Q6XQN1 (PNCB_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Alternative name(s):
Nicotinate phosphoribosyltransferase domain-containing protein 1

Gene names

Name:

Naprt1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	538 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells By similarity.
Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from direct assay PubMed 8694849. Source: RGD nicotinate nucleotide salvage Inferred from electronic annotation. Source: InterPro response to oxidative stress Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 538	538	Nicotinate phosphoribosyltransferase		PRO_0000315683

Sequences

	Sequence		Length	Mass (Da)
	Q6XQN1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0C68EF4A2C44D3D2	FASTA	538	58,565
	10 20 30 40 50 60 MEMELDDQGR MVVRPLLTDL YQATMGLGYW RAGRACEEAE FELFFRHCPF GGSFALTAGL 70 80 90 100 110 120 QDCIRFLRAF RLRDADVQFL ASVLPPDTDP AFFEHLRALD CSRVSVRALP EGSLAFPGVP 130 140 150 160 170 180 LLQVSGPLLL VQLLETPLLC LVSYASLVAT NAARLRLIAG PDKRLLEMGL RRAQGPDGGF 190 200 210 220 230 240 TASIYSYLGG FDSSSNTLAG QLRGVPVAGT LAHSFITSFL GSEVPPDPML APASSEGPAV 250 260 270 280 290 300 DLPASVNLWL KHVCIYLGLE EREPHLGERA AFVAYALAFP RAFQGLLDSY SVRRSGLPNF 310 320 330 340 350 360 LAVALALGEL GYRAVGVRLD SGDLLQQAKE IRGIFRTVGA EFQMPWLEFV PIAVSNNIDE 370 380 390 400 410 420 KELARLAQKG SEVNVIGIGT NVVTCPKQPS MGCVYKLVSV GGQPRIKLTE ESQKETLPGS 430 440 450 460 470 480 KAAFRFLVSE GSLLLDLLQL AEEPPPKAGQ ELRVWLQGAQ EPCTVKPAQV EPLLRLYLQQ 490 500 510 520 530 GQPYEPLPSL EESRAFAQQS LSRLRPAHKQ LQNPAVYQVA LSEKLRALVD SLSARGAL

References

[1]	"Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltranferase family." Huang C.-H., Peng J., Chen Y. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY214330 mRNA. Translation: AAP69608.1.
IPI	IPI00421490.
RefSeq	NP_997492.1. NM_207609.1.
UniGene	Rn.22665.
3D structure databases
HSSP	HSSP built from PDB template 2F7F based on UniProtKB Q830Y8.
ProteinModelPortal	Q6XQN1.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000010637.
Proteomic databases
PaxDb	Q6XQN1.
PRIDE	Q6XQN1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	315085.
KEGG	rno:315085.
UCSC	RGD:1302945. rat.
Organism-specific databases
CTD	93100.
RGD	1302945. Naprt1.
Phylogenomic databases
eggNOG	COG1488.
HOGENOM	HOG000001111.
HOVERGEN	HBG062439.
InParanoid	Q6XQN1.
KO	K00763.
OrthoDB	EOG4GF3FJ.
Enzyme and pathway databases
UniPathway	UPA00253; UER00457.
Gene expression databases
Genevestigator	Q6XQN1.
Family and domain databases
InterPro	IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR006405. Nic_PRibTrfase_put. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01513. NAPRTase_put. 1 hit.
ProtoNet	Search...
Other
NextBio	668628.

Entry information

Entry name

PNCB_RAT

Accession

Primary (citable) accession number: Q6XQN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program