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Q6XQN1 (PNCB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Alternative name(s):
Nicotinate phosphoribosyltransferase domain-containing protein 1
Gene names
Name:Naprt1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells By similarity.

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.

Subcellular location

Cytoplasmcytosol By similarity.

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 538538Nicotinate phosphoribosyltransferase
PRO_0000315683

Sequences

Sequence LengthMass (Da)Tools
Q6XQN1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 0C68EF4A2C44D3D2

FASTA53858,565
        10         20         30         40         50         60 
MEMELDDQGR MVVRPLLTDL YQATMGLGYW RAGRACEEAE FELFFRHCPF GGSFALTAGL 

        70         80         90        100        110        120 
QDCIRFLRAF RLRDADVQFL ASVLPPDTDP AFFEHLRALD CSRVSVRALP EGSLAFPGVP 

       130        140        150        160        170        180 
LLQVSGPLLL VQLLETPLLC LVSYASLVAT NAARLRLIAG PDKRLLEMGL RRAQGPDGGF 

       190        200        210        220        230        240 
TASIYSYLGG FDSSSNTLAG QLRGVPVAGT LAHSFITSFL GSEVPPDPML APASSEGPAV 

       250        260        270        280        290        300 
DLPASVNLWL KHVCIYLGLE EREPHLGERA AFVAYALAFP RAFQGLLDSY SVRRSGLPNF 

       310        320        330        340        350        360 
LAVALALGEL GYRAVGVRLD SGDLLQQAKE IRGIFRTVGA EFQMPWLEFV PIAVSNNIDE 

       370        380        390        400        410        420 
KELARLAQKG SEVNVIGIGT NVVTCPKQPS MGCVYKLVSV GGQPRIKLTE ESQKETLPGS 

       430        440        450        460        470        480 
KAAFRFLVSE GSLLLDLLQL AEEPPPKAGQ ELRVWLQGAQ EPCTVKPAQV EPLLRLYLQQ 

       490        500        510        520        530 
GQPYEPLPSL EESRAFAQQS LSRLRPAHKQ LQNPAVYQVA LSEKLRALVD SLSARGAL 

« Hide

References

[1]"Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
Huang C.-H., Peng J., Chen Y.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY214330 mRNA. Translation: AAP69608.1.
RefSeqNP_997492.1. NM_207609.1.
UniGeneRn.22665.

3D structure databases

ProteinModelPortalQ6XQN1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000010637.

Proteomic databases

PaxDbQ6XQN1.
PRIDEQ6XQN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID315085.
KEGGrno:315085.
UCSCRGD:1302945. rat.

Organism-specific databases

CTD93100.
RGD1302945. Naprt1.

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000001111.
HOVERGENHBG062439.
InParanoidQ6XQN1.
KOK00763.
PhylomeDBQ6XQN1.

Enzyme and pathway databases

UniPathwayUPA00253; UER00457.

Gene expression databases

GenevestigatorQ6XQN1.

Family and domain databases

InterProIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 2 hits.
TIGRFAMsTIGR01513. NAPRTase_put. 1 hit.
ProtoNetSearch...

Other

NextBio668628.

Entry information

Entry namePNCB_RAT
AccessionPrimary (citable) accession number: Q6XQN1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways