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Q6XQH0

- G3ST2_MOUSE

UniProt

Q6XQH0 - G3ST2_MOUSE

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Protein

Galactose-3-O-sulfotransferase 2

Gene

Gal3st2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency (By similarity).By similarity

Enzyme regulationi

Strongly inhibited by Cu2+ and Zn2+.By similarity

Pathwayi

GO - Molecular functioni

  1. galactosylceramide sulfotransferase activity Source: InterPro

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

UniPathwayiUPA00353.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-3-O-sulfotransferase 2 (EC:2.8.2.-)
Short name:
Gal3ST-2
Alternative name(s):
Beta-galactose-3-O-sulfotransferase 2
Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2
Gene namesi
Name:Gal3st2
Synonyms:Gm988
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2685834. Gal3st2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence Analysis
Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini30 – 394365LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Galactose-3-O-sulfotransferase 2PRO_0000085204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6XQH0.
PRIDEiQ6XQH0.

PTM databases

PhosphoSiteiQ6XQH0.

Expressioni

Gene expression databases

BgeeiQ6XQH0.
CleanExiMM_GAL3ST2.
GenevestigatoriQ6XQH0.

Structurei

3D structure databases

ProteinModelPortaliQ6XQH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26344.
GeneTreeiENSGT00390000013505.
HOGENOMiHOG000232148.
HOVERGENiHBG051681.
InParanoidiQ6XQH0.
KOiK09675.
OrthoDBiEOG7K0ZF1.
PhylomeDBiQ6XQH0.

Family and domain databases

InterProiIPR009729. Gal-3-0_sulfotransfrase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR14647. PTHR14647. 1 hit.
PfamiPF06990. Gal-3-0_sulfotr. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6XQH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWGSQHRSFQ VALWFLVLAV FLLVGFLHVD FRLLIPDKVQ EPPVTNIMFL
60 70 80 90 100
KTHKTASSTI LNILYRFSES HNLSTALPEG SRVHLGYPWF FVTRYVEGLK
110 120 130 140 150
QDAHLQHHFN IMCNHLRFNY PEVQKVMPRD TFYFSILRNP VFQLESSFIY
160 170 180 190 200
YKDYAPAFQR AKSLDEFLAD PWKYYNASVS LKNVYAKNNM WFDFGFDNNA
210 220 230 240 250
PADMDYVRKR LAEVEQRFHL VLIADYFDES MVLLRRRLRW QLDDVVSFKL
260 270 280 290 300
NVRSQSTVSH LTPESQERVQ HWCALDWQLY QHFNRTFWTQ LHAELSPRQL
310 320 330 340 350
TEEVEQLRER QRELMALCLQ DPEPKNLTHI DDQNLRPYQG GKANILGYNL
360 370 380 390
RHGLDTTTLH ICQRMAMPEL QHMAHMYSLQ FPDKTPKDIP FLKK
Length:394
Mass (Da):46,909
Last modified:July 5, 2004 - v1
Checksum:i20DB234D8A5ED6A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY216522 mRNA. Translation: AAP51032.1.
CCDSiCCDS56641.1.
RefSeqiNP_001192178.1. NM_001205249.1.
UniGeneiMm.417228.

Genome annotation databases

EnsembliENSMUST00000178757; ENSMUSP00000136012; ENSMUSG00000093805.
GeneIDi100041596.
KEGGimmu:100041596.
UCSCiuc029qsc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY216522 mRNA. Translation: AAP51032.1 .
CCDSi CCDS56641.1.
RefSeqi NP_001192178.1. NM_001205249.1.
UniGenei Mm.417228.

3D structure databases

ProteinModelPortali Q6XQH0.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6XQH0.

Proteomic databases

MaxQBi Q6XQH0.
PRIDEi Q6XQH0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000178757 ; ENSMUSP00000136012 ; ENSMUSG00000093805 .
GeneIDi 100041596.
KEGGi mmu:100041596.
UCSCi uc029qsc.1. mouse.

Organism-specific databases

MGIi MGI:2685834. Gal3st2.

Phylogenomic databases

eggNOGi NOG26344.
GeneTreei ENSGT00390000013505.
HOGENOMi HOG000232148.
HOVERGENi HBG051681.
InParanoidi Q6XQH0.
KOi K09675.
OrthoDBi EOG7K0ZF1.
PhylomeDBi Q6XQH0.

Enzyme and pathway databases

UniPathwayi UPA00353 .

Miscellaneous databases

NextBioi 401908.
PROi Q6XQH0.
SOURCEi Search...

Gene expression databases

Bgeei Q6XQH0.
CleanExi MM_GAL3ST2.
Genevestigatori Q6XQH0.

Family and domain databases

InterProi IPR009729. Gal-3-0_sulfotransfrase.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR14647. PTHR14647. 1 hit.
Pfami PF06990. Gal-3-0_sulfotr. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Seko A., Yamashita K.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Colon.

Entry informationi

Entry nameiG3ST2_MOUSE
AccessioniPrimary (citable) accession number: Q6XQH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3