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Q6XQN1

- PNCB_RAT

UniProt

Q6XQN1 - PNCB_RAT

Protein

Nicotinate phosphoribosyltransferase

Gene

Naprt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells By similarity.By similarity
    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. NAD biosynthetic process Source: RGD
    2. nicotinate nucleotide salvage Source: InterPro
    3. response to oxidative stress Source: UniProtKB

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
    Short name:
    NAPRTase
    Alternative name(s):
    Nicotinate phosphoribosyltransferase domain-containing protein 1
    Gene namesi
    Name:Naprt
    Synonyms:Naprt1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1302945. Naprt1.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538Nicotinate phosphoribosyltransferasePRO_0000315683Add
    BLAST

    Proteomic databases

    PaxDbiQ6XQN1.
    PRIDEiQ6XQN1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6XQN1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000010637.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6XQN1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.Curated

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000001111.
    HOVERGENiHBG062439.
    InParanoidiQ6XQN1.
    KOiK00763.
    PhylomeDBiQ6XQN1.

    Family and domain databases

    InterProiIPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 2 hits.
    TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6XQN1-1 [UniParc]FASTAAdd to Basket

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    MEMELDDQGR MVVRPLLTDL YQATMGLGYW RAGRACEEAE FELFFRHCPF    50
    GGSFALTAGL QDCIRFLRAF RLRDADVQFL ASVLPPDTDP AFFEHLRALD 100
    CSRVSVRALP EGSLAFPGVP LLQVSGPLLL VQLLETPLLC LVSYASLVAT 150
    NAARLRLIAG PDKRLLEMGL RRAQGPDGGF TASIYSYLGG FDSSSNTLAG 200
    QLRGVPVAGT LAHSFITSFL GSEVPPDPML APASSEGPAV DLPASVNLWL 250
    KHVCIYLGLE EREPHLGERA AFVAYALAFP RAFQGLLDSY SVRRSGLPNF 300
    LAVALALGEL GYRAVGVRLD SGDLLQQAKE IRGIFRTVGA EFQMPWLEFV 350
    PIAVSNNIDE KELARLAQKG SEVNVIGIGT NVVTCPKQPS MGCVYKLVSV 400
    GGQPRIKLTE ESQKETLPGS KAAFRFLVSE GSLLLDLLQL AEEPPPKAGQ 450
    ELRVWLQGAQ EPCTVKPAQV EPLLRLYLQQ GQPYEPLPSL EESRAFAQQS 500
    LSRLRPAHKQ LQNPAVYQVA LSEKLRALVD SLSARGAL 538
    Length:538
    Mass (Da):58,565
    Last modified:July 5, 2004 - v1
    Checksum:i0C68EF4A2C44D3D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY214330 mRNA. Translation: AAP69608.1.
    RefSeqiNP_997492.1. NM_207609.1.
    UniGeneiRn.22665.

    Genome annotation databases

    GeneIDi315085.
    KEGGirno:315085.
    UCSCiRGD:1302945. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY214330 mRNA. Translation: AAP69608.1 .
    RefSeqi NP_997492.1. NM_207609.1.
    UniGenei Rn.22665.

    3D structure databases

    ProteinModelPortali Q6XQN1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000010637.

    Proteomic databases

    PaxDbi Q6XQN1.
    PRIDEi Q6XQN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 315085.
    KEGGi rno:315085.
    UCSCi RGD:1302945. rat.

    Organism-specific databases

    CTDi 223646.
    RGDi 1302945. Naprt1.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000001111.
    HOVERGENi HBG062439.
    InParanoidi Q6XQN1.
    KOi K00763.
    PhylomeDBi Q6XQN1.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .

    Miscellaneous databases

    NextBioi 668628.

    Gene expression databases

    Genevestigatori Q6XQN1.

    Family and domain databases

    InterProi IPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 2 hits.
    TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
      Huang C.-H., Peng J., Chen Y.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPNCB_RAT
    AccessioniPrimary (citable) accession number: Q6XQN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3