Reviewed, UniProtKB/Swiss-Prot Q6XQN1 (PNCB_RAT)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase
      Short name=NAPRTase
    EC=2.4.2.11
Alternative name(s):
    Nicotinate phosphoribosyltransferase domain-containing protein 1

Gene names

Name:

Naprt1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	538 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells By similarity.
Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from direct assay. Source: RGD response to oxidative stress Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 538	538	Nicotinate phosphoribosyltransferase		PRO_0000315683

Sequences

	Sequence		Length	Mass (Da)
	Q6XQN1-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0C68EF4A2C44D3D2	FASTA	538	58,565
	10 20 30 40 50 60 MEMELDDQGR MVVRPLLTDL YQATMGLGYW RAGRACEEAE FELFFRHCPF GGSFALTAGL 70 80 90 100 110 120 QDCIRFLRAF RLRDADVQFL ASVLPPDTDP AFFEHLRALD CSRVSVRALP EGSLAFPGVP 130 140 150 160 170 180 LLQVSGPLLL VQLLETPLLC LVSYASLVAT NAARLRLIAG PDKRLLEMGL RRAQGPDGGF 190 200 210 220 230 240 TASIYSYLGG FDSSSNTLAG QLRGVPVAGT LAHSFITSFL GSEVPPDPML APASSEGPAV 250 260 270 280 290 300 DLPASVNLWL KHVCIYLGLE EREPHLGERA AFVAYALAFP RAFQGLLDSY SVRRSGLPNF 310 320 330 340 350 360 LAVALALGEL GYRAVGVRLD SGDLLQQAKE IRGIFRTVGA EFQMPWLEFV PIAVSNNIDE 370 380 390 400 410 420 KELARLAQKG SEVNVIGIGT NVVTCPKQPS MGCVYKLVSV GGQPRIKLTE ESQKETLPGS 430 440 450 460 470 480 KAAFRFLVSE GSLLLDLLQL AEEPPPKAGQ ELRVWLQGAQ EPCTVKPAQV EPLLRLYLQQ 490 500 510 520 530 GQPYEPLPSL EESRAFAQQS LSRLRPAHKQ LQNPAVYQVA LSEKLRALVD SLSARGAL

References

[1]	"Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltranferase family." Huang C.-H., Peng J., Chen Y. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY214330 mRNA. Translation: AAP69608.1.
IPI	IPI00421490.
RefSeq	NP_997492.1.
UniGene	Rn.22665
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6XQN1.
Proteomic databases
PRIDE	Q6XQN1.
Genome annotation databases
Ensembl	ENSRNOT00000010637; ENSRNOP00000010637; ENSRNOG00000007939; Rattus norvegicus. [Genome view]
GeneID	315085.
KEGG	rno:315085.
UCSC	NM_207609. rat.
Organism-specific databases
CTD	315085.
RGD	1302945. Naprt1.
Phylogenomic databases
HOVERGEN	Q6XQN1.
Enzyme and pathway databases
BRENDA	2.4.2.11. 248.
Gene expression databases
ArrayExpress	Q6XQN1.
Genevestigator	Q6XQN1.
Family and domain databases
InterPro	IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR006405. Nic_PRibTrfase_put. [Graphical view]
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
TIGRFAMs	TIGR01513. NAPRTase_put. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	668628.

Entry information

Entry name

PNCB_RAT

Accession

Primary (citable) accession number: Q6XQN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	October 13, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)