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Q6XR72

- ZNT10_HUMAN

UniProt

Q6XR72 - ZNT10_HUMAN

Protein

Zinc transporter 10

Gene

SLC30A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    May be involved in zinc transport out of the cell, being a zinc-efflux transporter.By similarity

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. zinc ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Protein family/group databases

    TCDBi2.A.4.2.5. the cation diffusion facilitator (cdf) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 10
    Short name:
    ZnT-10
    Alternative name(s):
    Solute carrier family 30 member 10
    Gene namesi
    Name:SLC30A10
    Synonyms:ZNT10, ZNT8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25355. SLC30A10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti309854. Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome.
    PharmGKBiPA142670903.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485Zinc transporter 10PRO_0000312580Add
    BLAST

    Proteomic databases

    MaxQBiQ6XR72.
    PaxDbiQ6XR72.
    PRIDEiQ6XR72.

    PTM databases

    PhosphoSiteiQ6XR72.

    Expressioni

    Tissue specificityi

    Specifically expressed in fetal liver and fetal brain.1 Publication

    Gene expression databases

    ArrayExpressiQ6XR72.
    BgeeiQ6XR72.
    CleanExiHS_SLC30A10.
    GenevestigatoriQ6XR72.

    Organism-specific databases

    HPAiHPA017989.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000355893.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6XR72.
    SMRiQ6XR72. Positions 27-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 409ExtracellularSequence Analysis
    Topological domaini62 – 8120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11311ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 244110CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 27813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini300 – 485186CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei41 – 6121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi253 – 2564Poly-Val
    Compositional biasi396 – 3994Poly-Leu

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1230.
    HOGENOMiHOG000166089.
    HOVERGENiHBG000588.
    InParanoidiQ6XR72.
    KOiK14697.
    OMAiGYQDAST.
    OrthoDBiEOG7034GQ.
    PhylomeDBiQ6XR72.
    TreeFamiTF313924.

    Family and domain databases

    Gene3Di1.20.1510.10. 2 hits.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6XR72-4) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRYSGKTCR LLFMLVLTVA FFVAELVSGY LGNSIALLSD SFNMLSDLIS    50
    LCVGLSAGYI ARRPTRGFSA TYGYARAEVV GALSNAVFLT ALCFTIFVEA 100
    VLRLARPERI DDPELVLIVG VLGLLVNVVG LLIFQDCAAW FACCLRGRSR 150
    RLQQRQQLAE GCVPGAFGGP QGAEDPRRAA DPTAPGSDSA VTLRGTSVER 200
    KREKGATVFA NVAGDSFNTQ NEPEDMMKKE KKSEALNIRG VLLHVMGDAL 250
    GSVVVVITAI IFYVLPLKSE DPCNWQCYID PSLTVLMVII ILSSAFPLIK 300
    ETAAILLQMV PKGVNMEELM SKLSAVPGIS SVHEVHIWEL VSGKIIATLH 350
    IKYPKDRGYQ DASTKIREIF HHAGIHNVTI QFENVDLKEP LEQKDLLLLC 400
    NSPCISKGCA KQLCCPPGAL PLAHVNGCAE HNGGPSLDTY GSDGLSRRDA 450
    REVAIEVSLD SCLSDHGQSL NKTQEDQCYV NRTHF 485
    Length:485
    Mass (Da):52,684
    Last modified:November 2, 2010 - v2
    Checksum:i96A3495EF026DE94
    GO
    Isoform 2 (identifier: Q6XR72-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-245: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:240
    Mass (Da):26,289
    Checksum:i8D3C17D391E719E6
    GO
    Isoform 3 (identifier: Q6XR72-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         214-223: GDSFNTQNEP → ELIHNTRFLL
         224-485: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:223
    Mass (Da):24,009
    Checksum:i3A7FDB2E11FF9459
    GO

