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Q6XQN1

- PNCB_RAT

UniProt

Q6XQN1 - PNCB_RAT

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Protein
Nicotinate phosphoribosyltransferase
Gene
Naprt, Naprt1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells By similarity.
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: UniProtKB
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: RGD
  2. nicotinate nucleotide salvage Source: InterPro
  3. response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Alternative name(s):
Nicotinate phosphoribosyltransferase domain-containing protein 1
Gene namesi
Name:Naprt
Synonyms:Naprt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1302945. Naprt1.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Nicotinate phosphoribosyltransferase
PRO_0000315683Add
BLAST

Proteomic databases

PaxDbiQ6XQN1.
PRIDEiQ6XQN1.

Expressioni

Gene expression databases

GenevestigatoriQ6XQN1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010637.

Structurei

3D structure databases

ProteinModelPortaliQ6XQN1.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000001111.
HOVERGENiHBG062439.
InParanoidiQ6XQN1.
KOiK00763.
PhylomeDBiQ6XQN1.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6XQN1-1 [UniParc]FASTAAdd to Basket

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MEMELDDQGR MVVRPLLTDL YQATMGLGYW RAGRACEEAE FELFFRHCPF    50
GGSFALTAGL QDCIRFLRAF RLRDADVQFL ASVLPPDTDP AFFEHLRALD 100
CSRVSVRALP EGSLAFPGVP LLQVSGPLLL VQLLETPLLC LVSYASLVAT 150
NAARLRLIAG PDKRLLEMGL RRAQGPDGGF TASIYSYLGG FDSSSNTLAG 200
QLRGVPVAGT LAHSFITSFL GSEVPPDPML APASSEGPAV DLPASVNLWL 250
KHVCIYLGLE EREPHLGERA AFVAYALAFP RAFQGLLDSY SVRRSGLPNF 300
LAVALALGEL GYRAVGVRLD SGDLLQQAKE IRGIFRTVGA EFQMPWLEFV 350
PIAVSNNIDE KELARLAQKG SEVNVIGIGT NVVTCPKQPS MGCVYKLVSV 400
GGQPRIKLTE ESQKETLPGS KAAFRFLVSE GSLLLDLLQL AEEPPPKAGQ 450
ELRVWLQGAQ EPCTVKPAQV EPLLRLYLQQ GQPYEPLPSL EESRAFAQQS 500
LSRLRPAHKQ LQNPAVYQVA LSEKLRALVD SLSARGAL 538
Length:538
Mass (Da):58,565
Last modified:July 5, 2004 - v1
Checksum:i0C68EF4A2C44D3D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY214330 mRNA. Translation: AAP69608.1.
RefSeqiNP_997492.1. NM_207609.1.
UniGeneiRn.22665.

Genome annotation databases

GeneIDi315085.
KEGGirno:315085.
UCSCiRGD:1302945. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY214330 mRNA. Translation: AAP69608.1 .
RefSeqi NP_997492.1. NM_207609.1.
UniGenei Rn.22665.

3D structure databases

ProteinModelPortali Q6XQN1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000010637.

Proteomic databases

PaxDbi Q6XQN1.
PRIDEi Q6XQN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 315085.
KEGGi rno:315085.
UCSCi RGD:1302945. rat.

Organism-specific databases

CTDi 93100.
RGDi 1302945. Naprt1.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000001111.
HOVERGENi HBG062439.
InParanoidi Q6XQN1.
KOi K00763.
PhylomeDBi Q6XQN1.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .

Miscellaneous databases

NextBioi 668628.

Gene expression databases

Genevestigatori Q6XQN1.

Family and domain databases

InterProi IPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 2 hits.
TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
    Huang C.-H., Peng J., Chen Y.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPNCB_RAT
AccessioniPrimary (citable) accession number: Q6XQN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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