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Protein

Nicotinate phosphoribosyltransferase

Gene

Naprt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells (By similarity).By similarity
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. NAD biosynthetic process Source: RGD
  2. nicotinate nucleotide salvage Source: InterPro
  3. response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BRENDAi6.3.4.21. 5301.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Alternative name(s):
Nicotinate phosphoribosyltransferase domain-containing protein 1
Gene namesi
Name:Naprt
Synonyms:Naprt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1302945. Naprt1.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Nicotinate phosphoribosyltransferasePRO_0000315683Add
BLAST

Proteomic databases

PaxDbiQ6XQN1.
PRIDEiQ6XQN1.

Expressioni

Gene expression databases

GenevestigatoriQ6XQN1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010637.

Structurei

3D structure databases

ProteinModelPortaliQ6XQN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000001111.
HOVERGENiHBG062439.
InParanoidiQ6XQN1.
KOiK00763.
PhylomeDBiQ6XQN1.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6XQN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMELDDQGR MVVRPLLTDL YQATMGLGYW RAGRACEEAE FELFFRHCPF
60 70 80 90 100
GGSFALTAGL QDCIRFLRAF RLRDADVQFL ASVLPPDTDP AFFEHLRALD
110 120 130 140 150
CSRVSVRALP EGSLAFPGVP LLQVSGPLLL VQLLETPLLC LVSYASLVAT
160 170 180 190 200
NAARLRLIAG PDKRLLEMGL RRAQGPDGGF TASIYSYLGG FDSSSNTLAG
210 220 230 240 250
QLRGVPVAGT LAHSFITSFL GSEVPPDPML APASSEGPAV DLPASVNLWL
260 270 280 290 300
KHVCIYLGLE EREPHLGERA AFVAYALAFP RAFQGLLDSY SVRRSGLPNF
310 320 330 340 350
LAVALALGEL GYRAVGVRLD SGDLLQQAKE IRGIFRTVGA EFQMPWLEFV
360 370 380 390 400
PIAVSNNIDE KELARLAQKG SEVNVIGIGT NVVTCPKQPS MGCVYKLVSV
410 420 430 440 450
GGQPRIKLTE ESQKETLPGS KAAFRFLVSE GSLLLDLLQL AEEPPPKAGQ
460 470 480 490 500
ELRVWLQGAQ EPCTVKPAQV EPLLRLYLQQ GQPYEPLPSL EESRAFAQQS
510 520 530
LSRLRPAHKQ LQNPAVYQVA LSEKLRALVD SLSARGAL
Length:538
Mass (Da):58,565
Last modified:July 4, 2004 - v1
Checksum:i0C68EF4A2C44D3D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY214330 mRNA. Translation: AAP69608.1.
RefSeqiNP_997492.1. NM_207609.1.
UniGeneiRn.22665.

Genome annotation databases

GeneIDi315085.
KEGGirno:315085.
UCSCiRGD:1302945. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY214330 mRNA. Translation: AAP69608.1.
RefSeqiNP_997492.1. NM_207609.1.
UniGeneiRn.22665.

3D structure databases

ProteinModelPortaliQ6XQN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010637.

Proteomic databases

PaxDbiQ6XQN1.
PRIDEiQ6XQN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi315085.
KEGGirno:315085.
UCSCiRGD:1302945. rat.

Organism-specific databases

CTDi315085.
RGDi1302945. Naprt1.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000001111.
HOVERGENiHBG062439.
InParanoidiQ6XQN1.
KOiK00763.
PhylomeDBiQ6XQN1.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.
BRENDAi6.3.4.21. 5301.

Miscellaneous databases

NextBioi668628.

Gene expression databases

GenevestigatoriQ6XQN1.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
    Huang C.-H., Peng J., Chen Y.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPNCB_RAT
AccessioniPrimary (citable) accession number: Q6XQN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 14, 2008
Last sequence update: July 4, 2004
Last modified: March 31, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.