Q6XR72 (ZNT10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc transporter 10
Short name=ZnT-10

Alternative name(s):
Solute carrier family 30 member 10

Gene names

Name:	SLC30A10
Synonyms:	ZNT10, ZNT8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in zinc transport out of the cell, being a zinc-efflux transporter By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Tissue specificity	Specifically expressed in fetal liver and fetal brain. Ref.5
Sequence similarities	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]
Sequence caution	The sequence AAP44332.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in position 427.

Ontologies

Keywords
Biological process	Ion transport Transport Zinc transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	zinc ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cation transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6XR72-4)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6XR72-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 3 (identifier: Q6XR72-3)

The sequence of this isoform differs from the canonical sequence as follows:
     214-223: GDSFNTQNEP → ELIHNTRFLL
     224-485: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Zinc transporter 10		PRO_0000312580
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Helical; Potential
	Topological domain	32 – 40	9	Extracellular Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Topological domain	62 – 81	20	Cytoplasmic Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Topological domain	103 – 113	11	Extracellular Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Topological domain	135 – 244	110	Cytoplasmic Potential
	Transmembrane	245 – 265	21	Helical; Potential
	Topological domain	266 – 278	13	Extracellular Potential
	Transmembrane	279 – 299	21	Helical; Potential
	Topological domain	300 – 485	186	Cytoplasmic Potential
	Compositional bias	253 – 256	4	Poly-Val
	Compositional bias	396 – 399	4	Poly-Leu
Amino acid modifications
	Modified residue	192	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	1 – 245	245	Missing in isoform 2.		VSP_029863
	Alternative sequence	214 – 223	10	GDSFNTQNEP → ELIHNTRFLL in isoform 3.		VSP_029864
	Alternative sequence	224 – 485	262	Missing in isoform 3.		VSP_029865

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 2. Checksum: 96A3495EF026DE94	FASTA	485	52,684
	10 20 30 40 50 60 MGRYSGKTCR LLFMLVLTVA FFVAELVSGY LGNSIALLSD SFNMLSDLIS LCVGLSAGYI 70 80 90 100 110 120 ARRPTRGFSA TYGYARAEVV GALSNAVFLT ALCFTIFVEA VLRLARPERI DDPELVLIVG 130 140 150 160 170 180 VLGLLVNVVG LLIFQDCAAW FACCLRGRSR RLQQRQQLAE GCVPGAFGGP QGAEDPRRAA 190 200 210 220 230 240 DPTAPGSDSA VTLRGTSVER KREKGATVFA NVAGDSFNTQ NEPEDMMKKE KKSEALNIRG 250 260 270 280 290 300 VLLHVMGDAL GSVVVVITAI IFYVLPLKSE DPCNWQCYID PSLTVLMVII ILSSAFPLIK 310 320 330 340 350 360 ETAAILLQMV PKGVNMEELM SKLSAVPGIS SVHEVHIWEL VSGKIIATLH IKYPKDRGYQ 370 380 390 400 410 420 DASTKIREIF HHAGIHNVTI QFENVDLKEP LEQKDLLLLC NSPCISKGCA KQLCCPPGAL 430 440 450 460 470 480 PLAHVNGCAE HNGGPSLDTY GSDGLSRRDA REVAIEVSLD SCLSDHGQSL NKTQEDQCYV NRTHF
	Isoform 2 [UniParc]. Checksum: 8D3C17D391E719E6	FASTA	240	26,289
	10 20 30 40 50 60 MGDALGSVVV VITAIIFYVL PLKSEDPCNW QCYIDPSLTV LMVIIILSSA FPLIKETAAI 70 80 90 100 110 120 LLQMVPKGVN MEELMSKLSA VPGISSVHEV HIWELVSGKI IATLHIKYPK DRGYQDASTK 130 140 150 160 170 180 IREIFHHAGI HNVTIQFENV DLKEPLEQKD LLLLCNSPCI SKGCAKQLCC PPGALPLAHV 190 200 210 220 230 240 NGCAEHNGGP SLDTYGSDGL SRRDAREVAI EVSLDSCLSD HGQSLNKTQE DQCYVNRTHF
	Isoform 3 [UniParc]. Checksum: 3A7FDB2E11FF9459	FASTA	223	24,009
	10 20 30 40 50 60 MGRYSGKTCR LLFMLVLTVA FFVAELVSGY LGNSIALLSD SFNMLSDLIS LCVGLSAGYI 70 80 90 100 110 120 ARRPTRGFSA TYGYARAEVV GALSNAVFLT ALCFTIFVEA VLRLARPERI DDPELVLIVG 130 140 150 160 170 180 VLGLLVNVVG LLIFQDCAAW FACCLRGRSR RLQQRQQLAE GCVPGAFGGP QGAEDPRRAA 190 200 210 220 DPTAPGSDSA VTLRGTSVER KREKGATVFA NVAELIHNTR FLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel mammalian zinc transporter, ZNT8." Huang L., Zhou B., Gitschier J. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-485 (ISOFORM 3). Tissue: Brain.
[5]	"In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression." Seve M., Chimienti F., Devergnas S., Favier A. BMC Genomics 5:32-32(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY212919 mRNA. Translation: AAP44332.1. Sequence problems. AL359609 mRNA. Translation: CAB94880.1. AC093562 Genomic DNA. No translation available. BC036078 mRNA. Translation: AAH36078.1.
IPI	IPI00000012. IPI00873331. IPI00876859.
PIR	T50628.
RefSeq	NP_061183.2. NM_018713.2.
UniGene	Hs.284450.
3D structure databases
ProteinModelPortal	Q6XR72.
SMR	Q6XR72. Positions 16-107.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000355893.
PTM databases
PhosphoSite	Q6XR72.
Polymorphism databases
DMDM	311033506.
Proteomic databases
PaxDb	Q6XR72.
PRIDE	Q6XR72.
Protocols and materials databases
DNASU	55532.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356609; ENSP00000349018; ENSG00000196660. ENST00000366926; ENSP00000355893; ENSG00000196660. ENST00000536446; ENSP00000439489; ENSG00000196660. ENST00000536992; ENSP00000440627; ENSG00000196660.
GeneID	55532.
KEGG	hsa:55532.
UCSC	uc001hlv.3. human. uc001hlw.3. human.
Organism-specific databases
CTD	55532.
GeneCards	GC01M219858.
H-InvDB	HIX0001600.
HGNC	HGNC:25355. SLC30A10.
HPA	HPA017989.
MIM	611146. gene.
neXtProt	NX_Q6XR72.
PharmGKB	PA142670903.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1230.
HOGENOM	HOG000166089.
HOVERGEN	HBG000588.
InParanoid	Q6XR72.
KO	K14697.
OMA	QDASTKI.
Gene expression databases
ArrayExpress	Q6XR72.
Bgee	Q6XR72.
CleanEx	HS_SLC30A10.
Genevestigator	Q6XR72.
Family and domain databases
InterPro	IPR002524. Cation_efflux. [Graphical view]
PANTHER	PTHR11562. PTHR11562. 1 hit.
Pfam	PF01545. Cation_efflux. 1 hit. [Graphical view]
TIGRFAMs	TIGR01297. CDF. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	55532.
NextBio	59970.
SOURCE	Search...

Entry information

Entry name

ZNT10_HUMAN

Accession

Primary (citable) accession number: Q6XR72
Secondary accession number(s): Q49AL9, Q9NPW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.