii 55532.
NextBioi 59970.
PROi Q6XR72.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6XR72.
Bgeei Q6XR72.
CleanExi HS_SLC30A10.
Genevestigatori Q6XR72.

Family and domain databases

Gene3Di 1.20.1510.10. 2 hits.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel mammalian zinc transporter, ZNT8."
    Huang L., Zhou B., Gitschier J.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-485 (ISOFORM 3).
    Tissue: Brain.
  5. "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression."
    Seve M., Chimienti F., Devergnas S., Favier A.
    BMC Genomics 5:32-32(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiZNT10_HUMAN
AccessioniPrimary (citable) accession number: Q6XR72
Secondary accession number(s): Q49AL9, Q9NPW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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