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Q6XQH0 (G3ST2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galactose-3-O-sulfotransferase 2

Short name=Gal3ST-2
EC=2.8.2.-
Alternative name(s):
Beta-galactose-3-O-sulfotransferase 2
Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2
Gene names
Name:Gal3st2
Synonyms:Gm988
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency By similarity.

Enzyme regulation

Strongly inhibited by Cu2+ and Zn2+ By similarity.

Pathway

Protein modification; carbohydrate sulfation.

Subcellular location

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein Probable.

Sequence similarities

Belongs to the galactose-3-O-sulfotransferase family.

Ontologies

Keywords
   Cellular componentGolgi apparatus
Membrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionTransferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbiosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentGolgi cisterna membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiongalactosylceramide sulfotransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Galactose-3-O-sulfotransferase 2
PRO_0000085204

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 2921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain30 – 394365Lumenal Potential

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation2841N-linked (GlcNAc...) Potential
Glycosylation3261N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6XQH0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 20DB234D8A5ED6A9

FASTA39446,909
        10         20         30         40         50         60 
MWGSQHRSFQ VALWFLVLAV FLLVGFLHVD FRLLIPDKVQ EPPVTNIMFL KTHKTASSTI 

        70         80         90        100        110        120 
LNILYRFSES HNLSTALPEG SRVHLGYPWF FVTRYVEGLK QDAHLQHHFN IMCNHLRFNY 

       130        140        150        160        170        180 
PEVQKVMPRD TFYFSILRNP VFQLESSFIY YKDYAPAFQR AKSLDEFLAD PWKYYNASVS 

       190        200        210        220        230        240 
LKNVYAKNNM WFDFGFDNNA PADMDYVRKR LAEVEQRFHL VLIADYFDES MVLLRRRLRW 

       250        260        270        280        290        300 
QLDDVVSFKL NVRSQSTVSH LTPESQERVQ HWCALDWQLY QHFNRTFWTQ LHAELSPRQL 

       310        320        330        340        350        360 
TEEVEQLRER QRELMALCLQ DPEPKNLTHI DDQNLRPYQG GKANILGYNL RHGLDTTTLH 

       370        380        390 
ICQRMAMPEL QHMAHMYSLQ FPDKTPKDIP FLKK 

« Hide

References

[1]Seko A., Yamashita K.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
Tissue: Colon.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY216522 mRNA. Translation: AAP51032.1.
RefSeqNP_001192178.1. NM_001205249.1.
UniGeneMm.417228.

3D structure databases

ProteinModelPortalQ6XQH0.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6XQH0.

Proteomic databases

PRIDEQ6XQH0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000178757; ENSMUSP00000136012; ENSMUSG00000093805.
GeneID100041596.
KEGGmmu:100041596.
UCSCuc029qsc.1. mouse.

Organism-specific databases

MGIMGI:2685834. Gal3st2.

Phylogenomic databases

eggNOGNOG26344.
GeneTreeENSGT00390000013505.
HOGENOMHOG000232148.
HOVERGENHBG051681.
InParanoidQ6XQH0.
KOK09675.
OrthoDBEOG7K0ZF1.
PhylomeDBQ6XQH0.

Enzyme and pathway databases

UniPathwayUPA00353.

Gene expression databases

BgeeQ6XQH0.
CleanExMM_GAL3ST2.
GenevestigatorQ6XQH0.

Family and domain databases

InterProIPR009729. Gal-3-0_sulfotransfrase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR14647. PTHR14647. 1 hit.
PfamPF06990. Gal-3-0_sulfotr. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

NextBio401908.
PROQ6XQH0.
SOURCESearch...

Entry information

Entry nameG3ST2_MOUSE
AccessionPrimary (citable) accession number: Q6XQH0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot