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Protein

Galactose-3-O-sulfotransferase 2

Gene

Gal3st2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency (By similarity).By similarity

Enzyme regulationi

Strongly inhibited by Cu2+ and Zn2+.By similarity

Pathwayi: carbohydrate sulfation

This protein is involved in the pathway carbohydrate sulfation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway carbohydrate sulfation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • glycolipid biosynthetic process Source: InterPro
  • glycoprotein biosynthetic process Source: MGI
  • sulfation Source: MGI

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

UniPathwayiUPA00353.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-3-O-sulfotransferase 2 (EC:2.8.2.-)
Short name:
Gal3ST-2
Alternative name(s):
Beta-galactose-3-O-sulfotransferase 2
Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2
Gene namesi
Name:Gal3st2
Synonyms:Gm988
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2685834. Gal3st2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini30 – 394LumenalSequence analysisAdd BLAST365

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000852041 – 394Galactose-3-O-sulfotransferase 2Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi326N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6XQH0.
PaxDbiQ6XQH0.
PRIDEiQ6XQH0.

PTM databases

PhosphoSitePlusiQ6XQH0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000093805.
CleanExiMM_GAL3ST2.
ExpressionAtlasiQ6XQH0. baseline and differential.
GenevisibleiQ6XQH0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136012.

Structurei

3D structure databases

ProteinModelPortaliQ6XQH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG5S. Eukaryota.
ENOG4110RXY. LUCA.
GeneTreeiENSGT00390000013505.
HOGENOMiHOG000232148.
HOVERGENiHBG051681.
InParanoidiQ6XQH0.
KOiK09675.
PhylomeDBiQ6XQH0.

Family and domain databases

InterProiView protein in InterPro
IPR009729. Gal-3-0_sulfotransfrase.
IPR027417. P-loop_NTPase.
PANTHERiPTHR14647. PTHR14647. 1 hit.
PfamiView protein in Pfam
PF06990. Gal-3-0_sulfotr. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6XQH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGSQHRSFQ VALWFLVLAV FLLVGFLHVD FRLLIPDKVQ EPPVTNIMFL
60 70 80 90 100
KTHKTASSTI LNILYRFSES HNLSTALPEG SRVHLGYPWF FVTRYVEGLK
110 120 130 140 150
QDAHLQHHFN IMCNHLRFNY PEVQKVMPRD TFYFSILRNP VFQLESSFIY
160 170 180 190 200
YKDYAPAFQR AKSLDEFLAD PWKYYNASVS LKNVYAKNNM WFDFGFDNNA
210 220 230 240 250
PADMDYVRKR LAEVEQRFHL VLIADYFDES MVLLRRRLRW QLDDVVSFKL
260 270 280 290 300
NVRSQSTVSH LTPESQERVQ HWCALDWQLY QHFNRTFWTQ LHAELSPRQL
310 320 330 340 350
TEEVEQLRER QRELMALCLQ DPEPKNLTHI DDQNLRPYQG GKANILGYNL
360 370 380 390
RHGLDTTTLH ICQRMAMPEL QHMAHMYSLQ FPDKTPKDIP FLKK
Length:394
Mass (Da):46,909
Last modified:July 5, 2004 - v1
Checksum:i20DB234D8A5ED6A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY216522 mRNA. Translation: AAP51032.1.
CCDSiCCDS56641.1.
RefSeqiNP_001192178.1. NM_001205249.1.
UniGeneiMm.417228.

Genome annotation databases

EnsembliENSMUST00000178757; ENSMUSP00000136012; ENSMUSG00000093805.
GeneIDi100041596.
KEGGimmu:100041596.
UCSCiuc029qsc.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiG3ST2_MOUSE
AccessioniPrimary (citable) accession number: Q6XQH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families