    Sequence cautioni

    The sequence AAP44332.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in position 427.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 245245Missing in isoform 2. 1 PublicationVSP_029863Add
    BLAST
    Alternative sequencei214 – 22310GDSFNTQNEP → ELIHNTRFLL in isoform 3. 1 PublicationVSP_029864
    Alternative sequencei224 – 485262Missing in isoform 3. 1 PublicationVSP_029865Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY212919 mRNA. Translation: AAP44332.1. Sequence problems.
    AL359609 mRNA. Translation: CAB94880.1.
    AC093562 Genomic DNA. No translation available.
    BC036078 mRNA. Translation: AAH36078.1.
    CCDSiCCDS31026.1. [Q6XR72-4]
    PIRiT50628.
    RefSeqiNP_061183.2. NM_018713.2. [Q6XR72-4]
    UniGeneiHs.284450.

    Genome annotation databases

    EnsembliENST00000356609; ENSP00000349018; ENSG00000196660. [Q6XR72-3]
    ENST00000366926; ENSP00000355893; ENSG00000196660. [Q6XR72-4]
    GeneIDi55532.
    KEGGihsa:55532.
    UCSCiuc001hlv.3. human. [Q6XR72-2]
    uc001hlw.3. human. [Q6XR72-4]

    Polymorphism databases

    DMDMi311033506.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY212919 mRNA. Translation: AAP44332.1 . Sequence problems.
    AL359609 mRNA. Translation: CAB94880.1 .
    AC093562 Genomic DNA. No translation available.
    BC036078 mRNA. Translation: AAH36078.1 .
    CCDSi CCDS31026.1. [Q6XR72-4 ]
    PIRi T50628.
    RefSeqi NP_061183.2. NM_018713.2. [Q6XR72-4 ]
    UniGenei Hs.284450.

    3D structure databases

    ProteinModelPortali Q6XR72.
    SMRi Q6XR72. Positions 27-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000355893.

    Protein family/group databases

    TCDBi 2.A.4.2.5. the cation diffusion facilitator (cdf) family.

    PTM databases

    PhosphoSitei Q6XR72.

    Polymorphism databases

    DMDMi 311033506.

    Proteomic databases

    MaxQBi Q6XR72.
    PaxDbi Q6XR72.
    PRIDEi Q6XR72.

    Protocols and materials databases

    DNASUi 55532.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356609 ; ENSP00000349018 ; ENSG00000196660 . [Q6XR72-3 ]
    ENST00000366926 ; ENSP00000355893 ; ENSG00000196660 . [Q6XR72-4 ]
    GeneIDi 55532.
    KEGGi hsa:55532.
    UCSCi uc001hlv.3. human. [Q6XR72-2 ]
    uc001hlw.3. human. [Q6XR72-4 ]

    Organism-specific databases

    CTDi 55532.
    GeneCardsi GC01M219858.
    GeneReviewsi SLC30A10.
    H-InvDB HIX0001600.
    HGNCi HGNC:25355. SLC30A10.
    HPAi HPA017989.
    MIMi 611146. gene.
    neXtProti NX_Q6XR72.
    Orphaneti 309854. Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome.
    PharmGKBi PA142670903.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1230.
    HOGENOMi HOG000166089.
    HOVERGENi HBG000588.
    InParanoidi Q6XR72.
    KOi K14697.
    OMAi GYQDAST.
    OrthoDBi EOG7034GQ.
    PhylomeDBi Q6XR72.
    TreeFami TF313924.

    Miscellaneous databases

    GenomeRNAii 55532.
    NextBioi 59970.
    PROi Q6XR72.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6XR72.
    Bgeei Q6XR72.
    CleanExi HS_SLC30A10.
    Genevestigatori Q6XR72.

    Family and domain databases

    Gene3Di 1.20.1510.10. 2 hits.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel mammalian zinc transporter, ZNT8."
      Huang L., Zhou B., Gitschier J.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-485 (ISOFORM 3).
      Tissue: Brain.
    5. "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression."
      Seve M., Chimienti F., Devergnas S., Favier A.
      BMC Genomics 5:32-32(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiZNT10_HUMAN
    AccessioniPrimary (citable) accession number: Q6XR72
    Secondary accession number(s): Q49AL9, Q9NPW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3