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Q6XQH0

- G3ST2_MOUSE

UniProt

Q6XQH0 - G3ST2_MOUSE

Protein

Galactose-3-O-sulfotransferase 2

Gene

Gal3st2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency By similarity.By similarity

    Enzyme regulationi

    Strongly inhibited by Cu2+ and Zn2+.By similarity

    Pathwayi

    GO - Molecular functioni

    1. galactosylceramide sulfotransferase activity Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00353.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galactose-3-O-sulfotransferase 2 (EC:2.8.2.-)
    Short name:
    Gal3ST-2
    Alternative name(s):
    Beta-galactose-3-O-sulfotransferase 2
    Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2
    Gene namesi
    Name:Gal3st2
    Synonyms:Gm988
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2685834. Gal3st2.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi cisterna membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Galactose-3-O-sulfotransferase 2PRO_0000085204Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ6XQH0.
    PRIDEiQ6XQH0.

    PTM databases

    PhosphoSiteiQ6XQH0.

    Expressioni

    Gene expression databases

    BgeeiQ6XQH0.
    CleanExiMM_GAL3ST2.
    GenevestigatoriQ6XQH0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6XQH0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini30 – 394365LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26344.
    GeneTreeiENSGT00390000013505.
    HOGENOMiHOG000232148.
    HOVERGENiHBG051681.
    InParanoidiQ6XQH0.
    KOiK09675.
    OrthoDBiEOG7K0ZF1.
    PhylomeDBiQ6XQH0.

    Family and domain databases

    InterProiIPR009729. Gal-3-0_sulfotransfrase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR14647. PTHR14647. 1 hit.
    PfamiPF06990. Gal-3-0_sulfotr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6XQH0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWGSQHRSFQ VALWFLVLAV FLLVGFLHVD FRLLIPDKVQ EPPVTNIMFL    50
    KTHKTASSTI LNILYRFSES HNLSTALPEG SRVHLGYPWF FVTRYVEGLK 100
    QDAHLQHHFN IMCNHLRFNY PEVQKVMPRD TFYFSILRNP VFQLESSFIY 150
    YKDYAPAFQR AKSLDEFLAD PWKYYNASVS LKNVYAKNNM WFDFGFDNNA 200
    PADMDYVRKR LAEVEQRFHL VLIADYFDES MVLLRRRLRW QLDDVVSFKL 250
    NVRSQSTVSH LTPESQERVQ HWCALDWQLY QHFNRTFWTQ LHAELSPRQL 300
    TEEVEQLRER QRELMALCLQ DPEPKNLTHI DDQNLRPYQG GKANILGYNL 350
    RHGLDTTTLH ICQRMAMPEL QHMAHMYSLQ FPDKTPKDIP FLKK 394
    Length:394
    Mass (Da):46,909
    Last modified:July 5, 2004 - v1
    Checksum:i20DB234D8A5ED6A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY216522 mRNA. Translation: AAP51032.1.
    CCDSiCCDS56641.1.
    RefSeqiNP_001192178.1. NM_001205249.1.
    UniGeneiMm.417228.

    Genome annotation databases

    EnsembliENSMUST00000178757; ENSMUSP00000136012; ENSMUSG00000093805.
    GeneIDi100041596.
    KEGGimmu:100041596.
    UCSCiuc029qsc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY216522 mRNA. Translation: AAP51032.1 .
    CCDSi CCDS56641.1.
    RefSeqi NP_001192178.1. NM_001205249.1.
    UniGenei Mm.417228.

    3D structure databases

    ProteinModelPortali Q6XQH0.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6XQH0.

    Proteomic databases

    MaxQBi Q6XQH0.
    PRIDEi Q6XQH0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000178757 ; ENSMUSP00000136012 ; ENSMUSG00000093805 .
    GeneIDi 100041596.
    KEGGi mmu:100041596.
    UCSCi uc029qsc.1. mouse.

    Organism-specific databases

    MGIi MGI:2685834. Gal3st2.

    Phylogenomic databases

    eggNOGi NOG26344.
    GeneTreei ENSGT00390000013505.
    HOGENOMi HOG000232148.
    HOVERGENi HBG051681.
    InParanoidi Q6XQH0.
    KOi K09675.
    OrthoDBi EOG7K0ZF1.
    PhylomeDBi Q6XQH0.

    Enzyme and pathway databases

    UniPathwayi UPA00353 .

    Miscellaneous databases

    NextBioi 401908.
    PROi Q6XQH0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6XQH0.
    CleanExi MM_GAL3ST2.
    Genevestigatori Q6XQH0.

    Family and domain databases

    InterProi IPR009729. Gal-3-0_sulfotransfrase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR14647. PTHR14647. 1 hit.
    Pfami PF06990. Gal-3-0_sulfotr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Seko A., Yamashita K.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Colon.

    Entry informationi

    Entry nameiG3ST2_MOUSE
    AccessioniPrimary (citable) accession number: Q6XQH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3