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Q6XQG8

- CHST7_RAT

UniProt

Q6XQG8 - CHST7_RAT

Protein

Carbohydrate sulfotransferase 7

Gene

Chst7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc By similarity.By similarity

    Catalytic activityi

    3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi109 – 1157PAPSBy similarity
    Nucleotide bindingi277 – 2859PAPSBy similarity

    GO - Molecular functioni

    1. chondroitin 6-sulfotransferase activity Source: UniProtKB-EC
    2. N-acetylglucosamine 6-O-sulfotransferase activity Source: Ensembl

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB-KW
    2. chondroitin sulfate biosynthetic process Source: Ensembl
    3. N-acetylglucosamine metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Enzyme and pathway databases

    ReactomeiREACT_198797. Chondroitin sulfate biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbohydrate sulfotransferase 7 (EC:2.8.2.-, EC:2.8.2.17)
    Alternative name(s):
    Chondroitin 6-sulfotransferase 2
    Short name:
    C6ST-2
    Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5
    Short name:
    GST-5
    N-acetylglucosamine 6-O-sulfotransferase 4
    Short name:
    GlcNAc6ST-4
    Short name:
    Gn6st-4
    Gene namesi
    Name:Chst7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi1303028. Chst7.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485Carbohydrate sulfotransferase 7PRO_0000085200Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ6XQG8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6XQG8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6XQG8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini34 – 485452LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71363.
    GeneTreeiENSGT00530000062902.
    HOGENOMiHOG000261614.
    HOVERGENiHBG050949.
    InParanoidiQ6XQG8.
    KOiK04743.
    OMAiDKGAGHC.
    OrthoDBiEOG7RZ5S0.
    PhylomeDBiQ6XQG8.
    TreeFamiTF342871.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR016469. Carbohydrate_sulfotransferase.
    IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view]
    PfamiPF00685. Sulfotransfer_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
    SUPFAMiSSF52540. SSF52540. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q6XQG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGRRRRRRE YCKFTLLLAL YTLLLLLVPS VLDSGSEQDK GGRDCPGLQR    50
    SLGVWSLEAA AAGEREQGAE VRFQAEGNPD RSPRPQGNLS AIRESVTQEK 100
    QHIYVHATWR TGSSFLGELF NQHPDVFYLY EPMWHLWQAL YPGNAESLQG 150
    ALRDMLRSLF RCDFSVLRLY AQPGDPAERA PDSANLTTAM LFRWRTNKVI 200
    CSPPLCPAAP RARADVGLVE DKACESTCPP VPLRALEAEC RKYPVVVIKD 250
    VRLLDLGVLV PLLRDPGLNL KVVQLFRDPR AVHNSRLKSR HGLLRESIQV 300
    LRTRQRGDRF QRVLLAHGVG ARPGGQSRAL PSAPRADFFL TSALEVICEA 350
    WLRDLLFTRG APTWLRRRYL RLRYEDLVWQ PQVQLRRLLR FSGLRTLAAL 400
    DAFAFNMTRG SAYGADRPFH LSARDAREAV HAWRERLSQE QVRQVEAACD 450
    PAMRLLAYPR SGDERDVKTV RKGETPLETN ANWAT 485
    Length:485
    Mass (Da):55,091
    Last modified:July 5, 2004 - v1
    Checksum:iC9A9C8F961478693
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY216524 mRNA. Translation: AAP51034.1.
    BC111079 mRNA. Translation: AAI11080.1.
    RefSeqiNP_997483.1. NM_207600.2.
    UniGeneiRn.153551.

    Genome annotation databases

    EnsembliENSRNOT00000005630; ENSRNOP00000005630; ENSRNOG00000004258.
    GeneIDi302302.
    KEGGirno:302302.
    UCSCiRGD:1303028. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY216524 mRNA. Translation: AAP51034.1 .
    BC111079 mRNA. Translation: AAI11080.1 .
    RefSeqi NP_997483.1. NM_207600.2.
    UniGenei Rn.153551.

    3D structure databases

    ProteinModelPortali Q6XQG8.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6XQG8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005630 ; ENSRNOP00000005630 ; ENSRNOG00000004258 .
    GeneIDi 302302.
    KEGGi rno:302302.
    UCSCi RGD:1303028. rat.

    Organism-specific databases

    CTDi 56548.
    RGDi 1303028. Chst7.

    Phylogenomic databases

    eggNOGi NOG71363.
    GeneTreei ENSGT00530000062902.
    HOGENOMi HOG000261614.
    HOVERGENi HBG050949.
    InParanoidi Q6XQG8.
    KOi K04743.
    OMAi DKGAGHC.
    OrthoDBi EOG7RZ5S0.
    PhylomeDBi Q6XQG8.
    TreeFami TF342871.

    Enzyme and pathway databases

    Reactomei REACT_198797. Chondroitin sulfate biosynthesis.

    Miscellaneous databases

    NextBioi 649413.
    PROi Q6XQG8.

    Gene expression databases

    Genevestigatori Q6XQG8.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR016469. Carbohydrate_sulfotransferase.
    IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view ]
    Pfami PF00685. Sulfotransfer_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
    SUPFAMi SSF52540. SSF52540. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. Seko A., Yamashita K.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.

    Entry informationi

    Entry nameiCHST7_RAT
    AccessioniPrimary (citable) accession number: Q6XQG8
    Secondary accession number(s): Q2TA65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3