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Q6XQG8

- CHST7_RAT

UniProt

Q6XQG8 - CHST7_RAT

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Protein
Carbohydrate sulfotransferase 7
Gene
Chst7
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc By similarity.

Catalytic activityi

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi109 – 1157PAPS By similarity
Nucleotide bindingi277 – 2859PAPS By similarity

GO - Molecular functioni

  1. N-acetylglucosamine 6-O-sulfotransferase activity Source: Ensembl
  2. chondroitin 6-sulfotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: Ensembl
  2. carbohydrate metabolic process Source: UniProtKB-KW
  3. chondroitin sulfate biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

ReactomeiREACT_198797. Chondroitin sulfate biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate sulfotransferase 7 (EC:2.8.2.-, EC:2.8.2.17)
Alternative name(s):
Chondroitin 6-sulfotransferase 2
Short name:
C6ST-2
Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5
Short name:
GST-5
N-acetylglucosamine 6-O-sulfotransferase 4
Short name:
GlcNAc6ST-4
Short name:
Gn6st-4
Gene namesi
Name:Chst7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi1303028. Chst7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei13 – 3321Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini34 – 485452Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Carbohydrate sulfotransferase 7
PRO_0000085200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi88 – 881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6XQG8.

Expressioni

Gene expression databases

GenevestigatoriQ6XQG8.

Structurei

3D structure databases

ProteinModelPortaliQ6XQG8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71363.
GeneTreeiENSGT00530000062902.
HOGENOMiHOG000261614.
HOVERGENiHBG050949.
InParanoidiQ6XQG8.
KOiK04743.
OMAiDKGAGHC.
OrthoDBiEOG7RZ5S0.
PhylomeDBiQ6XQG8.
TreeFamiTF342871.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.

Sequencei

Sequence statusi: Complete.

Q6XQG8-1 [UniParc]FASTAAdd to Basket

« Hide

MKGRRRRRRE YCKFTLLLAL YTLLLLLVPS VLDSGSEQDK GGRDCPGLQR    50
SLGVWSLEAA AAGEREQGAE VRFQAEGNPD RSPRPQGNLS AIRESVTQEK 100
QHIYVHATWR TGSSFLGELF NQHPDVFYLY EPMWHLWQAL YPGNAESLQG 150
ALRDMLRSLF RCDFSVLRLY AQPGDPAERA PDSANLTTAM LFRWRTNKVI 200
CSPPLCPAAP RARADVGLVE DKACESTCPP VPLRALEAEC RKYPVVVIKD 250
VRLLDLGVLV PLLRDPGLNL KVVQLFRDPR AVHNSRLKSR HGLLRESIQV 300
LRTRQRGDRF QRVLLAHGVG ARPGGQSRAL PSAPRADFFL TSALEVICEA 350
WLRDLLFTRG APTWLRRRYL RLRYEDLVWQ PQVQLRRLLR FSGLRTLAAL 400
DAFAFNMTRG SAYGADRPFH LSARDAREAV HAWRERLSQE QVRQVEAACD 450
PAMRLLAYPR SGDERDVKTV RKGETPLETN ANWAT 485
Length:485
Mass (Da):55,091
Last modified:July 5, 2004 - v1
Checksum:iC9A9C8F961478693
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY216524 mRNA. Translation: AAP51034.1.
BC111079 mRNA. Translation: AAI11080.1.
RefSeqiNP_997483.1. NM_207600.2.
UniGeneiRn.153551.

Genome annotation databases

EnsembliENSRNOT00000005630; ENSRNOP00000005630; ENSRNOG00000004258.
GeneIDi302302.
KEGGirno:302302.
UCSCiRGD:1303028. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY216524 mRNA. Translation: AAP51034.1 .
BC111079 mRNA. Translation: AAI11080.1 .
RefSeqi NP_997483.1. NM_207600.2.
UniGenei Rn.153551.

3D structure databases

ProteinModelPortali Q6XQG8.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6XQG8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005630 ; ENSRNOP00000005630 ; ENSRNOG00000004258 .
GeneIDi 302302.
KEGGi rno:302302.
UCSCi RGD:1303028. rat.

Organism-specific databases

CTDi 56548.
RGDi 1303028. Chst7.

Phylogenomic databases

eggNOGi NOG71363.
GeneTreei ENSGT00530000062902.
HOGENOMi HOG000261614.
HOVERGENi HBG050949.
InParanoidi Q6XQG8.
KOi K04743.
OMAi DKGAGHC.
OrthoDBi EOG7RZ5S0.
PhylomeDBi Q6XQG8.
TreeFami TF342871.

Enzyme and pathway databases

Reactomei REACT_198797. Chondroitin sulfate biosynthesis.

Miscellaneous databases

NextBioi 649413.
PROi Q6XQG8.

Gene expression databases

Genevestigatori Q6XQG8.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMi SSF52540. SSF52540. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Seko A., Yamashita K.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiCHST7_RAT
AccessioniPrimary (citable) accession number: Q6XQG8
Secondary accession number(s): Q2TA65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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